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| 1 | Effect of Laser Power on the Cladding Temperature Field and the Heat Affected Zone显示文摘H13 powder is cladded on steel P20(base)by continuous CO2 laser,and the influence of technological parameters such as the laser power is analyzed.The 3-D model of synchronous powder feeding is built under Gauss heat source.The simulative results in the heat affected zone are compared with the experimental ones,and the average errors of width and depth are 15% and 4.5%,respectively.It is found that the simulative results provide basic data for investigating of laser cladding further. | LUO Fang YAO Jian hua HU Xia xia CHAI Guo-zhong | 2011 | Journal of Iron and Steel Research(International)2011，18，1： | 25 |
| 2 | miR-20a targets BNIP2 and contributes chemotherapeutic resistance in colorectal adenocarcinoma SW480 and SW620 cell lines显示文摘化疗是为 colorectal 腺癌癌症的重要治疗;然而, colorectal 腺癌房间经常开发抵抗到化学疗法的药,导致恶化和差的耐心的预后。药抵抗的发展经常是一个 multifactor 过程,它包含了几基因和细胞的机制。microRNAs 是否定地在 post-transcriptional 水平调整基因表示的内长的小非编码的 RNA。在现在的学习,我们在调整 colorectal 腺癌房间 SW620 和 SW480 的药敏感调查了 microRNAs 的可能的角色。使用 microRNA 表达式数组和我们发现了房间展出了的那 SW620 的量的反向的 transcriptase (RT )-PCR, 与 SW480 房间相比提高了 miR-20a 表示。另外,这二房间行显示了不同敏感到化学疗法的药氟尿嘧啶, oxaliplatin,和 teniposide。miR-20a 的调整改变了 SW620 和 SW480 房间的敏感到这些药;miR-20a 击倒敏化的 SW620 房间到化学疗法的代理人,而在 SW480 房间的 miR-20a 的 overexpression 导致了 chemoresistance。内长的 BNIP2 mRNA 和 BNIP2 蛋白质层次是相反地由量的 RT-PCR 和西方的污点分析与是的 miR-20a 层次有关检测了。荧光记者试金显示出在 miR-20a 和 BNIP2 3UTR 之间的一个直接相互作用。一起拿,我们的调查结果建议 miR-20a 可以在 colorectal 腺癌癌症房间药抵抗起一个作用并且可以是对在 colorectal 腺癌的化疗药抵抗的一个治疗学的目标。 | Huijuan Chai Min Liu Ruiqing Tian Xin Li Hua Tang | 2011 | Acta Biochimica et Biophysica Sinica2011，43，3： | 18 |
| 3 | Simulation research on a minimum root-mean-square error rotation-fitting algorithm for gravity matching navigation显示文摘Gravity/inertial combination navigation is a leading issue in realizing passive navigation onboard a submarine. A new rotation-fitting gravity matching algorithm, based on the Terrain Contour Matching (TERCOM) algorithm, is proposed in this paper. The algorithm is based on the principle of least mean-square-error criterion, and searches for a certain matched trajectory that runs parallel to a trace indicated by an inertial navigation system on a gravity base map. A rotation is then made clockwise or counterclockwise through a certain angle around the matched trajectory to look for an optimal matched trajectory within a certain angle span range, and through weighted fitting with another eight suboptimal matched trajectories, the endpoint of the fitted trajectory is considered the optimal matched position. In analysis of the algorithm reliability and matching error, the results from simulation indicate that the optimal position can be obtained effectively in real time, and the positioning accuracy improves by 35% and up to 1.05 nautical miles using the proposed algorithm compared with using the widely employed TERCOM and SITAN methods. Current gravity-aided navigation can benefit from implementation of this new algorithm in terms of better reliability and positioning accuracy. | WANG HuBiao WANG Yong FANG Jian CHAI Hua ZHENG Hui | 2012 | Science China Earth Sciences2012，55，1： | 12 |
| 4 | The ubiquitin system: a critical regulator of innate immunity and pathogen-host interactions显示文摘ubiquitin 系统包括负责的酶因为 ubiquitination 和 deubiquitination,以及能够认出并且译解的 ubiquitin 受体 ubiquitin 代码,它在协作行动调整几乎所有主机细胞的进程,包括主人病原体相互作用。响应病原体感染,主人天生的免疫系统发射包含煽动性的发信号, phagosomal 成熟, autophagy 和 apoptosis 的一连串的不同抗菌剂活动,所有哪个被 ubiquitin 系统调整根除入侵的病原体并且减少伴随物主人损坏。由对比,病原体发展了优美策略的一个队躲避由篡夺招待天生的免疫为他们的自己的好处的 ubiquitin 系统。这里,我们关于 ubiquitin 的现在的最近的进展主人病原体相互影响的调停系统的调整,与的一个特定的焦点招待天生的有免疫力的防卫和细菌的病原体免疫者避免。 | Jie Li Qi-Yao Chai Cui Hua Liu | 2016 | Cellular & Molecular Immunology2016，13，5： | 8 |
| 5 | Vertical Distribution of Soil Carbon, Nitrogen, and Phosphorus in Typical Chinese Terrestrial Ecosystems显示文摘Characterization of the vertical distribution of soil organic carbon(C), nitrogen(N), and phosphorus(P) may improve our ability to accurately estimate soil C, N, and P storage. Based on a database of 21 354 records in 74 long-term monitoring plots from 2004 to 2013 in the Chinese Ecosystem Research Network(CERN), we built fitting functions to quantify the vertical distribution of soil C, N, and P(up to 100 cm depth) in the typical Chinese terrestrial ecosystems. The decrease of soil C, N, and P content with depth can be well fitted with various mathematical functions. The fitting functions differed greatly between artificial(agriculture) and natural(desert, forest, and grassland) ecosystems, and also differed with respect to soil C, N, and P content. In both the artificial and natural ecosystems, the best fitting functions were exponential functions for C, quadratic functions for N, and quadratic functions for P. Furthermore, the stoichiometric ratios of soil C, N, and P were ranked in descending order: grassland > forest > agriculture > desert, and were also associated with climate. This study is the first to build the fitting functions for the profile distribution of soil C, N, and P in China at a national scale. Our findings provide a scientific basis to accurately assess the storage of C, N, and P in soils at a large scale, especially for the integrative analysis of historical data. | CHAI Hua YU Guirui HE Nianpeng WEN Ding LI Jie FANG Jiangping | 2015 | Chinese Geographical Science2015，25，5： | 7 |
| 6 | Mycobacterium tuberculosis Mce2E suppresses the macrophage innate immune response and promotes epithelial cell proliferation显示文摘The intracellular pathogen Mycobacterium tuberculosis(Mtb)can survive in the host and cause disease by interfering with a variety of cellular functions.The mammalian cell entry 2(mce2)operon of Mtb has been shown to contribute to tuberculosis pathogenicity.However,little is known about the regulatory roles of Mtb Mce2 family proteins towards host cellular functions.Here we show that the Mce2 family protein Mce2E suppressed the macrophage innate immune response and promoted epithelial cell proliferation.Mce2E inhibited activation of the extracellular signal-regulated kinase(ERK)and Jun N-terminal kinase(JNK)mitogen-activated protein kinase(MAPK)signaling pathways in a non-canonical D motif(a MAPK-docking motif)-dependent manner,leading to reduced expression of TNF and IL-6 in macrophages.Furthermore,Mce2E promoted proliferation of human lung epithelium-derived lung adenoma A549 cells by inhibiting K48-linked polyubiquitination of eEF1A1 in aβstrand region-dependent manner.In summary,Mce2E is a novel multifunctional Mtb virulence factor that regulates host cellular functions in a niche-dependent manner.Our data suggest a potential novel target for TB therapy. | Lihua Qiang Jing Wang Yong Zhang Pupu Ge Qiyao Chai Bingxi Li Yi Shi Lingqiang Zhang George Fu Gao Cui Hua Liu | 2019 | Cellular & Molecular Immunology2019，16，4： | 7 |
| 7 | Lingbao Huxin Pill Alleviates Apoptosis and Inflammation at Infarct Border Zone through SIRT1-Mediated FOXO1 and NF-κB Pathways in Rat Model of Acute Myocardial Infarction显示文摘Objective To investigate whether Lingbao Huxin Pill(LBHX)protects against acute myocardial infarction(AMI)at the infarct border zone(IBZ)of myocardial tissue by regulating apoptosis and inflammation through the sirtuin 1(SIRT1)-mediated forkhead box protein O1(FOXO1)and nuclear factor-κB(NF-κB)signaling pathways.Methods Six-week-old Wistar rats with normal diet were randomized into the sham,the model,Betaloc(0.9 mg/kg daily),LBHX-L(0.45 mg/kg daily),LBHX-M(0.9 mg/kg daily),LBHX-H(1.8 mg/kg daily),and LBHX+EX527(0.9 mg/kg daily)groups according to the method of random number table,13 in each group.In this study,left anterior descending coronary artery(LADCA)ligation was performed to induce an AMI model in rats.The myocardial infarction area was examined using a 2,3,5-triphenyltetrazolium chloride solution staining assay.A TdT-mediated dUTP nick-end labeling(TUNEL)assay was conducted to assess cardiomyocyte apoptosis in the IBZ.The histopathology of myocardial tissue at the IBZ was assessed with Heidenhain,Masson and hematoxylineosin(HE)staining assays.The expression levels of tumor necrosis factorα(TNF-α),interleukin(IL)-6,IL-1β,and intercellular adhesion molecule-1 were measured using enzyme-linked immunosorbent assays(ELISAs).The mRNA expressions of SIRT1 and FOXO1 were detected by real-time qPCR(RT-qPCR).The protein expressions of SIRT1,FOXO1,SOD2,BAX and NF-κB p65 were detected by Western blot analysis.Results The ligation of the LADCA successfully induced an AMI model.The LBHX pretreatment reduced the infarct size in the AMI rats(P<0.01).The TUNEL assay revealed that LBHX inhibited cardiomyocyte apoptosis at the IBZ.Further,the histological examination showed that the LBHX pretreatment decreased the ischemic area of myocardial tissue(P<0.05),myocardial interstitial collagen deposition(P<0.05)and inflammation at the IBZ.The ELISA results indicated that LBHX decreased the serum levels of inflammatory cytokines in the AMI rats(P<0.05 or P<0.01).Furthermore,Western blot analysis revealed that the LBHX pretreatment upregulated the protein levels of SIRT1,FOXO1 and SOD2(P<0.05)and downregulated NF-κB p65 and BAX expressions(P<0.05).The RT-qPCR results showed that LBHX increased the SIRT1 mRNA and FOXO1 mRNA levels(P<0.05).These protective effects,including inhibiting apoptosis and alleviating inflammation in the IBZ,were partially abolished by EX527,an inhibitor of SIRT1.Conclusion LBHX could protect against AMI by suppressing apoptosis and inflammation in AMI rats and the SIRT1-mediated FOXO1 and NF-κB signaling pathways were involved in the cardioprotection effect of LBHX. | TAN Yu BIE Yu-long CHEN Li ZHAO Yi-han SONG Lei MIAO Li-na YU Yan-qiao CHAI Hua MA Xiao-juan SHI Da-zhuo | 2022 | Chinese Journal of Integrative Medicine2022，28，4： | 6 |
| 8 | Combined community ecology and floristics,a synthetic study on the upper montane evergreen broad-leaved forests in Yunnan,southwestern China显示文摘The upper montane evergreen broad-leaved forest in Yunnan occurs mainly in the zone of persistent cloud and has a discontinuous,island-like,distribution.It is diverse,rich in endemic species,and likely to be sensitive to climate change.Six 1-ha sampling plots were established across the main distribution area of the upper montane evergreen broad-leaved forest in Yunnan.All trees with d.b.h.>1 cm in each plot were identified.Patterns of seed plant distributions were quantified at the specific,generic and family levels.The forests are dominated by the families Fagaceae,Lauraceae,Theaceae and Magnoliaceae,but are very diverse with only a few species shared between sites.Floristic similarities at the family and generic level were high,but they were low at the specific level,with species complementarity between plots.Diversity varied greatly among sites,with greater species richness and more rare species in western Yunnan than central Yunnan.The flora is dominated by tropical biogeographical elements,mainly the pantropic and the tropical Asian distributions at the family and genus levels.In contrast,at the species level,the flora is dominated by the southwest or the southeast China distributions,including Yunnan endemics.This suggests that the flora of the upper montane forest in Yunnan could have a tropical floristic origin,and has adapted to cooler temperatures with the uplift of the Himalayas.Due to great sensitivity to climate,high endemism and species complementarity,as well as the discontinuous,island-like,distribution patterns of the upper montane forest in Yunnan,the regional conservation of the forest is especially needed. | Hua Zhu Yong Chai Shisun Zhou Lichun Yan Jipu Shi Guoping Yang | 2016 | Plant Diversity2016，38，6： | 6 |
| 9 | Plasma αl-antitrypsin: A Neglected Predictor of Angiographic Severity in Patients with Stable Angina Pectoris显示文摘Background: As an acute phase protein, ct I-antitrypsin (AAT) has been extensively studied in acute coronary syndrome, but it is unclear whether a relationship exists between AAT and stable angina pectoris (SAP). The purpose of the present study was to investigate the association between AAT plasma levels and SAP. Methods: Overall, 103 SAP patients diagnosed by coronary angiography and clinical manifestations and 118 control subjects matched for age and gender were enrolled in this case-control study. Plasma levels of AAT, high-sensitivity C-reactive protein (hsCRP), lipid profiles and other clinical parameters were assayed for all participants. The severity of coronary lesions was evaluated based on the Gensini score (GS) assessed by coronary angiography. Results: Positively correlated with the GS (r = 0.564, P 〈 0.001), the plasma AAT level in the SAP group was significantly higher than that in the control group (142.08 ± 19.61 mg/dl vs. 125.50 ± 19.67 mg/dl, P 〈 0.001). The plasma AAT level was an independent predictor tbr both SAP (odds ratio [OR] = 1.037, 95% confidence interval [C/]: 1.020-1.054, P 〈 0.001) and a high GS (OR = 1.087, 95% CI: 1.051-1.124, P 〈 0.001) in a multivariate logistic regression model. In the receiver operating characteristic curve analysis, plasma AAT level was found to have a larger area under the curve (AUC) for predicting a high GS (AUC = 0.858, 95% CI: 0.788-0.929, P 〈 0.001 ) than that of hsCRP (AUC = 0.665, 95% CI: 0.557-0.773, P = 0.006; Z = 2.9363, P 〈 0.001), with an optimal cut-off value of 137.85 mg/dl (sensitivity: 94.3%, specificity: 68.2%). Conclusions: Plasma AAT levels correlate with both the presence and severity of coronary stenosis in patients with SAP, suggesting that it could be a potential predictive marker of severe stenosis in SAP patients. | Hui Zhao Hong Liu Lin Chai Ping Xu Lu Hua Xiao-Yuan Guan Bing Duan Yi-Ling Huang Yi-Shi Li | 2015 | Chinese Medical Journal2015，，6： | 4 |
| 10 | Processing Environmental Stimuli in Paranoid Schizophrenia:Recognizing Facial Emotions and Performing Executive Functions显示文摘Objective To study the contribution of executive function to abnormal recognition of facial expressions of emotion in schizophrenia patients. Methods Abnormal recognition of facial expressions of emotion was assayed according to Japanese and Caucasian facial expressions of emotion (JACFEE), Wisconsin card sorting test (WCST), positive and negative symptom scale, and Hamilton anxiety and depression scale, respectively, in 88 paranoid schizophrenia patients and 75 healthy volunteers. Results Patients scored higher on the Positive and Negative Symptom Scale and the Hamilton Anxiety and Depression Scales, displayed lower JACFEE recognition accuracies and poorer WCST performances. The JACFEE recognition accuracy of contempt and disgust was negatively correlated with the negative symptom scale score while the recognition accuracy of fear was positively with the positive symptom scale score and the recognition accuracy of surprise was negatively with the general psychopathology score in patients. Moreover, the WCST could predict the JACFEE recognition accuracy of contempt, disgust, and sadness in patients, and the perseverative errors negatively predicted the recognition accuracy of sadness in healthy volunteers. The JACFEE recognition accuracy of sadness could predict the WCST categories in paranoid schizophrenia patients. Conclusion Recognition accuracy of social-/moral emotions, such as contempt, disgust and sadness is related to the executive function in paranoid schizophrenia patients, especially when regarding sadness. | YU Shao Hua ZHU Jun Peng XU You ZHENG Lei Lei CHAI Hao HE Wei LIU Wei Bo LI Hui Chun WANG Wei | 2012 | Biomedical and Environmental Sciences2012，25，6： | 3 |
| 11 | On the Generation Algorithm of VRS Virtual Observations显示文摘In the past few years, network RTK positioning technology, especially the VRS technology, has been widely used in some parts of China and in many countries around the world. The principle of the VRS technology is discussed with corresponding formula deduction, and detailed descriptions and applications of VRS corrections and virtual observations generation algorithm are given. | WEI Erhu CHAI Hua LIU Jingnan AN Zhiguo | 2007 | Geo-Spatial Information Science2007，10，2： | 3 |
| 12 | TRIM27 maintains gut homeostasis by promoting intestinal stem cell self-renewal显示文摘Dysregulation of gut homeostasis is associated with irritable bowel syndrome(IBS),a chronic functional gastrointestinal disorder affecting approximately 11.2%of the global population.The poorly understood pathogenesis of IBS has impeded its treatment.Here,we report that the E3 ubiquitin ligase tripartite motif-containing 27(TRIM27)is weakly expressed in IBS but highly expressed in inflammatory bowel disease(IBD),a frequent chronic organic gastrointestinal disorder.Accordingly,knockout of Trim27 in mice causes spontaneously occurring IBS-like symptoms,including increased visceral hyperalgesia and abnormal stool features,as observed in IBS patients.Mechanistically,TRIM27 stabilizesβ-catenin and thus activates Wnt/β-catenin signaling to promote intestinal stem cell(ISC)self-renewal.Consistent with these findings,Trim27 deficiency disrupts organoid formation,which is rescued by reintroducing TRIM27 orβ-catenin.Furthermore,Wnt/β-catenin signaling activator treatment ameliorates IBS symptoms by promoting ISC self-renewal.Taken together,these data indicate that TRIM27 is critical for maintaining gut homeostasis,suggesting that targeting the TRIM27/Wnt/β-catenin axis could be a potential treatment strategy for IBS.Our study also indicates that TRIM27 might serve as a potential biomarker for differentiating IBS from IBD. | Jing Wang Dongdong Zhao Zehui Lei Pupu Ge Zhe Lu Qiyao Chai Yong Zhang Lihua Qiang Yang Yu Xinwen Zhang Bingxi Li Shu Zhu Lingqiang Zhang Cui Hua Liu | 2023 | Cellular & Molecular Immunology2023，20，2： | 2 |
| 13 | A review of the Cu–Ni sulphide deposits in the Chinese Tianshan and Altay orogens (Xinjiang Autonomous Region, NW China): Principal characteristics and ore-forming processes显示文摘 | Jing Wen Mao Franco Pirajno Zuo Heng Zhang Feng Mei Chai Hua Wu Shi Ping Chen Lin Song Cheng Jian Min Yang Chang Qing Zhang | 2007 | Journal of Asian Earth Sciences2007，，2： | 1 |
| 14 | VRS Virtual Observations Generation Algorithm显示文摘 | WEI ERHU CHAI HUA AN ZHIGUO | 2006 | Journal of Global Positioning Systems2006，5，12： | 1 |
| 15 | Catalytic combustion of vinyl chloride emissions over Co_(3)O_(4) catalysts with different crystallite sizes显示文摘A series of Co_(3) O_(4) catalysts was prepared by ammonia(Co-AP) and oxalate(Co-OP) precipitation,solgel(Co-SG),and urea hydrothermal(Co-UH) methods,and their physicochemical properties were characterised by numerous techniques including X-ray diffraction(XRD),scanning electron microscopy(SEM),transmission electron microscopy(TEM),nitrogen sorption,X-ray photoelectron spectroscopy(XPS),temperature-programmed reduction of H_(2)(H_(2)-TPR),temperature-programmed desorption of O_(2)(O_(2)-TPD),and temperature-programmed desorption of NH_(3)(NH_(3)-TPD).The catalytic activity of each catalyst was estimated for the catalytic combustion of vinyl chloride(VC) emissions.The crystallite size of the Co_(3) O_(4) catalyst was found to be well correlated with the amounts of surface-adsorbed oxygen species and number of acid sites on the catalyst surface,and consequently,determined several physicochemical properties of the catalyst.Of the catalysts studied here,the Co-AP catalyst exhibits the smallest crystallite size,which increases the specific surface area and the concentration of Co^(2+) on the catalyst surface.This,in turn,enhances the redox property,oxygen mobility,and the number of acid sites associated with the Co-AP catalyst.In fact,the Co-AP catalyst exhibits the best catalytic activity for VC combustion at 360℃and does not produce any chlorinated by-products. | Wen-Chao Hua Ming-Qi Li Yang-Long Guo Guang-Tao Chai Hao Liu Yun Guo Li Wang Wang-Cheng Zhan | 2021 | Rare Metals2021，40，4： | 1 |
| 16 | VRS virtual observations generation algorithm 显示文摘 | Wei Erhu Chai Hua An Zhiguo | 2006 | Journal of Global Positioning Systems2006，5，12： | 1 |
| 17 | Genetic diversity and phylogenetic analysis of glycoprotein gp85of avian leukosis virus subgroup J wild-bird isolates from Northeast China显示文摘 | Jiang L Zeng X Hua Y Gao Q Fan Z Chai H Wang Q Qi X Wang Y Gao H Gao Y Wang X | 2014 | Arch Virol2014，159，7： | 1 |
| 18 | Physical principles and simulations on the structural evolution of c0o-industrial systems 显示文摘 | Cui Hua Huo Li He Chai | 2008 | Journal of Cleaner Production2008，16，18： | 1 |
| 19 | A review of tile Cu-Ni sulphide deposits in tile Chinese Tianshan and Altay orogens (Xinjiang Autonomous Region, NW China): Principal characteristics and ore-forming processes 显示文摘 | Mao Jing-wen Pirajno F Zhang Zuo-heng Chai Feng-mei Wu Hua Chert Shi-ping Cheng Lin-song Yang Jian-min Zhang Chang-qing | 2008 | J Asian Earth Sci2008，32，24： | 1 |
| 20 | Polyacrylamide hydrogels with phenylboronic acid moieties for the imprinting of proteins显示文摘在这封信, N-acryloyl-3-aminophenylboronic 酸(AAPBA ) 为蛋白质印作为新功能的单体被综合然后检验。与 acrylamide 被异分子聚合生产印血红素或印溶解酵素的 hydrogels 被允许。在重捆测试的模板,印的胶化随 prepolymerization 配方的 AAPBA 数量的增加在特定的绑定显示出重要增加。这些结果显示 AAPBA 可以是为它和蛋白质分子的中等相互作用的有用功能的单体。 | Yan Wang Zhi Hua Chai Hong Yan He Yi Zhe Jiang Guo Qi Fu | 2010 | Chinese Chemical Letters2010，21，12： | 1 |
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