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| 1 | Acinar cell injury induced by inadequate unfolded protein response in acute pancreatitis显示文摘Acute pancreatitis (AP) is an inflammatory disorder of pancreatic tissue initiated in injured acinar cells. Severe AP remains a significant challenge due to the lack of effective treatment. The widely-accepted autodigestion theory of AP is now facing challenges, since inhibiting protease activation has negligible effectiveness for AP treatment despite numerous efforts. Furthermore, accumulating evidence supports a new concept that malfunction of a self-protective mechanism, the unfolded protein response(UPR), is the driving force behind the pathogenesis of AP. The UPR is induced by endoplasmic reticulum(ER) stress, a disturbance frequently found in acinar cells, to prevent the aggravation of ER stress that can otherwise lead to cell injury. In addition, the UPR's signaling pathways control NFκB activation and autophagy flux, and these dysregulations cause acinar cell inflammatory injury in AP, but with poorly understood mechanisms. We therefore summarize the protective role of the UPR in AP, propose mechanistic models of how inadequate UPR could promote NFκB's pro-inflammatory activity and impair autophagy's protective function in acinar cells, and discuss its relevance to current AP treatment. We hope that insight provided in this review will help facilitate the research and management of AP. | Kaylene Barrera Albert Stanek Kei Okochi Zuzanna Niewiadomska Cathy Mueller Peiqi Ou Devon John Antonio E Alfonso Scott Tenner Chongmin Huan | 2018 | World Journal of Gastrointestinal Pathophysiology2018，9，2： | 9 |
| 2 | Acute pancreatitis in aging animals:Loss of pancreatitis-associated protein protection?显示文摘AIM:To investigate the effect of age on severity of acute pancreatitis(AP) using biochemical markers,histology and expression of the protective pancreatitisassociated proteins(PAPs).METHODS:AP was induced via intraductal injection of 4% sodium taurocholate in young and old rats.Sera and pancreata were assayed at 24 h for the parameters listed above;we also employed a novel molecular technique to assess bacterial infiltration using polymerase chain reaction to measure bacterial genomic ribosomal RNA.RESULTS:At 24 h after induction of AP,the pancreata of older animals had less edema(mean ± SE histologic score of young vs old:3.11 ± 0.16 vs 2.50 ±-0.11,P < 0.05),decreased local inflammatory response(histologic score of stromal infiltrate:3.11 ± 0.27 vs 2.00 ± 0.17,P < 0.05) and increased bacterial infiltration(174% ± 52% increase from sham vs 377% ± 4%,P < 0.05).A decreased expression of PAP1 and PAP2 was demonstrated by Western blotting analysis and immunohistochemical staining.There were no differences in serum amylase and lipase activity,or tissue myeloperoxidase or monocyte chemotactic protein-1 levels.However,in the most-aged group,serum C-reactive protein levels were higher(young vs old:0.249 ± 0.04 mg/dL vs 2.45 ± 0.68 mg/dL,P < 0.05).CONCLUSION:In older animals,there is depressed PAP expression related to a blunted inflammatory response in AP which is associated with worsened bacterial infiltration and higher C-reactive protein level;this may explain the more aggressive clinical course. | Sophia Fu Albert Stanek Cathy M Mueller Nefertti A Brown Chongmin Huan Martin H Bluth Michael E Zenilman | 2012 | World Journal of Gastroenterology2012，18，26： | 5 |
| 3 | Fmrl knockout mice : a model to study fragile X mental retardation显示文摘 | Cathy E Bakker A Coleta V | 1994 | Cell1994，78，： | 1 |
| 4 | Fmrl knot: koutmice : Amodel tostudy fragile Xmentalre tardation 显示文摘 | Cathy E Bakker Coleta Verheij | 1994 | Cell1994，78，： | 1 |
| 5 | Family presence during cardiopulmonary resuscitation and invasive proce- dures:Practices of critical care and emergency nurses显示文摘 | Susan L MacLean Cathie E Guzzetta Cheri White | 2003 | Am J Crit Care2003，12，： | 1 |
| 6 | A novel wound-inducible extensin gene is expressed early in newly isolated protoplasts of Nicotiana sylvestris显示文摘 | Yves Parmentier Andrée Durr Jacqueline Marbach Cathy Hirsinger Marie-Claire Criqui Jacqueline Fleck Elisabeth Jamet | 1995 | Plant Molecular Biology1995，，2： | 1 |
| 7 | Extractive fermentation of aroma with supercritical C02 显示文摘 | Cathy E Fabre Condoret J S Marty A | 1999 | Biotechnology and Bioengineering1999，64，4： | 1 |
| 8 | Transitional care in skilled nursing facilities:a muhiple case study显示文摘 | MARK T CATHI EEN C E MARRY D N | 2016 | BMC HealthServRes2016，，： | 1 |
| 9 | Spatial competition between grasses-rates of mutual invasion between four species and the interaction with grazing显示文摘 | Silvertown J Cathy E M Pam Dale M | 1994 | Journal of Ecology1994，82，： | 1 |
| 10 | Patient-related risk factors for fracture-healing complications in the United Kingdom General Practice Research Database显示文摘 | Rohini K Hernandez Thy P Do Cathy W Critchlow Ricardo E Dent Susan S Jick | 2012 | Acta Orthopaedica2012，，6： | 1 |
| 11 | Given capsule endoscopy in celiac disease显示文摘 | Rima Petroniene Elena Dubcenco Jeffrey P Baker Ralph E Warren Cathy J Streutker Geoffrey W Gardiner Khursheed N Jeejeebhoy | 2004 | Gastrointestinal Endoscopy Clinics of North Americ2004，，1： | 1 |
| 12 | Extractive fermentation of aroma with supercritical CO2 显示文摘 | Fabre Cathy E Condoret Jean-S Marty Alain | 1999 | Biotechnology and Bioengineering1999，64，4： | 1 |
| 13 | Mucopurulent cervicitis and Mycoplasma genitalium 显示文摘 | Lisa E Manhart Cathy W | 2003 | Infect Dis J2003，187，： | 1 |
| 14 | A multicenter comparison of intraaortic balloon pump utilization in isolated coronary artery bypass graft surgery显示文摘 | Roger J.F Baskett Gerald T O’Connor Gregory M Hirsch William A Ghali Kathy Sabadosa Jeremy R Morton Cathy S Ross Felix Hernandez William C Nugent Stephen J Lahey Donato A Sisto Lawrence J Dacey John D Klemperer Robert E Helm Andrew Maitland | 2003 | The Annals of Thoracic Surgery2003，，6： | 1 |
| 15 | Low occurrence of safety hazards in coagulase negative staphylococci isolated from fer- mented foodstuffs显示文摘 | Sergine E Sabine L Cathy C | 2010 | Int J Food Microblol2010，139，12： | 1 |
| 16 | The effect of epidermal growth factor on differentiation of isolated enterocytes after small bowel resection显示文摘 | Richard A Falcone Cathy E Shin Christopher R Erwin Brad W Warner | 1999 | Journal of Pediatric Surgery1999，，1： | 1 |
| 17 | Trends in the prevalence of diagnosed atrial fibrillation, its treatment with anticoagulation, and predictors of such treatment in UK primary care显示文摘 | Stephen DW Iain MC Cathy E | 2006 | Heart2006，92，1： | 1 |
| 18 | Lipoxygenase inhibitors as potential cancer chemopreventives显示文摘 | Vernon E Steele Cathy A | 1999 | Cancer Epidemiol Biomar Prev1999，5，8： | 1 |
| 19 | Fmrl knockout mice: a model to study fragile X mental retardation显示文摘 | CATHY E BAKKER A COLETA V | 1994 | Cell1994，78，： | 1 |
| 20 | Lipoxygenase inhibitors as potential cancer chemopreventives显示文摘 | Vernon E Steele Cathy A Holmes Ernest T Hawk | 1999 | Cancer Epidemiol Biomarkers Prev1999，5，8： | 1 |
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