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| 1 | 卒中或短暂性脑缺血发作患者的卒中预防指南 美国心脏协会/美国卒中协会为医疗卫生专业人员制定的指南显示文摘本指南旨在为缺血性卒中或短暂性脑缺血发作存活患者的卒中预防提供全面和及时的循证推荐,包括危险因素的控制、动脉粥样硬化性疾病的于预、心源性栓塞的抗栓治疗以及非心源性栓塞性卒中的抗血小板治疗。另外,还对其他许多特殊情况下的复发性卒中预防提供了推荐意见,包括动脉夹层分离、卯圆孔未闭、高同型半胱氨酸血症、高凝状态、镰状细胞病、脑静脉窦血栓形成、女性卒中(尤其是与妊娠和绝经后雌激素替代治疗相关性卒中)、脑出血后抗凝药的使用等,以及实施本指南及其在高危人群中应用的特定方法。 | Karen L. Furie Scott E. Kasner Robert J. Adams Gregory W. Albers Ruth L. Bush Susan C. Fagan Jonathan L. Halperin S. Claiborne Johnston Irene Katzan Walter N. Kernan Pamela H. Mitchell Bruce Ovbiagele Yuko Y. Palesch Ralph L. Sacco Lee H. Schwamm Sylvia Wassertheil-Smoller Tanya N. Turan Deidre Wentworth 李海峰(译) 刘涛(译) 杨潘(译) 王鹏(译) | 2011 | 国际脑血管病杂志2011，19，1： | 391 |
| 2 | Guidelines for the Prevention of Stroke in Patients With Stroke or Transient Ischemic Attack: A Guideline for Healthcare Professionals From the American Heart Association/American Stroke Association显示文摘 | Karen L. Furie Scott E. Kasner Robert J. Adams Gregory W. Albers Ruth L. Bush Susan C. Fagan Jonathan L. Halperin S. Claiborne Johnston Irene Katzan Walter N. Kernan Pamela H. Mitchell Bruce Ovbiagele Yuko Y. Palesch Ralph L. Sacco Lee H. Schwamm Sylvia W | 2011 | Stroke2011，，1： | 8 |
| 3 | Patterns of in-hospital mortality and bleeding complications following PCI for very elderly patients: insights from the Dartmouth Dynamic Registry显示文摘BackgroundVery 老病人(年龄 85 年) 是人口的一个很快增加的片断。作为一个组,他们经历跟随经皮的冠的干预(一种总线标准) 的在里面医院死亡和流血复杂并发症的高率。然而,在流血和死亡在之间的关系老 unknown.MethodsRetrospective 评论在 Dartmouth-Hitchcock 从 2000 ~ 2015 在 17,378 连续一种总线标准过程上被执行医学中心。在索引一种总线标准承认期间流血的发生(流血要求的输送,存取地点 hematoma > 5 厘米, pseudoaneurysm,和 retroperitoneal 流血)? 并且在里面医院死亡为四个年龄组被报导(< 65 年, 65-74 年, 75-84 年,和 85 年) 。承受了谁的流血复杂并发症和那些的病人的死亡被计算, multivariate 分析为在里面医院被执行死亡。最后,知道流血的预言者在病人年龄之间被比较 < 85 年和年龄 17,378 个病人学习了的 85 years.ResultsOf,(5.9%) 1019 经历了流血,(2.1%) 369 死了在里面医院追随者一种总线标准。流血和在里面医院死亡的发生与增加年龄 monotonically 增加了(死亡:0.94% , 2.27% , 4.24% 和 4.58% ;流血:3.96% , 6.62% , 10.68% 和 13.99% 好久 < 65, 65-74, 75-84 和 85 年,分别地) 。除了病人年龄 85 年,在 multivariate 分析上,流血为所有年龄组与增加的死亡被联系[机会比率(95% CI ) :变老 < 65 年, 3.65 (1.99-6.74 ) ;年龄 65-74 年, 2.83 (1.62-4.94 ) ;年龄 75-84 年, 3.86 (2.56-5.82 ) ,年龄 85 年:1.39 (0.49-3.95 )] 有增加的 .ConclusionsBleeding 和死亡追随者一种总线标准增加变老。为老尽管有流血的高率,流血在里面医院死亡追随者一种总线标准不再是预兆的。 | Shawn X Li Hannah I Chaudry Jiyong Lee Theodore B Curran Vishesh Kumar Kendrew K Wong Bruce W Andrus James T DeVries | 2018 | Journal of Geriatric Cardiology2018，15，2： | 6 |
| 4 | Impaired granulocyte-macrophage colony-stimulating factor bioactivity accelerates surgical recurrence in ileal crohn's disease显示文摘AIM To examine the relationship between elevated granulocyte-macrophage colony-stimulating factor(GMCSF) auto-antibodies(Ab) level and time to surgical recurrence after initial surgery for Crohn's disease(CD). METHODS We reviewed 412 charts from a clinical database at tertiary academic hospital. Patients included in the study had ileal or ileocolonic CD and surgical resection of small bowel or ileocecal region for management of disease. Serum samples were analyzed for serological assays including GM-CSF cytokine, GM-CSF Ab, ASCA Ig G and Ig A, and genetic markers including SNPs rs2066843, rs2066844, rs2066845, rs2076756 and rs2066847 in NOD2, rs2241880 in ATG16 L1, and rs13361189 in IRGM. Cox proportional-hazards models were used to assess the predictors of surgical recurrence.RESULTS Ninety six percent of patients underwent initial ileocecal resection(ICR) or ileal resection(IR) and subsequently 40% of patients required a second ICR/IR for CD. GMCSF Ab level was elevated at a median of 3.81 mcg/mL. Factors predicting faster time to a second surgery included elevated GM-CSF Ab [hazard ratio(HR) 3.52, 95%CI: 1.45-8.53, P = 0.005] and elevated GM-CSF cytokine(HR = 2.48, 95%CI: 1.31-4.70, P = 0.005). Factors predicting longer duration between first and second surgery included use of Immunomodulators(HR = 0.49, 95%CI: 0.31-0.77, P = 0.002), the interaction effect of low GM-CSF Ab levels and smoking(HR = 0.60, 95%CI: 0.45-0.81, P = 0.001) and the interaction effect of low GM-CSF cytokine levels and ATG16 L1(HR = 0.65, 95%CI: 0.49-0.88, P = 0.006).CONCLUSION GM-CSF bioavailability plays a critical role in maintaining intestinal homeostasis. Decreased bioavailability coupled with the genetic risk markers and/or smoking results in aggressive CD behavior. | Grace Gathungu Yuanhao Zhang Xinyu Tian Erin Bonkowski Leahana Rowehl Julia Krumsiek Billy Nix Claudia Chalk Bruce Trapnell Wei Zhu Rodney Newberry Lee Denson Ellen Li | 2018 | World Journal of Gastroenterology2018，24，5： | 5 |
| 5 | 阅读训练对儿童早期字词意识发展的作用显示文摘该研究探讨了幼儿园中、大班及小学一、二年级儿童在完成字 /词意识任务上的年龄差异以及阅读训练对字 /词意识发展的影响。实验结果表明 :(1) 5岁儿童的字词意识尚处于不断的发展之中。 6岁及 7岁儿童的字意识发展已经达到了成熟水平 ;但他们的词意识正处于不断的发展之中。 (2 )初级的阅读训练促进了5岁儿童字意识的发展 ,但对词意识的发展没有影响。 (3)小学语文教学对 6岁儿童的口头任务没有影响 ,但显著地促进了圈词任务成绩的提高。 | 徐芬 Bruce Homer Kang Lee | 2002 | 心理科学2002，25，6： | 5 |
| 6 | Long‐term entecavir therapy results in the reversal of fibrosis/cirrhosis and continued histological improvement in patients with chronic hepatitis B显示文摘 | Ting‐Tsung Chang Yun‐Fan Liaw Shun‐Sheng Wu Eugene Schiff Kwang‐Hyub Han Ching‐Lung Lai Rifaat Safadi Samuel S. Lee Waldemar Halota Zachary Goodman Yun‐Chan Chi Hui Zhang Robert Hindes Uchenna Iloeje Suzanne Beebe Bruce Kreter | 2010 | Hepatology2010，，： | 4 |
| 7 | Polydopamine and collagen coated micro-grated polydimethylsiloxane for human mesenchymal stem cell culture显示文摘Natural tissues contain highly organized cellular architecture.One of the major challenges in tissue engineering is to develop engineered tissue constructs that promote cellular growth in physiological directionality.To address this issue,micro-patterned polydimethylsiloxane(PDMS)substrates have been widely used in cell sheet engineering due to their low microfabrication cost,higher stability,excellent biocompatibility,and most importantly,ability to guide cellular growth and patterning.However,the current methods for PDMS surface modification either require a complicated procedure or generate a non-uniform surface coating,leading to the production of poor-quality cell layers.A simple and efficient surface coating method is critically needed to improve the uniformity and quality of the generated cell layers.Herein,a fast,simple and inexpensive surface coating method was analyzed for its ability to uniformly coat polydopamine(PD)with or without collagen on micro-grated PDMS substrates without altering essential surface topographical features.Topographical feature,stiffness and cytotoxicity of these PD and/or collagen based surface coatings were further analyzed.Results showed that the PD-based coating method facilitated aligned and uniform cell growth,therefore holds great promise for cell sheet engineering as well as completely biological tissue biomanufacturing. | Dhavan Sharma Wenkai Jia Fei Long Shweta Pati Qinghui Chen Yibing Qyang Bruce Lee Chang Kyong Choi Feng Zhao | 2019 | Bioactive Materials2019，4，1： | 4 |
| 8 | Tenecteplase Reperfusion therapy in Acute ischaemic Cerebrovascular Events-Ⅱ (TRACE Ⅱ): rationale and design显示文摘Background and purpose Tenecteplase(TNK)is a promising agent for treatment of acute ischaemic stroke(AIS).We hypothesised that recombinant human TNK tissue-type plasminogen activator(rhTNK-tPA)is non-inferior to rt-PA in achieving excellent functional outcome at 90 days,when administered within 4.5 hours of ischaemic stroke onset.Methods and design Tenecteplase Reperfusion therapy in Acute ischemic Cerebrovascular Events(TRACE)is a phase Ⅲ,multicentre,prospective,randomised,open-label,blinded-end point non-inferiority study.Patients eligible for intravenous thrombolysis therapy are randomised to rhTNK-tPA 0.25 mg/kg(single bolus)to a maximum of 25 mg or rt-PA 0.9 mg/kg(10%bolus+90%infusion/1 hour)to a maximum of 90 mg.Medications considered necessary for the patient’s health may be given at the discretion of the investigator during 90-day follow-up.Study outcomes The primary study outcome is excellent functional outcome defined as modified Rankin Scale(mRS)0–1 at 90 days.Secondary efficacy outcomes include favourable functional outcome defined as mRS≤2 at 90 days,ordinal distribution of mRS and major neurological improvement on the National Institutes of Health Stroke Scale.Safety outcomes are symptomatic intracranial haemorrhage within 36 hours and death from any cause.Discussion There is no completed registration study of TNK in AIS worldwide.TRACE Ⅱ strives to provide evidence for a new drug application for rhTNK-tPA in AIS within 4.5 hours through a well-designed and rigorously executed randomised trial in China. | Shuya Li Bruce C V Campbell Lee H Schwamm Marc Fisher Mark Parsons Hao Li Yuesong Pan Yongjun Wang | 2022 | Stroke & Vascular Neurology2022，7，1： | 2 |
| 9 | Collateral Flow Predicts Response to Endovascular Therapy for Acute Ischemic Stroke显示文摘 | Oh Young Bang Jeffrey L. Saver Suk Jae Kim Gyeong-Moon Kim Chin-Sang Chung Bruce Ovbiagele Kwang Ho Lee David S. Liebeskind | 2011 | Stroke2011，，3： | 2 |
| 10 | Renal Hemodynamic Effect of Sodium-Glucose Cotransporter 2 Inhibition in Patients With Type 1 Diabetes Mellitus显示文摘 | David Z.I. Cherney Bruce A. Perkins Nima Soleymanlou Maria Maione Vesta Lai Alana Lee Nora M. Fagan Hans J. Woerle Odd Erik Johansen Uli C. Broedl Maximilian von Eynatten | 2014 | Circulation2014，，： | 2 |
| 11 | Guidelines for the Prevention of Stroke in Patients With Stroke or Transient Ischemic Attack: A Guideline for Healthcare Professionals From the American Heart Association/American Stroke Association显示文摘 | Karen L. Furie Scott E. Kasner Robert J. Adams Gregory W. Albers Ruth L. Bush Susan C. Fagan Jonathan L. Halperin S. Claiborne Johnston Irene Katzan Walter N. Kernan Pamela H. Mitchell Bruce Ovbiagele Yuko Y. Palesch Ralph L. Sacco Lee H. Schwamm Sylvia W | 2011 | Stroke2011，，1： | 2 |
| 12 | Features of promising technologies for pretreatment of lignocellulosic biomass显示文摘 | Nathan Mosier Charles Wyman Bruce Dale Richard Elander Y.Y. Lee Mark Holtzapple Michael Ladisch | 2004 | Bioresource Technology2004，，： | 1 |
| 13 | A possible linkage between AMP‐activated protein kinase (AMPK) and mammalian target of rapamycin (mTOR) signalling pathway显示文摘 | NaokiKimura ChiharuTokunaga SushilaDalal ChristineRichardson Ken‐ichiYoshino KentaHara Bruce E.Kemp Lee A.Witters OsamuMimura KazuyoshiYonezawa | 2003 | Genes to Cells2003，，1： | 1 |
| 14 | 一个采用模型预测控制算法和可变进餐估计的闭环人工胰腺[J]显示文摘 | Hyunjin Lee Bruce A Buckingham Darrell MW and Bequette BW | 2009 | 糖尿病科技杂志2009，3，5： | 1 |
| 15 | Scanning probe microscopy显示文摘 | Richard J Colton^* David R Baselt Yves F Dufrkne John -Bruce D Greenand Gil U Lee | 1997 | Chemical Biology1997，1，： | 1 |
| 16 | Production and regeneration of Lactobacillus casei protoplasts显示文摘 | Lyang Ja Lee Wicknep Bruce M Chassy | 1984 | Appl Environ Microbiol1984，48，： | 1 |
| 17 | RFM and LV: Using Iso-value Curves for Customer Base Analysis 显示文摘 | Fader Peter S Bruce G S Hardie and Ka Lok Lee | 2005 | Journal of Marketing Research2005，42，5： | 1 |
| 18 | Leakage and Comparative Advan- tage Implications of Agricultural Participation in Greenhouse Gas Emission Mitigation 显示文摘 | Heng-Chi Lee Bruce McCarl | 2007 | Mitigation and Adaptation Strategies for Global Change2007，，12： | 1 |
| 19 | Islet cell tumor arising from a heterotopic pancreas in the duodenal wall with ulceration显示文摘 | Lucilene F Tolentino Hanson Lee Tony Maung Bruce E Stabile Kewang Li Samuel W French | 2003 | Experimental and Molecular Pathology2003，，1： | 1 |
| 20 | Design, analysis and simulation for development of the first clinical micro-CT scanner 1显示文摘 | Ge Wang Shiying Zhao Hengyong Yu Charles A. Miller Paul J. Abbas Bruce J. Gantz Seung Wook Lee Jay T. Rubinstein | 2005 | Academic Radiology2005，，4： | 1 |
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