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| 1 | Overview of recent advances in metastatic triple negative breast cancer显示文摘Metastatic triple negative breast cancer(TNBC)has an aggressive phenotype with a predilection for visceral organs and brain.Best responses to chemotherapy are predominately in the first line.Recent studies have demonstrated improved progression free survival with the combination of atezolizumab/pembrolizumab and chemotherapy in programmed death-ligand 1 positive metastatic TNBC.However,a recent trial in a similar population showed no benefit for atezolizumab and paclitaxel which led to a Food and Drug Administration alert.Two phase III trials(OLYMPIAD and BROCADE3)demonstrated a benefit in progression free survival(PFS)but not overall survival in patients with BRCAassociated metastatic TNBC treated with Olaparib or Talazoparib respectively.For those treated with Talazoparib,the time to deterioration in health related-quality of life was also longer compared to chemotherapy.The BROCADE3 trial demonstrated that the combination of a platinum and veliparib increased PFS in first-line metastatic TNBC but at the cost of increased toxicity.There are no headto-head comparisons of a poly(adenosine diphosphate-ribose)polymerase inhibitors(PARPi)and platinums.There are unanswered questions regarding the role of PARPi maintenance after platinum therapy as is standard of care in BRCAassociated ovarian cancer.Other areas of therapeutic interest include targeting aberrations in the phosphoinositide 3-kinase pathway,protein kinase B,mammalian target of rapamycin or utilising antibody drug conjugates.This review focusses on recent and emerging therapeutic options in metastatic TNBC.We searched PubMed,clinicaltrials.gov and recent international meetings from American Society of Clinical Oncology,San Antonio Breast Cancer Conference and the European Society of Medical Oncology. | David O'Reilly Maha Al Sendi Catherine M Kelly | 2021 | World Journal of Clinical Oncology2021，12，3： | 5 |
| 2 | Toward the understanding of the thermal degradation of Commercially Available Fire-resistant Cable显示文摘 | Catherine H Andre R Rudi C et al | 2000 | Material Letters2000，46，： | 1 |
| 3 | Early Recurrence After Liver Resection for Colorectal Metastases: Risk Factors, Prognosis, and Treatment. A LiverMetSurvey-Based Study of 6,025 Patients显示文摘 | Luca Viganò Lorenzo Capussotti Réal Lapointe Eduardo Barroso Catherine Hubert Felice Giuliante Jan N. M. Ijzermans Darius F. Mirza Dominique Elias René Adam | 2014 | Annals of Surgical Oncology2014，，4： | 1 |
| 4 | The immunobiology of the innate response to Toxoplasma gondii 显示文摘 | Catherine MM Nicola RB Rowan JI el al | 2009 | Int J Parasitol2009，39，： | 1 |
| 5 | Treatment of central nervous system toxoplasmosis with pyrirnethamine/sulfadiazine combination in 35 patients with the acquired immunodeficiency syndrome: Efficacy of long-term continuous therapy 显示文摘 | Catherine E Francois R Sophie M ct al | 1988 | AM J MED1988，84，1： | 1 |
| 6 | Spatial memory performance 2 weeks after general anesthesia in adult rats 显示文摘 | Catherine C Deborah JC Mark GB el al | 2005 | Anesth Analg2005，101，5： | 1 |
| 7 | Spectrum of Calcific Aortic Valve Disease: Pathogenesis, Disease Progression, and treatment Strategies显示文摘 | Rosario V Freeman Catherine M a al | 2005 | Circulation2005，111，： | 1 |
| 8 | Clinical practiceguidelines by the Infectious diseases society of America forthe treatment of methicillin-resistant Staphylococcus aureusinfection in adults and children: executive summary显示文摘 | Catherine Liu Bayer A Cosgrove SE e? al | 2011 | ClinInfect Dis2011，52，3： | 1 |
| 9 | Attention-deficit/ hyperactivity disorder in school-aged children: association with maternal mental health and use of health care resources显示文摘 | Catherine AL Susanna NV Carla PW | 2003 | Pediatrics2003，111，： | 1 |
| 10 | Chicken extract stimulates haemoglobin res- toration in iron deficient rats 显示文摘 | Catherine Geissler Mansour Boroumand - Naini Masami Harada ct al | 1996 | International Journal of Food S- ciences and Nutrition1996，47，4： | 1 |
| 11 | Flouroquinolone toxicity profiles:A review focusing on newer agents显示文摘 | Catherine A | 1999 | Clinical Infectious Diseases1999，28，2： | 1 |
| 12 | Use of a decision analysis model to assess the medicoeconomic implications of FDG PET imaging in diagnosing a solitary pulmonary nodule显示文摘 | Catherine Lejeune Kazem Al Zahouri Marie-Christine Woronoff-Lemsi Patrick Arveux Alain Bernard Christine Binquet Francis Guillemin | 2005 | The European Journal of Health Economics2005，，3： | 1 |
| 13 | Operating Conditions That Affect the Resistance of Lactic Acid Bacteria to Freezing and Frozen Storage显示文摘 | Fernanda Fonseca Catherine Béal Georges Corrieu | 2001 | Cryobiology2001，，3： | 1 |
| 14 | Hydrodynamic characterization of chemically degraded hyaluronic acid 显示文摘 | Sanya Hokputsa Komelia Jumel Catherine AL | 2003 | Carbohydrate Polymers J2003，52，： | 1 |
| 15 | Acetate/Di-2-pyridyl Ketone Oximate 'Blend' as a Source of High-Nuclearity Nickel(II) Clusters:Dependence of the Nuclearity on the Nature of the Inorganic Anion Present显示文摘 | Theocharis C Stamatatos Eleanna Diamantopoulou Catherine P Raptopoulou el al | 2007 | Inorg Chem2007，46，： | 1 |
| 16 | Emotional and Behavioral difficulties and impairments in everyday functioning among children with a history of attention-deficit/Hyperactivity显示文摘 | Tara WS Catherine AL Catherine AO | 2006 | Disorder Prey Chronic Dis2006，3，2： | 1 |
| 17 | Validation of ITD mutations in FLT3 as a therapeutic target in human acute myeloidleukaemia 显示文摘 | CATHERINE C S QI W CHIN C S ef al | 2012 | Nature2012，485，7397： | 1 |
| 18 | Flouroquinolone toxicity profiles: A review focusing on newer agents显示文摘 | Benjamin AL Catherine A | 1999 | Clinical Infectious Diseases1999，28，2： | 1 |
| 19 | AIDS prevention through peer education显示文摘 | Alan J F Catherine M Sally G el al | 2005 | S Afr Med J2005，95，4： | 1 |
| 20 | Mother-child conversational interactions as events unfold: linkages to sub-sequent remembering显示文摘 | Catherine AH Peter AO Carol OE at al | 2001 | Child Development2001，72，4： | 1 |
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