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| 1 | Safety of biological therapies for psoriasis: effects on reproductive potential and outcomes in male and female patients显示文摘 | Z.Z.N. Yiu C.E.M. Griffiths R.B. Warren | 2014 | Br J Dermatol2014，，3： | 1 |
| 2 | 英夫利昔单抗诱导和维持治疗中重度银屑病的Ⅲ期临床多中心双盲对照试验显示文摘Background: Tumour necrosis factor α(TNFα) is thought to play a part in the pathogenesis of psoriasis. We assessed the efficacy and safety of continuous treatment with infliximab, a monoclonal antibody that binds to and neutralises the activity of TNFα, in patients with psoriasis. Methods: In this phase III, multi centre, double-blind Rial , 378 patients with moderate-to-severe plaque psori asis were allocated in a 4:1 ratio to receive infusions of either infliximab 5 m g/kg or placebo at weeks 0, 2, and 6, then every 8 weeks to week 46. At week 24, placebo treated patients crossed over to infliximab treatment. Skin and nail signs of psoriasis were assessed using the psoriasis area and severity index (PASI ) and nail psoriasis severity index (NAPSI), respectively. The primary endpoint, analysed on an intention-to-treat-basis, was the proportion of patients achi eving at least a 75%improvement in PASI from baseline to week 10. Findings: At week 10, 80%(242/301) of patients treated with infliximab achieved at least a 7 5%improvement from their baseline PASI (PASI 75) and 57%(172/301) achieved at least a 90%improvement (PASI 90), compared with 3%and 1%in the placebo group, respectively (p< 00001). At week 24, PASI 75 (82%for infliximab vs 4%for pl acebo) and PASI 90 (58%vs 1%) were maintained (p< 00001). At week 50, 61%ac hieved PASI 75 and 45%achieved PASI 90 in the infliximab group. Infliximab was generally well tolerated in most patients. Interpretation: Infliximab is effecti ve in both an induction and maintenance regimen for the treatment of moderate-t o-severe psoriasis, with ahigh percentage of patients achieving sustained PASI 75 and PASI 90 improvement through 1 year. | Reich K Nestle F.O Papp K. C.E.M. Griffiths 党倩丽 | 2006 | 世界核心医学期刊文摘(皮肤病学分册)2006，0，1： | 1 |
| 3 | 治疗中重度银屑病的未尽之需:调查报告结果和图表回顾显示文摘Background: Conventional systemic therapies and phototherapy for psoriasis are limited by safety concerns that may preclude long-term treatment with these agents. Objectives: To estimate the unmet need for safe and effective treatments for psoriasis. Methods: A survey was conducted at three psoriasis outpatient clinics in Europe. Male and female patients of any age with psoriasis requiring more than topical treatment were eligible to participate in the survey. Patient data were obtained from patients’answers to a questionnaire as well as by a chart review of each participating patient. The survey questionnaire addressed various aspects of psoriasis, including demographics and disease characteristics, treatment history, pre-existing medical conditions, and patient satisfaction with treatments received. Results: A total of 301 patients participated in the survey, with approximately 100 patients from each centre. Nearly 90%of patients had received at least one systemic therapy or phototherapy for psoriasis, with 39%of patients receiving three or more. Ultraviolet B (UVB), methotrexate, psoralen plus ultraviolet A (PUVA), retinoids and cyclosporin were the most commonly used agents. Inadequate response, reported by patients as no change or worsening of disease with treatment, ranged from 10%to 50%. Contraindications to conventional systemic therapies were reported by 9-22%of patients. A substantial number of patients (42%) were not satisfied with these therapies. Conclusions: This survey highlights the unmet need for safe and effective therapies for moderate to severe psoriasis. | Christophers E. Griffiths C.E.M. Gaitanis G. Van De Kerkhof P 李政霄 | 2006 | 世界核心医学期刊文摘(皮肤病学分册)2006，，12： | 0 |
| 4 | 银屑病患者下丘脑-垂体-肾上腺轴对心理应激的反应显示文摘Background: Psoriasis may, in some patients, be triggered and/or exacerbated by stress. Objectives: As activation of the hypothalamic-pituitary- adrenal (HPA) axis is critical to a successful stress response we investigated this in patients with psoriasis. Methods: Forty patients with chronic plaque psoriasis and 40 age-matched normal controls experienced three randomly presented acute psychological stressors (cognitive, emotional and social). Serial serum cortisol, pulse rate and blood pressure assessments were undertaken at baseline and following each of the stressors. Salivary cortisol samples were collected at 09.00 h on the day of testing. Results: In control subjects there was a significant (r = 0.38; P < 0.05) correlation between pulse rate and serum cortisol level following the social performance stressor; this was not evident in the psoriasis group (r = 0.07; not significant). Patients who believed that their psoriasis was highly stress responsive had significantly lower salivary cortisol levels at baseline (P < 0.01) and lower serum cortisol levels following the social performance Stressor (P = 0.016) than patients with nonstress-responsive disease who believed that stress had no impact. In contrast, there was no difference between the groups for change in pulse rate poststressor. Conclusions: This study shows that patients with psoriasis, and in particular those whose disease appears to be stress responsive, exhibit an altered HPA response to acute social stress. The implication is that such patients may perhaps be primed to flares of their psoriasis. Whether this is genetically predetermined and/or a consequence of the distress of living with psoriasis remains to be determined. | Richards H. L. Ray D. W. Kirby B. C.E.M. Griffiths 刘艳(译) | 2006 | 世界核心医学期刊文摘(皮肤病学分册)2006，2，3： | 0 |
| 5 | 延胡索酸酯治疗重症银屑病的58例病例回顾 | Harries M.J. Chalmers R.J.G. Griffiths C.E.M. 刘艳 | 2005 | 世界核心医学期刊文摘(皮肤病学分册)2005，0，12： | 0 |
| 6 | 成功治疗银屑病可改善银屑病患者的特异心理因素,但对患者的一般心理因素无显著改善 | Fortune D.G. Richards H.L. Kirby B. et al. C.E.M. Griffiths 牛新武 | 2005 | 世界核心医学期刊文摘(皮肤病学分册)2005，0，5： | 0 |
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