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| 1 | Characterization of focal liver masses using acoustic radiation force impulse elastography显示文摘AIM:To investigate the diagnostic performance of acoustic radiation force impulse(ARFI) elastography for characterizing focal liver mass by quantifying their stiffness.METHODS:This prospective study included 62 patients with a focal liver mass that was well visualized on conventional ultrasonography performed in our institution from February 2011 to November 2011.Among them,12 patients were excluded for ARFI measurement failure due to a lesion that was smaller than the region of the interest and at an inaccessible location(deeper than 8 cm)(n = 7) or poor compliance to hold their breath as required(n = 5).Finally,50 patients with valid ARFI measurements were enrolled.If a patient had multiple liver masses,only one mass of interest was chosen.The masses were diagnosed by histological examination or clinical diagnostic criteria.During ultrasonographic evaluation,stiffness,expressed as velocity,was checked 10 times per focal liver mass and the surrounding liver parenchyma.RESULTS:After further excluding three masses that were non-diagnostic on biopsy,a total of 47 focal mass lesions were tested,including 39(83.0%) malignant masses [24 hepatocellular carcinomas(HCC),seven cholangiocellular carcinomas(CCC),and eight liver metastases] and eight(17.0%) benign masses(five hemangiomas and three focal nodular hyperplasias,FNH).Thirty-seven(74.0%) masses were confirmed by histological examination.The mean velocity was 2.48 m/s in HCCs,1.65 m/s in CCCs,2.35 m/s in metastases,1.83 m/s in hemangiomas,and 0.97 m/s in FNHs.Although considerable overlap was still noted between malignant and benign masses,significant differences in ARFI values were observed between malignant and benign masses(mean 2.31 m/s vs 1.51 m/s,P = 0.047),as well as between HCCs and benign masses(mean 2.48 m/s vs 1.51 m/s,P = 0.006).The areas under the receiver operating characteristics curves(AUROC) for discriminating the malignant masses from benign masses was 0.724(95%CI,0.566-0.883,P = 0.048),and the AUROC for discriminating HCCs from benign masses was 0.813(95%CI,0.649-0.976,P = 0.008).To maximize the sum of sensitivity and specificity,an ARFI value of 1.82 m/s was selected as the cutoff value to differentiate malignant from benign liver masses.Furthermore,the cutoff value for distinguishing HCCs from benign masses was also determined to be 1.82 m/s.The diagnostic performance of the sum of the ARFI values for focal liver masses and the surrounding liver parenchyma to differentiate liver masses improved(AUROC = 0.853;95%CI,0.745-0.960;P = 0.002 in malignant liver masses vs benign ones and AUROC = 0.948;95%CI,0.896-0.992,P < 0.001 in HCCs vs benign masses).CONCLUSION:ARFI elastography provides additional information for the differential diagnosis of liver masses.However,our results should be interpreted in clinical context,because considerable overlap in ARFI values existed among liver masses. | Hana Park Jun Yong Park Do Young Kim Sang Hoon Ahn Chae Yoon Chon Kwang-Hyub Han Seung Up Kim | 2013 | World Journal of Gastroenterology2013，19，2： | 22 |
| 2 | Low grade gastric mucosa associated lymphoid tissue lymphoma:Treatment strategies based on 10 year follow-up显示文摘AIM:To deduce strategic guidelines of gastric mucosa associated lymphoid tissue lymphoma (MALTOMA) by evaluating the long-term outcome of patients in respect to various treatment modalities.METHODS:A total of 55 patients with MALTOMA from May 1992 to August 2002 were retrospectively reviewed.RESULTS: Complete remission was obtained in 24 (82.8%) of 29 patients treated with anti Helicobacter pylori(H pylori) regimen only. The duration to reach complete remission was 12 months (85 percentile, 2-33 months).Five patients showed complete remission with radiation therapy (26-86 months).Two of them were Hpyloritreatment failure cases.CONCLUSION: Hpylorieradication is an effective primary treatment option for low grade MALTOMA and radiation therapy could be considered in patients with no evidence of Hpyloninfection or who do not respond to Hpylorieradication therapy 12 months after successful eradication. | Sang Kil Lee Yong Chan Lee Jae Bock Chung Chae Yoon Chon Young Myoung Moon Jin Kyung Kang In-Suh Park Chang Ok Suh Woo Ik Yang | 2004 | World Journal of Gastroenterology2004，10，2： | 12 |
| 3 | Hepatocellular carcinoma in Budd-Chiari syndrome:A single center experience with long-term follow-up in South Korea显示文摘AIM:To evaluate long-term clinical course of BuddChiari syndrome(BCS) and predictive factors associated with the development of hepatocellular carcinoma(HCC) and survival.METHODS:We analyzed 67 patients with BCS between June 1988 and May 2008.The diagnosis of BCS was confirmed by hepatic venous outflow obstruction shown on abdominal ultrasound sonography,computed tomography,magnetic resonance imaging,or venography.The median follow-up period was 103 ± 156 [interquartile range(IQR)] mo.RESULTS:The median age of the patients was 47 ± 16(IQR) years.At diagnosis,54 patients had cirrhosis,25(37.3%) Child-Pugh class A,23(34.3%) Child-Pugh class B,and six(9.0%) patients Child-Pugh class C.During the follow-up period,HCC was developed in 17 patients,and the annual incidence of HCC in patients with BCS was 2.8%.Patients in HCC group(n = 17) had higher hepatic venous pressure gradient(HVPG) than those in non-HCC group(n = 50)(21 ± 12 mmHg vs 14 ± 7 mmHg,P = 0.019).The survival rate of BCS patients was 86.2% for 5 years,73.8% for 10 years,and 61.2% for 15 years.In patients with BCS and HCC,survival was 79% for 5 years,43.1% for 10 years,and 21.5% for 15 years.CONCLUSION:The incidence of HCC in patients with BCS was similar to that in patients with other etiologic cirrhosis in South Korea.The HVPG is expected to provide additional information for predicting HCC development in BCS patients. | Hana Park Jin Young Yoon Kyeong Hye Park Do Young Kim Sang Hoon Ahn Kwang-Hyub Han Chae Yoon Chon Jun Yong Park | 2012 | World Journal of Gastroenterology2012，18，16： | 12 |
| 4 | Antiviral efficacy of lamivudine versus entecavir in patients with hepatitis B virus‐related advanced hepatocellular carcinoma显示文摘 | Hye Sun Shin Seung Up Kim Jun Yong Park Do Young Kim Kwang‐Hyub Han Chae Yoon Chon Oidov Baatarkhuu Sang Hoon Ahn | 2012 | Journal of Gastroenterology and Hepatology2012，，9： | 3 |
| 5 | Efficacy of switching to telbivudine plus adefovir in suboptimal responders to lamivudine plus adefovir显示文摘AIM:To examine the efficacy of telbivudine(LdT)+adefovir(ADV)vs continuation of lamivudine(LAM)+ADV in patients with LAM-resistant chronic hepatitis B(CHB)who show a suboptimal response to LAM+ADV.METHODS:This was a randomized,active-control,open-label,single-center,parallel trial.All eligible patients were enrolled in this study in Severance Hospital,Yonsei University College of Medicine,Seoul,South Korea,between March 2010 and March 2011.Hepatitis Be antigen(HBeAg)-positive CHB patients whose serum hepatitis B virus(HBV)DNA remained detectable despite at least 6 mo of LAM+ADV therapy were included.Enrolled patients were randomized to either switching to LdT(600 mg/d orally)plus ADV(10 mg/d orally)(LdT+ADV group)or to continuation with LAM(100 mg/d orally)plus ADV(10 mg/d orally)(LAM+ADV group),and were followed for 48 wk.One hundred and six patients completed the 48-wk treatment period.Serum HBV DNA,HBeAg status,liver biochemistry and safety were monitored at baseline and week 12,24,36 and 48.RESULTS:The duration of prior LAM+ADV treatment was 18.3(LdT+ADV)and 14.9 mo(LAM+ADV),respectively(P=0.131).No difference was seen in baseline serum HBV DNA between the two groups[3.66(LdT+ADV)vs 3.76(LAM+ADV)log10IU/mL,P=0.729].At week 48,although there was no significant difference in the mean reduction of serum HBV DNA from baseline between LdT+ADV group and LAM+ADV group(-0.81 vs-0.47 log10IU/mL,P=0.167),more patients in the LdT+ADV group had undetectable HBV DNA levels compared to those in the LAM+ADV group(30.2%vs 11.5%,P=0.019).Three patients with LdT+ADV treatment and 2 patients with LAM+ADV treatment achieved HBeAg loss.The patients in both groups tolerated the treatment well without serious adverse events.The proportion of patients with estimated glomerular filtration rate≥90 mL/min per 1.73 m2in the LdT+ADV group increased from 49.1%(26/53)at baseline to 58.5%(31/53)at week 48,while that in the LAM+ADV group decreased from 37.7%(20/53)at baseline to 30.2%(16/53)at week 48.CONCLUSION:The switch to LdT+ADV in suboptimal responders to LAM+ADV showed a significantly higher rate of virologic response at week 48.These results suggest that LdT+ADV could be a therapeutic option for patients who are unable to use enofovir disoproxil fumarate for any reason. | Hana Park Jun Yong Park Seung Up Kim Do Young Kim Kwang-Hyub Han Chae Yoon Chon Sang Hoon Ahn | 2013 | World Journal of Gastroenterology2013，19，43： | 3 |
| 6 | Outcome after curative resection for a huge (≥10 cm) hepatocellular carcinoma and prognostic significance of gross tumor classification显示文摘 | Gi Hong Choi Dai Hoon Han Dong Hyun Kim Sae Byeol Choi Chang Moo Kang Kyung Sik Kim Jin Sub Choi Young Nyun Park Jun Yong Park Do Young Kim Kwang-Hyub Han Chae Yoon Chon Woo Jung Lee | 2009 | The American Journal of Surgery2009，，5： | 2 |
| 7 | Controlled attenuation parameter ( CAP ) for detection of hepatic steatosis in patients with chronic liver diseases: a prospective study of a native Korean population显示文摘 | Young Eun Chon Kyu Sik Jung Seung Up Kim Jun Yong Park Young Nyun Park Do Young Kim Sang Hoon Ahn Chae Yoon Chon Hye Won Lee Yehyun Park Kwang‐Hyub Han | 2014 | Liver Int2014，，1： | 2 |
| 8 | The Accuracy of Noninvasive Methods in Predicting the Development of Hepatocellular Carcinoma and Hepatic Decompensation in Patients With Chronic Hepatitis B显示文摘 | Young Eun Chon Eun Suk Jung Jun Yong Park Do Young Kim Sang Hoon Ahn Kwang-Hyub Han Chae Yoon Chon Kyu Sik Jung Seung Up Kim | 2012 | Journal of Clinical Gastroenterology2012，，6： | 2 |
| 9 | Liver Stiffness Measurement Using Acoustic Radiation Force Impulse (ARFI) Elastography and Effect of Necroinflammation显示文摘 | Ki Yoon Sun Lim Jun Park Do Kim Sang Ahn Kwang-Hyub Han Chae Chon Mong Cho Jun Lee Seung Kim | 2012 | Digestive Diseases and Sciences2012，，6： | 2 |
| 10 | Survival of Hepatocellular Carcinoma Patients May be Improved in Surveillance Interval not More Than 6 Months Compared With More Than 6 Months: A 15-Year Prospective Study显示文摘 | Kwang-Hyub Han Do Young Kim Jun Yong Park Sang Hoon Ahn Jieun Kim Seung Up Kim Ja Kyung Kim Kwan Sik Lee Chae Yoon Chon | 2013 | Journal of Clinical Gastroenterology2013，，6： | 1 |
| 11 | Liver Stiffness Measurement Using Acoustic Radiation Force Impulse (ARFI) Elastography and Effect of Necroinflammation显示文摘 | Ki Tae Yoon Sun Min Lim Jun Yong Park Do Young Kim Sang Hoon Ahn Kwang-Hyub Han Chae Yoon Chon Mong Cho Jun Woo Lee Seung Up Kim | 2012 | Digestive Diseases and Sciences2012，，6： | 1 |
| 12 | Combination treatment of localized concurrent chemoradiation therapy and transarterial chemoembolization in locally advanced hepatocellular carcinoma with intrahepatic metastasis显示文摘 | Mi Sung Park Seung Up Kim Jun Yong Park Do Young Kim Sang Hoon Ahn Kwang Hyub Han Chae Yoon Chon Jinsil Seong | 2013 | Cancer Chemotherapy and Pharmacology2013，，1： | 1 |
| 13 | Non-invasive assessment of changes in liver fibrosis via liver stiffness measurement in patients with chronic hepatitis B: impact of antiviral treatment on fibrosis regression显示文摘 | Seung Up Kim Jun Yong Park Do Young Kim Sang Hoon Ahn Eun Hee Choi Jae Yeon Seok Jung Min Lee Young Nyun Park Chae Yoon Chon Kwang-Hyub Han | 2010 | Hepatology International2010，，4： | 1 |
| 14 | Prediction of postoperative hepatic insufficiency by liver stiffness measurement (FibroScan?) before curative resection of hepatocellular carcinoma: a pilot study显示文摘 | Seung Up Kim Sang Hoon Ahn Jun Yong Park Do Young Kim Chae Yoon Chon Jin Sub Choi Kyung Sik Kim Kwang-Hyub Han | 2008 | Hepatology International2008，，4： | 1 |
| 15 | Liver Stiffness Measurement Using Acoustic Radiation Force Impulse (ARFI) Elastography and Effect of Necroinflammation显示文摘 | Ki Tae Yoon Sun Min Lim Jun Yong Park Do Young Kim Sang Hoon Ahn Kwang-Hyub Han Chae Yoon Chon Mong Cho Jun Woo Lee Seung Up Kim | 2012 | Digestive Diseases and Sciences2012，，6： | 1 |
| 16 | Usefulness of FibroScan for Detection of Early Compensated Liver Cirrhosis in Chronic Hepatitis B显示文摘 | Do Young Kim Seung Up Kim Sang Hoon Ahn Jun Yong Park Jung Min Lee Young Nyun Park Ki Tae Yoon Yong Han Paik Kwan Sik Lee Chae Yoon Chon Kwang-Hyub Han | 2009 | Digestive Diseases and Sciences2009，，8： | 1 |
| 17 | Non-invasive assessment of changes in liver fibrosis via liver stiffness measurement in patients with chronic hepatitis B: impact of antiviral treatment on fibrosis regression显示文摘 | Seung Up Kim Jun Yong Park Do Young Kim Sang Hoon Ahn Eun Hee Choi Jae Yeon Seok Jung Min Lee Young Nyun Park Chae Yoon Chon Kwang-Hyub Han | 2010 | Hepatology International2010，，4： | 1 |
| 18 | Liver Stiffness Measurement Using Acoustic Radiation Force Impulse (ARFI) Elastography and Effect of Necroinflammation显示文摘 | Ki Yoon Sun Lim Jun Park Do Kim Sang Ahn Kwang-Hyub Han Chae Chon Mong Cho Jun Lee Seung Kim | 2012 | Digestive Diseases and Sciences2012，，6： | 1 |
| 19 | Liver Stiffness Measurement in Combination With Noninvasive Markers for the Improved Diagnosis of B-viral Liver Cirrhosis显示文摘 | Seung Up Kim Sang Hoon Ahn Jun Yong Park Wonseok Kang Do Young Kim Young Nyun Park Chae Yoon Chon Kwang Hyub Han | 2009 | Journal of Clinical Gastroenterology2009，，3： | 1 |
| 20 | Gastroduodenal Complications After Concurrent Chemoradiation Therapy in Patients With Hepatocellular Carcinoma: Endoscopic Findings and Risk Factors显示文摘 | Young Eun Chon Jinsil Seong Beom Kyung Kim Jihye Cha Seung Up Kim Jun Yong Park Sang Hoon Ahn Kwang-Hyub Han Chae Yoon Chon Sung Kwan Shin Do Young Kim | 2011 | International Journal of Radiation Oncology, Biology, Physics2011，，5： | 1 |
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