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| 1 | Efficacy of pancreatoscopy for pancreatic duct stones:A systematic review and meta-analysis显示文摘BACKGROUND Pancreatic duct stones can lead to significant abdominal pain for patients.Per oral pancreatoscopy(POP)-guided intracorporal lithotripsy is being increasingly used for the management of main pancreatic duct calculi(PDC)in chronic pancreatitis.POP uses two techniques:Electrohydraulic lithotripsy(EHL)and laser lithotripsy(LL).Data on the safety and efficacy are limited for this procedure.We performed a systematic review and meta-analysis with a primary aim to calculate the pooled technical and clinical success rates of POP.The secondary aim was to assess pooled rates of technical success,clinical success for the two individual techniques,and adverse event rates.AIM To perform a systematic review and meta-analysis of POP,EHL and LL for management of PDC in chronic pancreatitis.METHODS We conducted a comprehensive search of multiple electronic databases and conference proceedings including PubMed,EMBASE,Cochrane,Google Scholar and Web of Science databases(from 1999 to October 2019)to identify studies with patient age greater than 17 and any gender that reported on outcomes of POP,EHL and LL.The primary outcome assessed involved the pooled technical success and clinical success rate of POP.The secondary outcome included the pooled technical success and clinical success rate for EHL and LL.We also assessed the pooled rate of adverse events for POP,EHL and LL including a subgroup analysis for the rate of adverse event subtypes for POP:Hemorrhage,post-endoscopic retrograde cholangiopancreatography pancreatitis(PEP),perforation,abdominal pain,fever and infections.Technical success was defined as the rate of clearing pancreatic duct stones and clinical success as the improvement in pain.Randomeffects model was used for analysis.Heterogeneity between study-specific estimates was calculated using the Cochran Q statistical test and I2 statistics.Publication bias was ascertained,qualitatively by visual inspection of funnel plot and quantitatively by the Egger test.RESULTS A total of 16 studies including 383 patients met the inclusion criteria.The technical success rate of POP was 76.4%(95%CI:65.9-84.5;I2=64%)and clinical success rate was 76.8%(95%CI:65.2-85.4;I2=66%).The technical success rate of EHL was 70.3%(95%CI:57.8-80.3;I2=36%)and clinical success rate of EHL was 66.5%(95%CI:55.2-76.2;I2=19%).The technical success rate of LL was 89.3%(95%CI:70.5-96.7;I2=70%)and clinical success rate of LL was 88.2%(95%CI:66.4-96.6;I2=77%).The incidence of pooled adverse events for POP was 14.9%(95%CI:9.2-23.2;I2=49%),for EHL was 11.2%(95%CI:5.9-20.3;I2=15%)and for LL was 13.1%(95%CI:6.3-25.4;I2=31%).Subgroup analysis of adverse events showed rates of PEP at 7%(95%CI:3.5-13.6;I2=38%),fever at 3.7%(95%CI:2-6.9;I2=0),abdominal pain at 4.7%(95%CI:2.7-7.8;I2=0),perforation at 4.3%(95%CI:2.1-8.4;I2=0),hemorrhage at 3.4%(95%CI:1.7-6.6;I2=0)and no mortality.There was evidence of publication bias based on funnel plot analysis and Egger’s test.CONCLUSION Our study highlights the high technical and clinical success rates for POP,EHL and LL.POP-guided lithotripsy could be a viable option for management of chronic pancreatitis with PDC. | Syed M Saghir Harmeet S Mashiana Babu P Mohan Banreet S Dhindsa Amaninder Dhaliwal Saurabh Chandan Neil Bhogal Ishfaq Bhat Shailender Singh Douglas G Adler | 2020 | World Journal of Gastroenterology2020，26，34： | 5 |
| 2 | Development of a com- puter model for determination of cut off grade for metalliferous deposits显示文摘 | Mishra B Chandan B Sen P | 2006 | Journal of Mines Metals and Fuels2006，54，67： | 1 |
| 3 | Fixed Points in a Hopfield Model with Random Asymmetric Interactions 显示文摘 | Zhang Cheng-xiang Chandan Dasgupta | 1995 | Phys Rev1995，52，： | 1 |
| 4 | Retrieval Properties of a Hopfield Model with Random Asymmetric Interactions 显示文摘 | Chandan Dasgupta Singh M P | 2000 | Neural Computation2000，12，： | 1 |
| 5 | Hydrogenolysis of glyeerol to 1, 2-propanediol over nano-fibrous Ag-OMS-2 catalysts 显示文摘 | Yadav G D Chandan P A Tekale D P | 2011 | Industrial & Engineering Chemistry Research2011，51，4： | 1 |
| 6 | Prodction of cell - bound proteinase by lactobacillus bulgaricus and its location in the bacterial cell显示文摘 | ARGYLE P J MATHSON G E CHANDAN R C | 1976 | Applied Bacterial1976，41，： | 1 |
| 7 | Mercury isotope frac- tionation during aqueous photoreduction of monomethyhner- cury in the presence of dissolved organic matter显示文摘 | Chandan P Ghosh S Bergquist B A | 2014 | Environ- mental Science & Technology2014，49，1： | 1 |
| 8 | Antioxidant and redoxregulation of genetranscription显示文摘 | Lester P | 1996 | FASEB J1996，10，2： | 1 |
| 9 | Antioxidant and redoxregulation of genetranscription显示文摘 | Chandan KS Lester P | 1996 | FASAB J1996，10，： | 1 |
| 10 | Phosphorylation of SATB1,a global gene regulator,acts as a molecular switch regulating its transcriptional activity in vivo显示文摘 | Pavan Kumar P Prabhat Kumar Purbey Chandan Kumar Sinha | 2006 | Molecular Cell2006，22，： | 1 |
| 11 | Poly(amidoamine) Dendrimer-Based Multifunctional Engineered Nanodevice for Cancer Therapy显示文摘 | Istvan J M Thommey P T Chandan B M | 2005 | Journal of Medicinal Chemistry2005，48，： | 1 |
| 12 | Numbness over the distri-bution of trigeminal nerve-trigeminal trophic syndrome or viralneuritis: a diagnostic dilemma 显示文摘 | Patil P Chandan S Singh V | 2013 | J Craniofac Surg2013，24，4： | 1 |
| 13 | Antioxidant and redoxregulation of gene-transcription 显示文摘 | Chandan K S Lester P | 1996 | FASEBJ1996，10，： | 1 |
| 14 | Advances in CT imaging for urolithiasis显示文摘 | Yasir A Manuel P Chandan JD | 2015 | Indian J Urol2015，31，3： | 1 |
| 15 | Antioxidant and redox regula-tion of genetransription显示文摘 | Chandan KS Lester P | 1996 | FASEBJ1996，10，： | 1 |
| 16 | Production of ceil-bound proteinase by LactobaciUus bulgaricus and its location in the bacterial cell显示文摘 | ARGYLE P J MATHISON G E CHANDAN R C | 1976 | J Appl Bacteriol1976，41，： | 1 |
| 17 | Drug prescribing pattern and prescription error in elderly:A retrospective study of inpatient record显示文摘 | Sujata S Nawin P Chandan S | 2011 | Asian Journal of Pharmaceutical and Clinical Research2011，4，3： | 1 |
| 18 | Antioxidant and redoxregulation of genetranscription显示文摘 | Chandan KS Lester P | 1996 | FASEB J1996，10，： | 1 |
| 19 | Dynamic strain ageing of an austenitic superalloy: Temperature and strain rate effects显示文摘 | AJIT K R JOYDEEP P CHANDAN M | 2008 | Materials Science and Engi- neering A2008，474，12： | 1 |
| 20 | Comparison of two risk functions using the Pareto distribution显示文摘 | Chandan K P | 2004 | Pak J Statist2004，20，3： | 1 |
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