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| 1 | 左前额叶参与非相关词对的语义编码过程──来自光学成像的佐证显示文摘通过研究左前额叶在非相关词对的语义编码过程中的作用,探讨近红外光学成像技术用于脑高级认知活动检测的可行性。被试在两种实验条件下分别学习视觉呈现的20个汉字非相关词对,要求被试或将词对组成一个有意义的句子(深加工),或判断两个词是否具有相同的结构组合(浅加工)。光学成像器即时记录连续光透过额骨及前额皮层后760nm和850nm的漫射光强变化,以此推测相应脑组织的血容量变化。结果表明,与浅加工相比,左下前额叶在深加工时的血容量增多,尤其是背外侧部分。 | 杨炯炯 曾绍群 骆清铭 管林初 匡培梓 龚辉 Britton Chance | 2001 | 心理学报2001，33，1： | 11 |
| 2 | 用近红外光学漫射成象方法观测语义编码在前额叶的响应显示文摘本文采用近红外光学漫射成象技术成功观测了左右前额区在知觉与语义编码中的活动. 发现大脑在完成上述两任务时,左前额的活动显著地强于右前额,语义加工引起的活动显著地强于知觉加工. 对于每一侧而言,与浅加工相比,深加工时的活动主要集中在下前额叶.上述结果进一步证实了左前额叶在语义加工中的作用. | 曾绍群 杨炯炯 龚辉 骆清铭 Britton Chance | 2000 | 光子学报2000，29，1： | 6 |
| 3 | 编码非相关词对是否具有半球对称性?一项近红外光学成像的研究(英文)显示文摘目的本研究采用近红外光学成像技术(fNIRS),探讨双侧前额叶在非相关词对的语义编码过程中的作用。方法48名被试者分别在深、浅加工2种实验条件下对非相关词对进行编码,光学成像器即时记录在前额叶皮层,波长为760nm和850nm的漫射光强变化,以此推测相应脑组织的血容量变化。结果与浅加工相比,在深加工条件下,双侧前额叶中与背外侧前额叶相对应区域的血容量变化都较为明显,尤其是左侧前额叶。本研究结果并不完全支持HERA模型,但与其它相关的脑成像研究结果相似。结论材料的特异性是影响记忆编码中半球一侧化的重要因素,当需要对刺激间的联系进行加工时,右侧前额叶也会参与记忆的编码过程。本研究还提示fNIRS技术可用于记忆等脑高级认知功能的研究。 | 杨炯炯 曾少群 骆清铭 管林初 匡培梓 龚辉 Lichty Wemara Chance Britton | 2005 | 航天医学与医学工程2005，18，5： | 3 |
| 4 | MITOCHONDRIAL REDOX IMAGING FOR CANCER DIAGNOSTIC AND THERAPEUTIC STUDIES显示文摘Mitochondrial redox states provide important information about energy-linked biological processes and signaling events in tissues for various disease phenotypes including cancer.The redox scanning method developed at the Chance laboratory about 30 years ago has allowed 3D highresolution(∼50×50×10µm^(3))imaging of mitochondrial redox state in tissue on the basis of the fluorescence of NADH(reduced nicotinamide adenine dinucleotide)and Fp(oxidized flavoproteins including flavin adenine dinucleotide,i.e.,FAD).In this review,we illustrate its basic principles,recent technical developments,and biomedical applications to cancer diagnostic and therapeutic studies in small animal models.Recently developed calibration procedures for the redox imaging using reference standards allow quantification of nominal NADH and Fp concentrations,and the concentration-based redox ratios,e.g.,Fp/(Fp+NADH)and NADH/(Fp+NADH)in tissues.This calibration facilitates the comparison of redox imaging results acquired for different metabolic states at different times and/or with different instrumental settings.A redox imager using a CCD detector has been developed to acquire 3D images faster and with a higher in-plane resolution down to 10µm.Ex vivo imaging and in vivo imaging of tissue mitochondrial redox status have been demonstrated with the CCD imager.Applications of tissue redox imaging in small animal cancer models include metabolic imaging of glioma and myc-induced mouse mammary tumors,predicting the metastatic potentials of human melanoma and breast cancer mouse xenografts,differentiating precancerous and normal tissues,and monitoring the tumor treatment response to photodynamic therapy.Possible future directions for the development of redox imaging are also discussed. | LIN Z.LI HE N.XU MAHSA RANJI SHOKO NIOKA BRITTON CHANCE | 2009 | Journal of Innovative Optical Health Sciences2009，2，4： | 3 |
| 5 | QUANTITATIVE REDOX SCANNING OF TISSUE SAMPLES USING A CALIBRATION PROCEDURE显示文摘The fluorescence properties of reduced nicotinamide adenine dinucleotide(NADH)and oxidizedflavoproteins(Fp)including flavin adenine dinucleotide(FAD)in the respiratory chain are sensitive indicators of intracellular metabolic states and have been applied to the studies of mitochondrial function with energy-linked processes.The redox scanner,a three-dimensional(3D)low temperature imager previously developed by Chance et al.,measures the in vivo metabolicproperties of tissue samples by acquiring fluorescence images of NADH and Fp.The redox ratios,i.e.Fp/(Fp+NADH)and NADH/(Fp+NADH),provided a sensitive index of the mitochondrialredox state and were determined based on relative signal intensity ratios.Here we report thefurther development of the redox scanning technique by using a calibration method to quantifythe nominal concentration of the fluorophores in tissues.The redox scanner exhibited very goodlinear response in the range of NADH concentration between 165–1318µM and Fp between90–720µM using snap-frozen solution standards.Tissue samples such as human tumor mousexenografts and various mouse organs were redox-scanned together with adjacent NADH and Fpstandards of known concentration at liquid nitrogen temperature.The nominal NADH and Fpconcentrations as well as the redox ratios in the tissue samples were quantified by normalizing the tissue NADH and Fp fluorescence signal to that of the snap-frozen solution standards.This calibration procedure allows comparing redox images obtained at different time,independent of instrument settings.The quantitative multi-slice redox images revealed heterogeneity inmitochondrial redox state in the tissues. | HE N.XU BAOHUA WU SHOKO NIOKA BRITTON CHANCE LIN Z.LI | 2009 | Journal of Innovative Optical Health Sciences2009，2，4： | 2 |
| 6 | Photon migration in the presence of a single defect: a perturbation analysis显示文摘 | She-chao Feng Fan-an Zeng Britton Chance | 1995 | Applied Optics1995，34，19： | 1 |
| 7 | Time-resolved photon emission from layered turbid media显示文摘 | Andreas H Hielscher Han- li liu Britton Chance | 1996 | Applied Optics1996，35，4： | 1 |
| 8 | DETECTION OF Ca^(2+)-DEPENDENT NEURONAL ACTIVITY SIMULTANEOUSLY WITH DYNAMIC CHANGES IN CEREBRAL BLOOD VOLUME AND TISSUE OXYGENATION FROM THE LIVE RAT BRAIN显示文摘We present a catheter-based optical diffusion and fluorescence(ODF)probe to study the functional changes of the brain in vivo.This ODF probe enables the simultaneous detection ofthe multi-wavelength absorbance and fluorescence emission from the living rat brain.Our previous studies,including a transient stroke experiment of the rat brain as well as the brainresponse to cocaine,have established the feasibility of simultaneously determining changes incerebral blood volume(CBV),tissue oxygenation(StO2)and intracellular calcium([Ca^(2+)]i,using the fluorescence indicator Rhod2).Here,we present our preliminary results of somatosensory response to electrical forepaw stimulation obtained from the rat cortical brain by using theODF probe,which indicate that the probe could track brain activation by directly detecting[Ca^(2+)]i along with separately distinguishing CBV and StO2 in real time.The changes of CBV,StO2 and[Ca^(2+)]i are comparable with the blood-oxygen-level-dependent(BOLD)response tothe stimulation obtained using functional magnetic resonance imaging(fMRI).However,thehigh temporal resolution of the optical methodology is advanced,thus providing a new modalityfor brain functional studies to understand the hemodynamic changes that underlie the neuronalactivity. | CONGWU DU ZHONGCHI LUO MEI YU HELENE BENVENISTE MELISSA TULLY RUBING PAN BRITTON CHANCE | 2009 | Journal of Innovative Optical Health Sciences2009，2，2： | 0 |
| 9 | This research was supported by E.U.FP6 Integrated Project“Molecular Imaging”LSHG-CT-2003-503259 and E.U.FP7 Collaborative Project“FMT-XCT”.R.F.acknowledges support from the Marie Curie Program EST-MolecImag Early Stage Training MEST-CT-2004-007643.显示文摘We have imaged mitochondrial oxidation-reduction states by taking a ratio of mitochondrial fluorophores:NADH(reduced nicotinamide adenine dinucleotide)to Fp(oxidized flavoprotein).Although NADH has been investigated for tissue metabolic state in cancer and in oxygen deprived tissues,it alone is not an adequate measure of mitochondrial metabolic state since the NADH signal is altered by dependence on the number of mitochondria and by blood absorption.The redox ratio,NADH/(Fp+NADH),gives a more accurate measure of steady-state tissue metabolism since it is less dependent on mitochondrial number and it compensates effectively for hemodynamic changes.This ratio provides important diagnostic information in living tissues.In this study,the emitted fluorescence of mouse colon in situ is passed through an emission filter wheel and imaged on a CCD camera.Redox ratio images of the healthy and hypoxic mouse intestines clearly showed significant differences.Furthermore,the corrected redox ratio indicated an increase from an average value of 0.51±0.10 in the healthy state to 0.92±0.03 in dead tissue due to severe ischemia(N=5).We show that the CCD imaging system is capable of displaying the metabolic differences in normal and ischemic tissues as well as quantifying the redox ratio in vivo as a marker of these changes. | MAHSA RANJI SHOKO NIOKA HE N.XU BAOHUA WU LIN Z.LI DWIGHT L.JAGGARD BRITTON CHANCE | 2009 | Journal of Innovative Optical Health Sciences2009，2，4： | 0 |
| 10 | A NOVEL TIME-SHARED FLUOROMETER GIVES THE MITOCHONDRIAL REDOX STATE AS THE RATIO OF TWO COMPONENTS OF THE RESPIRATORY CHAIN OF THE ANIMAL AND HUMAN BUCCAL CAVITY WITH QUANTITATIVE MEASURES OF THE REDOX ENERGY STATE显示文摘The source of energy for life is the tissue mitochondria and they demand a complex chain of biochemicals to ensure proper physiological function.Classically,the blood levels,and not the tissue levels of these metabolites,are determined by expensive and time-consuming biochemical analyses.Since the tissue mitochondria are the consumers of the substrates of glycolysis and of fatty acid metabolism,their redox state is a unique accessible monitor of tissue metabolism and its blockade due to toxins. | BRITTON CHANCE SHOKO NIOKA AQUO JENQ-RUEY HORNG | 2010 | Journal of Innovative Optical Health Sciences2010，3，4： | 0 |
| 11 | IMAGING REDOX STATE HETEROGENEITY WITHIN INDIVIDUAL EMBRYONIC STEM CELL COLONIES显示文摘Redox state mediates embryonic stem cell(ESC)differentiation and thus offers an important complementary approach to understanding the pluripotency of stem cells.NADH redox ratio(NADH/(Fp t NADH)),where NADH is the reduced form of nicotinamide adenine dinucleotide and Fp is the oxidizedflavoproteins,has been established as a sensitive indicator of mitochondrial redox state.In this paper,we report our redox imaging data on the mitochondrial redox state of mouse ESC(mESC)colonies and the implications thereof.The low-temperature NADH/Fp redox scanner was employed to image mESC colonies grown on a feeder layer of gamma-irradiated mouse embryonicfibroblasts(MEFs)on glass cover slips.The result showed significant heterogeneity in the mitochondrial redox state within individual mESC colonies(size:~200-440μm),exhibiting a core with a more reduced state than the periphery.This more reduced state positively correlates with the expression pattern of Oct4,a well-established marker of pluripotency.Our observation is thefirst to show the heterogeneity in the mitochondrial redox state within a mESC colony,suggesting that mitochondrial redox state should be further investigated as a potential new biomarker for the stemness of embryonic stem cells. | HE N.XU RUSSELL C.ADDIS DAVIDA F.GOINGS SHOKO NIOKA BRITTON CHANCE JOHN D.GEARHART LIN Z.LI | 2011 | Journal of Innovative Optical Health Sciences2011，4，3： | 0 |
| 12 | HISTORY AND PRESENT STATE OF TRANSLATIONAL ELECTRO-OPTICAL APPLICATIONS TO MEDICINE显示文摘This paper reviews the history of the optoelectric devices applied to biomedical sciences in 20th century.It describes history of Vacuum tubes and Spectroscopies with the author’s personal experiences,especially doublebeam spectroscopy.Further,the present developments of Near Infra Red(NIR)devices are described in translational biomedical applications.It includes particulary micro optoelectronics developments and present status of NIR breast cancer detection.Lastly,intrinsic molecular biomarkers are discussed especially NIR measurements of angiogenensis,hypermetabolism and heat production for cancer detection. | BRITTON CHANCE SHOKO NIOKA | 2008 | Journal of Innovative Optical Health Sciences2008，1，1： | 0 |
| 13 | ANAGRAM PROBLEM-SOLVING AND LEARNING IN ANTERIOR PREFRONTAL CORTEX显示文摘We utilized Near-Infrared(NIR)spectroscopy to closely investigate the activation change in anterior prefrontal cortex(aPFC)during verbal anagram problem-solving and learning.We used a parametric design of anagram-solving with three difficulty levels and evaluated anagram skill with two sets of subjects and protocols.The first protocol was a one-time evaluation of untrained subjects(n=10)and the second protocol evaluated subjects over 6 weeks of training(n=6).The untrained subjects in the first protocol demonstrated blood oxygenation corresponding to neuronal activation in the aPFC in response to medium and hard difficulty levels of the stimuli,while the easy anagram task deoxygenated the aPFC bilaterally,corresponding to deactivation.Higher performers have more aPFC activation than lower performers in the medium difficulty level anagram-solving task.Six weeks of training in the second protocol showed that training reduced oxygenation in aPFC.In particular,subjects with lower baseline skill in anagram production showed a larger reduction in oxygenation where true performance gains occurred(medium difficulty)and smaller reduction where the performance gains were limited(hard anagrams).Association of the aPFC activation with the difficulty of the complex task suggests that aPFC is a part of a circuit for execution of task performance.In addition,more use of aPFC by untrained high performers suggests that the role of the aPFC is to increase efficiency of a problem-solving task.Thus,the NIR spectroscopy showed that the aPFC is a key structure in the circuit implementing the development of anagram skill. | SHOKO NIOKA JOSEPH I.TRACY SHANE RAINES SCOTT BUNCE BRITTON CHANCE | 2008 | Journal of Innovative Optical Health Sciences2008，1，2： | 0 |
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