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| 1 | Transhiatal versus transthoracic esophagectomy for esophageal cancer显示文摘Esophageal cancer continues to represent a formidable challenge for both patients and clinicians. Relative 5-year survival rates for patients have improved over the past three decades, probably linked to a combination of improved surgical outcomes, progress in systemic chemotherapy and radiotherapy, and the increasing acceptance of multimodality treatment. Surgical treatment remains a fundamental component of the treatment of localized esophageal adenocarcinoma. Multiple approaches have been described for esophagectomy, which can be thematically grouped under two major categories: either transthoracic or transhiatal. The main controversy rests on whether a more extended resection through thoracotomy provides superior oncological outcomes as opposed to resection with relatively limited morbidity and mortality through a transhiatal approach. After numerous trials have addressed these issues, neither approach has consistently proven to be superior to the other one, and both can provide excellent short-term results in the hands of experienced surgeons. Moreover, the available literature suggests that experience of the surgeonand hospital in the surgical management of esophageal cancer is an important factor for operative morbidity and mortality rates, which could supersede the type of approach selected. Oncological outcomes appear to be similar after both procedures. | J Camilo Barreto Mitchell C Posner | 2010 | World Journal of Gastroenterology2010，16，30： | 16 |
| 2 | Cytokine production in patients with cirrhosis and TLR4 polymorphisms显示文摘AIM:To analyze the cytokine production by peripheral blood cells from cirrhotic patients with and without TLR4 D299G and/or T399I polymorphisms.METHODS:The study included nine patients with cirrhosis and TLR4 D299G and/or T399I polymorphisms,and 10 wild-type patients matched for age,sex and degree of liver failure.TLR4 polymorphisms were determined by sequence-based genotyping.Cytokine production by peripheral blood cells was assessed spontaneously and also after lipopolysaccharide(LPS)and lipoteichoic acid(LTA)stimulation.RESULTS:Patients with TLR4 polymorphisms had a higher incidence of previous hepatic encephalopathy than wild-type patients(78%vs 20%,P=0.02).Spontaneous production of interleukin(IL)-6 and IL-10 was lower in patients with TLR4 polymorphisms than in wild-type patients[IL-6:888.7(172.0-2119.3)pg/m L vs 5540.4(1159.2-26053.9)pg/m L,P<0.001;IL-10:28.7(6.5-177.1)pg/m L vs 117.8(6.5-318.1)pg/m L,P=0.02].However,the production of tumor necrosis factor-α,IL-6 and IL-10 after LPS and LTA stimulation was similar in the two groups.CONCLUSION:TLR4 polymorphisms were associated with a distinctive pattern of cytokine production in cirrhotic patients,suggesting that they play a role in the development of cirrhosis complications. | Juan Camilo Nieto Elisabet Sánchez Eva Román Silvia Vidal Laia Oliva Carlos Guarner-Argente Maria Poca Xavier Torras Cándido Juárez Carlos Guarner German Soriano | 2014 | World Journal of Gastroenterology2014，20，46： | 5 |
| 3 | Toll-like receptor 4 polymorphisms and bacterial infections in patients with cirrhosis and ascites显示文摘AIM To assess the relationship between the presence of toll-like receptor 4(TLR4) polymorphisms and bacterial infections in cirrhotic patients with ascites. METHODS We prospectively included consecutive patients with cirrhosis and ascites hospitalized during a 6-year period. Patients with human immunodeficiency virus(HIV) infection or any other immunodeficiency, patients with advanced hepatocellular carcinoma(beyond Milan's criteria) or any other condition determining poor short-term prognosis, and patients with a permanent urinary catheter were excluded. The presence of D299 G and/or T399 I TLR4 polymorphisms was determined by sequencing and related to the incidence and probability of bacterial infections, other complications of cirrhosis, hepatocellular carcinoma, and mortality during follow-up. A multivariate analysis to identify predictive variables of mortality in the whole series was performed. RESULTS We included 258 patients: 28(10.8%) were carriers of D299G and/or T399I TLR4 polymorphisms(polymorphism group) and 230 patients were not(wildtype group). The probability of developing any bacterial infection at one-year follow-up was 78% in the polymorphism group and 69% in the wild-type group(P = 0.54). The one-year probability of presenting infections caused by gram-negative bacilli(51% vs 44%, P = 0.68), infections caused by gram-positive cocci(49% vs 40%, P = 0.53), and spontaneous bacterial peritonitis(29% vs 34%, respectively, P = 0.99) did not differ between the two groups. The oneyear probability of transplant-free survival was 55% in the polymorphism group and 66% in the wild-type group(P = 0.15). Multivariate analysis confirmed that age, Child-Pugh score, active alcohol intake, previous hepatic encephalopathy, hepatocellular carcinoma and serum creatinine were associated with a higher risk of death during follow-up. CONCLUSION Genetic polymorphisms D299 G and/or T399 I of TLR4 do not seem to play a relevant role in the predisposition of cirrhotic patients with ascites to bacterial infections. | Edilmar Alvarado-Tapias Carlos Guarner-Argente Elida Oblitas Elisabet Sánchez Silvia Vidal Eva Román Mar Concepción Maria Poca Cristina Gely Oana Pavel Juan Camilo Nieto Cándido Juárez Carlos Guarner Germán Soriano | 2018 | World Journal of Hepatology2018，10，1： | 3 |
| 4 | Synthesis and properties of hydrophilic networks based on poly (ethylene glycol) and β-eyclodextrin 显示文摘 | Luis C Camilo A Ramirez D | 2007 | Macromol Chem Phys2007，208，8： | 1 |
| 5 | Prparation and characterization of (3-aminopropyl) triethoxysilane-coated magnetite nanoparticles 显示文摘 | YAMAURA M CAMILO R L SAMPAIO L C | 2004 | J Magn Magn Mater2004，279，23： | 1 |
| 6 | Podophyllotoxin显示文摘 | Camilo C Rita M M Franck E D | 2005 | Phyto-chemistry2005，4，： | 1 |
| 7 | Institutions Influence Preferences:Evidence from a Common Pool Resource Experiment显示文摘 | Rodriguez-Sickert Carlos Guzmán Ricardo Andrés Cárdenas Juan Camilo | | 0，，01： | 1 |
| 8 | Prparation and characterization of(3-aminopropyl)triethoxysilane-coated magnetite nanoparticles显示文摘 | Yamaura M Camilo R L Sampaio L C | 2004 | J Magn Magn Mater2004，279，： | 1 |
| 9 | Preparation and characterization of triethoxysilane-coated magnetite nanoparticles显示文摘 | Yamaura M Camilo R L Sampaio L C | 2004 | Journal of Magnetism and Magnetic Materials2004，279，： | 1 |
| 10 | Pancreatic heteroto-pias:clinicopathological analysis of 18 patients 显示文摘 | Bromberg SH Camilo Neto C Borges AF | 2010 | Rev Col BrasCir2010，37，6： | 1 |
| 11 | Prparation and characterization of (3-aminopropyl) tfiethoxysilane-coated magnetite nanoparticles显示文摘 | Yamaura M Camilo R L Sampaio L C | 2004 | J Magn Magn Mater2004，27，9： | 1 |
| 12 | Preparation and characterization of ( 3-aminopropyl ) triethoxysilane-coated magnetite nanoparticles显示文摘 | Yamaura M Camilo R L Sampaio L C | 2004 | J Magnet Magnet Mater2004，279，： | 1 |
| 13 | Surface-relief gratings and photoinduced birefringence in layer-by-layer films of chitosan and an azopolymer显示文摘 | Camilo C S Rodrigues J J Vega M L | 2003 | Biomacromolecules2003，4，6： | 1 |
| 14 | Fusion induces tumor rejection显示文摘 | IAN H CAMILO C | 1997 | Nature1997，388，： | 1 |
| 15 | A third order model for the doubly fed induction machine显示文摘 | Feijoo A Cidrss J Camilo C | 2000 | Electric Power Research2000，56，2： | 1 |
| 16 | Prparation and characterization of(3-aminopropyl)triethoxysilanecoated magnetite nanoparticles显示文摘 | Yamaura M Camilo R L Sampaio L C | 2004 | J Magn Magn Mater2004，279，23： | 1 |
| 17 | Validation of the Malnutrition Universal Screening Tool(MUST)in cancer显示文摘 | Boléo-Tomé C Monteiro-Grillo I Camilo M | | 0，，06： | 1 |
| 18 | An experimental investigation into hydraulic fracture propagation under different applied stresses in tight sands using acoustic emissions显示文摘 | YASHWANTH C CAMILO M CARL S | 2013 | Journal of Petroleum Science and Engineering2013，108，： | 1 |
| 19 | Survey of optimization of iron ore grinding显示文摘 | MAGNO R R RITA V G D S CAMILO C D S | 2002 | Metallurgic & Materials2002，58，526： | 1 |
| 20 | Manufacturing of porous alumina scaffolds with bio-glass and hap coating: Mechanical and in vitro evaluation 显示文摘 | CAMILO C C FORTULAN C A IKEGAMI R A | 2009 | Key Engineering Material2009，396，： | 1 |
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