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| 1 | Glutamine and glutamate supplementation raise milk glutamine concentrations in lactating gilts显示文摘Glutamine is the most abundant amino acid in milk, and lactation is associated with increased glutamine utilization both for milk synthesis and as a fuel for the enlarged small intestine. A number of recent studies have indicated that lactation is accompanied by a mild catabolic state in which skeletal muscle proteins are degraded to provide amino acids that are used to synthesize additional glutamine. In this study we tested the hypothesis that supplemental L-glutamine or the commercially available glutamine supplement Aminogut (2.5% by weight mixed into daily feed) provided to gilts from 30 days prior to parturition until 21 days post-parturition would prevent a decrease in skeletal muscle glutamine while increasing the glutamine content of the milk. Muscle glutamine content decreased (P < 0.05) in control animals during lactation but this was prevented by supplementation with either L-glutamine or Aminogut. In this study, neither lactation nor supplementation had any effect on plasma glutamine or glutamate content. Free glutamine, and the total glutamine plus glutamate concentrations in milk from the control and the Aminogut group rose (P < 0.05) during the first 7 days of lactation, with milk concentrations in the L-glutamine supplemented group showing a similar trend (P = 0.053). Milk glutamate remained constant between day 7 and 21 of lactation in the control and L-glutamine supplemented groups, but by day 21 of lactation the free glutamine, glutamate, and glutamine plus glutamate concentrations in milk from Aminogut-treated gilts were higher than those of control gilts. Thus dietary glutamine supplementation can alleviate the fall in intramuscular glutamine content during lactation in gilts, and may alleviate some of the catabolic effects of lactation. Furthermore, the increased milk glutamine content in the supplemented gilts may provide optimum nutrition for piglet development. | Helena Emilia CCC Manso Helio C Manso Filho Luiz E de Carvalho Marianne Kutschenko Eduardo T Nogueira Malcolm Watford | 2012 | Journal of Animal Science and Biotechnology2012，3，1： | 3 |
| 2 | Association of Helicobacter pylori infection and giardiasis: Results from a study of surrogate markers for fecal exposure among children显示文摘AIM: To investigate whether Helicobacter pylori (H pykori)infection is associated with hepatitis A virus (HAV) infection, presence of enteroparasites, and other surrogates of fecal exposure.METHODS: We conducted a cross-sectional study in 121 children consecutively admitted at a pediatric hospital inSalvador, Brazil.H pylori and HAV infection were identified by the presence of serum antibodies. Stool specimens were examined for the presence of ova and parasites. A structured questionnaire inquiring about sanitary conditions and life style was applied to each subject. RESULTS: Fifty-one of the 121 children (42.1%) werefound to be seropositive for H pylori, and 45 (37.2%) for HAV. The seroprevalence ofHpyloriand HAV both increased significantly with age. Cross-tabulation of data showed that 26 (21.5%) were seropositive and 51 (42.1%) were negative for bothHpyloriand HAV antibodies (χ2 = 7.18,OR = 2.8, CI 1.30-5.97). The age adjusted OR for an HAV-infected child being H pylori positive was 2.3 (CI1.02-5.03). The agreement between H pylori and HAVseropositivity was fair (κ = 0.24). After controlling for possible confounding, the variables remaining independently associated with seropositivity to H pyloriwere age,presence of Giardia lamblia in feces (OR = 3.2, 95%CI, 1.1-9.5) and poor garbage disposal quality (OR = 2.4,95%CI, 1.1-5.1).CONCLUSION: Our data suggest that H pylori infection is associated with surrogate markers of fecal exposure. Thus, we conclude that the fecal-oral route is relevant in the transmission of HP among children in an urban setting of a developing country. The association observed between G. lamblia and H pylori infection may have several explanations. Further studies to investigate this relationship are warranted. | Edson Duarte Moreira Jr Victor Bastos Nassri Rafaela Sousa Santos Junísia Ferraz Matos Wilson Andrade de Carvalho Célia Stolve Silvani Círia Santana e Sant'Ana | 2005 | World Journal of Gastroenterology2005，11，18： | 3 |
| 3 | Lack of microRNA‐101 causes E‐cadherin functional deregulation through EZH2 up‐regulation in intestinal gastric cancer显示文摘 | Joana Carvalho Nicole C van Grieken Patricia M Pereira Sónia Sousa Marianne Tijssen Tineke E Buffart Bego?a Diosdado Heike Grabsch Manuel AS Santos Gerrit Meijer Raquel Seruca Beatriz Carvalho Carla Oliveira | 2012 | J Pathol2012，，1： | 3 |
| 4 | Improving the effectiveness of routine prenatal screening for major congenital heart defects 显示文摘 | Carvalho JS Mavrides E Shineboume ES | 2002 | Heart2002，88，4： | 1 |
| 5 | Tip grafts in closed rhiiloplasty:insertion and fixation made easy显示文摘 | FERNANDEZ D E da SIL VA CARVALHO G | 2008 | Plast Reconstr Surg2008，121，3： | 1 |
| 6 | Establishment of primary cUltures of rat and human parotid epithelial cells for transfection experiment显示文摘 | Prasad KN Edwards-Prasad J Carvalho E | 1992 | In Vitro Cell Dev Biol1992，28，78： | 1 |
| 7 | Morphological, mechanical andthermal properties of nylon 6/ABS blends using glycidyl methacrylate-methyl methacrylate co-polymers 显示文摘 | Araujo E M Hage E Carvalho A J F | 2005 | Journal of Materials Science2005，40，16： | 1 |
| 8 | Nucleatingeffect and dynamic crystallization of a poly (propylene) / talcsystem显示文摘 | De Medeiros E Tocchetto R De Carvalho L | 2001 | Journal of Thermal Analysis and Calorimetry2001，66，2： | 1 |
| 9 | Treatment of astigmatism during phacoemulsification 显示文摘 | Freitas G O Boteon J E Carvalho M J | 2014 | Arq Bras Ofta-tool2014，77，1： | 1 |
| 10 | Effects of herbivory by Hyblaea puera ( Hyblaeidae : Lepidop- tera) on litter production in the mangrove on the coast of Brazi- lian Amazonia显示文摘 | FERNANDES M E B NASCIMENTO A A M CARVALHO M L | 2009 | Journal of Tropical Ecology2009，25，3： | 1 |
| 11 | Central role of brown adipose tissue thyroxine 5 ' -deiodinase on thyroid hormone-dependent thermogenic response to cold显示文摘 | CARVALHO S D KIMURA E T BIANCO A C | 1991 | Endocrinology1991，128，4： | 1 |
| 12 | Prognostic impact of p53,C-erbB2 and epidermal growth factor receptor on head and neck carcinoma显示文摘 | PARISE JUNIOR O CARVALHO L V MIGUEL R E | 2004 | Sao Paulo Med J2004，122，： | 1 |
| 13 | Effect of PUFA-rich supplements from marine sources in the feed of laying hens on lipid composition and the percent- age of incorporation of n-6 PUFAs in egg yolk 显示文摘 | CARVALHO P R PITA M C G PIBER N E | 2009 | Ar- quivous do Instituto Biologico2009，76，2： | 1 |
| 14 | Coordinated direct and relay transmission with linear non-regenerative relay beamform- ing显示文摘 | SUN F DE CARVALHO E POPOVSKI P | 2012 | IEEE Signal Processing Letters2012，19，10： | 1 |
| 15 | High resolution microarray comparative genomic hybridisation analysis using spotted oligonucleotides显示文摘 | Carvalho B Ouwerkerk E Meijer G A | 2004 | J Clin Pathol2004，57，6： | 1 |
| 16 | Pineal yolk sac tumor:correlation between neuroimaging and pathological findings显示文摘 | Davaus T Gasparetto E L Carvalho Neto A | 2007 | Arq Neuropsiquiatr2007，65，2： | 1 |
| 17 | Predicting smear negative pulmonary tuberculosis with classification trees and logistic regression: a cross-sectional study 显示文摘 | Fernanda Carvalho de Queiroz Mello Luiz Gustavo do Valle Bastos Sergio Luiz Machado Soares Valeria MC Rezende Marcus Barreto Conde Richard E Chaisson Afranio Lineu Kritski Antonio Ruffino Netto Guilherme Looreiro Wet neck | 2006 | BMC Public Health2006，23，6： | 1 |
| 18 | Maternal anxiety and depression and development of prematurely horn infants in the first year of life显示文摘 | Carvalho A E Martinez F E Linhares M B | 2008 | Span J Psychol2008，11，2： | 1 |
| 19 | A network flow model for short-term hydro-dominated hydrothermal scheduling problems显示文摘 | Franco P E C Carvalho M F Soares S | 1994 | IEEE Transactions on Power Systems1994，9，2： | 1 |
| 20 | Renal diseases: a 27-year renal biopsy study显示文摘 | Carvalho E do-Sameiro-Faria M Nunes J P | 2006 | J Nephrol2006，19，4： | 1 |
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