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| 1 | Hippo pathway in mammary gland development and breast cancer显示文摘积累的证据建议表明小径的河马在乳腺开发和乳癌起关键作用。河马小径的关键部件调整胸上皮的房间增长,移植,侵略,和 stemness。另外,河马小径调整胸肿瘤生长,转移,和药电阻。河马小径将为乳癌提供新奇治疗学的目标,这被期望。这评论将在乳腺开发和乳癌讨论并且总结河马小径的几个核心部件的角色。 | Peiguo Shi Jing Feng Ceshi Chen | 2015 | Acta Biochimica et Biophysica Sinica2015，47，1： | 7 |
| 2 | WWOX suppresses KLF5 expression and breast cancer cell growth显示文摘The WW domain-containing oxidoreductase(WWOX) is a tumor suppressor in a variety of cancers, including breast cancer. Reduced WWOX expression is associated with the basal-like subtype and a relatively poor disease-free survival rate among breast cancer patients. Though several WWOX partners have been identified, the functional mechanisms of WWOX's role in cancers have not been fully addressed to date. In the current study, we found WWOX suppresses expression of KLF5—an oncogenic transcription factor—at protein level, and suppresses cancer cell proliferation in both bladder and breast cancer cell lines. Furthermore, we demonstrated that WWOX physically interacts with KLF5 via the former's WW domains and the latter's PY motifs. Interestingly, we found the expression of WWOX negatively correlates with KLF5 expression in a panel of breast cancer cell lines. Taken together, we conjecture that WWOX may suppress cancer cell proliferation partially by reducing the expression of KLF5. | Fei Ge Wenlin Chen Runxiang Yang Zhongmei Zhou Nanshan Chang Ceshi Chen Tianning Zou Rong Liu Jing Tan Guosheng Ren | 2014 | Chinese Journal of Cancer Research2014，26，5： | 7 |
| 3 | CC chemokine receptor 7 promotes triple-negative breast cancer growth and metastasis显示文摘 | Jiao Wu Lu Li Jianing Liu Yang Wang Zehua Wang Yangdan Wang Wenjing Liu Zhongmei Zhou Ceshi Chen Rong Liu Runxiang Yang | 2018 | Acta Biochimica et Biophysica Sinica2018，50，9： | 5 |
| 4 | EphA2:A promising therapeutic target in breast cancer显示文摘Ephrin type-A receptor 2(EphA2),a receptor tyrosine kinase,is overexpressed in human breast cancers often linked to poor patient prognosis.Accumulating evidence demonstrates that EphA2 plays important roles in several critical processes associated with malignant breast progression,such as proliferation,survival,migration,invasion,drug resistance,metastasis,and angiogenesis.As its inhibition through multiple approaches can inhibit the growth of breast cancer and restore drug sensitivity,EphA2 has become a promising therapeutic target for breast cancer treatment.Here,we summarize the expression,functions,mechanisms of action,and regulation of EphA2 in breast cancer.We also list the potential therapeutic strategies targeting EphA2.Furthermore,we discuss the future directions of studying EphA2 in breast cancer. | Ping Zhao Dewei Jiang Yunchao Huang Ceshi Chen | 2021 | Journal of Genetics and Genomics2021，48，4： | 5 |
| 5 | Tobacco carcinogen NNK-induced lung cancer animal models and associated carcinogenic mechanisms显示文摘烟草用法是在为肺癌症的发展,前进,和结果的一个主要风险因素。与肺癌症联系的致癌物,烟草特定的 nitrosamines 4-(methylnitrosamino )-1-(3-pyridyl)-1-butanone (NNK ) 在大多数之中有势力一。NNK 的 oncogenic 机制完全没被理解,妨碍为阻止并且对待联系烟的肺癌症的有效策略的发展。这里,我们在不同种类和它的潜在的机制介绍导致 NNK 的肺癌症动物模型。最后,我们总结代理人从这些动物模型开发了的几 chemopreventive。 | Guang-Zhe Ge Tian-Rui Xu Ceshi Chen | 2015 | Acta Biochimica et Biophysica Sinica2015，47，7： | 5 |
| 6 | Transforming growth factor-beta increases breast cancer stem cell population partially through upregulating PMEPA1 expression显示文摘前列腺 transmembrane 蛋白质,导致雄激素(PMEPA1 ) 1 以前被显示了在许多癌症,而是角色支持稳固的恶意,在乳癌的 PMEPA1 的机制充分没被探讨。这里,我们发现 PMEPA1 是在乳癌房间线以及在一套临床的侵略的胸 ductal 癌的 upregulated。有趣地, PMEPA1 的弄空减少了乳癌干细胞(CSC ) 充实人口,当 PMEPA1 的宫外的 overexpression 增加了胸时充实 CSC 的人口。而且,转变生长因素 --(TGF-) 治疗也在三元组否定的乳癌细胞线被发现到 upregulate PMEPA1 表示和充实 CSC 的人口。TGF -- 导致的 PMEPA1 表示部分贡献了 TGF -- 导致的胸 CSC 维护。这些调查结果建议那 TGF -- PMEPA1 轴可能为乳癌治疗提供新诊断和治疗学的目标。 | Zhi Nie Chunyan Wang Zhongmei Zhou Ceshi Chen Rong Liu Dianhua Wang | 2016 | Acta Biochimica et Biophysica Sinica2016，48，2： | 3 |
| 7 | EZH2 induces the expression of miR-1301 as a negative feedback control mechanism in triple negative breast cancer显示文摘 | Qiuju Wu Zekun Chen Guihua Zhang Wenhui Zhou You Peng Rong Liu Ceshi Chen Jing Feng | 2018 | Acta Biochimica et Biophysica Sinica2018，50，7： | 2 |
| 8 | Cyst(e)ine in nutrition formulation promotes colon cancer growth and chemoresistance by activating mTORCl and scavenging ROS显示文摘Weight loss and cachexia are common problems in colorectal cancer patients;thus,parenteral and enteral nutrition support play important roles in cancer care.However,the impact of nonessential amino acid components of nutritional intake on cancer progression has not been fully studied.In this study,we discovered that gastrointestinal cancer patients who received cysteine as part of the parenteral nutrition had shorter overall survival(P<0.001)than those who did not.Cystine indeed robustly promotes colon cancer cell growth in vitro and in immunodeficient mice,predominately by inhibiting SESN2 transcription via the GCN2-ATF4 axis,resulting in mTORCl activation.mTORCl inhibitors Rapamycin and Everolimus block cystine-induced cancer cell proliferation.In addition,cystine confers resistance to oxaliplatin and irinotecan chemotherapy by quenching chemotherapy-induced reactive oxygen species via synthesizing glutathione.We demonstrated that dietary deprivation of cystine suppressed colon cancer xenograft growth without weight loss in mice and boosted the antitumor effect of oxaliplatin.These findings indicate that cyst(e)ine;as part of supplemental nutrition,plays an important role in colorectal cancer and manipulation of cyst(e)ine content in nutritional formulations may optimize colorectal cancer patient survival. | Jiao Wu Sai-Ching Jim Yeung Sicheng Liu Aiham Qdaisat Dewei Jiang Wenli Liu Zhuo Cheng Wenjing Liu Haixia Wang Lu Li Zhongmei Zhou Rong Liu Chuanyu Yang Ceshi Chen Runxiang Yang | 2021 | Signal Transduction and Targeted Therapy2021，6，6： | 2 |
| 9 | Ursolic acid derivative FZU-03,010 inhibits STAT3 and induces cell cycle arrest and apoptosis in renal and breast cancer cells显示文摘 | Wei Li Hongxiu Zhang Mingxiu Nie Yanlei Tian Xu Chen Ceshi Chen Haijun Chen Rong Liu | 2017 | Acta Biochimica et Biophysica Sinica2017，49，4： | 2 |
| 10 | The Nedd4-like family of E3 ubiquitin ligases and cancer显示文摘 | Ceshi Chen Lydia E. Matesic | 2007 | Cancer and Metastasis Reviews (-)2007，，3： | 1 |
| 11 | Glucose-6-phosphate dehydrogenase neutralizes stresses by supporting reductive glutamine metabolism and AMPK activation显示文摘Dear Editor,Glucose-6-phosphate dehydrogenase(G6PD)is the rate-limiting enzyme in the oxidative pentose phosphate pathway(oxPPP)that can generate cytosolic NADPH(Fig.1a)for biosynthesis and oxidative defence.Here,we reveal a previously unidentified function of G6PD.It,even the natural G6PD deficiency-associated mutant without the activity to maintain the normal oxPPP,can antagonize the stresses by supporting the reductive glutamine metabolism and AMPK activation,independently of the NADPH generation by the oxPPP. | Benfu Zhong Dewei Jiang Yang Hong Lifang Li Li Qiu Ronghui Yang Xiaohan Jin Yawen Song Ceshi Chen Binghui Li | 2021 | Signal Transduction and Targeted Therapy2021，6，3： | 1 |
| 12 | The Nedd4-1ike family of E3 ubiquitin ligases and cancer 显示文摘 | CHEN Ceshi MATESIC LE | 2007 | Cancer Metastasis Rev2007，26，34： | 1 |
| 13 | A functional missense variant in ITIH3 affects protein expression and neurodevelopment and confers schizophrenia risk in the Han Chinese population显示文摘The Psychiatric Genomics Consortium(PGC)has recently identified 10 potential functional coding variants for schizophrenia.However,how these coding variants confer schizophrenia risk remains largely unknown.Here,we investigate the associations between eight potential functional coding variants identified by PGC and schizophrenia in a large Han Chinese sample(n=4022 cases and 9270 controls).Among the eight tested single nucelotide polymorphisms(SNPs),rs3617(a missense variant,p.K315 Q in the ITIH3 gene)showed genome-wide significant association with schizophrenia in the Han Chinese population(P=8.36×10-16),with the same risk allele as in PGC.Interestingly,rs3617 is located in a genomic region that is highly evolutionarily conserved,and its schizophrenia risk allele(C allele)was associated with lower ITIH3 mRNA and protein expression.Intriguingly,mouse neural stem cells stably overexpressing ITIH3 with different alleles of rs3617 exhibited significant differences in proliferation,migration,and differentiation,suggesting the impact of rs3617 on neurodevelopment.Subsequent transcriptome analysis found that the differentially expressed genes in neural stem cells stably overexpressing different alleles of rs3617 were significantly enriched in schizophrenia-related pathways,including cell adhesion,synapse assembly,MAPK and PI3 K-AKT pathways.Our study provides convergent lines of evidence suggesting that rs3617 in ITIH3 likely affects protein function and neurodevelopment and thereby confers risk of schizophrenia. | Kaiqin Li Yifan Li Junyang Wang Yongxia Huo Di Huang Shiwu Li Jiewei Liu Xiaoyan Li Rong Liu Xiaogang Chen Yong-Gang Yao Ceshi Chen Xiao Xiao Ming Li Xiong-Jian Luo | 2020 | Journal of Genetics and Genomics2020，47，5： | 1 |
| 14 | PTEN / PIK3CA genes are frequently mutated in spontaneous and medroxyprogesterone acetate-accelerated 7,12-dimethylbenz(a)anthracene-induced mammary tumours of tree shrews显示文摘 | Hou-Jun Xia Bao-Li He Chun-Yan Wang Hai-Lin Zhang Guang-Zhe Ge Yuan-Xu Zhang Long-Bao Lv Jian-Lin Jiao Ceshi Chen | 2014 | European Journal of Cancer2014，，： | 1 |
| 15 | Targeting HECTD3-IKKα axis inhibits inflammation-related metastasis显示文摘Metastasis is the leading cause of cancer-related death.The interactions between circulating tumor cells and endothelial adhesion molecules in distant organs is a key step during extravasation in hematogenous metastasis.Surgery is a common intervention for most primary solid tumors.However,surgical trauma-related systemic inflammation facilitates distant tumor metastasis by increasing the spread and adhesion of tumor cells to vascular endothelial cells(ECs).Currently,there are no effective interventions to prevent distant metastasis.Here,we show that HECTD3 deficiency in ECs significantly reduces tumor metastasis in multiple mouse models.HECTD3 depletion downregulates expression of adhesion molecules,such as VCAM-1,ICAM-1 and E-selectin,in mouse primary ECs and HUVECs stimulated by inflammatory factors and inhibits adhesion of tumor cells to ECs both in vitro and in vivo.We demonstrate that HECTD3 promotes stabilization,nuclear localization and kinase activity of IKKa by ubiquitinating IKKa with K27-and K63-linked polyubiquitin chains at K296,increasing phosphorylation of histone H3 to promote NF-kB target gene transcription.Knockout of HECTD3 in endothelium significantly inhibits tumor cells lung colonization,while conditional knockin promotes that.IKKa kinase inhibitors prevented LPS-induced pulmonary metastasis.These findings reveal the promotional role of the HECTD3-IKKa axis in tumor hematogenous metastasis and providea potential strategy for tumormetastasis prevention. | Fubing Li Huichun Liang Hua You Ji Xiao Houjun Xia Xi Chen Maobo Huang Zhuo Cheng Chuanyu Yang Wenjing Liu Hailin Zhang Li Zeng Yingying Wu Fei Ge Zhen Li Wenhui Zhou Yi Wen Zhongmei Zhou Rong Liu Dewei Jiang Ni Xie Bin Liang Zhenzhen Liu Yanjie Kong Ceshi Chen | 2022 | Signal Transduction and Targeted Therapy2022，7，9： | 1 |
| 16 | HDAC inhibitors induce proline dehydrogenase (POX) transcription and anti-apoptotic autophagy in triple negative breast cancer显示文摘Triple-negative breast cancer(TNBC)is the most aggressive subtype of breast cancer w ith poor clinical outcom es and w itho ut effective targeted therapies.Numerous studies have suggested that HDAC inhibitors(TSA/SAHA)may be effective in TNBCs.Proline oxidase,also known as proline dehydrogenase(POX/PRODH),is a key enzyme in the proline m etabolism pathway and plays a vital role in tum origenesis.In this study,we found that HDAC inhibitors(TSA/SAHA)significantly increased POX expression and autophagy through activating AMPK.Depletion of POX decreased autophagy and increased apoptosis induced by HDAC inhibitors in TNBC cells.These results suggest that POX contributes to cell survival under chemotherapeutic stresses and might serve as a potential target for treatm ent of TNBC. | Huan Fang Guangshi Du Qiuju Wu Rong Liu Ceshi Chen Jing Feng | 2019 | Acta Biochimica et Biophysica Sinica2019，51，10： | 0 |
| 17 | Changes in the mammary gland during aging and its links with breast diseases显示文摘The functional capacity of organisms declines in the process of aging.In the case of breast tissue,abnormal mammary gland development can lead to dysfunction in milk secretion,a primary function,as well as the onset of various diseases,such as breast cancer.In the process of aging,the terminal duct lobular units(TDLUs)within the breast undergo gradual degeneration,while the proportion of adipose tissue in the breast continues to increase and hormonal levels in the breast change accordingly.Here,we review changes in morphology,internal structure,and cellular composition that occur in the mammary gland during aging.We also explore the emerging mechanisms of breast aging and the relationship between changes during aging and breast-related diseases,as well as potential interventions for delaying mammary gland aging and preventing breast disease. | Junqiang Lin Shihui Ye Hao Ke Liang Lin Xia Wu Mengfei Guo Baowei Jiao Ceshi Chen Limin Zhao | 2023 | Acta Biochimica et Biophysica Sinica2023，55，6： | 0 |
| 18 | CACA Guidelines for Holistic Integrative Management of Breast Cancer显示文摘Purpose:Breast cancer is now the most common malignant tumor worldwide.About one-fourth of female cancer patients all over the world sufer from breast cancer.And about one in six female cancer deaths worldwide is caused by breast cancer.In terms of absolute numbers of cases and deaths,China ranks frst in the world.The CACA Guidelines for Holistic Integrative Management of Breast Cancer were edited to help improve the diagnosis and comprehensive treatment in China.Methods:The Grading of Recommendations Assessment,Development and Evaluation(GRADE)was used to classify evidence and consensus.Results:The CACA Guidelines for Holistic Integrative Management of Breast Cancer include the epidemiology of breast cancer,breast cancer screening,breast cancer diagnosis,early breast cancer treatment,advanced breast cancer treatment,follow-up,rehabilitation,and traditional Chinese medicine treatment of breast cancer patients.Conclusion:We to standardize the diagnosis and treatment of breast cancer in China through the formulation of the CACA Guidelines. | Jiong Wu Daiming Fan Zhimin Shao Binghe Xu Guosheng Ren Zefei Jiang Yongsheng Wang Feng Jin Jin Zhang Qingyuan Zhang Fei Ma Jinli Ma Zhonghua Wang Shusen Wang Xiaojia Wang Shu Wang Haibo Wang Tao Wang Xiang Wang Jing Wang Jia Wang Biyun Wang Li Fu Hongyuan Li Yehui Shi Lu Gan Yunjiang Liu Jian Liu Zhenzhen Liu Qiang Liu Qiang Sun Wenwu Cheng Keda Yu Zhongsheng Tong Xinhong Wu Chuangui Song Jianguo Zhang Jian Zhang Junjie Li Bin Li Man Li Huiping Li Wentao Yang Hongjian Yang Benlong Yang Hong Bu Juping Shen Zhenzhou Shen Yiding Chen Ceshi Chen Da Pang Zhimin Fan Ying Zheng Xiaoli Yu Guangyu Liu Xichun Hu Yiqun Ling Jinhai Tang Yongmei Yin Cuizhi Geng Peng Yuan Yajia Gu Cai Chang Xuchen Cao Yuan Sheng Yuanxi Huang Jian Huang Weijun Peng Xiaohua Zeng Yuntao Xie Ning Liao Committee of Breast Cancer Society,Chinese Anti-Cancer Association | 2022 | Holistic Integrative Oncology2022，1，1： | 0 |
| 19 | Comprehensive analysis of long noncoding RNAs and mRNAs expression profiles and functional networks during chondrogenic differentiation of murine ATDC5 cells显示文摘Chondrogenic differentiation is a coordinated biological process orchestrated by various cell signaling pathways,involving complex pathways regulated at both transcriptional and post-transcriptional levels.Long noncoding RNAs(lncRNAs)are emerging as important regulators in the modulation of multiple cell processes.However,the potential roles of lncRNAs and their regulatory mechanisms in chondrogenic differentiation remain largely unclear.In this study,microarray was performed to detect the expression profiles of lncRNAs and messenger RNAs(mRNAs)during chondrogenic differentiation of murine chondrogenic cell line ATDC5.Gene ontology(GO)and Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway analysis were performed to explore their functions.Coding-noncoding co-expression(CNC)and competing endogenous RNA(ceRNA)networks were also constructed with bioinformatics methods.The results revealed that 1009 lncRNAs and 1206 mRNAs were differentially regulated during chondrogenic differentiation.GO and KEGG pathway analysis indicated that the principal functions of the transcripts were associated with system development and extracellular matrix-receptor interaction,TGF-βsignaling,and PI3K-Akt signaling pathways.The CNC network showed that lncRNA AK136902 was positively correlated with prostaglandin F receptor(FP).The ceRNA network covered 3 lncRNAs,121 miRNAs and 241 edges.The upregulated lncRNA AK136902,AK016344,and ENSMUST00000180767 might promote chondrogenic differentiation by acting as ceRNAs.Knockdown of lncRNA AK136902 could inhibit the mRNA expression of FP and other chondrogenic related genes,including Aggrecan and Col2a1 during chondrogenic differentiation.Our results provide a new perspective on the modulation of lncRNAs during chondrogenic differentiation. | Wei Wang Yu Ding Yanhua Xu Hefeng Yang Wenjing Liu Haixia Wang Ceshi Chen Rong Liu Song Li | 2019 | Acta Biochimica et Biophysica Sinica2019，51，8： | 0 |
| 20 | Characterization of tree shrew telomeres and telomerase显示文摘The use of tree shrews as experimental animals for biomedical research is a new practice.Several recent studies suggest that tree shrews are suitable for studying cancers,including breast cancer,glioblastoma,lung cancer,and hepatocellular carcinoma.However,the telomeres and the telomerase of tree shrews have not been studied to date.Here,we characterize telomeres and telomerase in tree shrews.The telomere length of tree shrews is approximately 23 kb,which is longer than that of primates and shorter than that of mice,and it is extended in breast tumor tissues according to Southern blot and flow-fluorescence in situ hybridization(FISH)analyses.Tree shrew spleen,bone marrow,testis,ovary,and uterus show high telomerase activities,which are increased in breast tumor tissues by telomeric repeat amplification protocol assays.The telomere length becomes shorter,and telomerase activity decreases with age.The tree shrew TERT and TERC are more highly similar to primates than to rodents.These findings lay a solid foundation for using tree shrews to study aging and cancers. | Jian Sun Wenjing Liu Yongbo Guo Hailin Zhang Dewei Jiang Ying Luo Rong Liu Ceshi Chen | 2021 | Journal of Genetics and Genomics2021，48，7： | 0 |
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