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| 1 | Sex-specific effects of Eugenia punicifolia extract on gastric ulcer healing in rats显示文摘AIM To evaluate the sex-specific effects of a hydroalcoholic extract from Eugenia punicifolia(HEEP) leaves on gastric ulcer healing.METHODS In this rat study involving males, intact(cycling) females, and ovariectomized females, gastric ulcers were induced using acetic acid. A vehicle, lansoprazole, or HEEP was administered for 14 d after ulcer induction. Body weight was monitored throughout the treatment period. At the end of treatment, the rats were euthanized and the following in vivo and in vitro investigations were performed: macroscopic examination of the lesion area and organ weights, biochemical analysis, zymography, and evaluation of protein expression levels. Additionally, the concentration-dependent effect of HEEP was evaluated in terms of subacute toxicity and cytotoxicity.RESULTS Compared to the vehicle, HEEP demonstrated a great healing capacity by substantially reducing the ulcerative lesion area in males(52.44%), intact females(85.22%), and ovariectomized females(65.47%), confirming that HEEP accelerates the healing of acetic acidinduced gastric lesions and suggesting that this effect is modulated by female sex hormones. The antiulcer effect of HEEP was mediated by prostaglandin E2 only in male rats. Overall, the beneficial effect of HEEP was the highest in intact females. Notably, HEEP promoted the expression of vascular endothelial growth factor(intact vs ovariectomized females) and decreased the expression of Caspase-8 and Bcl-2(intact female vs male or ovariectomized female). Additionally, HEEP enhanced fibroblast proliferation and migration into a wounded area in vitro, confirming its healing effect. Finally, no sign of subacute toxicity or cytotoxicity of HEEP was observed.CONCLUSION In gastric ulcers, HEEP-induced healing(modulated by female sex hormones; in males, mediated by prostaglandin) involves extracellular matrix remodeling, with gastric mucosa cell proliferation and migration. | Larissa Lucena Périco Vinícius Peixoto Rodrigues Rie Ohara Gabriela Bueno Vania Vasti Alfieri Nunes Raquel Cássia dos Santos Ana Carolina Lima Camargo Luis Antuio Justulin Joior Sérgio Faloni de Andrade Viviane Miranda Bispo Steimbach Luísa Mota da Silva Lúcia Regina Machado da Rocha Wagner Vilegas Catarina dos Santos Clélia Akiko Hiruma-Lima | 2018 | World Journal of Gastroenterology2018，24，38： | 3 |
| 2 | Induction of cytochrome c-mediated apoptosis by amyloid β 25- 35 requires functional mitochondria 显示文摘 | Sandra M C Russell H S Catarina R O | 2002 | Brain Research2002，931，2： | 1 |
| 3 | Induction of cytochrome e-mediated apoptosis by amyloid β 25-35 requires functional mitochondria显示文摘 | Sandra M C Russell H S Catarina R O | 2002 | Brain Research2002，931，2： | 1 |
| 4 | Optimiza- tion of metal forming processes 显示文摘 | ANTONIO C C CATARINA C SOUSA L C | 2004 | Computers and Structures2004，82，1719： | 1 |
| 5 | Nicotine Promotes Initiation and Progression of KRAS-Induced Pancreatic Cancer via Gata6- Dependent Dedifferentiation of Acinar Cells in Mice显示文摘 | Patrick C. Hermann Patricia Sancho Marta Ca?amero Paola Martinelli Francesc Madriles Patrick Michl Thomas Gress Ricardo de Pascual Luis Gandia Carmen Guerra Mariano Barbacid Martin Wagner Catarina R. Vieira Alexandra Aicher Francisco X. Real Bruno Sainz C | 2014 | Gastroenterology2014，，： | 1 |
| 6 | Effects of salts on Debaryomyces hansenii and Saccharomyces cerevisiae under stress conditions显示文摘 | Anabel Almagro Catarina Prista Santiago Castro Célia Quintas Amandio Madeira-Lopes José Ramos Maria C Loureiro-Dias | 2000 | International Journal of Food Microbiology2000，，2： | 1 |
| 7 | Free amino acid composition of Annona(Annonaceae)fruit species of economic interest显示文摘 | Egydio P M Catarina C S Floha E S | 2013 | Industrial Crops and Products2013，45，： | 1 |
| 8 | the Role of A Proof of Concept Center in A University Ecosystem: An Exploratory Study 显示文摘 | Catarina M Jao C | 2013 | Journal of Technology Transfer2013，38，5： | 1 |
| 9 | Application of PCR ribotyping and tDNA-PCR for Klebsiella pneumoniae identification显示文摘 | Ana Catarina S L Juliana F R Maysa B M C | 2007 | Mere Inst Oswaldo Cruz Rio de Janeiro2007，102，7： | 1 |
| 10 | Potency against enterotoxemia o- a recombinant Clostridium perfringens type D epsilon toxoid in ruminants显示文摘 | Francisco C F Lobatoa Catarina G R | 2010 | Vaccine2010，28，： | 1 |
| 11 | Temperature and feed strategy effects on sulfate and organic matter removal in an AriSBB 显示文摘 | Augusto L O C Catarina S A C Suzana M R | 2011 | Joumal of Environmental Management2011，92，： | 1 |
| 12 | Extending modules with injective or semisimple summands 显示文摘 | Catarina S C | 1998 | J Pure Applied Alg1998，127，2： | 1 |
| 13 | Fatty acid com-position of several wild microalgae and cyanobacteria, with afocus on eicosapentaenoic,docosahexaenoic and a-linolenicacids for eventual dietary uses显示文摘 | Catarina G A Amaro H M Barbosa C R | 2011 | Food Research Internation-al2011，44，9： | 1 |
| 14 | A proinflammatory genetic profile increases the risk for chronic atrophic gastritis and gastric carcinoma显示文摘 | José Carlos Machado Céu Figueiredo Paulo Canedo Paul Pharoah Ralph Carvalho Sérgio Nabais Catarina Castro Alves Maria Luisa Campos Leen-jan Van Doorn Carlos Caldas Raquel Seruca Fátima Carneiro Manuel Sobrinho-Sim?es | 2003 | Gastroenterology2003，，2： | 1 |
| 15 | Hydroxyapatite micro-and nanoparticles:Nucle- ation and growth mechanisms in the presence of citrate species 显示文摘 | MANUEL A M CATARINA S MARIA M A MARIA E V C | 2008 | Journal of Colloid and Interface Science2008，318，： | 1 |
| 16 | Psychosocial working conditions and exhaustion in a working population sample of Swedish middle- aged men and women 显示文摘 | Sara IL Mafia BC Catarina C | 2011 | Eur J Public Health2011，21，： | 1 |
| 17 | A proinflammatory genetic profile increases the risk for chronic atrophic gastritis and gastric carcinoma显示文摘 | José Carlos Machado Céu Figueiredo Paulo Canedo Paul Pharoah Ralph Carvalho Sérgio Nabais Catarina Castro Alves Maria Luisa Campos Leen-jan Van Doorn Carlos Caldas Raquel Seruca Fátima Carneiro Manuel Sobrinho-Sim?es | 2003 | Gastroenterology2003，，2： | 1 |
| 18 | Study of the migration of photoinitiators used in printed food-packaging materials into food simulants显示文摘 | ANA S S CATARINA A ISABEL C | | 0，，20： | 1 |
| 19 | Electroactive biofilms of sulphate reducing bacteria 显示文摘 | Cristina M C L-Tiago G Catarina X | 2008 | Electrochim Acta2008，54，： | 1 |
| 20 | Depression in acute stroke显示文摘 | Jose M Catarina O | 2006 | J Psychiatry Neurosci2006，31，： | 1 |
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