|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Effect of omeprazole on symptoms and ultrastructural esophageal damage in acid bile reflux显示文摘AIM: To value whether omeprazole could induce the healing of DIS and regression of symptoms in patients with DGER.METHODS: We enrolled 15 symptomatic patients with a pathological esophageal 24-h pH-metry and bilimetry.Patients underwent endoscopy and biopsies were taken from the distal esophagus. Specimens were analyzed at histology and transmission electron microscopy (TEM).Patients were treated with omeprazole 40 mg/d for 3 mo and then endoscopy with biopsies was repeated. Patients with persistent heartburn and/or with an incomplete recovery of DIS were treated for 3 more months and endoscopy with biopsies was performed.RESULTS: Nine patients had a non-erosive reflux disease at endoscopy (NERD) while 6 had erosive esophagitis (ERD). At histology, of the 6 patients with erosive esophagus,5 had mild esophagitis and 1 moderate esophagitis. No patients with NERD showed histological signs of esophagitis.After 3 mo of therapy, 13/15 patients (86.7%, P<0.01)showed a complete recovery of DIS and disappearance of heartburn. Of the 2 patients treated for 3 more months,complete recovery of DIS and heartburn were achieved in one.CONCLUSION: Three or 6 mo of omeprazole therapy led to a complete regression of the ultrastructural esophageal damage in 86.7% and in 93% of patients with DGER, NERD and ERD respectively. The ultrastructural recovery of the epithelium was accompanied by regression of heartburn in all cases. | Carlo Calabrese Anna Fabbri Mauro Bortolotti Giovanna Cenacchi Scialpi Carlo Desiree Zahlane Mario Miglioli Giulio Di Febo | 2005 | World Journal of Gastroenterology2005，11，12： | 3 |
| 2 | Esophageal cell proliferation in gastroesophageal reflux disease: Clinical-morphological data before and after pantoprazole显示文摘AIM: To evaluate esophageal mucosal defense mechanisms at an epithelial level to establish if pantoprazole treatment can induce ultrastructural healing and improvement in the proliferation activity of the esophageal epithelium in gastroesophageal reflux disease (GERD). METHODS: This was a single-blinded study for pHmonitoring, and histological, ultrastructural and MIB1 immunostaining evaluation. Fifty eight patients with GERD were enrolled and underwent 24 h pH-monitoring and endoscopy. Patients were treated for 12 and 24 mo with pantoprazole. Esophageal specimens were taken for histological and ultrastructural evaluation, before and after the treatment. RESULTS: With transmission electron microscopy, all patients with GERD showed ultrastructural signs of damage with dilation of intercellular spaces (DIS). After 3 mo of therapy the mean DIS values showed asignificant reduction and the mean MIB1-LI values of GERD showed an increase in cell proliferation. A further 3 mo of therapy significantly increased cell proliferation only in the erosive esophagitis (ERD) group. CONCLUSION: Three months of pantoprazole therapy induced ultrastructural healing of mucosal damage in 89% and 93% of ERD and non-erosion patients, respectively. Moreover, long-term pantoprazole treatment may be helpful in increasing the capability for esophageal cell proliferation in GERD, particularly in ERD patients. | Carlo Calabrese Davide Treré Giuseppina Liguori Veronica Gabusi Manuela Vici Giovanna Cenacchi Massimo Derenzini Giulio Di Febo | 2009 | World Journal of Gastroenterology2009，15，8： | 2 |
| 3 | Ultrastructural changes in LGMD 1F显示文摘 | Cenacchi G Peterle E Fanin M | 2013 | Neuropathology2013，33，： | 1 |
| 4 | Primaryendocervical extraosseous Ewing's sarcoma/PNET显示文摘 | Cenacchi G Pasquinelli G Montanaro L | 1998 | Int JGynecol Pathol1998，17，1： | 1 |
| 5 | Bone reconstruction of large defects using bone marrow derived autologous stem cells显示文摘 | Lucarelli E Donati D Cenacchi A | 2004 | Transfus Apher Sci2004，30，： | 1 |
| 6 | Uhrastructural changes in dysferlinopathy support defective membrane repair mechanism 显示文摘 | Cenacchi G Fanin M De Giorgi LB | 2005 | J Clin Pathol2005，58，： | 1 |
| 7 | Cognitive decline in the elderly:a double-blind,placebo-controlled multicenter study on efficacy of phosphatidylserine administration显示文摘 | Cenacchi T Bertoldin T Farina C | | 0，，： | 1 |
| 8 | Melanotic schwannoma of the sympathetic ganglia: A histologic, immunohistochemical and ultrastructural study显示文摘 | Camillo Di Bella Paolo Declich Agnese Assi Giovanna Cenacchi Maria Sironi Luigi Cozzi Arturo Griner | 1997 | Journal of Neuro - Oncology1997，，2： | 1 |
| 9 | Emerging tumor entities and variants of CNS neoplasms显示文摘 | Cenacchi G Giangaspero F | 2004 | J Neuropathol Exp Neurol2004，63，： | 1 |
| 10 | Emerging tumor entities and variants of CNS neoplasms显示文摘 | Cenacchi G Giangaspero F | 2004 | J Neuropathol Exp Neurol2004，63，3： | 1 |
| 11 | Extraventricular neoplasms with neurocytoma features:a clinicopathological study of 11 cases显示文摘 | Giangaspero F Cenacchi G Losi L | 1997 | Am J Surg Pathol1997，21，： | 1 |
| 12 | Bone reconstruction oflarge defects using bone marrow derived autologous stem cells显示文摘 | Lucarelli E Donati D Cenacchi A | 2004 | Trans?fus Apher Sci2004，30，： | 1 |
| 13 | Progression on metastatic neuroendocrine carcinoma from a recurrent prolac- tinoma: a case report 显示文摘 | Sironi M Cenacchi G Cozzi L | 2002 | J Clin Pathol2002，55，2： | 1 |
| 14 | Mixed tumors, myoepitheliomas, and oncocytomas of the soft tissues are likely members of the same family: a clinicopathologic and ultrastructural study 显示文摘 | Bisceglia M Cardone M Fantasia L Cenacchi G Pasquinelli G | 2001 | Ultrastruct Pathol2001，25，5： | 1 |
| 15 | Ultrastructural and immunohistochemical contribution to the histogenesis of human cardiac myxoma显示文摘 | Govoni E Severi B Cenacchi G | 1988 | Ultrastruct Pathol1988，12，2： | 1 |
| 16 | Primary endocervical extraosseous Ewing's sarcoma/PNET显示文摘 | Cenacchi G Pasquinelli G Montanaro L | | 0，，01： | 1 |
| 17 | ‘Spindle cell oncocytoma' of the adenohypophysis显示文摘 | Roncaroli F Scheithauer BW Cenacchi G | 2002 | Am J Surg Pathol2002，26，8： | 1 |
| 18 | ‘Spindle cell oncocytoma' of the adenohypophysis: a tumor of folliculostellate cells显示文摘 | Roncaroli F Scheithauer BW Cenacchi G | 2002 | Am J Surg Pathol2002，26，10： | 1 |
| 19 | 'Spindle cell oncocytoma' of the adenohypophysis: a tumor of folliculostellate cells? 显示文摘 | Roncaroli F Scheithauer BW Cenacchi G | 2002 | Am J Surg Pathol2002，26，8： | 1 |
| 20 | Primary en- docervical extraosseous Ewing's Sarcoma/PNET显示文摘 | Cenacchi G Pasquinelli G Montanaro L | 1998 | Int J Gy- necol Pathol1998，17，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员