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| 1 | 卒中相关性肺炎的诊断卒中肺炎共识小组的推荐意见显示文摘背景和目的下呼吸道感染常并发于卒中并对转归造成不利影响。对于并发于卒中的下呼吸道感染性疾病,目前尚无公认的专业术语或诊断金标准,这导致临床诊疗和研究受到影响。本共识旨在提出急性卒中并发下呼吸道感染的标准化术语和可操作性诊断标准。方法对多个文献数据库进行系统检索,经过证据回顾和2轮讨论,最后于2014年9月在英国曼彻斯特召开共识会议,经75%以上共识小组成员达成一致意见后形成共识。结果达成的共识如下:(1)推荐使用卒中相关性肺炎(stroke-associated pneumonia, SAP )作为卒中发病后7 d内发生的下呼吸道感染性疾病的专业术语。(2)提议对 SAP 使用经过改良的美国疾病控制预防中心(Centers for Disease Control and Prevention, CDC)诊断标准:①很可能的 SAP:符合 CDC 诊断标准,但复查或动态监测胸部 X 片仍缺乏典型改变;②确诊的 SAP:符合 CDC 诊断标准,且胸部 X 片有典型改变。(3)关于白细胞计数或 C反应蛋白在 SAP 诊断中的作用证据有限。(4)其他生物学标记物(如降钙素原)的证据不足。结论提议根据 CDC 诊断标准对 SAP 的术语和诊断制定可操作性的共识标准,需要在卒中患者中进行前瞻性研究来确定其信度、效度以及对医生行为(包括抗生素选择)和临床转归的影响。 | Craig J. Smith Amit K Kishore Andy Vail Angel Chamorro Javier Garau Stephen J. Hopkins Mario Di Napoli Lalit Kalra Peter Langhorne Joan Montaner Christine Roffe Anthony G. Rudd Pippa J. TyrreU Diederik van de Peek Mark Woodhead Andreas Meisel 范琳琳 宿英英 | 2016 | 国际脑血管病杂志2016，24，2： | 17 |
| 2 | Proinflammatory Cytokines and Early Neurological Worsening in Ischemic Stroke显示文摘 | Nicolás Vila José Castillo Antonio Dávalos ángel Chamorro | 2000 | Stroke: Journal of the American Heart Association2000，，10： | 2 |
| 3 | Alcoholic liver disease and hepatitis C virus infection显示文摘Alcohol consumption and hepatitis C virus(HCV) infection have a synergic hepatotoxic effect, and the coexistence of these factors increases the risk of advanced liver disease. The main mechanisms of this effect are increased viral replication and altered immune response, although genetic predisposition may also play an important role. Traditionally, HCV prevalence has been considered to be higher(up to 50%) in alcoholic patients than in the general po pulation. However, the presence of advanc e d alcoholic liver disease(ALD) or intravenous drug use(IDU) may have confounded the results of previous studies, and the real prevalence of HCV infection in alcoholic patients without ALD or prior IDU has been shown to be lower. Due to the toxic combined effect of HCV and alcohol, patients with HCV infection should be screened for excessive ethanol intake. Patients starting treatment for HCV infection should be specifically advised to stop or reduce alcohol consumption because of its potential impact on treatment efficacy and adherence and may benefi t from addi tionalsupport during antiviral therapy. This recommendation might be extended to all currently recommended drugs for HCV treatment. Patients with alcohol dependence and HCV infection, can be treated with acamprosate, nalmefene, topiramate, and disulfiram, although baclofen is the only drug specifically tested for this purpose in patients with ALD and/or HCV infection. | Ignacio Novo-Veleiro Lucía Alvela-Suárez Antonio-Javier Chamorro Rogelio González-Sarmiento Francisco-Javier Laso Miguel Marcos | 2016 | World Journal of Gastroenterology2016，22，4： | 2 |
| 4 | Cerebral hemodynamics and silent cerebral white matter lesions in middle-aged essential hypertensive patients显示文摘 | Sierra C de la Sierra A Chamorro A | 2004 | Blood Press2004，13，： | 1 |
| 5 | Infection after acute ischemic stroke:a manifestation of brain-induced immunodepression显示文摘 | Chamorro A Urra X Planas AM | 2007 | Stroke2007，38，3： | 1 |
| 6 | AG490 prevents cell death after exposure of rat astrocytes to hydrogen peroxide or proinflammatory cytokines:involvement of the Jak2/STAT pathway显示文摘 | Gorina R Petegnief V Chamorro A | 2005 | J Neurochem2005，92，3： | 1 |
| 7 | Spatial dispersion in cournot competition显示文摘 | José María Chamorro Rivas | | Spanish Economic Review0，，： | 1 |
| 8 | Prognostic signigi-cance of uric acid serum concentration in patients with acute ischemic stroke显示文摘 | Chamorro A Obach V Cervera A | 2002 | Stroke2002，33，4： | 1 |
| 9 | Changes in polyphenol and polysaecharide content of grape seed extract and grape pomace after enzymatic treatment 显示文摘 | CHAMORRO S VIVEROS A ALVAREZ I | 2012 | Food Chemistry2012，133，2： | 1 |
| 10 | Thrombectomy within 8 hours after symptom onset in ischemic stroke显示文摘 | Jovin TG Chamorro A Cobo E | 2015 | N Engl J Med2015，372，： | 1 |
| 11 | Signalling pathways mediating inflammatory responses in brain ischaemia显示文摘 | Planas AM Gorina R Chamorro A | 2006 | Biochem Soc Trans2006，34，6： | 1 |
| 12 | Plasma homocysteine levels in patients withischemic cerebral infarction 显示文摘 | VILA N DEULOFEU R CHAMORRO A | 1998 | Med Clin (Barc)1998，110，： | 1 |
| 13 | Interleukin 10, monocytes and increase risk of early infection in ischaemic stroke显示文摘 | Chamorro A Amaro S Vargas M | 2006 | J Neurol Neurosurg Psychiatry2006，77，11： | 1 |
| 14 | Reactivation of hepatitis B in an HIV-infected patient with antibodies against hepatitis B core antigen as the only serological marker显示文摘 | A. J. Chamorro J. L. Casado D. Bellido S. Moreno | 2005 | European Journal of Clinical Microbiology & Infectious Diseases2005，，7： | 1 |
| 15 | The early systemic prophylaxis of infection after stroke study:a randomized clinical trial显示文摘 | Chamorro A Horcajada JP Obach V | 2005 | Stroke2005，36，7： | 1 |
| 16 | Prognostic Significance of Uric Acid Serum Concentration in Patients With Acute Ischemic Stroke显示文摘 | ángel Chamorro Victor Obach álvaro Cervera Marian Revilla Ramón Deulofeu John H. Aponte | 2002 | Stroke: Journal of the American Heart Association2002，，： | 1 |
| 17 | Hemodynamic role of ophthalmic artery collateral in internal carotid artery occlusion 显示文摘 | Tatemichi TK Chamorro A Petty GW | 1990 | Neurology1990，40，： | 1 |
| 18 | Plasma homocysteine levels in patients with ischemic cerebral infarction显示文摘 | Vila M Decllofeule Chamorro A | 1998 | Med Clin Brit1998，110，： | 1 |
| 19 | Prognostic significance of Uric acid serum concentration in parients with ischemic stroke显示文摘 | Chamorro A Obach V Cercera A | 2002 | Stroke2002，33，： | 1 |
| 20 | TLR triggering on tolerogenic dendritic cells results in TLR2 up-regulation and a reduced proinflammatory immune program显示文摘 | Chamorro S García-Vallejo JJ Unger WW | | 0，，5： | 1 |
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