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| 1 | Comparative outcome of stapled trans-anal rectal resection and macrogol in the treatment of defecation disorders显示文摘AIM:To prospectively assess the eff icacy and safety of stapled trans-anal rectal resection(STARR) compared to standard conservative treatment,and whether preoperative symptoms and findings at defecography and anorectal manometry can predict the outcome of STARR.METHODS:Thirty patients(Female,28;age:51 ± 9 years) with rectocele or rectal intussusception,a defecation disorder,and functional constipation were submitted for STARR.Thirty comparable patients(Female,30;age 53 ± 13 years),who presented with symptoms of rectocele or rectal intussusception and were treated with macrogol,were assessed.Patients were interviewed with a standardized questionnaire at study enrollment and 38 ± 18 mo after the STARR procedure or during macrogol treatment.A responder was def ined as an absence of the Rome Ⅲ diagnostic criteria for functional constipation.Defecography and rectoanal manometry were performed before and after the STARR procedure in 16 and 12 patients,respectively.RESULTS:After STARR,53% of patients were responders;during conservative treatment,75% were responders.After STARR,30% of the patients reported the use of laxatives,17% had intermittent anal pain,13% had anal leakage,13% required digital facilitation,6% experienced defecatory urgency,6% experienced fecal incontinence,and 6% required re-intervention.During macrogol therapy,23% of the patients complained of abdominal bloating and 13% of borborygmi,and 3% required digital facilitation.No preoperative symptom,defecographic,or manometric finding predicted the outcome of STARR.Post-operative defecography showed a statistically significant reduction(P < 0.05) of the rectal diameter and rectocele.The postoperative anorectal manometry showed that anal pressure and rectal sensitivity were not significantly modified,and that rectal compliance was reduced(P = 0.01).CONCLUSION:STARR is not better and is less safe than macrogol in the treatment of defecation disorders.It could be considered as an alternative therapy in patients unresponsive to macrogol. | Ivano Biviano Danilo Badiali Laura Candeloro Fortunée Irene Irene Habib Massimo Mongardini Angelo Caviglia Fiorella Anzini Enrico S Corazziari | 2011 | World Journal of Gastroenterology2011，17，37： | 3 |
| 2 | Chemoimmunotherapy in the treatment of metastatic gastric cancer显示文摘 | Recchia F Saggio G Candeloro G | 2007 | Anticancer Drugs2007，18，5： | 1 |
| 3 | Chemoradioimmunother- apy in locally advanced pancreatic and biliary tree adanocarci- noma: a muhicenter phase II study 显示文摘 | Recchia F Sica G Candeloro G | 2009 | Pancreas2009，38，： | 1 |
| 4 | Fabrication and Applications of Micro/Nanostructured Devices for Tissue Engineering显示文摘Nanotechnology allows the realization of new materials and devices with basic structural unit in the range of1–100 nm and characterized by gaining control at the atomic, molecular, and supramolecular level. Reducing the dimensions of a material into the nanoscale range usually results in the change of its physiochemical properties such as reactivity,crystallinity, and solubility. This review treats the convergence of last research news at the interface of nanostructured biomaterials and tissue engineering for emerging biomedical technologies such as scaffolding and tissue regeneration. The present review is organized into three main sections. The introduction concerns an overview of the increasing utility of nanostructured materials in the field of tissue engineering. It elucidates how nanotechnology, by working in the submicron length scale, assures the realization of a biocompatible interface that is able to reproduce the physiological cell–matrix interaction. The second, more technical section, concerns the design and fabrication of biocompatible surface characterized by micro- and submicroscale features, using microfabrication, nanolithography, and miscellaneous nanolithographic techniques.In the last part, we review the ongoing tissue engineering application of nanostructured materials and scaffolds in different fields such as neurology, cardiology, orthopedics, and skin tissue regeneration. | Tania Limongi Luca Tirinato Francesca Pagliari Andrea Giugni Marco Allione Gerardo Perozziello Patrizio Candeloro Enzo Di Fabrizio | 2017 | Nano-Micro Letters2017，9，1： | 1 |
| 5 | Adjuvant ovari- an suppression,high-dose chemotherapy and immunother- apy for premenopausal patients with high-risk breast can- cer显示文摘 | Recchia F Candeloro G Rosselli M | 2015 | Anticancer Res2015，35，12： | 1 |
| 6 | Anthracyclinebased induction chemotherapy followed by concurrent cyclophosphamide,methotrexate and 5-fluorouracil and radiation therapy in surgically resected axillary node-positive breast cancer显示文摘 | Recchia F Candeloro G Cesta A | 2014 | Mol Clin Oncol2014，2，3： | 1 |
| 7 | 显示文摘 | Candeloro N Bertini i Melchiorri G | 1995 | Minerva Endocrinol1995，20，4： | 1 |
| 8 | Chemo- immunotherapy in the treatment of metastatic gastric cancer 显示文摘 | Recchia F Saggio G Candeloro G | 2007 | Anticancer Drugs2007，18，5： | 1 |
| 9 | Drug interaction be tween carbapenems and extended-release divalproex sodium in a patient with schizoaffective disorder显示文摘 | Muzyk AJ Candeloro CL Christopher EJ | 2010 | Gen Hosp Psychiatry2010，32，5： | 1 |
| 10 | Effect of supple- mentation of calcium and Vitamin D on bone mineral density and bone mineral content in peri-and pos-menopause women: A double-blind, randomized, controlled trial 显示文摘 | Daniele ND Carbonelli MG Candeloro N | 2004 | Pharmacological Research2004，50，： | 1 |
| 11 | Single high-dose steroid treatment in episodic cluster headache显示文摘 | Antonaci F Costa A Candeloro E | 2005 | Cephalalgia2005，25，4： | 1 |
| 12 | Short Circuit Behavior of IGBTs Correlated to the Intrinsic Device Structure and on the Application Circuit 显示文摘 | Letor R Candeloro Aniceto G | 1995 | IEEE Transactions on Industry Applications1995，31，2： | 1 |
| 13 | Steroid-cell autoantibodies are preferentially expressed in women with premature ovarian failure who have adrenal autoimmunity显示文摘 | Falorni A Laureti S Candeloro P | 2002 | Fertil Steril2002，78，2： | 1 |
| 14 | Singe high-dose steroid treatmentin episodic duster headache显示文摘 | Antonaci F Costa A Candeloro E | 2005 | Cephalagia2005，25，4： | 1 |
| 15 | Premenopausal hormone-responsive breast cancer with extensive axillary nodes involvement:total estrogen blockade and chemotherapy显示文摘 | Recchia F Candeloro G Necozione S | 2011 | Anticancer Res2011，31，2： | 1 |
| 16 | Fatigue in multiple sclerosis: Multidimensional assessment and response to symptomatic treatment显示文摘 | Romani A Bergamaschi R Candeloro E | 2004 | Multiple Sclerosis2004，10，4： | 1 |
| 17 | Maintenance immunotherapy in recurrent ovarian cancer,long term follow-up of a phase Ⅱ study显示文摘 | Recchia F Di Orio F Candeloro G | 2010 | Gynecol Oncol2010，116，2： | 1 |
| 18 | Maintenace immunotherapy in re-current ovarian cancer:long term follow up of a phase II study显示文摘 | Recchia F Di Orio F Candeloro G | | 0，，： | 1 |
| 19 | Maintenance im munotherapy in recurrent ovarian cancer: long term follow up of a phase Ⅱ study 显示文摘 | Recchia F Di Orio F Candeloro G | 2010 | Gynecol Oncol2010，116，2： | 1 |
| 20 | Single high-dose steroid treatment in episodic cluster headache显示文摘 | Antonaci F Costa A Candeloro E | 2005 | Cephalalgia2005，25，4： | 1 |
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