|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Risk factors and natural history of breast cancer in younger Chinese women显示文摘AIM: To investigate the age differences in the risk factors, clinicopathological characteristics and patterns of treatment of female breast cancer patients. METHODS: Seven thousand one hundred and fiftytwo women with primary breast cancer from the Hong Kong Breast Cancer Registry were recruited after receiving patients' consent, they were asked to complete standardized questionnaires which captured their sociodemographic characteristics and risk factors associated with breast cancer development. Among them, clinicopathological data and patterns of treatment were further collected from medical records of 5523 patients with invasive breast cancers. Patients were divided into two groups according to the age at diagnosis: younger(< 40 years old) vs older patients(≥ 40 years old) for subsequent analyses.RESULTS: Analysis on the sociodemographic characteristics and exposure to risk factors were performed on 7152 women with primary breast cancer and the results revealed that younger patients were more likely to have unhealthy lifestyles; these include a lack of exercise(85.4% vs 73.2%, P < 0.001), having high stress in life(46.1% vs 35.5%, P < 0.001), having dairy/meat-rich diets(20.2% vs 12.9%, P < 0.001),having alcohol drinking habit(7.7% vs 5.2%, P = 0.002). Younger patients were also more likely to have hormone-related risk factors including nulliparity(43.3% vs 17.8%, P < 0.001) and an early age at menarche(20.7% vs 13.2%, P < 0.001). Analyses on clinicopathological characteristics and patterns of treatment were performed on 5523 women diagnosed with invasive breast cancer. The invasive tumours in younger patients showed more aggressive pathological features such as having a higher percentage of grade 3 histology(45.7% vs 36.5%, P < 0.001), having a higher proportion of tumours with lymphovascular invasion(39.6% vs 33.2%, P = 0.003), and having multifocal disease(15.7% vs 10.3%, P < 0.001); they received different patterns of treatment than their older counterparts.CONCLUSION: Younger patients in Hong Kong are more likely to encounter risk factors associated with breast cancer development and have more aggressive tumours than their older counterparts. | Winnie Yeo Hang-Mei Lee Amy Chan Emily YY Chan Miranda CM Chan Keeng-Wai Chan Sharon WW Chan Foon-Yiu Cheung Polly SY Cheung Peter HK Choi Josette SY Chor William WL Foo Wing-Hong Kwan Stephen CK Law Lawrence PK Li Janice WH Tsang Yuk Tung Lorna LS Wong Ting-Ting Wong Chun-Chung Yau Tsz-Kok Yau Benny CY Zee | 2014 | World Journal of Clinical Oncology2014，5，5： | 4 |
| 2 | 慢性阻塞性肺疾病急性加重患者感染性致病因素分析显示文摘背景和目的:反复急性发作是慢性阻塞性肺疾病(COPD)的临床特点,同时也是患者住院的主要原因,呼吸道感染常常是急性发作的诱因。适当的经验性应用抗生素对于降低此类患者的住院率和病死率非常有意义。不同居住地的COPD患者引起急性发作的病原谱是不同的,因而地区性资料对于指导临床治疗很重要。本研究的目的是阐明我国香港地区COPD急性发作的病原学及其治疗。方法:研究人员分析了我国香港2004年5月至2005年4月因COPD急性发作而住院的患者, | Ko FW Ip M Chan PK 李翠联 曹彬 | 2007 | 中华结核和呼吸杂志2007，30，5： | 2 |
| 3 | Genetic evolution of enterovirus 71: epidemiological and pathological implications 显示文摘 | Bible JM Pantelidis P Chan PK | 2007 | Rev Med Virol2007，17，6： | 1 |
| 4 | Lamivudine for the prevention of hepatitis B virus reactivation in hepatitis B s-antigen seropositive cancer patients undegoing cytotoxic chemotherapy显示文摘 | Yeo W Chan PK Ho WM | 2004 | JCO2004，22，5： | 1 |
| 5 | Clinical features and rapid viral diagnosis of human disease associated with avian influenza A H5N1 virus 显示文摘 | Yuen KY Chan PK Peiris M | 1998 | Lancet1998，351，9101： | 1 |
| 6 | HLA-B alleles,high-risk HPV infection and risk for cervical neoplasia in southern Chinese women显示文摘 | Chan PK Cheung JL Cheung TH | 2006 | Int J Cancer2006，118，6： | 1 |
| 7 | Genetic evolution of en-terovirus 71 : epidemiological and pathological implications 显示文摘 | Bible JM Pantelidis P Chan PK | 2007 | Revmed Virol2007，17，6： | 1 |
| 8 | Modes of Helicobacter coloni- zation and gastric epithelial damage 显示文摘 | Chan WY Hui PK Leung KM | 1992 | Histopathology1992，21，6： | 1 |
| 9 | Procalcitonin as a marker of bacterial infection in the emergency department: an observational study显示文摘 | Chan YL Tseng CP Tsay PK | 2004 | Crit Care2004，8，1： | 1 |
| 10 | Epidemiologic risk profile of infection with different groups of human papillomaviruses 显示文摘 | Chan PK Ho WC Wong MC | 2009 | J Med Virol2009，81，9： | 1 |
| 11 | A prescription survey in a hospital hypertension outpatient clinic显示文摘 | Lee PK Li RK Chan JC | 1997 | Br J Clin Pharmacol1997，44，6： | 1 |
| 12 | Identification of viral arid atypicai bacterial pathogens in children hospitalizedwith acute respiratory infections in Hong Kong by multiplex PCR assays显示文摘 | Sung RY Chan PK Tsen T | 2009 | J Med Virol2009，8，1： | 1 |
| 13 | Outbreak of avian influenza A (H5N1)virus infection in Hong Kong in 1997 显示文摘 | Chan PK | 2002 | Clin Infect Dis2002，34，12： | 1 |
| 14 | Outbreak of avian influenza A ( H5N1 ) virus infection in Hong Kong in 1997 显示文摘 | Chan PK | 2002 | Clinical infectious diseases : an official publication of the Infectious Diseases Society of America2002，34，2： | 1 |
| 15 | Frequncy of hepatitis B virus rcacetivation in cancer patients undergoing eytotoxie chemotherapy a prospective study of 626 patients with identification of rish factors 显示文摘 | YEO W CHAN PK ZHONG S | 2000 | J Med virol2000，62，3： | 1 |
| 16 | Prevalence and genotype distribution of cervical human pap illomavirus infection:Comparison between pregnant women and non-pregnant controls显示文摘 | Chan PK Chang AR Tam WH | 2002 | J Med Virol2002，67，： | 1 |
| 17 | Genetic evolution of enterovirus 71:epidemiological and pat hological implications显示文摘 | Bible JM Pantelidis P Chan PK | 2007 | RevMed Virol2007，17，6： | 1 |
| 18 | Seasonal influenza activity in Hong Kong and its association with meteorological variations 显示文摘 | Chan PK Mok HY Lee TC | 2009 | J Med Virol2009，81，10： | 1 |
| 19 | Activation of the JNK pathway promotes phosphorylation and degradation of BimEL--a novel mechanism of chemoresistance in T-cell acute lymphoblastic leukemia显示文摘 | Leung KT Li KK Sun SS Chan PK | 2008 | Carcinogenesis2008，29，3： | 1 |
| 20 | High prevalence of human papillomavirus type 58 in Chinese women with cervical cancer and precancerous lesions显示文摘 | Chan PK Li WH Chan MY | 1999 | J Med Virol1999，59，2： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员