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| 1 | Matrix metalloproteases and their tissue inhibitors in non-alcoholic liver fibrosis of human immunodeficiency virus-infected patients显示文摘AIM To investigate the relationships among diverse metalloproteases(MMPs) and their tissue inhibitors(TIMPs) and non-alcoholic liver fibrosis in human immunodeficiency virus(HIV)-infected patients.METHODS Single nucleotide polymorphisms(SNPs) in MMPs, TNF-α and CCR5 genes, and serum levels of MMPs and TIMPs were determined in HIV-infected individuals with/out hepatitis C virus(HCV) coinfection. A total of 158 patients were included, 57 of whom were HCVcoinfected. All patients drank < 50 g ethanol/day. Diverse SNPs(MMP-1-1607 1G/2G, MMP-8-799C/T, MMP-9-1562 C/T, MMP-13-77A/G, TNF-α-308 G/A,CCR5-?32), and serum levels of MMPs(2, 3, 8, 9 and 10) and TIMPs(1, 2 and 4) were assessed. Liver fibrosis was determined by transient elastometry, although other non-invasive markers of fibrosis were also considered. Significant liver fibrosis(F ≥ 2) was defined by a transient elastometry value ≥ 7.1 kP a.RESULTS A total of 34 patients(21.5%) had liver fibrosis ≥ F2. MMP-2 and TIMP-2 serum levels were higher in patients with liver fibrosis ≥ F2(P = 0.02 and P = 0.03, respectively) and correlated positively with transient elastometry values(P = 0.02 and P = 0.0009, respectively), whereas MMP-9 values were negatively correlated with transient elastometry measurements(P = 0.01). Multivariate analyses showed that high levels of MMP-2(OR = 2.397; 95%CI: 1.191-4.827, P = 0.014) were independently associated with liver fibrosis ≥ F2 in the patients as a whole. MMP-2(OR = 7.179; 95%CI: 1.210-42.581, P = 0.03) and male gender(OR = 10.040; 95%CI: 1.621-62.11, P = 0.013) were also independent predictors of fibrosis ≥ F2 in the HCV-infected subgroup. Likewise, MMP-2, TIMP-2 and MMP-9 were independently associated with transient elastometry values and other non-invasive markers of liver fibrosis. None of the six SNPs evaluated had any significant association with liver fibrosis ≥ F2.CONCLUSION Certain MMPs and TIMPs, particularly MMP-2, seems to be associated with non-alcoholic liver fibrosis in HIVinfected patients with/without HCV coinfection. | Julio Collazos Eulalia Valle-Garay Tomás Suárez-Zarracina Angel-Hugo Montes José A Cartón Víctor Asensi | 2017 | World Journal of Virology2017，6，2： | 3 |
| 2 | Atherosclerotic plaque rupture in symptomatic carotid artery stenosis显示文摘 | Cart S Farb A Pearce WH | 1996 | J Vasc Surg1996，23，： | 1 |
| 3 | Effects of lamb age, hormone stimulation and response to hormone stimulation on the yield and in vitro developmental competence of prepubertal lamb oocytes显示文摘 | Morton K M Cart S L | 2005 | Reproduction Fertility and Development2005，17，： | 1 |
| 4 | Effects of a selective cyclooxygenase-2 inhibitor on cancer cells in vitro 显示文摘 | Fife R S Stott B Cart RE | 2004 | Cancer Biol Ther2004，3，2： | 1 |
| 5 | Mutations in 15- hydroxyprostaglandin dehydrogenase cause primary hypertrophic osteoarthropathy显示文摘 | Uppal S Diggle CP Cart IM | 2008 | Nat Genet2008，40，6： | 1 |
| 6 | 15-Acetylthioxyfurodysinin lactone, a potent LTB4 re-ceptor partial agonist from a marine sponge of the ge-nus Dysidea 显示文摘 | CARTE B MONG S POEHLAND B | 1989 | Tetrahedron Lett1989，30，21： | 1 |
| 7 | ABC method and biomass size spectra: what about macrozoobenthic biomass on hard substrata 显示文摘 | PAGOLA CARTE S | 2004 | Hydrobiologia2004，527，1： | 1 |
| 8 | The impact of work/family demand on work -family conflict 显示文摘 | Boyar S L Maertz Jr C P Mosley Jr D C Cart J C | 2008 | Journal of Managerial Psychology2008，23，3： | 1 |
| 9 | Evaluation of a water manage- ment model for a Louisiana sugar cane field显示文摘 | GAYLE G A SKAGC S R W CARTE C E | 1985 | Journal-American Society of Sugar Cane Technologists1985，4，： | 1 |
| 10 | MR Imaging of the heart with cinc true fast imaging with steadystate precession : influence of spatial and temporal resolutions on left ventricular functional pa- rameters 显示文摘 | Miller S Simonetti OP Cart J | 2002 | Radiology2002，223，1： | 1 |
| 11 | Detection of intraspecific DNA sequence variation in the mitochondrial cytochrome b gene of Atlantic cod (Gadus morhua) by the polymorase chain reaction显示文摘 | Cart S M Marshall H D | 1991 | Can J Fish Aqua Sci1991，1，： | 1 |
| 12 | Mitochondrial DNA and two perspectives on evolutionary genetics显示文摘 | Wilson A C Cann R L Cart S M | 1985 | Biology Journal of the Linnean Society1985，26，4： | 1 |
| 13 | Functional defect of regulatory CD4(+) CD25 + T cells in the thymus of patients with autoimmune myasthenia gravis显示文摘 | Balandina A Lécart S Dartevelle P et at | | 0，，： | 1 |
| 14 | Identification of miR- NAs associated with the follicular-luteal transition in the ruminant ovary 显示文摘 | McBride D Carté W Sontakke S D | 2012 | Reproduction2012，144，2： | 1 |
| 15 | Genetic characte- ristics of leucine-rich repeat kinase 2 ( LRRK2 ) associated Parkinson' s disease 显示文摘 | Bardien S Lesage S Brice A Cart J | 2011 | Parkinsonism Relat Disord2011，17，7： | 1 |
| 16 | Local recurrence of low rectal cancer after abdominoperineal and anterior reseetion显示文摘 | Ruiller E Laurente C Cartes S | 1997 | Br J Surg1997，84，： | 1 |
| 17 | Local recurrence of low rectal cancer after abdominoperineal and anterior reseetion显示文摘 | Ruiller E Laureate C Cartes S | 1997 | Br J Surg1997，84，： | 1 |
| 18 | Development and evaluation of sediment quality guidelines for Florida coastal waters 显示文摘 | MacDonald D D Cart R S Calder F D | 1996 | Ecotoxicology1996，5，： | 1 |
| 19 | The comparative effects of postoperative analgesic the rapies on pulmonary outcome: cumulative metaanalyses of randomized, controlled trials显示文摘 | Ballantyne JC Cart DB de Ferranti S | 1998 | Anesth Analg1998，86，： | 1 |
| 20 | Forage and nitrogen yield of barley-pea and oat-pea intercrops 显示文摘 | Cart P M Martin G B Caton J S | 1998 | Agronomy Journal1998，90，： | 1 |
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