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| 1 | Learning curve of computer-assisted navigation system in spine surgery显示文摘用帮助计算机的航行(罐头) 的背景脊骨外科被证明了导致低螺丝钉误放率,放射暴露的低发生和看的优秀的起作用的地对常规 intraoperative 图象 intensifier (C) 。不管多么当我们知道,以前的研究描述了的很少二个连续盒子队与不同经验背景, A 和 B 在花梗螺丝钉精确性和二位脊骨外科医生的起作用的时间上学习的在我们执行了的脊骨 surgery.Methods 的罐头的学习曲线,在一个机构在一样的时期期间。外皮的穿孔率和操作使用的一样的类型的起作用的时间装的腰部的花梗螺丝钉被分析并且比较了为二位外科医生使用 C 在起始,当四年的全部的盒子被包括时, 6 个月和 12 月罐头 usage.Results 罐头脊骨外科为外科医生 A 和 B 队与 C 相比有全面更低的外皮的穿孔率和不太吝啬的起作用的时间。它错过了是统计上重要的,与 3.3% 对 4.7%(P=0.191 ) 并且为外科医生 A 的 125.7 对 132.3 分钟(P=0.428 ) 并且 3.6% 对 6.4%(P=0.058 ) ,并且为外科医生 B 的 183.2 对 213.2 分钟(P=0.070 ) 。在一次尝试到表明学习曲线,在 6 月在每位外科医生的队的罐头系统以后的盒子被比较。穿孔率在 2.4% 减少了(P=0.039 ) 并且 4.3%(P=0.003 ) 并且起作用的时间分别地为外科医生 A 和 B 的 CAN 组到 31.8 分钟(P=0.002 ) 和 14.4 分钟(P=0.026 ) 被减少。当仅仅盒子表现在 12 以后时,用 CAN 系统的月被考虑,穿孔率在3.9%减少了( P=0.006 )并且5.6%( P 0.001 )并且起作用的时间为外科医生 A 和 B 的 CAN 组到 20.9 分钟( P 0.001 )和 40.3 分钟( P 0.001 )被减少, respectively.Conclusions 长远来说,罐头脊骨外科减少了腰部的螺丝钉外皮的穿孔率和起作用的时间。在 6 月使用在 12 个月以后装那 plateaued 以后,学习曲线显示出锋利的落下;它被穿孔率和起作用的时间数据表明。数据的小心的分析证明罐头是特别有用的让更少的富有经验的外科医生减少穿孔率和 intraoperative 时间,尽管进一步比较的研究被期望。 | BAI Yu-shu ZHANG Ye CHEN Zi-qiang WANG Chuan-feng ZHAO Ying-chuan SHI Zhi-cai LI Ming LIU Ka Po Gabriel | 2010 | Chinese Medical Journal2010，，21： | 8 |
| 2 | Transarterial chemoembolization with PD-(L)1 inhibitors plus molecular targeted therapies for hepatocellular carcinoma(CHANCE001)显示文摘There is considerable potential for integrating transarterial chemoembolization(TACE),programmed death-(ligand)1(PD-[L]1)inhibitors,and molecular targeted treatments(MTT)in hepatocellular carcinoma(HCC).It is necessary to investigate the therapeutic efficacy and safety of TACE combined with PD-(L)1 inhibitors and MTT in real-world situations.In this nationwide,retrospective,cohort study,826 HCC patients receiving either TACE plus PD-(L)1 blockades and MTT(combination group,n=376)or TACE monotherapy(monotherapy group,n=450)were included from January 2018 to May 2021.The primary endpoint was progression-free survival(PFS)according to modified RECIST.The secondary outcomes included overall survival(OS),objective response rate(ORR),and safety.We performed propensity score matching approaches to reduce bias between two groups.After matching,228 pairs were included with a predominantly advanced disease population.Median PFS in combination group was 9.5 months(95%confidence interval[CI],8.4-11.0)versus 8.0 months(95%CI,6.6-9.5)(adjusted hazard ratio[HR],0.70,P=0.002).OS and ORR were also significantly higher in combination group(median OS,19.2[16.1-27.3]vs.15.7 months[13.0-20.2];adjusted HR,0.63,P=0.001;ORR,60.1%vs.32.0%;P<0.001).Grade 3/4 adverse events were observed at a rate of 15.8%and 7.5%in combination and monotherapy groups,respectively.Our results suggest that TACE plus PD-(L)1 blockades and MTT could significantly improve PFS,OS,and ORR versus TACE monotherapy for Chinese patients with predominantly advanced HCC in real-world practice,with an acceptable safety profile. | Hai-Dong Zhu Hai-Liang Li Ming-Sheng Huang Wei-Zhu Yang Guo-Wen Yin Bin-Yan Zhong Jun-Hui Sun Zhi-Cheng Jin Jian-Jian Chen Nai-Jian Ge Wen-Bin Ding Wen-Hui Li Jin-Hua Huang Wei Mu Shan-Zhi Gu Jia-Ping Li Hui Zhao Shu-Wei Wen Yan-Ming Lei Yu-Sheng Song Chun-Wang Yuan Wei-Dong Wang Ming Huang Wei Zhao Jian-Bing Wu Song Wang Xu Zhu Jian-Jun Han Wei-Xin Ren Zai-Ming Lu Wen-Ge Xing Yong Fan Hai-Lan Lin Zi-Shu Zhang Guo-Hui Xu Wen-Hao Hu Qiang Tu Hong-Ying Su Chuan-Sheng Zheng Yong Chen Xu-Ya Zhao Zhu-Ting Fang Qi Wang Jin-Wei Zhao Ai-Bing Xu Jian Xu Qing-Hua Wu Huan-Zhang Niu Jian Wang Feng Dai Dui-Ping Feng Qing-Dong Li Rong-Shu Shi Jia-Rui Li Guang Yang Hai-Bin Shi Jian-Song Ji Yu-E Liu Zheng Cai Po Yang Yang Zhao Xiao-Li Zhu Li-Gong Lu Gao-Jun Teng | 2023 | Signal Transduction and Targeted Therapy2023，8，3： | 7 |
| 3 | Overexpression of carbonic anhydrase Ⅱ and Ki-67 proteins in prognosis of gastrointestinal stromal tumors显示文摘AIM: To investigate the expression and prognostic value of carbonic anhydrase Ⅱ (CA Ⅱ) and Ki-67 in gastrointestinal stromal tumors (GISTs). METHODS: One hundred and thirteen GIST patients admitted to Chinese People's Liberation Army General Hospital from January 2004 to December 2010 were retrospectively followed up, and immunohistochemistry was used to detect CA Ⅱ, Ki-67 and CD117 expression in tumor samples. The survival rates of the patients were analyzed using the Kaplan-Meier method. Log-rank test, χ 2 test and Cox proportional hazards model were used to determine the relationships between CA Ⅱ, Ki-67 and CD117 expression and prognostic value in GISTs. RESULTS: The survival rates at 1, 3 and 5 years were 90.0%, 82.0% and 72.0% in all patients. However, in patients with positive CA Ⅱ or Ki-67, the survival rates were 92.0%, 83.0% and 77.0% or 83.0%, 66.6% and 53.0%, respectively. Compared with the negative groups, the survival rates in the positive groups were significantly lower (CA Ⅱ log-rankP = 0.000; Ki-67 logrank P = 0.004). Multivariate Cox analysis revealed that CA Ⅱ, CD117 and Ki-67 were considerable immune factors in prognosis of GIST patients (CA Ⅱ P = 0.043; CD117 P = 0.042; Ki-67 P = 0.007). Besides, tumor diameter, mitotic rate, tumor site, depth of invasion, complete resection, intraoperative rupture, and adjuvant therapy were important prognosis predictive factors. Our study indicated that CA Ⅱ had strong expression in GISTs and the prognosis of GISTs with high CA Ⅱ expression was better than that of GISTs with low or no expression, suggesting that CA Ⅱ is both a diagnostic and prognostic biomarker for GIST. CONCLUSION: CA Ⅱ and Ki-67 are significant prognostic factors for GISTs. CA Ⅱ associated with neovascular endothelia could serve as a potential target for cancer therapy. | Li-Cheng Liu Wen-Tong Xu Xin Wu Po Zhao Ya-Li Lv Lin Chen | 2013 | World Journal of Gastroenterology2013，19，16： | 5 |
| 4 | Analysis of leakage current in GaAs micro-solar cell arrays显示文摘The output characteristics of micro-solar cell arrays are analyzed on the basis of a modified model in which the shunt resistance between cell lines results in current leakage.The modification mainly consists of adding a shunt resistor network to the traditional model.The obtained results agree well with the reported experimental results.The calculation results demonstrate that leakage current in substrate affects seriously the performance of GaAs micro-solar cell arrays.The performance of arrays can be improved by reducing the number of cells per line.In addition,at a certain level of integration,an appropriate space occupancy rate of the single cell is recommended for ensuring high open circuit voltages,and it is more appropriate to set the rates at 80%-90% through the calculation. | WANG YanShuo1,CHEN NuoFu1,2,3,ZHANG XingWang1,BAI YiMing1,WANG Yu1,HUANG TianMao1,ZHANG Han1 & SHI HuiWei1 1 Key Laboratory of Semiconductor Materials Science,Institute of Semiconductors,Chinese Academy of Sciences,PO Box 912,Beijing 100083,China 2 School of Renewable Energy Engineering,North China Electric Power University,Beijing 102206,China 3 National Laboratory of Micro-Gravity,Institute of Mechanics,Chinese Academy of Sciences,Beijing 100080,China | 2010 | Science China(Technological Sciences)2010，53，5： | 5 |
| 5 | Plastic limit load analysis for pressure pipe with incomplete welding defects based on the extended Net Section Collapse Criteria显示文摘With von Mises yield criterion,the loading range of Net Section Collapse(NSC) Criteria is extended from combined tension and bending loadings to combined bending,torsion and internal pressure loadings.A new theoretical analyzing method of plastic limit load for pressure pipe with incomplete welding defects based on the extended NSC Criteria is presented and the correlative formulas are deduced,the influences of pipe curvature,circumferential length and depth of incomplete welding defects on the plastic limit load of pressure pipe are considered as well in this method.Meanwhile,according to the orthogonal experimental design method,the plastic limit loads are calculated by the finite element method and compared with the theoretical values.The results show that the expressions of plastic limit load of pressure pipe with incomplete welding defects under bending,torsion and internal pressure based on extended NSC criteria are reliable.The study provides an important theoretical basis for the establishment of safety assessment measure towards pressure pipe with incomplete welding defects. | Zhi-jiang JIN Cheng-hang JIANG Xian-ping WAN Po CHEN Xiao-fang WANG | 2010 | Journal of Zhejiang University-Science A(Applied Physics & Engineering)2010，11，6： | 4 |
| 6 | Quantifying the effectiveness of SiO_2/Au light trapping nanoshells for thin film poly-Si solar cells显示文摘In order to enhance light absorption of thin film poly-crystalline silicon(TF poly-Si)solar cells over a broad spectral range, and quantify the effectiveness of nanoshell light trapping structure over the full solar spectrum in theory,the effective photon trapping flux(EPTF)and effective photon trapping efficiency(EPTE)were firstly proposed by considering both the external quantum efficiency of TF poly-Si solar cell and scattering properties of light trapping structures.The EPTF,EPTE and scattering spectrum exhibit different behaviors depending on the geometric size and density of nanoshells that form the light trapping layer.With an optimum size and density of SiO2/Au nanoshell light trapping layer,the EPTE could reach up to 40%due to the enhancement of light trapping over a broad spectral range,especially from 500 to 800 nm. | BAI YiMing 1 ,WANG Jun 2 ,CHEN NuoFu 1,3 ,YAO JianXi 1 ,YIN ZhiGang 3 ,ZHANG Han 3 , ZHANG XingWang 3 ,HUANG TianMao 3 ,WANG YanShuo 3 &YANG XiaoLi 3 1School of Renewable Energy Engineering,North China Electric Power University,Beijing 102206,China 2 National Engineering Research Center for Optoelectronic Devices,Institute of Semiconductors, Chinese Academy of Sciences,PO Box 912,Beijing 100083,China 3 Key Laboratory of Semiconductor Materials Science,Institute of Semiconductors, Chinese Academy of Sciences,PO Box 912,Beijing 100083,China | 2010 | Science China(Technological Sciences)2010，53，8： | 4 |
| 7 | Chromosome-scale genome assembly of sweet cherry(Prunus avium L.)cv.Tieton obtained using long-read and Hi-C sequencing显示文摘Sweet cherry(Prunus avium)is an economically significant fruit species in the genus Prunus.However,in contrast to other important fruit trees in this genus,only one draft genome assembly is available for sweet cherry,which was assembled using only Illumina short-read sequences.The incompleteness and low quality of the current sweet cherry draft genome limit its use in genetic and genomic studies.A high-quality chromosome-scale sweet cherry reference genome assembly is therefore needed.A total of 65.05 Gb of Oxford Nanopore long reads and 46.24 Gb of Illumina short reads were generated,representing~190x and 136x coverage,respectively,of the sweet cherry genome.The final de novo assembly resulted in a phased haplotype assembly of 344.29 Mb with a contig N50 of 3.25 Mb.Hi-C scaffolding of the genome resulted in eight pseudochromosomes containing 99.59%of the bases in the assembled genome.Genome annotation revealed that more than half of the genome(59.40%)was composed of repetitive sequences,and 40,338 protein-coding genes were predicted,75.40%of which were functionally annotated.With the chromosomescale assembly,we revealed that gene duplication events contributed to the expansion of gene families for salicylic acid/jasmonic acid carboxyl methyltransferase and ankyrin repeat-containing proteins in the genome of sweet cherry.Four auxin-responsive genes(two GH3s and two SAURs)were induced in the late stage of fruit development,indicating that auxin is crucial for the sweet cherry ripening process.In addition,772 resistance genes were identified and functionally predicted in the sweet cherry genome.The high-quality genome assembly of sweet cherry obtained in this study will provide valuable genomic resources for sweet cherry improvement and molecular breeding. | Jiawei Wang Weizhen Liu Dongzi Zhu Po Hong Shizhong Zhang Shijun Xiao Yue Tan Xin Chen Li Xu Xiaojuan Zong Lisi Zhang Hairong Wei Xiaohui Yuan Qingzhong Liu | 2020 | Horticulture Research2020，7，1： | 4 |
| 8 | Activation of anterior thalamic reticular nucleus GABAergic neurons promotes arousal from propofol anesthesia in mice显示文摘Propofol is widely used for the induction and maintenance of anesthesia,which causes a rapid loss of consciousness.However,the mechanisms underlying the hypnosis effect of propofol are still not fully understood.The thalamic reticular nucleus(TRN)is crucial for regulating wakefulness,sleep rhythm generation,and sleep stability,while the role of TRN in the process of propofol-induced anesthesia is still unknown.Here,we investigated the function of the anterior TRN in propofol general anesthesia.Our results demonstrated that the neural activity of anterior TRN is suppressed during propofol anesthesia,whereas it is robustly activated from anesthesia by recording the calcium signals using fiber photometry technology.The results showed that the activation of anterior TRN neurons by chemogenetic and optogenetic methods shortens the emergency time without changing the induction time.Conversely,chemogenetic or optogenetic inhibition of the TRN neurons leads to a delay in the recovery time.Our study showed that anterior TRN is crucial for behavioral arousal without affecting the induction time of propofol anesthesia. | Yanjun Liu Bing Chen Yirong Cai Yuan Han Ying Xia Nanqi Li Bingqian Fan Tianjie Yuan Junli Jiang Po Gao Weifeng Yu Yingfu Jiao Wenxian Li | 2021 | Acta Biochimica et Biophysica Sinica2021，53，7： | 3 |
| 9 | Hippocampus is more vulnerable to neural damages induced by repeated sevoflurane exposure in the second trimester than other brain areas显示文摘During the rapidly developing and sensitive period of the central nervous system (CNS), a harmful stimulus may have serious consequences. The effect of anesthetic exposure on the development of the offspring’s CNS during pregnancy is still unclear and has been widely concerned. In the present study, we compared the susceptibility of the hippocampus with those of other brain regions in offsprings when the mother mice were exposed to repeated sevoflurane. We found that other than affecting motor sensation, emotion, or social behavior of offspring mice, repeated sevoflurane exposure induced significant memory deficiency. Compared with other brain regions, the hippocampus, which is the key component of the brain serving for learning and memory, was more vulnerable to repeated sevoflurane exposure. We also found that repeated sevoflurane exposure to mother mice could inhibit the axon development of hippocampal neurons. We also predicted that N6-methyladenosine modification of mRNA might play an essential role in the vulnerability of the hippocampus to sevoflurane, while the underlying cellular mechanism needs to be explored in the future. Our study may provide a new perspective for studying the mechanism of hippocampus-specific injury induced by sevoflurane exposure. | Bing Chen Yanjun Liu Yirong Cai Dan Tang Saihong Xu Po Gao Weifeng Yu Yingfu Jiao Wenxian Li | 2020 | Acta Biochimica et Biophysica Sinica2020，52，8： | 3 |
| 10 | A day-ahead scheduling framework for thermostatically controlled loads with thermal inertia and thermal comfort model显示文摘This paper proposes a day-ahead dispatch framework of thermostatically controlled loads(TCLs) for system peak load reduction. The proposed day-ahead scheduling framework estimates the user’s indoor thermal comfort degree through the building thermal inertia modelling. Based on the thermal comfort estimation, a dayahead TCL scheduling model is formulated, which consists of 3 stages: TCL aggregator estimates maximal controllable TCL capacities at each scheduling time interval by solving a optimization model;[ the system operator performs the day-ahead system dispatch to determine the load shedding instruction for each aggregator;and ′the TCL aggregator schedules the ON/OFFcontrol actions of the TCL groups based on the instruction from the system operator. A heuristic based optimization method, history driven differential evolution(HDDE)algorithm, is employed to solve the day-ahead dispatch model of the TCL aggregator side. Simulations are conducted to validate the proposed model. | Yingying CHEN Fengji LUO Zhaoyang DONG Ke MENG Gianluca RANZI Kit Po WONG | 2019 | Journal of Modern Power Systems and Clean Energy2019，7，3： | 3 |
| 11 | Is High Serum Uric Acid a Risk Marker or a Target for Treatment? Examination of its Independent Effect in a Large Cohort With Low Cardiovascular Risk显示文摘 | Chi Pang Wen Ting-Yuan David Cheng Hui Ting Chan Min Kuang Tsai Wen-Shen Isabella Chung Shan Pou Tsai Mark L. Wahlqvist Yi Chen Yang Shiuan Be Wu Po Huang Chiang Sung Feng Wen | 2010 | American Journal of Kidney Diseases2010，，2： | 2 |
| 12 | Large deviation principle for diffusion processes under a sublinear expectation显示文摘We represent the exponential moment of the Brownian functionals under a nonlinear expectation according to the solution to a backward stochastic differential equation.As an application,we establish a large deviation principle of the Freidlin and Wentzell type under the corresponding nonlinear probability for diffusion processes with a small diffusion coefficient. | CHEN ZengJing 1,2 & XIONG Jie 3,4,1 School of Mathematics,Shandong University,Jinan 250100,China 2 Department of Financial Engineering,Ajou University,Suwon 443749,Korea 3 Department of Mathematics,University of Macao,PO Box 3001,Macao,China 4 Department of Mathematics,University of Tennessee,Knoxville,TN 37996-1300,USA | 2012 | Science China Mathematics2012，55，11： | 2 |
| 13 | The Thermal Character of the Underwater Heat Exhausting Source显示文摘The underwater heat exhausting source can cause the thermal difference of the surrounding and surface water.In this paper,the thermal character caused by the underwater heat exhausting source is studied by numerical simulation and experiment.The results show that the thermal floating distance is related with the sailing velocity of the underwater target.The higher the velocity is,the longer the hot wake is,and the broader the hot scope is.The relative distance of the thermal floating spot is almost in a logarithmic law with the velocity.The experimental results are accordant with the numerical simulation,and the obvious hot wake can be observed by the moving underwater heat exhausting source testing with temperature sensors and infrared camera. | Shengtao Chen,Huanying Liu and Yi Qi Science and Technology on Underwater Test and Control Laboratory,PO Box 67,Dalian,Liaoning 116013 | 2010 | Journal of Thermal Science2010，19，5： | 2 |
| 14 | Accelerating the discontinuous Galerkin method for seismic wave propagation simulations using multiple GPUs with CUDA and MPI显示文摘We have successfully ported an arbitrary highorder discontinuous Galerkin method for solving the threedimensional isotropic elastic wave equation on unstructured tetrahedral meshes to multiple Graphic Processing Units(GPUs)using the Compute Unified Device Architecture(CUDA)of NVIDIA and Message Passing Interface(MPI)and obtained a speedup factor of about 28.3 for the single-precision version of our codes and a speedup factor of about 14.9 for the double-precision version.The GPU used in the comparisons is NVIDIA Tesla C2070 Fermi,and the CPU used is Intel Xeon W5660.To effectively overlap inter-process communication with computation,we separate the elements on each subdomain into inner and outer elements and complete the computation on outer elements and fill the MPI buffer first.While the MPI messages travel across the network,the GPU performs computation on inner elements,and all other calculations that do not use information of outer elements from neighboring subdomains.A significant portion of the speedup also comes from a customized matrix–matrix multiplication kernel,which is used extensively throughout our program.Preliminary performance analysis on our parallel GPU codes shows favorable strong and weak scalabilities. | Dawei Mu Po Chen Liqiang Wang | 2013 | Earthquake Science2013，26，6： | 2 |
| 15 | Silk-based hydrogel incorporated with metal-organic framework nanozymes for enhanced osteochondral regeneration显示文摘Osteochondral defects(OCD)cannot be efficiently repaired due to the unique physical architecture and the pathological microenvironment including enhanced oxidative stress and inflammation.Conventional strategies,such as the control of implant microstructure or the introduction of growth factors,have limited functions failing to manage these complex environments.Here we developed a multifunctional silk-based hydrogel incorporated with metal-organic framework nanozymes(CuTA@SF)to provide a suitable microenvironment for enhanced OCD regeneration.The incorporation of CuTA nanozymes endowed the SF hydrogel with a uniform microstructure and elevated hydrophilicity.In vitro cultivation of mesenchymal stem cells(MSCs)and chondrocytes showed that CuTA@SF hydrogel accelerated cell proliferation and enhanced cell viability,as well as had antioxidant and antibacterial properties.Under the inflammatory environment with the stimulation of IL-1β,CuTA@SF hydrogel still possessed the potential to promote MSC osteogenesis and deposition of cartilage-specific extracellular matrix(ECM).The proteomics analysis further confirmed that CuTA@SF hydrogel promoted cell proliferation and ECM synthesis.In the full-thickness OCD model of rabbit,CuTA@SF hydrogel displayed successfully in situ OCD regeneration,as evidenced by micro-CT,histology(HE,S/O,and toluidine blue staining)and immunohistochemistry(Col I and aggrecan immunostaining).Therefore,CuTA@SF hydrogel is a promising biomaterial targeted at the regeneration of OCD. | Zhicheng Cao Hongmei Wang Jialin Chen Yanan Zhang Qingyun Mo Po Zhang Mingyue Wang Haoyang Liu Xueyang Bao Yuzhi Sun Wei Zhang Qingqiang Yao | 2023 | Bioactive Materials2023，，2： | 2 |
| 16 | Simultaneous determination of nitrate and nitrite in saliva and food stufs by non- up-pressed ion chromatography with bulk acoustic wave detector 显示文摘 | YU Bingsheng CHEN Po NIE Lihua | 2001 | Anal Sci2001，17，4： | 1 |
| 17 | Emphysematous pyelonephritis: Clinical characteristics and prognostic factors显示文摘 | Yu‐Chuan Lu Bing‐Juin Chiang Yuan‐Hung Pong Chung‐Hsin Chen Yeong‐Shiau Pu Po‐Ren Hsueh Chao‐Yuan Huang | 2014 | Int J Urol2014，，3： | 1 |
| 18 | Sludge Dewatering and Drying显示文摘 | Guohua Chen Po L Y Mujumdar A S | 2002 | Drying Technology2002，，5： | 1 |
| 19 | Stress analysis of distal locking screws for femoral interlocking nailing 显示文摘 | Lin J Lin SJ Chen PO | 2001 | J Orthop Res2001，19，1： | 1 |
| 20 | lntragastric acid suppres- sion and pharmacokinetics of twice-daily esomeprazole: a ran domized, three-way crossover study 显示文摘 | Katz PO Castell DO Chen Y | 2004 | Aliment Pharmacol Ther2004，20，4： | 1 |
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