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| 1 | Helicobacter pylori and pregnancy-related disorders显示文摘Helicobacter pylori(H.pylori)infection is investigated in gastric diseases even during pregnancy.In particular,this Gram-negative bacterium seems to be associated with hyperemesis gravidarum,a severe form of nausea and vomiting during pregnancy.During the last decade,the relationship among H.pylori and several extra-gastric diseases strongly emerged in literature.The correlation among H.pylori infection and pregnancy-related disorders was mainly focused on iron deficiency anemia,thrombocytopenia,fetal malformations,miscarriage,pre-eclampsia and fetal growth restriction.H.pylori infection may have a role in the pathogenesis of various pregnancy-related disorders through different mechanisms:depletion of micronutrients(iron and vitamin B12)in maternal anemia and fetal neural tube defects;local or systemic induction of pro-inflammatory cytokines release and oxidative stress in gastrointestinal disorders and pre-eclampsia;cross-reaction between specific anti-H.pylori antibodies and antigens localized in placental tissue and endothelial cells(preeclampsia,fetal growth restriction,miscarriage).Since H.pylori infection is most likely acquired before pregnancy,it is widely believed that hormonal and immunological changes occurring during pregnancy could activate latent H.pylori with a negative impact not only on maternal health(nutritional deficiency,organ injury,death),but also on the fetus(insufficient growth,malformation,death)and sometime consequences can be observed later in life.Another important issue addressed by investigators was to determine whether it is possible to transmit H.pylori infection from mother to child and whether maternal anti-H.pylori antibodies could prevent infant’s infection.Studies on novel diagnostic and therapeutic methods for H.pylori are no less important,since these are particularly sensitive topics in pregnancy conditions.It could be interesting to study the possible correlation between H.pylori infection and other pregnancy-related diseases of unknown etiology,such as gestational diabetes mellitus,obstetric cholestasis and spontaneous preterm delivery.Since H.pylori infection is treatable,the demonstration of its causative role in pregnancy-related disorders will have important social-economic implications. | Simona Cardaropoli Alessandro Rolfo Tullia Todros | 2014 | World Journal of Gastroenterology2014，20，3： | 12 |
| 2 | Helicobacter pylori's virulence and infection persistence define pre-eclampsia complicated by fetal growth retardation显示文摘AIM: To better understand the pathogenic role of Helicobacter pylori (H. pylori) in pre-eclampsia (PE), and whether it is associated or not with fetal growth retardation (FGR). METHODS: Maternal blood samples were collected from 62 consecutive pregnant women with a diagnosis of PE and/or FGR, and from 49 women with uneventful pregnancies (controls). Serum samples were evaluated by immunoblot assay for presence of specific antibodies against H. pylori antigens [virulence: cytotoxin-associated antigen A (CagA); ureases; heat shock protein B; flagellin A; persistence: vacuolating cytotoxin A (VacA)]. Maternal complete blood count and liver enzymes levels were assessed at delivery by an automated analyzer. RESULTS: A significantly higher percentage of H. pyloriseropositive women were found among PE cases (85.7%) compared to controls (42.9%, P < 0.001). There were no differences between pregnancies complicated by FGR without maternal hypertension (46.2%) and controls. Importantly, persistent and virulent infections (VacA/ CagA seropositive patients, intermediate leukocyte blood count and aspartate aminotransferase levels) were exclusively associated with pre-eclampsia complicated by FGR, while virulent but acute infections (CagA positive/ VacA negative patients, highest leukocyte blood count and aspartate aminotransferase levels) specifically correlated with PE without FGR. CONCLUSION: Our data strongly indicate that persistent and virulent H. pylori infections cause or contribute to PE complicated by FGR, but not to PE without feto-placental compromise. | Simona Cardaropoli Alessandro Rolfo Annalisa Piazzese Antonio Ponzetto Tullia Todros | 2011 | World Journal of Gastroenterology2011，17，47： | 9 |
| 3 | Infectious and inflammatory stimuli decrease endothelial nitric oxide synthase activity in vitro显示文摘 | Simona Cardaropoli Francesca Silvagno Emanuella Morro | 2003 | Journal of Hypertension2003，21，： | 1 |
| 4 | Socket preserva- tion using bovine bone mineral and collagen membrane: a random- ized controlled clinical trial with histologic analysis显示文摘 | Cardaropoli D Tamagnone L Roffredo A | 2012 | Int J Peri- odontics Restorative Dent2012，32，4： | 1 |
| 5 | Bodily tooth movement through the maxillary sinus with implant anchorage for single tooth replacement 显示文摘 | Re S Cardaropoli D Corrente G | 2001 | Clin Orthod Res2001，4，3： | 1 |
| 6 | Manufac- turing of porous biomaterials for dental implant ap- plications through selective laser melting 显示文摘 | Cardaropoli F Alfieri V Caiazzo F | 2012 | Adv Mater Res2012，6，535537： | 1 |
| 7 | Reconstruction of the maxillary midline papilla following a combined orthodontic-periodontic treatment in adult periodontal patients 显示文摘 | Cardaropoli D Re S Corrente G | 2004 | J Clin Period- ontol2004，31，2： | 1 |
| 8 | Nucleated red blood cells in term fetuses: reference values using an automated analyzer显示文摘 | Rolfo A Maconi M Cardaropoli S | 2007 | Neonatology2007，92，3： | 1 |
| 9 | The Papilla Presence Index (PPI) : a new system to assess interproximal papillary levels 显示文摘 | Cardaropoli D Re S Corrente G | 2004 | lnt J Periodont Restorat Dent2004，24，5： | 1 |
| 10 | Dynamics of bone tissue forma- tion in tooth extraction sites, An experimental study in dogs 显示文摘 | Cardaropoli G Araujo M Lindhe J | 2003 | J Clin Periodontol2003，30，9： | 1 |
| 11 | Reduction of gingival recession following orthodontic intrusion in periodontally compro- mised patients 显示文摘 | Re S Cardaropoli D Abundo R | 2004 | Orthod Craniofae Res2004，7，1： | 1 |
| 12 | Tissue alterations at implant-supported single-tooth replacements:a 1-year prospective clinical study显示文摘 | Cardaropoli G Lekholm U Wennstrom JL | | 0，，02： | 1 |
| 13 | Healing of extraction sockets and surgically produced-augmented and non-augmenteddefects in the alveolar ridge: An experimental study in the dog显示文摘 | Cardaropoli G Araujo M Hayacibara R | 2005 | Journal of Clinical Periodontology2005，32，： | 1 |
| 14 | Socketpreservation using bovine bone mineral and collagenmembrane: a randomized controlled clinical trial withhistologic analysis显示文摘 | Cardaropoli D Tamagnone L Roffredo A | 2012 | Int J Periodontics Restorative Dent2012，32，4： | 1 |
| 15 | Reconstruction of the maxillary midline papilla following a combined orthodontic- periodontic treatment in adult periodontal patients 显示文摘 | Cardaropoli D Re S Corrente G | 2004 | J Clin Periodontol2004，31，2： | 1 |
| 16 | Tissue altera- tions at implant-supported single-tooth replacementsza 1-year prospective clinical study显示文摘 | Cardaropoli G Lekholm U Wennstrom JL | 2006 | Clin Oral Implants Res2006，17，2： | 1 |
| 17 | Tissuealterations at implant-supported single-tooth replacements:a 1-year prospective clinical study显示文摘 | Cardaropoli G Lekholm U Wennstrom JL | 2006 | Clin Oral ImplantsRes2006，17，2： | 1 |
| 18 | Supportive periodontal therapy and dental implants:an analysis of patients'compliance显示文摘 | Cardaropoli D Gaveglio L | 2012 | Clin Oral Implants Res2012，23，12： | 1 |
| 19 | Preservation of thepostextraction alveolar ridge: a clinical and histologic study显示文摘 | Cardaropoli D Cardaropoli G | 2008 | Int J Periodontics Restorative Dent2008，28，5： | 1 |
| 20 | Preservation of the postextraction alveolar ridge:a clinical and histologic study显示文摘 | Cardaropoli D Cardaropoli G | 2008 | Int J Periodontics Restorative Dent2008，28，5： | 1 |
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