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| 1 | Importance of gastrin in the pathogenesis and treatment of gastric tumors显示文摘In addition to regulating acid secretion, the gastric antral hormone gastrin regulates several important cellular processes in the gastric epithelium including proliferation, apoptosis, migration, invasion, tissue remodelling and angiogenesis. Elevated serum concentrations of this hormone are caused by many conditions, particularly hypochlorhydria (as a result of autoimmune or Helicobacter pylori (H pylori)-induced chronic atrophic gastritis or acid suppressing drugs) and gastrin producing tumors (gastrinomas). There is now accumulating evidence that altered local and plasma concentrations of gastrin may play a role during the development of various gastric tumors. In the absence of H pylori infection, marked hypergastrinemia frequently results in the development of gastric enterochromaffi n cell-like neuroendocrine tumors and surgery to remove the cause of hypergastrinemia may lead to tumor resolution in this condition. In animal models such as transgenic INS-GAS mice, hypergastrinemia has also been shown to act as a cofactor with Helicobacter infection during gastric adenocarcinoma development. However, it is currently unclear as to what extent gastrin also modulates human gastric adenocarcinoma development. Therapeutic approaches targeting hypergastrinemia,such as immunization with G17DT, have been evaluated for the treatment of gastric adenocarcinoma, with some promising results. Although the mild hypergastrinemia associated with proton pump inhibitor drug use has been shown to cause ECL-cell hyperplasia and to increase H pylori-induced gastric atrophy, there is currently no convincing evidence that this class of agents contributes towards the development of gastric neuroendocrine tumors or gastric adenocarcinomas in human subjects. | Michael D Burkitt Andrea Varro D Mark Pritchard | 2009 | World Journal of Gastroenterology2009，15，1： | 36 |
| 2 | Effects of trans-resveratrol on copper-dependent hydroxyl radical formation and DNA damage: evidence for hydroxyl radical scavenging and a novel,glutathione-sparing mechanism of action显示文摘 | Duncan J | 2000 | Arch Biochem Biophys2000，381，： | 1 |
| 3 | Review article:Pathogenesis and management of gastrie carcinoid tum,rs显示文摘 | Burkitt MD Pritchard DM | 2006 | Aliment Pharmacol Ther2006，24，9： | 1 |
| 4 | Veteran,primary care provider,and specialist satisfaction with electronic consultation显示文摘 | Rodniguez KL Burkitt KH Bayliss NK | 2015 | JMIR Med Inform2015，3，1： | 1 |
| 5 | Phenylbutyrate interferes with the Fanconi anemia and BRCA pathway and sensitizes head and neck cancer cells to cisplatin 显示文摘 | Burkitt K Ljungman M | 2008 | Molecular Cancer2008，7，： | 1 |
| 6 | Review article:pathogenesis and man-agement of gastric carcinoid tumours显示文摘 | Burkitt MD Pritchard DM | | 0，，12： | 1 |
| 7 | Hypoxia-inducible fac- tor-1 target genes as indicators of tumor vessel response to vascular endothelial growth factor inhibition显示文摘 | Dang DT Chun SY Burkitt K | 2008 | Cancer Res2008，68，6： | 1 |
| 8 | Effects of Trans-resvera- trol on Copper-dependent Hydroxyl-radical Formation and DNA Damage: evidence for Hydroxyl-radical Scar-enging and a Novel,Glutathione-sparing Mechanism of Action显示文摘 | BURKITT M J DUNCAN J | 2000 | Archives of Biochemistry and Biophysics2000，381，2： | 1 |
| 9 | Varicose veins,deep vein thrombosis,and hemorrhoids:epidemiology and suggested aetiology显示文摘 | Burkitt D P | 1972 | Br Med J1972，2，： | 1 |
| 10 | 中国人吃上安全食品为何这么难显示文摘墨汁、染料、漂白、石蜡和有毒化学物质——这些只是最近被曝光的一连串被禁用在食品中的物质中的几样。尽管中国政府誓言要打击污染食品,但这些物质还是再次引起人们对食品安全的担忧。 | Laurie Burkitt 吴慧雯 | 2011 | 生命与灾害2011，0，5： | 1 |
| 11 | Targeting both HIF - 1 and HIF - 2 in human colon cancer cells improves tumor response to sunitinib treatment 显示文摘 | Burkitt K Chun SY Dang DT | 2009 | Mol Cancer Ther2009，12，： | 1 |
| 12 | Effects of trans-resveratrol on copperdependent hydroxyl-radical formation and DNA damage: evidence for hydroxyl-radical scavenging and a novel, glutathionEsparing mechanism of action显示文摘 | Burkitt MJ Duncan J | 2000 | Arch Biochem Biophys2000，381，： | 1 |
| 13 | A sarcoma involving the jaws in African children显示文摘 | Denis Burkitt | 1958 | British Journal of Surgery1958，22，6： | 1 |
| 14 | Dietary fiber and disease显示文摘 | Burlcitt D PJ Burkitt Walker A R P Painter N J | 1974 | Journal of Am Med Assoc1974，229，： | 1 |
| 15 | Hypoxia-inducible factor-1target genes as indicators of tumor vessel response to vascular endothelial growth factor inhibition显示文摘 | Dang DT Chun SY Burkitt K | 2008 | Cancer Res2008，68，6： | 1 |
| 16 | Food fiber and disease prevention显示文摘 | Burkitt D | 1975 | Compr Ther1975，1，5： | 1 |
| 17 | Critical illness-related corticosteroid insu-fficiency in a dog with septic shock 显示文摘 | Peyton JL Burkitt JM | 2009 | J Vet Emerg Crit Care(San Antonio)2009，19，3： | 1 |
| 18 | Cleavage of heterogeneous nuclear ribonucleoprotein A1 by caspase 3 显示文摘 | Brockstedt E Rickers A Kostka S et aL Identification of apoptosis-associated proteins in a human Burkitt lymphoma cell line | 1998 | The Journal of Biological Chemistry1998，273，28： | 1 |
| 19 | Effect of dietary fibre on stools and transit-times,and its role in the causation of disease显示文摘 | Burkitt D P | 1972 | Lancet1972，30，： | 1 |
| 20 | Compromised Fanconi anemia response due to BRCA1 deficiency in cisplatin-sensitive head and neck cancer cell lines显示文摘 | Kyunghee Burkitt Mats Ljungman | 2007 | Cancer Letters2007，，1： | 1 |
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