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| 1 | 北京PM_(2.5)化学物种的质量平衡特征显示文摘以北京 2个采样点连续采集的样品对PM2 5中的元素、水溶性离子和含碳组分进行分析 .车公庄和清华园PM2 5中有机物的含量分别为 2 7 8%和 30 9% ,是含量最丰富的物种 ,其次是二次无机粒子、土壤尘、元素碳和微量元素 .PM2 5中约有 2 4 %的质量未能鉴别成分 ,相关性分析表明 ,含碳物种的估算所引起的偏差可能是主要的原因 .采暖期重污染周和春季沙尘周PM2 5的化学物种构成悬殊 ,反映了季节性变化的源排放和特殊气象条件的综合作用 . | 杨复沫 贺克斌 马永亮 张强 Cadle S H Chan T Mulawa P A | 2004 | 环境化学2004，23，3： | 63 |
| 2 | 膳食中钠(盐)与血压的关系及其他膳食因素可能的调节作用显示文摘现有资料表明,膳食钠(盐)与血压直接相关。以往大多数研究结果来自缺乏膳食数据的研究;因此,这种钠-血压关系是否受其他膳食因素调节尚不清楚。国际宏量/微量营养素和血压研究(international study on macro/micronutrients and blood pressure,INTERMAP)结果显示,在控制多种非膳食因素情况下,年龄40~59岁的男性和女性4680人(中国、日本、英国和美国的17个人口样本)的血压与24h尿钠排泄和尿钠/钾直接相关。 | 刘莉 叶鹏 Stamler J Chan Q Daviglus ML Dyer AR Van Horn L Garside DB Miura K Wu Y Ueshima H Zhao L Elliott P INTERMAP Research Group | 2018 | 中华高血压杂志2018，26，4： | 8 |
| 3 | Response to endoscopic therapy for biliary anastomotic strictures in deceased versus living donor liver transplantation显示文摘BACKGROUND:Endoscopic therapy has been successful in the management of biliary complications after both deceased donor liver transplantation(DDLT) and living donor liver transplantation(LDLT).LDLT is thought to be associated with higher rates of biliary complications,but there are few studies comparing the success of endoscopic management of anastomotic strictures between the two groups.This study aims to compare our experience in the endoscopic management of anastomotic strictures in DDLT versus LDLT.METHODS:This is a retrospective database review of all liver transplant patients undergoing endoscopic retrograde cholangiopancreatography(ERCP) after liver transplantation.The frequency of anastomotic stricture and the time to develop and to resolve anastomotic stricture were compared between DDLT and LDLT.The response of anastomotic stricture to endoscopic therapy was also analyzed.RESULTS:A total of 362 patients underwent liver transplantation between 2003 and 2011,with 125 requiring ERCP to manage biliary complications.Thirty-three(9.9%) cases of DDLT and 8(27.6%) of LDLT(P=0.01) were found to have anastomotic stricture.When comparing DDLT and LDLT,there was no difference in the mean time to the development of anastomotic strictures(98±17 vs 172±65 days,P=0.11),likelihood of response to ERCP [22(66.7%) vs 6(75.0%),P=0.69],mean time to the resolution of anastomotic strictures(268±77 vs 125±37 days,P=0.34),and the number of ERCPs required to achieve resolution(3.9±0.4 vs 4.7±0.9,P=0.38).CONCLUSIONS:Endoscopic therapy is effective in the majority of biliary complications relating to liver transplantation.Anastomotic strictures occur more frequently in LDLT compared with DDLT,with equivalent endoscopic treatment response and outcomes for both groups. | Calvin HY Chan Fergal Donnellan Michael F Byrne Alan Coss Mazhar Haque Holly Wiesenger Charles H Scudamore Urs P Steinbrecher Alan A Weiss Eric M Yoshida | 2013 | Hepatobiliary & Pancreatic Diseases International2013，12，5： | 7 |
| 4 | Uptake and mitochondrial dysfunction of alpha-synuclein in human astrocytes, cortical neurons and fibroblasts显示文摘The accumulation and aggregation of alpha-synuclein(α-syn)in several tissue including the brain is a major pathological hallmark in Parkinson’s disease(PD).In this study,we show that α-syn can be taken up by primary human cortical neurons,astrocytes and skin-derived fibroblasts in vitro.Our findings that brain and peripheral cells exposed to α-syn can lead to impaired mitochondrial function,leading to cellular degeneration and cell death,provides additional evidence for the involvement of mitochondrial dysfunction as a mechanism of toxicity of α-syn in human cells. | Nady Braidy Wei-Ping Gai Ying Hua Xu Perminder Sachdev Gilles J Guillemin Xing-Mai Jiang J William O Ballard Martin P Horan Zhi Ming Fang Beng H Chong Daniel Kam Yin Chan | 2013 | Translational Neurodegeneration2013，2，1： | 4 |
| 5 | Transgenic mice and knockout mutants in the study of oxidative stress in brain injury显示文摘 | Chan P H Epstein C J Li Y | 1995 | J Neurotrauma1995，12，5： | 2 |
| 6 | Axial strain enhances osteotomy repair with a concomitant increase in connexin43 expression显示文摘The mechanical environment is known to influence fracture healing. We speculated that connexin43(Cx43) gap junctions, which impact skeletal homeostasis, fracture healing and the osteogenic response to mechanical load,may play a role in mediating the response of the healing bone to mechanical strain. Here, we used an established rat fracture model, which uses a 2 mm osteotomy gap stabilized by an external fixator, to examine the impact of various cyclical axial loading protocols(2%, 10%, and 30% strain) on osteotomy healing. We examined the presence of Cx43 in the osteotomy-healing environment and assessed how mechanical strain modulates Cx43 expression patterns in the callus. We demonstrated that increased cyclical axial strain results in increased radiographic and histologic bone formation. In addition, we show by immunohistochemistry that Cx43 is abundantly expressed in the healing callus, with the expression most robust in samples exposed to increased cyclical axial strain. These data are consistent with the concept that an increase in Cx43 expression by mechanical load may be part of the mechanisms by which mechanical forces enhances fracture healing. | Rishi R Gupta Hyunchul Kim Yu-Kwan Chan Carla Hebert Leah Gitajn David J Yoo Robert V O’Toole Adam H Hsieh Joseph P Stains | 2015 | Bone Research2015，3，2： | 2 |
| 7 | The 40-50 day oscillation and El Nino/Southern Oscillation:A new perspective显示文摘 | Lau K M Chan P H | 1986 | Bull Amer Meteor Soc1986，67，5： | 2 |
| 8 | DJ-1 could predict worse prognosis in esophageal squamous cell carcinoma显示文摘 | YUEN H F CHAN Y P LAW S | 2008 | Cancer Epidemiol Biomarkers Prev2008，17，12： | 1 |
| 9 | Temporal and spatial trends of mercury in fish collected in the English-Wabigoon river system in Ontario, Canada显示文摘 | Kinghorn A Solomon P Chan H M | 2007 | Science of the Total Environment2007，372，2： | 1 |
| 10 | The effect of excimer laser surface treatment on the pitting corrosion fatigue behaviour of alnminium alloy 7075 显示文摘 | Chan C P Yue T M Man H C | 2003 | Journal of Materials Science2003，15，12： | 1 |
| 11 | Increased alpha-B-crystallin expression in mammary metaplastic carcinomas 显示文摘 | Chan S K Lui P C Tan P H | 2011 | Histopatholo- gy2011，59，2： | 1 |
| 12 | Temporal and spatial trends of mercury in fish collected in the English-Wabigoon river system in Ontario, Canada 显示文摘 | Kinghorn A Solomon P Chan H M | 2007 | Science of the Total Environment2007，372，23： | 1 |
| 13 | Recent advances in the tumour biology of the GPI anchored carcinoembryonic antigen family members CEACAM5 and CEACAM6显示文摘 | CHAN C H STANNERS C P | 2007 | Curt Oncol2007，14，2： | 1 |
| 14 | Neuroprotection by interleukin 6 is mediated by signal transducer and activator of transcription 3 and antioxidative signaling in isehemic stroke 显示文摘 | JUNG J E KIM G S CHAN P H | 2011 | Stroke2011，42，12： | 1 |
| 15 | Blockade of glutamate excitotoxicity and itsclinical applications显示文摘 | Hirose K Chan P H | 1993 | Neurochem Res1993，18，4： | 1 |
| 16 | Microstructure and current-voltage characteristics of ZnO-V2O5-MnO2 varistor system显示文摘 | Hng H H Chan P L | 2003 | Ceramic international2003，，12： | 1 |
| 17 | Free radical pathways in CNS injury显示文摘 | LEWEN A MATZ P CHAN P H | 2000 | J Neurotrauma2000，17，10： | 1 |
| 18 | Lateral error recovery for media streaming in application-level multicast显示文摘 | Yiu W P K Wong K F S Chan S H G | 2006 | IEEE2006，8，2： | 1 |
| 19 | High prevalence of human papillomavirus type 58 in Chinese women with cervical cancer and precancerous lesions显示文摘 | Chan P K Li W H Chan M Y | 1999 | J Med Viral1999，59，2： | 1 |
| 20 | Synthesizing two character interactions by merging captured interaction samples with their spacetime relationships显示文摘 | Chan J C P Tang J K T Leung H | 2013 | Computer Graphics Forum2013，32，7： | 1 |
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