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| 1 | 北京PM_(2.5)化学物种的质量平衡特征显示文摘以北京 2个采样点连续采集的样品对PM2 5中的元素、水溶性离子和含碳组分进行分析 .车公庄和清华园PM2 5中有机物的含量分别为 2 7 8%和 30 9% ,是含量最丰富的物种 ,其次是二次无机粒子、土壤尘、元素碳和微量元素 .PM2 5中约有 2 4 %的质量未能鉴别成分 ,相关性分析表明 ,含碳物种的估算所引起的偏差可能是主要的原因 .采暖期重污染周和春季沙尘周PM2 5的化学物种构成悬殊 ,反映了季节性变化的源排放和特殊气象条件的综合作用 . | 杨复沫 贺克斌 马永亮 张强 Cadle S H Chan T Mulawa P A | 2004 | 环境化学2004，23，3： | 63 |
| 2 | Th1 cytokines promote T-cell binding to antigen-presenting cells via enhanced hyaluronan production and accumulation at the immune synapse显示文摘Hyaluronan(HA)production by dendritic cells(DCs)is known to promote antigen presentation and to augment T-cell activation and proliferation.We hypothesized that pericellular HA can function as intercellular‘glue’directly mediating T cell–DC binding.Using primary human cells,we observed HA-dependent binding between T cells and DCs,which was abrogated upon pre-treatment of the DCs with 4-methylumbelliferone(4-MU),an agent which blocks HA synthesis.Furthermore,T cells regulate HA production by DCs via T cell-derived cytokines in a T helper(Th)subset-specific manner,as demonstrated by the observation that cell-culture supernatants from Th1 but not Th2 clones promote HA production.Similar effects were seen upon the addition of exogenous Th1 cytokines,IL-2,interferon c(IFN-c)and tumor necrosis factor a(TNF-a).The critical factors which determined the extent of DC–T cell binding in this system were the nature of the pre-treatment the DCs received and their capacity to synthesize HA,as T-cell clones which were pre-treated with monensin,added to block cytokine secretion,bound equivalently irrespective of their Th subset.These data support the existence of a feedforward loop wherein T-cell cytokines influence DC production of HA,which in turn affects the extent of DC–T cell binding.We also document the presence of focal deposits of HA at the immune synapse between T-cells and APC and on dendritic processes thought to be important in antigen presentation.These data point to a pivotal role for HA in DC–T cell interactions at the IS. | Paul L Bollyky Stephen P Evanko Rebecca P Wu Susan Potter-Perigo S Alice Long Brian Kinsella Helena Reijonen Kelly Guebtner Brandon Teng Christina K Chan Kathy R Braun John A Gebe Gerald T Nepom Thomas N Wight | 2010 | Cellular & Molecular Immunology2010，7，3： | 3 |
| 3 | Integrating Environmental Criteria into the Supplier Selection Process显示文摘 | HUMPHREYS P K WONG Y K CHAN F T S | 2003 | Journal of Materials Processing Technology2003，138，6： | 1 |
| 4 | Clarithromycin resistance and efficacy of clarithromycin-containing triple eradication therapy for Helicobacter pylori infection in type 2 diabetes mellitus patients显示文摘 | Hung IF Chan P Leung S | 2009 | Helicobacter2009，14，6： | 1 |
| 5 | Crk I and Crk Ⅱ funtion as key signaling integrators for migration and invasion of cancer cells显示文摘 | Rodrigues S P Fathers K E Chan G | 2005 | Mol Cancer Res2005，3，4： | 1 |
| 6 | DJ-1 could predict worse prognosis in esophageal squamous cell carcinoma显示文摘 | YUEN H F CHAN Y P LAW S | 2008 | Cancer Epidemiol Biomarkers Prev2008，17，12： | 1 |
| 7 | Polymerase chain reaction enzyme-linked immunosorbent assay detection of mycoplasma consensus gene in sperm with low oocyte penetration capacity 显示文摘 | Kalugdan T Chan P J S eraj IM | 1996 | Journal Article Fertility and Sterility1996，66，5： | 1 |
| 8 | Relationship between high-grade lymphoma and low-grade B-cell MALTorna of the stomach显示文摘 | CHAN J K C NG C S ISAACSON P G | 1990 | Am J Pathol1990，136，： | 1 |
| 9 | Rational harmonic active and passive modelocking in a figure-of-eight fiber laser显示文摘 | LI S P LOU C Y CHAN K T | 1998 | Electronics Letters1998，34，4： | 1 |
| 10 | A PhysiologicallyBased Pharmacokinetic Model for Endosulfan in the MaleSprague-Dawley Rats显示文摘 | Chan M P Morisawa S Nakayama A | 2006 | Environmental Toxicology2006，21，5： | 1 |
| 11 | Supplementation-time dependence of growth factors in promoting tendon healing显示文摘 | Chan B P Fu S C Qin L | 2006 | Clin Orthop Relat Res2006，448，1： | 1 |
| 12 | Increased alpha-B-crystallin expression in mammary metaplastic carcinomas 显示文摘 | Chan S K Lui P C Tan P H | 2011 | Histopatholo- gy2011，59，2： | 1 |
| 13 | Cloning of a cDNA encoding a pu- tative molt-inhibiting hormone from the eyestalk of the sand shrimp Metapenaeus ensis 显示文摘 | Gu P L Chan S M | 1998 | Mol Marine Bio- tech1998，7，3： | 1 |
| 14 | Tillage-induced increases in carbon dioxide loss from soil显示文摘 | Robert s W P Chan K Y | 1990 | Soil&Tillage Research1990，17，： | 1 |
| 15 | Vibration and Deflection Characteristics of Semi Rigid Jointed Frames 显示文摘 | Peter P T C Chan S L | 1997 | Engineering Structures1997，19，10： | 1 |
| 16 | Neuroprotection by interleukin 6 is mediated by signal transducer and activator of transcription 3 and antioxidative signaling in isehemic stroke 显示文摘 | JUNG J E KIM G S CHAN P H | 2011 | Stroke2011，42，12： | 1 |
| 17 | Presenilin mutations and calcium signaling defects in the nervous and immune systems显示文摘 | Mattson M P Chan S L Camandola S | 2001 | Bioessays2001，23，8： | 1 |
| 18 | Lateral error recovery for media streaming in application-level multicast显示文摘 | Yiu W P K Wong K F S Chan S H G | 2006 | IEEE2006，8，2： | 1 |
| 19 | Fast fingerprint verification using sub-regions of fingerprint images显示文摘 | Chan K C Moon Y S and Cheng P S | 2004 | IEEE Transactions on Circuits and Systems for Video Technology2004，14，1： | 1 |
| 20 | Investigation of crystallinity effects on the surface of oxygen plasma treated low density polyethylene using X-ray photoelectron spectroscopy显示文摘 | Kwang S K Chang M R Chan S P | 2003 | Polymer2003，，44： | 1 |
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