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| 1 | Tight junction disruption: Helicobacter pylori and dysregulation of the gastric mucosal barrier显示文摘Long-term chronic infection with Helicobacter pylori(H. pylori) is a risk factor for gastric cancer development. In the multi-step process that leads to gastric cancer,tight junction dysfunction is thought to occur and serve as a risk factor by permitting the permeation of luminal contents across an otherwise tight mucosa. Mechanisms that regulate tight junction function and structure in the normal stomach,or dysfunction in the infected stomach,however,are largely unknown. Although conventional tight junction components are expressed in gastric epithelial cells,claudins regulate paracellular permeability and are likely the target of inflammation or H. pylori itself. There are 27 different claudin molecules,each with unique properties that render the mucosa an intact barrier that is permselective in a way that is consistent with cell physiology. Understanding the architecture of tight junctions in the normal stomach and then changes that occur during infection is important but challenging,because most of the reports that catalog claudin expression in gastric cancer pathogenesis are contradictory. Furthermore,the role of H. pylori virulence factors,such as cytotoxin-associated gene A and vacoulating cytotoxin,in regulating tight junction dysfunction during infection is inconsistent in different gastric cell lines and in vivo,likely because non-gastric epithelial cell cultures were initially used to unravel the details of their effects on the stomach. Hampering further study,as well,is the relative lack of cultured cell models that have tight junction claudins that are consistent with native tissues. This summary will review the current state of knowledge about gastric tight junctions,normally and in H. pylori infection,and make predictions about the consequences of claudin reorganization during H. pylori infection. | Tyler J Caron Kathleen E Scott James G Fox Susan J Hagen | 2015 | World Journal of Gastroenterology2015，21，40： | 7 |
| 2 | Broad antiretroviral defence by human APOBEC3G through lethal editing of nascent reverse transcripts 显示文摘 | Mangeat B Turelli P Caron G etal | 2003 | Nature2003，424，6944： | 1 |
| 3 | Analysis of bacterial function by multi - colour fluorescence flow cytometry and single cell sorting 显示文摘 | Nebe V Caron G Stephens P J | 2000 | J Microbiol Methods2000，42，1： | 1 |
| 4 | Effectiveness of different final irrigant activation protocols on smear layer removal in curved canals显示文摘 | Caron G Nham K Bronnec F | 2010 | J Endod2010，36，8： | 1 |
| 5 | TGF-beta expression during rat pregnancy and activity on decidual cell survival显示文摘 | Shooner C Caron PL Fr chette-Frigon G | 2005 | Reprod Biol Endocrinol2005，31，3： | 1 |
| 6 | Beta-adrenergic receptors: solubilization of (-)(3H)alprenolol binding sites from frog erythrocyte membranes 显示文摘 | Caron M G Lefkowitz R J | 1976 | Biochem Biophys Res Commun1976，68，2： | 1 |
| 7 | Genetic heterogeneity of hepatitis E virus in Darfur, Sudan, and neighboring Chad显示文摘 | Nicand E Armstrong G L Enouf V Guthmann J P Guerin J P Caron M Nizou J Y Andraghetti R | 2005 | Med Virol2005，，7： | 1 |
| 8 | Mechanical behavior and processing of DS and single crystal superalloys显示文摘 | Khan T Caron P Nakagawa Y G | 1986 | Journal of Metals1986，，7： | 1 |
| 9 | Optical eye model for photo-refractive surgery evaluation显示文摘 | GOBBI P G CARONES F BRANCATO R | 1999 | SPIE1999，3591，： | 1 |
| 10 | Following the trace of elusive amines 显示文摘 | Premont R T Gainedinov R R Caron M G | 2001 | Proceedings of the National Academy of Sciences2001，98，5： | 1 |
| 11 | Catecholamine- induced subsensitivity of adelnylate cyclase associated with loss of beta-adrenergic receptor binding sites显示文摘 | Mukherjee C Caron M G Lefkowitz R J | 1975 | Proc Natl Acad Sci USA1975，72，5： | 1 |
| 12 | Evaluation of a theoretically based AIDS/STD peer education program on postponing sexual inter course and on condom use among adolescents attending high school 显示文摘 | Caron F Godin G Otis J | 2004 | Health Educ Res2004，19，2： | 1 |
| 13 | Beta-adrenergic receptor kinase; identification of a novel protein kinase that phosphorylates the agonist-occupied form of the receptor 显示文摘 | Benovic J L Strasser R H Caron M G | 1986 | Proc Natl Acad Sci USA1986，83，9： | 1 |
| 14 | The assignment problem with seniority and job priority constraints显示文摘 | Caron G Hansen P Jaumard B | 1999 | Operations Research1999，47，3： | 1 |
| 15 | Growth and dietary niche in Salvelinus alpinus and Salvelinus fontinalis as revealed by stable isotope analysis显示文摘 | Power M Power G Caron F | 2002 | Environmental Biology of Fishes2002，64，13： | 1 |
| 16 | BIOLOGICAL ELIMINATION OF VOLATILE ORGANIC COMPOUNDS FROM WASTE GASES IN A BIOFOLTER显示文摘 | G WU J C CHABOT J J CARON | 1998 | Water Air and Soil Pollution1998，101，： | 1 |
| 17 | Regions of the alpha 1-adrenergic receptor involved in coupling to phosphatidylinositol hydrolysis and enhanced sensitivity of biological function 显示文摘 | Cotecchia S Exum S Caron M G | 1990 | Proc Natl Acad Sci USA1990，87，8： | 1 |
| 18 | Evaluation of a theoretically Based AIDS/STD peer education program on postponing sexual inter- course and on condom use among adolescent attending high school 显示文摘 | Caron F Godin G Otis J | 2004 | Health Education Research2004，19，2： | 1 |
| 19 | Broad antiretrovral defence by human APOBEC3G through lethal editing of nascent reverse transcripts显示文摘 | Mangeat B Turelli P Caron G | 2003 | Nature2003，424，： | 1 |
| 20 | Phosphorylation and palmitoylation of the human D2L dopamine receptor in St9 cells 显示文摘 | Ng G Y O'Dowd B F Caron M | 1994 | JNeurochem1994，63，5： | 1 |
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