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| 1 | Hepatic drug transporters and nuclear receptors:Regulation by therapeutic agents显示文摘The canalicular membrane represents the excretory pole of hepatocytes.Bile is an important route of elimination of potentially toxic endo-and xenobiotics(including drugs and toxins),mediated by the major canalicular transporters:multidrug resistance protein 1(MDR1, ABCB1),also known as P-glycoprotein,multidrug resistance-associated protein 2(MRP2,ABCC2),and the breast cancer resistance protein(BCRP,ABCG2).Their activities depend on regulation of expression and proper localization at the canalicular membrane,as regulated by transcriptional and post-transcriptional events,respectively.At transcriptional level,specific nuclear receptors(NR)s modulated by ligands,co-activators and co-repressors,mediate the physiological requirements of these transporters.This complex system is also responsible for alterations occurring in specific liver pathologies.We briefly describe the major ClassⅡNRs, pregnane X receptor(PXR)and constitutive androstane receptor(CAR),and their role in regulating expression of multidrug resistance proteins.Several therapeutic agents regulate the expression of relevant drug transporters through activation/inactivation of these NRs.We provide some representative examples of the action of therapeutic agents modulating liver drug transporters, which in addition,involve CAR or PXR as mediators. | Aldo D Mottino Viviana A Catania | 2008 | World Journal of Gastroenterology2008，14，46： | 5 |
| 2 | Endobronchial tumor in children:Unusual finding in recurrent pneumonia,report of three cases显示文摘We are reporting 3 cases of pediatric endobronchialtumors presented with recurrent pneumonia. The median age of patients, at time of presentation, was 10.6 years. All patients presented with recurrent pneumonia with a mean time to occurrence, after onset of symptoms, of 14 mo. Bronchoscopy was early performed as part of diagnostic work-up and it revealed an endobronchial mass in every case. Complete surgical resection was performed in all cases, with lung preservation in two of them. Neither post-operative chemotherapy nor radiotherapy was required. The mean duration of follow-up was 7 years and all patients are still alive and disease-free. Recurrent pneumonia, in pediatrics, should raise the suspicion of an obstructing lesion, congenital malformation or systemic disease. A systematic approach is useful for organize the clinicians initial workup. Prompt diagnosis allows parenchymal-sparing surgery, which offers the best chance of cure and reduces clinical and functional complications in these patients. | Silvia Madafferi Vincenzo D Catania Antonella Accinni Renata Boldrini Alessandro Inserra | 2015 | World Journal of Clinical Pediatrics2015，4，2： | 5 |
| 3 | Hepatocellular carcinoma and the risk of occupational exposure显示文摘Hepatocellular carcinoma(HCC)is the most common type of liver cancer.The main risk factors for HCC are alcoholism,hepatitis B virus,hepatitis C virus,nonalcoholic steatohepatitis,obesity,type 2 diabetes,cirrhosis,aflatoxin,hemochromatosis,Wilson’s disease and hemophilia.Occupational exposure to chemicals is another risk factor for HCC.Often the relationship between occupational risk and HCC is unclear and the reports are fragmented and inconsistent.This review aims to summarize the current knowledge regarding the association of infective and non-infective occupational risk exposure and HCC in order to encourage further research and draw attention to this global occupational public health problem. | Venerando Rapisarda Carla Loreto Michele Malaguarnera Annalisa Ardiri Maria Proiti Giuseppe Rigano Evelise Frazzetto Maria Irene Ruggeri Giulia Malaguarnera Nicoletta Bertino Mariano Malaguarnera Vito Emanuele Catania Isidoro Di Carlo Adriana Toro Emanuele Bertino Dario Mangano Gaetano Bertino | 2016 | World Journal of Hepatology2016，8，13： | 5 |
| 4 | Role of matrix metalloproteinases in renal pathophysiologies 显示文摘 | Catania JM Chen G Parrish AR | 2007 | Am J Physiol Renal Physiol2007，292，3： | 1 |
| 5 | Central Visual System of the Naked Mole-Rat (Heterocephalus glaber) 显示文摘 | Crish SD Dengler-Crish CM Catania KC | 2006 | Anat Rec A Discov Mol Cell Evol Biol2006，288，2： | 1 |
| 6 | Deactivation and reactivation of somatosen- sory cortex after dorsal spinal cord injury显示文摘 | Jain N Catania KC Kaas JH | 1997 | Nature1997，386，6624： | 1 |
| 7 | Mixed tumour ( spin- dle cell epithelioma) of the vagina: report of a case显示文摘 | D' Andrea V Catania A Biancari F | 1998 | Ann ltal Chit1998，69，2： | 1 |
| 8 | Integrating XML and Databases显示文摘 | B Catania | 2001 | IEEE Internet Computing2001，5，4： | 1 |
| 9 | PUPPI:The Pressure Ulcer Prevention Protocol Interventions显示文摘 | Kimberly Catania Cheryl Huang Polly James | 2007 | American Journal of Nursing2007，107，4： | 1 |
| 10 | Abdominal wall reconstruction with intraperitoneal prosthesis in desmoid tumors surgery显示文摘 | Catania G Ruggeri L Iuppa G | 2012 | Updates Surg2012，64，1： | 1 |
| 11 | Endoscopic treatment of intrauterine adhesions 显示文摘 | Pace S Stentella P Catania R | 2003 | Clin Exp Obstet Gynecol2003，30，1： | 1 |
| 12 | Integrating XML and databases显示文摘 | BERTINO E CATANIA B | 2001 | Internet Computing2001，5，4： | 1 |
| 13 | Role of matrix metalloproteinases in renal pathophysiologies 显示文摘 | Catania J M Chen G Parrish A R | 2007 | Am J Pbysiol Renal Physiol2007，292，3： | 1 |
| 14 | A recessive mutation in the APP gene with dominant-negative effect on amyloidogenesis 显示文摘 | Di Fede G Catania M Morbin M | 2009 | Scinenee2009，323，5920： | 1 |
| 15 | alpha-MSH production,receptors,and influence on neopterin in a human monocyte/macrophage cell line显示文摘 | Rajora N Ceriani G Catania A | | 0，，02： | 1 |
| 16 | Interpreting HIV prevalence and incidence among Americans: Bridging data and public policy 显示文摘 | Mills TC Stall R Catania JA | 1997 | Am J Public Health1997，87，： | 1 |
| 17 | Role of matrix metalloproteinases in renal pathophysiologies显示文摘 | Catania JM Chen G Parrish AR | 2007 | Am J Physiol Renal Physiol2007，292，3： | 1 |
| 18 | Knowledge and attitudes about cancer pain management: a national survey of Italian oncology nurses显示文摘 | Bemardi M Catania G Lambert A | 2007 | Eur J Oncol Nurs2007，11，3： | 1 |
| 19 | Implementation and analysis of a new selection strategy for adaptive routing in networks-on-chip显示文摘 | Ascia G Catania V | 2008 | IEEE Transaction on Computers2008，57，6： | 1 |
| 20 | Structure and innervation of the sensory organs on the snout of the star-nosed mole显示文摘 | CATANIA K C | 1995 | J Comp Neurol1995，351，： | 1 |
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