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1Evaluation of chronic kidney disease in chronic heart failure: From biomarkers to arterial renal resistances显示文摘Chronic kidney disease and its worsening are recurring conditions in chronic heart failure(CHF) which are independently associated with poor patient outcome.The heart and kidney share many pathophysiological mechanisms which can determine dysfunction in each organ. Cardiorenal syndrome is the condition in which these two organs negatively affect each other, therefore an accurate evaluation of renal function in the clinical setting of CHF is essential. This review aims to revise the parameters currently used to evaluate renal dysfunction in CHF with particular reference to the usefulness and the limitations of biomarkers in evaluating glomerular dysfunction and tubular damage. Moreover, it is reported the possible utility of renal arterial resistance index(a parameter associated with abnormalities in renal vascular bed) for a better assesment of kidney disfunction.Massimo Iacoviello Marta Leone Valeria Antoncecchi Marco Matteo Ciccone 2015World Journal of Clinical Cases2015,3,1:8
2Agglomeration effects in Europe显示文摘Antonio Ciccone 2002European Economic Review2002,,2:3
3Etiology of chronic liver diseases in the Northwest of Italy, 1998 through 2014显示文摘AIM To assess the etiology of chronic liver diseases(CLD) from 1998 to 2014 at the outpatient clinic of Gastroenterology of the main hospital in Northwest of Italy among those dedicated to hepatology.METHODS A random sample of charts of patients referred to for increased liver enzymes between January 1998 and December 2006, and between January 2012 and December 2014 were reviewed. Etiology search included testing for hepatitis B virus(HBV), hepatitis C virus(HCV), autoimmune hepatitis, primary biliary cirrhosis, Wilson's disease and hereditary hemocromatosis. A risky alcohol consumption was also considered. Nonalcoholic fatty liver disease(NAFLD) was diagnosed in patients with histological and/or ultrasound evidence of steatosis/steatohepatitis, and without other causes of CLD.RESULTS The number of patients included was 1163. Of them, 528(45%) had positivity for HCV and 85(7%) for HBV. Among the virus-free patients, 417(36%) had metabolic disorders whereas the remaining had history of alcohol abuse, less prevalent causes of CLD or concomitant conditions. In comparison to 1998-2000(41%), a reduction of HCV alone-related cases was detected during the periods 2001-2003(35%, OR = 0.75, 95%CI: 0.53-1.06), 2004-2006(33%, OR = 0.70, 95%CI: 0.50-0.97) and 2012-2014(31%, OR = 0.64, 95%CI: 0.46-0.91). On the contrary, in comparison to 1998-2000(31%), metabolic-alone disorders increased in the period 2004-2006(39%, OR = 1.37, 95%CI: 0.99-1.91) and 2012-2014(41%, OR = 1.53, 95%CI: 1.09-2.16). The other etiologies remained stable. The increase of incidence of metabolic-alone etiology during the period 2004-2006 and 2012-2014 tended to be higher in older patients(≥ 50 years) compared to younger(P = 0.058).CONCLUSION In the Northwest of Italy, during this study period, the prevalence of HCV infection decreased notably whereas that of NAFLD increased.Giorgio Maria Saracco Andrea Evangelista Sharmila Fagoonee Giovannino Ciccone Elisabetta Bugianesi Gian Paolo Caviglia Maria Lorena Abate Mario Rizzetto Rinaldo Pellicano Antonina Smedile 2016World Journal of Gastroenterology2016,22,36:2
4Orthostatic hypotension,an often-neglected problem in community-dwelling older people:discrepancies between studies and real life显示文摘Orthostatic hypotension (OH)is a common condition in older persons.According to the 2011criteria,OH is defined by a sustained reduction of systolic blood pressure of 20 mmHg or a 10mmHg-fall of diastolic blood pressure,[1] Its prevalence increases with age and according to a recent systematic review the pooled prevalence in community dwelling older people is 22.2%.[2]Although OH is largely explained by concurrent clinical conditions (in particular, hypertension,diabetes,malnutrition,vascular encephalopa- thy,anemia,Parkinson's disease)[3],aging per se determines a series of physiological dysfunctions potentially representing its biological substratum (e.g.,reduction in barore- flex-mediated cardiovascular function,altered salt and water balance at renal level,impaired cardiac diastolic filling).It is also noteworthy that age-related changes in pharmacokinetic and pharmacodynamic mechanisms of drugs (especially in the context of polypharmacy)also increase the risk of OH.Sarah Damanti Dario Consormi Annalisa Valentini Benedetta Cerasoli Martina Biotto Federica Conti Marta Clerici Pasqualina Iannuzzi Emanuela Manzo Paolo D Rossi Simona Ciccone Matteo Cesari 2018Journal of Geriatric Cardiology2018,15,10:2
5Serum vitamin D content is associated with semen|parameters and serum testosterone levels in men显示文摘The present study aimed to evaluate the influence of serum vitamin D levels on semen quality and testosterone levels.This is a crosssectional study conducted at Androscience,Science and Innovation Center in Andrology and High-Complex Clinical and Andrology Laboratory in Sao Paulo,Brazil,with 508 male patients,aged 18-60 years,from 2007 to 2017.Seminal parameters and serum sexual hormones were correlated with serum vitamin D concentrations in 260 men selected by strict selection criteria.Patients were divided into normozoospermic group(NZG,n=124)and a group with seminal abnormalities(SAG,n=136).Evaluation included complete physical examination,past medical history,habits and lifestyle factors,two complete seminal analysis with sperm functional tests,serum levels of 25-hydroxy-vitamin D_(3)(25(OH)VD_(3)),total and free testosterone,luteinizing hormone(LH),follicle-stimulating hormone(FSH),sex hormone-binding globulin(SHBG),total cholesterol,homeostatic model assessment of insulin resistance(HOMA-IR)index,and karyotype.The mean concentration of 25(OH)VD_(3)was significantly lower in the SAG(P<0.001)and positively correlated with all baseline seminal parameters and total testosterone levels.In addition,serum vitamin D_(3)concentration was found to be positively correlated with sperm concentration(β=2.103;P<0.001),total number of spermatozoa with progressive motility(β=2.069;P=0.003),total number of motile spermatozoa(β=2.571;P=0.015),and strict morphology(β=0.056;P=0.006),regardless of other variables.This is the first comparative study to address the issue of serum vitamin D_(3)content between normozoospermic patients and those with sperm abnormalities.It clearly demonstrates a direct and positive relationship between serum vitamin D level and overall semen quality,male reproductive potential,and testosterone levels.Inari M Ciccone Elaine MF Costa Juliana R Pariz Thiago A Teixeira Joel R Drevet Parviz Gharagozloo Robert J Aitken Jorge Hallak 2021Asian Journal of Andrology2021,23,1:2
6Evidence of a natural killer(NK) - cell repertoire for(allo) antigen: definition of five distinct NK determined allospecificities in humans 显示文摘Ciccone E Pende D Viale O 1992J Exp Med1992,175,6:2
7Agglomeration effects in Europe显示文摘CICCONE A 0,,2:1
8Intrapleural intercos- tal nerve block associated with mini-thoracotomy improves pain control after major lung resection显示文摘ErAndrilli A Ibrahim M Ciccone AM 2006Eur J Cardiothorac Surg2006,29,5:1
9Neuroglobin and neuroprotection:the role of natural and synthetic compounds in neuroglobin pharmacological induction显示文摘Neuroglobin(Ngb)is a 17 kDa monomeric hexa-coordinated heme protein belonging to the globin family.Ngb is mainly expressed in neurons of the central and peripheral nervous system,although moderate levels of Ngb have been detected in non-nervous tissues.In the past decade,Ngb has been studied for its neuroprotective role in a large number of neurological disorders such as Alzheimer’s disease,Huntington’s disease,brain ischemia and hypoxia.This review discusses and summarizes the natural compounds and the small synthetic molecules capable of modulating Ngb expression that exhibits a protective role against various neurodegenerative diseases.Lidia Ciccone Susanna Nencetti Simone Socci Elisabetta Orlandini 2021Neural Regeneration Research2021,16,12:1
10Effectiveness of a lifestyle intervention on metabolic syndrome:a randomized controlled trial显示文摘Bo S Ciccone G Baldi C 2007J Gen Intern Med2007,22,12:1
11Red tape and delayed entry显示文摘CICCONE A E PAPAIOANNOU 2007The European Economic Association2007,5,3:1
12Reconstruction of the pul- monary artery for lung cancer : Long - term results 显示文摘Venuta F Ciccone AM Anile M 2007General Thoracic Sarg2007,138,5:1
13Correlation between coronary ar-tery disease severity,left ventricular mass index and ca-rotid intima media thickness,assessed by radio-frequen-cy显示文摘Ciccone M M Scicchitano P Zito A Agati L GesualdoM Mandolesi S 2011Cardiovasc Ultrasound2011,9,:1
14Wake-up stroke and TIA due to paradoxical embolism during long obstructive sleep apnoeas:a cross-sectional study显示文摘Ciccone A Proserpio P Roccatagliata DV 2013Thorax2013,68,1:1
15Productivity and the Density of Economic Activity显示文摘Ciccone A Hall R E 0,,01:1
16Agglomeration Effects in Europe显示文摘Ciccone A 2002European Economic Review2002,46,2:1
17Productivity and the density of economic activity显示文摘Ciccone A Hall R E 1996American Economic Review1996,86,1:1
18Plasma leptin is independently associated with the intima-media thickness of the common carotid artery 显示文摘 Vettor R Pannacciulli N 2001Int J Obes Relat Metab Disord2001,25,6:1
19显示文摘Ciccone M Vettor R Pannacciulli N 2001Int J Obes Relat Metab Disord2001,25,6:1
20Lighting regimes and plasma LH and FSH in broiler breeders显示文摘Lewis P D Ciacciariello M Ciccone N A 2005Br Poult Sei2005,46,:1
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