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| 1 | Palmitoylation stabilizes PD-L1 to promote breast tumor growth显示文摘Dear Editor,PD-L1 is a well-known transmembrane protein, which is highly expressed on many types of cancer cells. By binding to its receptor PD-1 on T cells, PD-L1 significantly inhibits T cells activation and activity, and thus plays a pivotal role in driving the escape of tumor cells from immune surveillance.^1. | Yi Yang Jung-Mao Hsu Linlin Sun Li-Chuan Chan Chia-Wei Li Jennifer L. Hsu Yongkun Wei Weiya Xia Junwei Hou Yufan Qiu Mien-Chie Hung | 2019 | Cell Research2019，29，1： | 14 |
| 2 | Digital assembly technology based on augmented reality and digital twins: a review显示文摘Product assembly simulation is considered as one of the key technologies in the process of complex product design and manufacturing.Virtual assembly realizes the assembly process design,verification,and optimization of complex products in the virtual environment,which plays an active and effective role in improving the assembly quality and efficiency of complex products.In recent years,augmented reality(AR)and digital twin(DT)technology have brought new opportunities and challenges to the digital assembly of complex products owing to their characteristics of virtual reality fusion and interactive control.This paper expounds the concept and connotation of AR,enumerates a typical AR assembly system structure,analyzes the key technologies and applications of AR in digital assembly,and notes that DT technology is the future development trend of intelligent assembly research. | Chan QIU Shien ZHOU Zhenyu LIU Qi GAO Jianrong TAN | 2019 | Virtual Reality & Intelligent Hardware2019，1，6： | 7 |
| 3 | Effects of dexmedetomidine on the expression of inflammatory factors in children with congenital heart disease undergoing intraoperative cardiopulmonary bypass:A randomized controlled trial显示文摘Importance:Dexmedetomidine inhibits the inflammatory response associated with cardiopulmonary bypass(CPB)and protects neural function.However,the mechanism of dexmedetomidine’s anti-inflammatory pathway is unclear.Objective:To investigate the effect of dexmedetomidine on the cognitive level and expression of inflammatory factors in children with congenital heart disease undergoing intraoperative CPB.Methods:Ninety children with congenital heart disease were recruited and randomly divided into 3 groups of 30 children in each.In Group 1,a 1.0μg·kg-1·h-1 intravenous bolus of dexmedetomidine was administered 10 minutes after induction of anesthesia,followed by a 0.2μg·kg-1·h-1 infusion until the surgical incision.In Group 2,a 0.5μg/kg intravenous bolus of dexmedetomidine was administered 10 minutes after induction of anesthesia,followed by a 0.1μg·kg-1·h-1 infusion until the surgical incision.The control group was given physiological saline using the same method as in Groups 1 and 2.The serum levels of nuclear factor-kappa B(NF-κB),S-100βprotein,neuron-specific enolase(NSE),tumor necrosis factor-α(TNF-α),and interleukin-6(IL-6)were measured before the surgery(T1),at the end of CPB(T2),2 hours after CPB(T3),6 hours after CPB(T4),and 24 hours after CPB(T5).The Wechsler Intelligence Scale for children(WISC)was measured before the operation and at 3,6,and 12 months after the operation to evaluate the neurodevelopmental state of the children.Results:The levels of the NF-κB,S-100βprotein,NSE,TNF-α,IL-6 were significantly higher at T2,T3,or T4 than before the surgery(T1)in the control group or the dexmedetomidine groups.However,the increases of NF-κB,TNF-α,IL-6,S-100βand NSE levels were significantly smaller in the dexmedetomidine groups than those in the control group(P<0.017).The WISC scores were similar among the three groups before or after the operation.Interpretation:The increases in NF-κB,TNF-α,and IL-6 levels indicated aggravation of the inflammatory reaction and the increase S-100βprotein and NSE levels indicated that the nervous system was damaged.Administration of dexmedetomidine to children with congenital heart disease undergoing intraoperative CPB can inhibit the inflammatory response and may ameliorate the neurodevelopmental damage caused by CPB. | Yongsheng Qiu Chan Li Xiaoqin Li Yingping Jia | 2020 | Pediatric Investigation2020，4，1： | 6 |
| 4 | 基于Bézier曲线的柔性曲面装配变动分析(英文)显示文摘在装配过程中,柔性零件表面特征会发生形状变化,相比刚性体,其变动分析复杂许多。现有柔性装配变动分析方法大多未考虑零件表面邻近点的相互关系,或者将零件表面上所有特征点的概率分布情况视为统一。本文将柔性曲面零件装配简化为边侧线匹配问题,提出基于Bézier曲线来表征曲面零件边侧线的方法,解决了柔性零件装配中考虑表面连续性的曲面零件装配变动分析问题。该方法利用控制点变动来获取零件边侧线上特征点的偏差,并将它们作为输入参数进行有限元分析,从而计算出最终产品变形量。通过天线表面装配的两个实例,对所提方法进行了验证。 | Zhen-yu LIU Shi-en ZHOU Jin CHENG Chan QIU Jian-rong TAN | 2018 | Frontiers of Information Technology & Electronic Engineering2018，19，6： | 2 |
| 5 | Pharmaco- kinetic interaction of paeoniflorin and sinomenine: pharmacoki- netic parameters and tissue distribution characteristics in rats and protein binding ability in vitro显示文摘 | Zhong Qiu Liu Zhi Hong Jiang Kelvin Chan | 2005 | Journal of Pharmacolog- ical Sciences2005，99，： | 1 |
| 6 | Acute and chronic toxicities of tributyhin to various life stages of the marine polychaete Hydroides elegans显示文摘 | Lau M Chan KM Leung KM Luan TG Yang MS Qiu JW | 2007 | Chemosphere2007，69，1： | 1 |
| 7 | Comparison of three methods for respiratory virus detection between induced sputum and nasopharyngeal aspirate specimens in acute asthma 显示文摘 | Xiang X Y Qiu D W Chan K P | 2002 | J Virol Methods2002，101，： | 1 |
| 8 | A New Class of Versatile Chiral-Bridged Atropisomeric Diphosphine Ligands:Remarkably Efficient Ligand Syntheses and Their Applications in Highly Enantioselective Hydrogenation Reactions显示文摘 | Qiu L Kwong F.Y Wu J Lam W.H Chan S Yu W.-Y Li Y.-M Guo R Zhou Z Chan A.S.C | | 0，，17： | 1 |
| 9 | Minimum length of sequencehomology required for in vivo cloning by homologous recombina-tion in yeast]显示文摘 | ua S B Qiu M Chan E | 1997 | Plasmid1997，38，2： | 1 |
| 10 | Construction of efficient solid emitters with conventional and AIE luminogens for blue or- ganic light-emitting diodes显示文摘 | Zhao Z J Chen S M Deng C M Lam J W Y Chan C Y K Lu P Wang Z M Hu B B Chen X P Lu P Kwok H S Ma Y G Qiu H Y Tang B Z | 2011 | Journal of Materials Che- mistry2011，21，10： | 1 |
| 11 | Internet connectedness and inequality:Beyond the'Divide'显示文摘 | Jung Joo-Young Qiu Jack Linchuan and Kim Yong- Chan | 2001 | Communication Research2001，28，4： | 1 |
| 12 | Adiponectin regulates albuminuria and podocyte function in mice显示文摘 | Sharma Kumar RamachandraRao Satish Qiu Gang Usui Hitomi Kataoka Zhu Yanqing Dunn Stephen R Ouedraogo Raogo Hough Kelly McCue Peter Chan Lawrence Falkner Bonita Goldstein Barry J | 2008 | Journal of Clinical Investigation2008，，5： | 1 |
| 13 | The Mycoplasma gallisepticum α-enolase is cell surface-exposed and mediates adherence by binding to chicken plasminogen显示文摘 | Hongjun Chen Shengqing Yu Xinyue Shen Danqing Chen Xvsheng Qiu Cuiping Song Chan Ding | 2011 | Microbial Pathogenesis2011，，： | 1 |
| 14 | Comparison of three methods for respiratory virus detection between sputum and nasopharyngeal aspirate specimens in acute asthma显示文摘 | Xueyu X Qiu D Chan KP | 2002 | J Virol Method2002，101，： | 1 |
| 15 | P300 aberration in first-episode schizophrenia patients: a meta-analysis 显示文摘 | Qiu YQ Tang Y Chan R | 2014 | PLoS One2014，9，97： | 1 |
| 16 | LAN-based control for load shedding显示文摘 | Yilu Liu Eng Kiat Chan Lawrence L J Cao | 2002 | IEEE Computer Applications in Power2002，11，： | 1 |
| 17 | The effects of sinomenine on intestinal absorption of paeoniflorin by the everted rat gut sac model显示文摘 | Kelvin Chan Zhong Qiu Liu Zhi Hong Jiang | 2006 | Journal of Ethnopharmacology2006，103，： | 1 |
| 18 | Whole genome sequencing and biological characterization of Duck/JS/10, a new lentogenic class I Newcastle disease virus显示文摘 | Chunchun Meng Xvsheng Qiu Shiqiang Jin Shengqing Yu Hongjun Chen Chan Ding | 2012 | Archives of Virology2012，，5： | 1 |
| 19 | Design Theory and Method of Complex Products:A Review显示文摘Design is a high-level and complex thinking activity of human beings,using existing knowledge and technology to solve problems and create new things.With the rise and development of intelligent manufacturing,design has increasingly reflected its importance in the product life cycle.Firstly,the concept and connotation of complex product design is expounded systematically,and the different types of design are discussed.The four schools of design theory are introduced,including universal design,axiomatic design,TRIZ and general design.Then the research status of complex product design is analyzed,such as innovative design,digital design,modular design,reliability optimization design,etc.Finally,three key scientific issues worthy of research in the future are indicated,and five research trends of“newer,better,smarter,faster,and greener”are summarized,aiming to provide references for the equipment design and manufacturing industry. | Chan Qiu Jianrong Tan Zhenyu Liu Haoyang Mao Weifei Hu | 2022 | Chinese Journal of Mechanical Engineering2022，35，5： | 1 |
| 20 | Adaptive filtering of evoked potentials with radial-basis-function neural network prefilter 显示文摘 | Qiu W Fung KSM Chan FHY | 2002 | IEEE Trans BME2002，49，3： | 1 |
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