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| 1 | Addition of statins to the standard treatment in patients with cirrhosis:Safety and efficacy显示文摘This review summarizes the safety and efficacy of statins in patients with cirrhosis.Due to concerns about the safety of statins in patients with impaired liver function,they have recently been investigated as a potential treatment option in cirrhosis.The most clinically significant adverse event is statin-related myopathy,and this may be related to the high serum statin concentrations in the setting of severely impaired liver function.Rhabdomyolysis is the most serious and potentially life-threatening manifestation.It has recently been demonstrated that the recommended dose of simvastatin in patients with decompensated cirrhosis would be 20 mg/d because higher values,such as 40 mg/d,are associated with many adverse events,especially muscle injury.Likewise,simvastatin should not be administered to patients with Model for End-stage Liver Disease score>12 and/or Child-Pugh class C because of the high risk of severe muscle injury.Due to the pleiotropic effects,the focus on statins has shifted from being considered harmful to something useful.Through these effects,statins could prevent liver-related morbidity and mortality in cirrhotic patients.Observational studies in large populations of patients with cirrhosis have shown that treatment with statins to decrease high cholesterol levels was associated with a reduced risk of hepatic decompensation,hepatocellular carcinoma development and death.The few randomized controlled trials in patients with cirrhosis and portal hypertension showed that statins lower portal pressure,quite likely through a reduction in hepatic resistance.Another large randomized controlled trial in patients with variceal bleeding showed that simvastatin in addition to standard of care did not prevent rebleeding but improved survival rate.Despite these encouraging outcomes,the quality of the evidence regarding the use of statins is low or very low due to the observational characteristics of most of the studies involved.Therefore,it is advisable to perform further randomized controlled trials on a large series of patients with hard clinical endpoints,using different statin types and varying doses.The objectives would be to prevent liver-related morbidity and mortality rather than treating cirrhosis complications to take additional information that makes it possible to add statins to the standard of care of these patients. | Alberto E Muñoz Florencia D Pollarsky Mónica Marino Mariano Cartier Horacio Vázquez Pablo Salgado Gustavo Romero | 2021 | World Journal of Gastroenterology2021，27，28： | 4 |
| 2 | Risk factors of acute kid- hey injury according to RIFLE criteria after lung cancer surgery显示文摘 | Licker M Cartier V Robert J | 2011 | Ann Thorac Surg2011，91，： | 1 |
| 3 | Hospital-wide muhidisciplinary, muhimodal intervention programme to reduce central venous catheter-associated bloodstream infection显示文摘 | Zing W Cartier V Inan C | 2014 | PLoS One2014，9，93： | 1 |
| 4 | New syntheses and potential antimalarial activities of new 'retinoid-like chalcones′显示文摘 | ALAIN V A VALLA B CARTIER D | 2006 | Eur J Med Chem2006，41，： | 1 |
| 5 | Ef- fective electron mobility in Si inversion layers in metal-oxide semiconductor systems with a high-k insulator: the role o{ re mote phonon scattering 显示文摘 | FISCHETTI M V NEUMAYER D A CARTIER E A | 2001 | Journal of Applied Physics2001，90，9： | 1 |
| 6 | Effective electron mobility in Si inversion layers in metaloxide-semiconductor systems with a high-insulator:The role of remote phonon scattering显示文摘 | Fischetti M V Neumayer D A Cartier E A | 2001 | J Appl Phys2001，90，9： | 1 |
| 7 | Impact of anesthesia technique on the incidence of major complications after open aortic abdominal surgery:a cohort study显示文摘 | Licker M Christoph E Cartier V | 2013 | J Clin Anesth2013，25，4： | 1 |
| 8 | A marketed fermented dairy product containing Bifidobacterium lactis CNCM I‐2494 suppresses gut hypersensitivity and colonic barrier disruption induced by acute stress in rats显示文摘 | S.Agostini M.Goubern V.Tondereau C.Salvador‐Cartier V.Bezirard M.Lévèque H.Ker?nen V.Theodorou S.Bourdu‐Naturel N.Goupil‐Feuillerat S.Legrain‐Raspaud H.Eutamene | 2012 | Neurogastroenterology & Motility2012，，4： | 1 |
| 9 | Hospital-wide multidiscipli- nary, multimodal intervention programme to reduce central venous catheter-associated bloodstream infection 显示文摘 | Zingg W Cartier V Inan C | 2014 | PLoS One2014，9，93： | 1 |
| 10 | Identification of Snow Crab proteins that elicit IgE reactivity in Snow Crab proces sing workers 显示文摘 | GILL B V CARTIER A HORTH S L | 2004 | J Allergy Clin Immunol2004，111，2： | 1 |
| 11 | Effective electron mobility in Si inversion layers in metaloxide semiconductor systems with a high-k insulator:the role of remote phonon scattering 显示文摘 | FISCHETTI M V NEUMAYER D A CARTIER E A | 2001 | J Appl Phys2001，90，3： | 1 |
| 12 | Implemen- ration of a fast-track-pathway including analgo-sedation with local anaesthesia for outpatient varicose vein surgery: a cohort study显示文摘 | Licker M Brandao-Farinelli E Cartier V | 2013 | Phlebology2013，28，8： | 1 |
| 13 | Diagnosis of hepatocellular carcinoma显示文摘 | Cartier V AubéC | 2014 | Diagn Interv Imaging2014，95，8： | 1 |
| 14 | Identification of Snow Crab proteins that elicit IgE reactivity in Snow Crab processing workers 显示文摘 | Gill B V Cartier A Horth-Susin L | 2004 | Journal of Allergy Clin Immunol2004，111，2： | 1 |
| 15 | Homo-and heterodimerization of peroxisomal ATP-binding cassette half-transporters显示文摘 | Liu L X Janvier K Berteaux-Lecellier V Cartier N Benarous R Aubourg P | 1999 | J Biol Chem1999，274，32： | 1 |
| 16 | Impact of anesthesia technique on the incidence of major complications after open aortic abdominal surgery: a cohort study 显示文摘 | Licker M Christoph E Cartier V | 2013 | J Clin Anesth2013，25，4： | 1 |
| 17 | Establishment of renal proximal tubule cell lines by targeted oncogenesis in transgenic mice using the L-pyruvate kinase-SV40 (T) antigen hybrid gene显示文摘 | Cartier N Lacave R Vallet V | 1993 | J Cell Sci1993，104，： | 1 |
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