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| 1 | Device-associated infection rates, mortality, length of stay and bacterial resistance in intensive care units in Ecuador: International Nosocomial Infection Control Consortium's findings显示文摘AIM To report the results of the International Nosocomial Infection Control Consortium(INICC) study conducted in Quito, Ecuador.METHODS A device-associated healthcare-acquired infection(DAHAI) prospective surveillance study conducted from October 2013 to January 2015 in 2 adult intensive care units(ICUs) from 2 hospitals using the United States Centers for Disease Control/National Healthcare Safety Network(CDC/NHSN) definitions and INICC methods. RESULTS We followed 776 ICU patients for 4818 bed-days. The central line-associated bloodstream infection(CLABSI) rate was 6.5 per 1000 central line(CL)-days, the ventilator-associated pneumonia(VAP) rate was 44.3 per 1000 mechanical ventilator(MV)-days, and the catheterassociated urinary tract infection(CAUTI) rate was 5.7 per 1000 urinary catheter(UC)-days. CLABSI and CAUTI rates in our ICUs were similar to INICC rates [4.9(CLABSI) and 5.3(CAUTI)] and higher than NHSN rates [0.8(CLABSI) and 1.3(CAUTI)]- although device use ratios for CL and UC were higher than INICC and CDC/NSHN's ratios. By contrast, despite the VAP rate was higher than INICC(16.5) and NHSN's rates(1.1), MV DUR was lower in our ICUs. Resistance of A. baumannii to imipenem and meropenem was 75.0%, and of Pseudomonas aeruginosa to ciprofloxacin and piperacillin-tazobactam was higher than 72.7%, all them higher than CDC/NHSN rates. Excess length of stay was 7.4 d for patients with CLABSI, 4.8 for patients with VAP and 9.2 for patients CAUTI. Excess crude mortality in ICUs was 30.9% for CLABSI, 14.5% for VAP and 17.6% for CAUTI. CONCLUSION DA-HAI rates in our ICUs from Ecuador are higher than United States CDC/NSHN rates and similar to INICC international rates. | Estuardo Salgado Yepez Maria M Bovera Victor D Rosenthal Hugo A González Flores Leonardo Pazmino Francisco Valencia Nelly Alquinga Vanessa Ramirez Edgar Jara Miguel Lascano Veronica Delgado Cristian Cevallos Gasdali Santacruz Cristian Pelaéz Celso Zaruma Diego Barahona Pinto | 2017 | World Journal of Biological Chemistry2017，8，1： | 23 |
| 2 | Relevance of MUC1 mucin variable number of tandem repeats polymorphism in H pylori adhesion to gastric epithelial cells显示文摘AIM:To evaluate the influence of MUC1 mucin variable number of tandem repeats (VNTR) variability on H pylori adhesion to gastric cells. METHODS: Enzyme linked immunosorbent assay (ELISA)-based adhesion assays were performed to measure the adhesion of different H pylori strains (HP26695 and HPTx30a) to gastric carcinoma cell lines (GP202 and MKN45) and GP202 clones expressing recombinant MUC1 with different VNTR lengths. RESULTS: Evaluation of adhesion results shows that H pylori pathogenic strain HP26695 has a significantly higher (P < 0.05) adhesion to all the cell lines and clones tested, when compared to the non-pathogenic strain HPTx30a. Bacteria showed a significantly higher (P < 0.05) adhesion to the GP202 cell line, when compared to the MKN45 cell line. Furthermore, both strains showed a significantly higher (P < 0.05) adhesion to GP202 clones with larger MUC1 VNTR domains. CONCLUSION: This work shows that MUC1 mucin variability conditions H pylori binding to gastric cells. The extent of bacterial adhesion depends on the size of theMUC1 VNTR domain. The adhesion is further dependent on bacterial pathogenicity and the gastric cell line. MUC1 mucin variability may contribute to determine H pylori colonization of the gastric mucosa. | Natália R Costa Nuno Mendes Nuno T Marcos Celso A Reis Thomas Caffrey Michael A Hollingsworth Filipe Santos-Silva | 2008 | World Journal of Gastroenterology2008，14，9： | 4 |
| 3 | Lansoprazole quantification in human plasma by liquid chromatography-electrospray tandem mass spectrometry显示文摘 | Celso H O Rafael E B A Eduardo A | 2003 | J Chromatogr B2003，783，： | 1 |
| 4 | Reliability challengesin large systems 显示文摘 | Daniel A R Charng-da L? Celso L M | 2006 | Future Generation Computer Systems2006，22，3： | 1 |
| 5 | Oxidative stress in digestive gland and gill of the brown mussel (Pema pema) exposed to air and re-submersed 显示文摘 | Eduardo A Almeida Afonso Celso Dias Bainy Alcir Luiz Dafre | 2005 | Journal of Experimental Marine Biology and Ecology2005，318，： | 1 |
| 6 | Free Amino Acids in leaves of cotton plants under water deficit 显示文摘 | MARUR C J Sodek L Celso A | 1994 | R Bras Fisiol Veg1994，6，： | 1 |
| 7 | Controlling chaos显示文摘 | Edward O Celso G James A Y | 1990 | Physical Review Letters1990，64，11： | 1 |
| 8 | Osteopontin is an autocrine mediator of hepatocyte growth factor-induced invasive growth显示文摘 | Medico E Gentile A Celso CL | 2001 | Cancer Res2001，61，15： | 1 |
| 9 | Lansoprazole quantifica-tion in human plasma by liquid chromatography - electrospraytandem mass spectrometry显示文摘 | Celso HO Rafael EB Eduardo A | 2003 | J Chromatogra B2003，783，2： | 1 |
| 10 | Beta-catenin and Hedgehog signal strength can specify number and loca tion of hair follicles in adult epidermis without recruitment of bulge stem cells显示文摘 | Silva-Vargas V Lo Celso C Giangreco A | 2005 | Dev Ce112005，9，12： | 1 |
| 11 | Beta - catenin and Hedgehog signal strength can specify number and location of hair follicles in adult epidermis without recruitment of bulge stem cells 显示文摘 | Silva - Vargas V Lo Celso C Giangreco A | 2005 | Dev Cell2005，9，1： | 1 |
| 12 | Discovery of unique African Helicobacter pylori CagAmultimerization motif in the Dominican Republic显示文摘BACKGROUND Helicobacter pylori(H.pylori)colonizes the human stomach and is a major cause of peptic ulcer disease and gastric cancer.However,although the prevalence of H.pylori is high in Africa,the incidence of gastric cancer is low,and this phenomenon is called to be African enigma.The CagA protein produced by H.pylori is the most studied virulence factor.The carcinogenic potential of CagA is associated with the Glu-Pro-Ile-Tyr-Ala(EPIYA)patterns and CagAmultimerization(CM)motifs.AIM To better understand the EPIYA patterns and CM motifs of the cagA gene.METHODS Gastric mucosal biopsy specimens were obtained from 258 patients with dyspepsia living in the Dominican Republic,from which 120 H.pylori strains were cultured.After the bacterial DNA extraction,the EPIYA pattern and CM motif genotypes were determined using a polymerase chain reaction-based sequencing.The population structure of the Dominican Republic strains was analyzed using multilocus sequence typing(MLST).Peptic ulcer disease and gastric cancer were identified via endoscopy,and gastric cancer was confirmed by histopathology.Histological scores of the gastric mucosa were evaluated using the updated Sydney system.RESULTS All CagA-positive strains carried the Western-type CagA according to the identified EPIYA patterns.Twenty-seven kinds of CM motifs were observed.Although the typical Western CM motif(FPLKRHDKVDDLSKVG)was observed most frequently,the typical East Asian CM motif(FPLRRSAAVNDLSKVG)was not observed.However,“FPLRRSAKVEDLSKVG”,similar to the typical East Asian CM motif,was found in 21 strains.Since this type was significantly more frequent in strains classified as hpAfrica1 using MLST analysis(P=0.034),we termed it Africa1-CM(Af1-CM).A few hpEurope strains carried the Af1-CM motif,but they had a significantly higher ancestral Africa1 component than that of those without the Af1-CM motif(P=0.030).In 30 cagA-positive strains,the'GKDKGPE'motif was observed immediately upstream of the EPIYA motif in the EPIYA-A segment,and there was a significant association between strains with the hpAfrica1 population and those containing the“GKDKGPE”motif(P=0.018).In contrast,there was no significant association between the CM motif patterns and histological scores and clinical outcomes.CONCLUSION We found the unique African CM motif in Western-type CagA and termed it Africa1-CM.The less toxicity of this motif could be one reason to explain the African enigma. | Takaaki Ono Modesto Cruz Hiroyuki Nagashima Phawinee Subsomwong Junko Akada Takashi Matsumoto Tomohisa Uchida Rumiko Suzuki Celso Hosking Jose A Jimenez Abreu Yoshio Yamaoka | 2020 | World Journal of Gastroenterology2020，26，45： | 1 |
| 13 | Spray forming high speedsteel~properties and processing 显示文摘 | RAFAEL A M CELSO A B | 2004 | Materials Science andEngineering A2004，383，1： | 1 |
| 14 | Resistance to flexural fatigue of reciproc R25 files under continuous rotation and recip- rocating movement显示文摘 | Giulio G Celso LC Eduardo A | 2012 | J Endod2012，38，5： | 1 |
| 15 | Chemical composition and free radical scavenging activity of pollen stinglcss bee melipona ducke显示文摘 | TANIA M S S CELSO A CAMARA B ct al | 2006 | Food Composition and Analysis2006，19，11： | 1 |
| 16 | Osteopontin is an autocrine mediator of hepatocyte growth factor- induced invasive growth显示文摘 | Medico E Gentile A Celso CL | 2001 | Cancer Res2001，61，： | 1 |
| 17 | Spray forming high speed steel-properties and processing 显示文摘 | Rafael A M Celso A B | 2004 | Materials Science and Engineering: A2004，383，1： | 1 |
| 18 | Guanine nu- cleotide exchange factor Vavl regulates perivascular homing and bone marrow retention of hematopoietic stem and pro- genitor cells显示文摘 | Sanchez-Aguilera A Lee YJ Lo Celso C | 2011 | Proc Natl Acad Sci U S A2011，108，23： | 1 |
| 19 | Kinetic properties of four plasmid-mediated AmpC β-lactamases显示文摘 | Bauvois C Ibuka AS Celso A | 2005 | Antimicrob Agents Chemother2005，49，10： | 1 |
| 20 | Increased hepatic expression of insulin-like growth factor-Ⅰreceptor in chronic hepatitis C显示文摘瞄准:尽管增加像胰岛素的生长因素 -- 我受体(IGF 红外) 基因表示在肝细胞癌被报导了,在长期的丙肝(CHC ) 估计 IGF 红外的研究和肝硬化是少见的。我们因此试图与 CHC 从病人在肝评估 IGF 红外和 IGF-I mRNA 表示。方法:IGF 红外和 IGF-I mRNA 内容被半量的 RT-PCR 决定, IGF 红外蛋白质表示由在以前与 CHC 从病人获得的肝的织物(34 个病人) 并且在以后的 immunohisto 化学是坚定的(10 个病人) 有 interferon-alpha 和 ribavirin 的治疗。结果:IGF 红外 mRNA 内容的增加在从所有 CHC 病人以及从与正常的肝相比跟随 orthopic 移植(评估正常的肝的一次尝试) 的 6 个尸体肝施主获得的肝的织物被观察,当没有相关修正在 IGF-I mRNA 内容被检测时。组织化学的结果显示出的免疫在 IGF 红外 mRNA 的加薪满足,这与 ductular 反应并且到在 hepatocytes 的增加的 IGF 红外表示相关。在 IGF 红外 mRNA 内容的减少在在治疗以后完成了持续 virological 反应的病人被观察,建议处于肝的损坏的改进。结论:在有 CHC 的病人的 hepatocytes 的 IGF 红外表示的起来规定能组成一次尝试刺激 hepatocyte 新生。考虑到那个肝是有 IGF-I 的高水平的机关,我们在尖锐、长期的肝的损坏以后发现增加的 IGF 红外表示加亮需要让另外的研究阐明在肝的 IGF-I 的角色新生。 | José Tadeu Stefano Maria Lúcia Corr(e|^)a-Giannella Cristiane Maria Freitas Ribeiro Ven(a|^)ncio Avancini Ferreira Alves Paulo Celso Bosco Massarollo Marcel Cerqueira Cesar Machado Daniel Giannella-Neto | 2006 | World Journal of Gastroenterology2006，12，24： | 1 |
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