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| 1 | Ovarian cancer stem cells: Can targeted therapy lead to improved progression-free survival?显示文摘Despite significant effort and research funds, epithelial ovarian cancer remains a very deadly disease. There are no effective screening methods that discover early stage disease; the majority of patients are diagnosed with advanced disease. Treatment modalities consist primarily of radical debulking surgery followed by taxane and platinum-based chemotherapy. Newer therapies including limited targeted agents and intraperitoneal delivery of chemotherapeutic drugs have improved disease-free intervals, but failed to yield longlasting cures in most patients. Chemotherapeutic resistance, particularly in the recurrent setting, plagues the disease. Targeting the pathways and mechanisms behind the development of chemoresistance in ovarian cancer could lead to significant improvement in patient outcomes. In many malignancies, including blood and other solid tumors, there is a subgroup of tumor cells, separate from the bulk population, called cancer stem cells(CSCs). These CSCs are thought to be the cause of metastasis, recurrence and resistance. However, todate, ovarian CSCs have been difficult to identify, isolate, and target. It is felt by many investigators that finding a putative ovarian CSC and a chemotherapeutic agent to target it could be the key to a cure for this deadly disease. This review will focus on recent advances in this arena and discuss some of the controversies surrounding the concept. | Christen L Walters Haygood Rebecca C Arend J Michael Straughn Donald J Buchsbaum | 2014 | World Journal of Stem Cells2014，6，4： | 7 |
| 2 | Quantification and control of the sulfur c(2 × 2) superstructure on {100} (100) Ni for optimization of YSZ, CeO2 and SrTiO3 seed layer texture显示文摘 | Cantoni C Christen D K Heatherly L | 2002 | Journal of Materials Research2002，17，10： | 1 |
| 3 | Assessment of effluent contaminants from three facilities discharging marcellus shale wastewater to surface waters in pennsylvania显示文摘 | Ferrar K J Michanowicz D R Christen C L | 2013 | Environmental Science & Technology2013，47，7： | 1 |
| 4 | Assess- ment of Effluent Contaminants from Three Facilities Dischar- ging Marcellus Shale Wastewater to Surface Waters in Penn- sylvania 显示文摘 | Ferrar K J Michanowicz D R Christen C L | 2013 | Environmental Science & Technology2013，47，7： | 1 |
| 5 | Stimulation of different functional groups of bacteria by various plant residues as a driver of soil priming effect 显示文摘 | Pascault N Ranjard L Kaisermann A Bachar D Christen R Terrat S Mathieu O Leveque J Mougel C Henault C Lemanceau P Pean M Boiry S Fontaine S Maron PA | 2013 | Ecosystems2013，16，5： | 1 |
| 6 | Growth of oxide seed layers on Ni and other technologically interesting metal substrates: Issues related to formation and control of sulfur superstructures for texture optimization显示文摘 | CANTONI C CHRISTEN D K GOYAL A HEATHERLY L LIST F A OWNBY G W ZEHNER D M CHRISTEN H M ROULEAU C M | 2003 | IEEE Trans Appl Supercond2003，13，： | 1 |
| 7 | Polarization- mode -dispersion monitoring for phase-modulated signals usingDGD -generated interferometric filter 显示文摘 | Zhang L Christen L C Zhang B | 2008 | IEEE PhotonicsTechnology Letters2008，20，2： | 1 |
| 8 | 显示文摘 | Cantoni C Christen D K Heatherly L | 2002 | J Mater Res2002，17，： | 1 |
| 9 | 显示文摘 | BIERI S ILIAS Y BICCHI C VEUTHEY J L CHRISTEN P | 2006 | J Chromatogr:A2006，1112，12： | 1 |
| 10 | From Piezoelectric Actuator to Piezomotor显示文摘 | Bernard Y Christen J L Hernandez C | 2001 | Piers On- line2001，7，5： | 1 |
| 11 | Stimulation of different functional groups of bacteria by various plant residues as a driver of soil priming effect显示文摘 | Pascault N Ranjard L Kaisermann A Bachar D Christen R Terrat S Mathieu O Lév(e)que J Mougel C Henault C Lemanceau P Péan M Boiry S Fontaine S Maron PA | | 0，，： | 1 |
| 12 | Folate and folate receptor alpha antagonists mechanism of action in ovarian cancer 显示文摘 | Christen L Waiters Rebecca C | | Gynecol Oncol0，131，2： | 1 |
| 13 | Assessment of effluent contaminants from three facilities discharging Marcellus shale wastewater to surface waters in Pennsylvania 显示文摘 | FERRAR K J MICHANOWICZ D R CHRISTEN C L | 2013 | Environmental Science & Technology2013，47，7： | 1 |
| 14 | Growth and characterization of conductive SrRuO3 and LaNiO3 multilayers on textured Ni tapes for high-Jc YBa2Cu3O7-δ coated conductors 显示文摘 | Aytug T Kang B W Cantoni C Specht E D Paranthaman M Goyal A Christen D K Verebelyi D T Wu J Z Ericson R E Thomas C L Yang C Y Babcock S E | 2001 | Journal of Material Research2001，16，9： | 1 |
| 15 | CD8aα-mediated survival and differentiation of CD8 memory T cell preoursors显示文摘 | Madakamutil L T Christen U Lena C J | 2004 | Science2004，304，： | 1 |
| 16 | All-Optical XOR Gate Using Polarization Rotation in Single Highly Nonlinear Fiber显示文摘 | Yu C Y Christen L Luo T | | 0，，06： | 1 |
| 17 | All-Optical XOR gate using polarization rotation in single highly nonlinear fiber显示文摘 | Yu C Christen L Luo T | 2005 | IEEE Photonies Technology Letters2005，17，6： | 1 |
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