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| 1 | Vascular invasion in pancreatic cancer:Imaging modalities,preoperative diagnosis and surgical management显示文摘Pancreatic cancer is associated with a poor prognosis,and surgical resection remains the only chance for curative therapy.In the absence of metastatic disease,which would preclude resection,assessment of vascular invasion is an important parameter for determining resectability of pancreatic cancer.A frequent error is to misdiagnose an involved major vessel.Obviously,surgical exploration with pathological examination remains the'gold standard'in terms of evaluation of resectability,especially from the point of view of vascular involvement.However,current imaging modalities have improved and allow detection of vascular invasion with more accuracy.A venous resection in pancreatic cancer is a feasible technique and relatively reliable.Nevertheless,a survival benefit is not achieved by curative resection in patients with pancreatic cancer and vascular invasion.Although the discovery of an arterial invasion during the operation might require an aggressive management,discovery before the operation should be considered as a contraindication.Detection of vascular invasion remains one of the most important challenges in pancreatic surgery.The aim of this article is to provide a complete review of the different imaging modalities in the detection of vascular invasion in pancreatic cancer. | Nicolas C Buchs Michael Chilcott Pierre-Alexandre Poletti Leo H Buhler Philippe Morel | 2010 | World Journal of Gastroenterology2010，16，7： | 29 |
| 2 | Management of hepatocellular adenoma: Solitary-uncomplicated, multiple and ruptured tumors显示文摘AIM: While hepatocellular adenomas (Has) have often been studied as a unique entity, we aimed to better define current management of the various forms of Has.METHODS: Twenty-five consecutive patients operated for solitary-uncomplicated (9), multiple (6), and ruptured (10)Has were reviewed according to management strategies and outcomes.RESULTS: All solitary-uncomplicated Has (ranged 2.2-14 cm in size) were removed. Out of 25 Has, 2 (8%) included foci of carcinoma. In the multiple HA group, previously undiagnosed tumors were identified during surgery in 5/6cases. In three cases with multiple spread HA, several lesions had to be left unresected. They remained unmodified after 4-, 6-, and 6-year radiological follow-up. Patients with ruptured HA (ranged 1.7-10 cm in size) were initially managed with hemodynamic support and angiography,allowing the embolization of actively bleeding tumors in two patients. All ruptured tumors were subsequently removed 5.5 d (range 4-70 d) after admission. CONCLUSION: Tumors suspected of HA, regardless of the size, should be resected, because of high chances of rupture causing bleeding, and/or containing malignant foci.Although it is desirable to remove all lesions of multiple HA, this may not be possible in some patients, for whom long-term radiological follow-up is advised. Ruptured HA can be managed by hemodynamic support and angiography,allowing scheduled surgery. | Christian Toso Pietro Majno Axel Andres Laura Rubbia-Brandt Thierry Berney Leo Buhler Philippe Morel Gilles Mentha | 2005 | World Journal of Gastroenterology2005，11，36： | 9 |
| 3 | Soluble CD40 ligand in prediction of acute severe pancreatitis显示文摘瞄准:在胰腺炎严厉估计可溶的 CD40L (sCD40L ) 的早可预测性。方法:在 2000 年 2 月和 2003 年 2 月之间,有尖锐胰腺炎的 279 个连续病人有希望地在我们的学习被注册。在这份报告, 40 个病人与温和并且有严重胰腺炎的 40 个病人随机被学习。sCD40L 集中被测量在承认以后的 48 个小时。结果:sCD40L 层次显著地更高在在严重胰腺炎的承认以后的 48 个小时比在温和胰腺炎。用 1000 的截止,检测疾病的一堂严重功课的 sCD40L 的 pg/L,敏感和特性为 CRP 与 72% 和 81% 相比分别地是 78% 和 62% 。发现那 CRP 的逻辑回归分析统计上是唯一的能检测疾病的一堂严重功课的重要标记。结论:这些调查结果显示 CRP 仍然是一个珍贵标记而 sCD40L 层次应该在进一步的研究被估计,决定尖锐胰腺炎的严厉和预后。 | Jean Louis Frossard Philippe Morel Brenda Kwak Catherine Pastor Thierry Berney Léo Buhler Alain Von Laufen Sandrine Demulder Francois Mach | 2006 | World Journal of Gastroenterology2006，12，10： | 2 |
| 4 | An audit of surgical management of gastrointestinal stromal tumours (GIST)显示文摘 | P. Bucher J.-F. Egger P. Gervaz F. Ris D. Weintraub P. Villiger L.H. Buhler Ph. Morel | 2005 | European Journal of Surgical Oncology2005，，3： | 2 |
| 5 | Unsaturated fatty acids inhibit the expression of tumor suppressor phosphatase and tensin homolog (PTEN) via microRNA‐21 up‐regulation in hepatocytes显示文摘 | Manlio Vinciguerra Antonino Sgroi Christelle Veyrat‐Durebex Laura Rubbia‐Brandt Leo H. Buhler Michelangelo Foti | 2009 | Hepatology2009，，4： | 2 |
| 6 | Ionic reactions and pyrolysis of glycerol as competing reaction pathways in near-and supercritical water显示文摘 | DINJUS E EDERER H J | 2002 | J Sup Fluids2002，22，1： | 1 |
| 7 | The role of lumbar lordosis, vertebral end-plate inclination, disc height, and facet orientation in degenerative spondylolisthesis 显示文摘 | Berlemann U Jeszenszky D J Buhler DW | 1999 | J Spinal Disord1999，12，1： | 1 |
| 8 | How effective is the sponsorship of global sports events? A comparison of the FIFA World Cups in 2006 and 1998 显示文摘 | Gerd Nufer and Andre Buhler | 2010 | International Journal of Sports Marketing & Sponsorship2010，，7： | 1 |
| 9 | Theoretical and practical challenges to an IPM approach to weed management 显示文摘 | Buhler D D | 2000 | Weed Science2000，48，3： | 1 |
| 10 | Anti-PSMA immunotoxin as novel treatment for prostate cancer? High and specific antitumor activity on human prostate xenograft tumors in SCID mice显示文摘 | Wolf P Ah K Buhler P | 2008 | Prostate2008，68，2： | 1 |
| 11 | X-ray diffraction study on the structure of molten MgxZn100-x alloys显示文摘 | Buhler E Lamparter P | 1987 | Z Naturforsch A1987，42，： | 1 |
| 12 | 查看详情显示文摘 | Mlynek A Reich M Giannone L Treutterer W Behler K Blank H Buhler A Cole R Eixenberger H Fischer R Lohs A Lüddecke K Merkel R Neu G Ryter F Zasche D the ASDEX Upgrade Team | | 0，，： | 1 |
| 13 | Finding motifs using random projections 显示文摘 | BUHLER J TOMPA M | 2002 | Journal of Computational Biology2002，9，2： | 1 |
| 14 | Study of morphological behavior of single diamond crystals显示文摘 | Buhler J Prior Y | 2000 | J Crystal Growth2000，209，： | 1 |
| 15 | Matrix metalloproteinase-7 facilitates immune access to the CNS in experimental autoimmune encephalomyelitis显示文摘 | Buhler LA Samara R Guzman E | 2009 | BMC Neurosci2009，10，： | 1 |
| 16 | Cardiovascular remodeling and its correction toward a comprehensive strategy显示文摘 | Buhler F R Laragh J H Holzgreve H | 1993 | Am J Med Sci1993，94，4： | 1 |
| 17 | p38 MAPK inhibitors: a patent review (2012 - 2013)显示文摘 | Buhler S Laufer SA | 2014 | Expert Opin Ther Patents2014，24，5： | 1 |
| 18 | Impact of recipient age on outcome of ABO-incompatible living-donor liver transplantation显示文摘 | Egawa H Oike F Buhler L | 2004 | Transplantation2004，77，3： | 1 |
| 19 | Analysis of a simplified hopping robot 显示文摘 | Buhler M | 1991 | International Journal of Robotics Research1991，10，6： | 1 |
| 20 | HVEM/LIGHT/BTLA/ CD160 cosigualing pathways as targets for immune regulation显示文摘 | Del Rio ML Lucas CL Buhler L | 2010 | J Leukoc Biol2010，87，2： | 1 |
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