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| 1 | Preservation solutions used during abdominal transplantation:Current status and outcomes显示文摘Organ preservation remains an important contributing factor to graft and patient outcomes. During donor organ procurement and transportation, cellular injury is mitigated through the use of preservation solutions in conjunction with hypothermia. Various preservation solutions and protocols exist with widespread variability among transplant centers. In this review of abdominal organ preservation solutions, evolution of transplantation and graft preservation are discussed followed by classification of preservation solutions according to the composition of electrolytes, impermeants, buffers, antioxidants, and energy precursors. Lastly, pertinent clinical studies in the setting of hepatic, renal, pancreas, and intestinal transplantation are reviewed for patient and graft survival as well as financial considerations. In liver transplants there may be some benefit with the use of histidine-tryptophan-ketoglutarate(HTK) over University of Wisconsin solution in terms of biliary complications and potential cost savings. Renal grafts may experience increased initial graft dysfunction with the use of Euro-Collins thereby dissuading its use in support of HTK which can lead to substantial cost savings. University of Wisconsin solution and Celsior are favored in pancreas transplants given the concern for pancreatitis and graft thrombosis associated with HTK. No difference was observed with preservation solutions with respect to graft and patient survival in liver, renal, and pancreas transplants. Studies involving intestinal transplants are sparse but University of Wisconsin solution infused intraluminally in combination with an intra-vascular washout is a reasonable option until further evidence can be generated. Available literature can be used to ameliorate extensive variation across centers while potentially minimizing graft dysfunction and improving associated costs. | Nicholas Latchana Joshua R Peck Bryan A Whitson Mitchell L Henry Elmahdi A Elkhammas Sylvester M Black | 2015 | World Journal of Transplantation2015，5，4： | 5 |
| 2 | Gastric intestinal metaplasia is associated with gastric dysplasia but is inversely correlated with esophageal dysplasia显示文摘AIM To determine which clinical factors might be associated with gastric intestinal metaplasia(IM) in a North American population.METHODS Pathology and endoscopy databases at an academicmedical center were reviewed to identify patients with and without gastric IM on biopsies for a retrospective cohort study. Patient demographics, insurance status, and other clinical factors were reviewed.RESULTS Four hundred and sixty-eight patients with gastric IM(mean age: 61.0 years ± 14.4 years, 55.5% female) and 171 without gastric IM(mean age: 48.8 years ± 20.8 years, 55.0% female) were compared. The endoscopic appearance of atrophic gastritis correlated with finding gastric IM on histopathology(OR = 2.05, P = 0.051). Gastric IM was associated with histologic findings of chronic gastritis(OR = 2.56, P < 0.001), gastric ulcer(OR = 6.97, P = 0.015), gastric dysplasia(OR = 6.11, P = 0.038), and gastric cancer(OR = 6.53, P = 0.027). Histologic findings of Barrett's esophagus(OR = 0.28, P = 0.003) and esophageal dysplasia(OR = 0.11, P = 0.014) were inversely associated with gastric IM. Tobacco use(OR = 1.73, P = 0.005) was associated with gastric IM.CONCLUSION Patients who smoke or have the endoscopic finding of atrophic gastritis are more likely to have gastric IM and should have screening gastric biopsies during esophagogastroduodenoscopy(EGD). Patients with gastric IM are at increased risk for having gastric dysplasia and cancer, and surveillance EGD with gastric biopsies in these patients might be reasonable. | Justin M Gomez James T Patrie Wissam Bleibel Jeanetta W Frye Bryan G Sauer Vanessa M Shami Edward B Stelow Christopher A Moskaluk Andrew Y Wang | 2017 | World Journal of Gastrointestinal Endoscopy2017，9，2： | 3 |
| 3 | Animal models of ex vivo lung perfusion as a platform for transplantation research显示文摘Ex vivo lung perfusion(EVLP) is a powerful experimental model for isolated lung research. EVLP allows for the lungs to be manipulated and characterized in an external environment so that the effect of specific ventilation/perfusion variables can be studied independent of other confounding physiologic contributions. At the same time,EVLP allows for normal organ level function and real-time monitoring of pulmonary physiology and mechanics. As a result,this technique provides uniqueadvantages over in vivo and in vitro models. Small and large animal models of EVLP have been developed and each of these models has their strengths and weaknesses. In this manuscript,we provide insight into the relative strengths of each model and describe how the development of advanced EVLP protocols is leading to a novel experimental platform that can be used to answer critical questions in pulmonary physiology and transplant medicine. | Kevin Nelson Christopher Bobba Samir Ghadiali Don Hayes Jr Sylvester M Black Bryan A Whitson | 2014 | World Journal of Experimental Medicine2014，4，2： | 2 |
| 4 | Immunohistichemical localization of endothelial nitric oxide synthase in human testis,epididymis,and vas deferens suggests a possible role for nitric oxide in spermatogenesis,sperm maturation,and programmed cell death 显示文摘 | Zini A O'Bryan M K Magid M S etal | 1996 | Bio Reprod1996，55，： | 1 |
| 5 | Nitric oxide synthase activi ty in human seminal plasma 显示文摘 | Zini A O'Bryan M K Schlegel P N | 2001 | Urology2001，58，1： | 1 |
| 6 | The role of soil surface crusting in desertification and strategies to reduce crusting显示文摘 | Fox D M Bryan R B Price A G | 2004 | Environmental Monitoring and Assessment2004，99，13： | 1 |
| 7 | Repression of an altemative mechanism for lengthening of telomeres in somatic cell hybrids 显示文摘 | Perrem K Bryan T M Englezou A | 1999 | Oncogene1999，18，： | 1 |
| 8 | Routine screening for post parturn depression显示文摘 | Georgiopoulos A M Bryan T L Wollan P et a1 | 2001 | J Fam Pract2001，50，2： | 1 |
| 9 | Identification of the DNA Binding specificity and potential target genes for the farnesold X-activated receptor显示文摘 | Bryan A L Heidi R K Catherine M N | 2000 | J Biol Chem2000，275，10： | 1 |
| 10 | Comparison of fungi within the Gaeumannomyces-Phialophora complex by analysis of ribosomal DNA sequences 显示文摘 | Bryan G T Daniels M J Osbourn A E | 1995 | Applied and Environmental Microbiology1995，61，： | 1 |
| 11 | A PCR-based method for the detection ofhexaploid bread wheat adulteration of durum wheat and pasta显示文摘 | Bryan G J Dixon A Gale M D | 1998 | Journal of Cereal Science1998，28，： | 1 |
| 12 | Decomposition of laser altimeter waveforms 显示文摘 | Michelle A H Jean B M Bryan J | 2000 | IEEE Transaction on Geoseienee and Remote Sensing2000，38，4： | 1 |
| 13 | Human sperm endothelial nitric oxide synthase expression:correlation with sperm motility显示文摘 | O'Bryan M K Zini A Cheng C Y | 1998 | Fertil Steril1998，70，： | 1 |
| 14 | EpichloO endophytes grow by intercalary hyphal extension in elongating grass leaves显示文摘 | Christensen M J Bennett R J Ansari H A Koga H Johnson R D Bryan G T Simpson W R Koolaard J P Nickless E M Voisey C R | 2008 | Fungal Genetics and Biology2008，45，2： | 1 |
| 15 | Difference in radar returns from ice-covered North Slope lakes 显示文摘 | Weeks W F Fountain A G Bryan M L | 1978 | Journal of Geophysical Research1978，83，8： | 1 |
| 16 | Strong room-temperature ferromagnetism in Co^2+-doped TiO2 made from colloidal nanocrystals显示文摘 | BRYAN J D HEALD S M CHAMBERS S A GAMELIN D R | 2004 | J Am Chem Soc2004，126，11： | 1 |
| 17 | P2 purinoceptor-mediated dilations in the rat middle cerebral artery after ischemia reperfusion显示文摘 | Marrelli S P Khorovets A Johnson T D Childres W F Bryan R M Jr | 1999 | Am J Physiol1999，276，12： | 1 |
| 18 | The influence of slope angle on final infiltration rate for interrill conditions显示文摘 | Fox D M Bryan R B Price A G | 1997 | Geoderma1997，80，12： | 1 |
| 19 | Genome sequence and analysis of the tuber crop potato显示文摘 | Xu X Pan S Cheng S Zhang B Mu D Ni P Zhang G Yang S Li R Wang J Orjeda G Guzman F Tones M Lnzano R Ponce O Martinez D De la Cruz G Chakrabarti S K Patil V U Skryabin K G Kuznetsov B B Ravin N V Kolganova T V Beletsky A V Mardanov A V Di Genova A Bolser D M Martin D M Li G Yang Y Kuang H Hu Q Xiong X Bishop G J Sagredo B Mejia N Zagorski W Gromadka R Gawor J Szczesny P Huang S Zhang Z Liang C He J Li Y He Y Xu J Zhang Y Xie B Du Y Qu D Bonierbale M Ghislain M Herrera Mdel R Giuliano G Pietrella M Perrotta G Faeella P O 'Brien K Feingold S E Barreiro L E Massa G A Diambra L Whitty B R Vaillancourt B Lin H Massa A N Geoffroy M Lundback S DellaPenna D Buell C R Sharma S K Marshall D F Waugh R Bryan G J Destefanis M Nagy I Milbourne D Thomson S J Fiefs M Jacobs J M Nielsen K L Sonderkaer M Iovene M Tortes G A Jiang J Veilleux R E Bachem C W de Boer J Bonn T Kloosterman B van Eck H Datema E Hekkert B Goverse A van Ham R C Visser R G | 2011 | Nature2011，475，7355： | 1 |
| 20 | Supplementing intensively grazed late-gestation and early-lactation dairy cattle with chromium显示文摘 | Bryan M A Socha M T Tomlinson D J | 2004 | J Dairy Sci2004，87，： | 1 |
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