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| 1 | Endoscopic balloon catheter dilatation via retrograde or static technique is safe and effective for cricopharyngeal dysfunction显示文摘AIM To evaluate the safety and efficacy of upper esophageal sphincter(UES) dilatation for cricopharyngeal(CP) dysfunction. To determine if:(1) indication for dilatation; or(2) technique of dilatation correlated with symptom improvement.METHODS All balloon dilatations performed at our institution from over a 3-year period were retrospectively analyzed for demographics, indication and dilatation site. All dilatations involving the UES underwent further review to determine efficacy, complications, and factors that predict success. Dilatation technique was separated into static(stationary balloon distention) and retrograde(brusque pull-back of a fully distended balloon across the UES).RESULTS Four hundred and eighty-eight dilatations were reviewed. Thirty-one patients were identified who underwent UES dilatation. Median age was 63 years(range 27-81)and 55% of patients were male. Indications included dysphagia(28 patients), globus sensation with evidence of UES dysfunction(2 patients) and obstruction to echocardiography probe with cricopharyngeal(CP)bar(1 patient). There was evidence of concurrent oropharyngeal dysfunction in 16 patients(52%) and a small Zenker's diverticula(≤ 2 cm) in 7 patients(23%). Dilator size ranged from 15 mm to 20 mm. Of the 31 patients, 11 had dilatation of other esophageal segments concurrently with UES dilatation and 20 had UES dilatation alone.Follow-up was available for 24 patients for a median of 2.5 mo(interquartile range 1-10 mo), of whom 19 reported symptomatic improvement(79%). For patients undergoing UES dilatation alone, follow-up was available for 15 patients, 12 of whom reported improvement(80%).Nineteen patients underwent retrograde dilatation(84%response) while 5 patients had static dilatation(60%response); however, there was no significant difference in symptom improvement between the techniques(P = 0.5).Successful symptom resolution was also not significantly affected by dilator size, oropharyngeal dysfunction,Zenker's diverticulum, age or gender(P > 0.05). The only complication noted was uvular edema and a shallow ulcer after static dilatation in one patient, which resolved spontaneously and did not require hospital admission.CONCLUSION UES dilatation with a through-the-scope balloon by either static or retrograde technique is safe and effective for the treatment of dysphagia due to CP dysfunction. To our knowledge, this is the first study evaluating retrograde balloon dilatation of the UES. | Vinay Chandrasekhara Joyce Koh Lakshmi Lattimer Kerry B Dunbar William J Ravich John O Clarke | 2017 | World Journal of Gastrointestinal Endoscopy2017，9，4： | 6 |
| 2 | Fundus changes in pregnancy induced hypertension显示文摘AIM: To determine the prevalence of retinal changes in pregnancy induced hypertension (PIH) and any association between the retinal changes and blood pressure, proteinuria, and severity of the disease. METHODS: All the patients admitted with diagnosis of PIH were included in this study. Age, race, gravida, gestation period, blood pressure, and proteinuria were noted from the case records. After taking history for any eye symptoms, fundus examination was done after dilating the pupils with direct ophthalmoscope in the ward itself. All the findings were noted on a data sheet, and were analyzed using SPSS programme. RESULTS: A total of 78 patients of PIH were examined. Majority (75.6%) were Malays. The mean age of patients was 30.2 years (range 21-45 years). The gestation period ranged from 25 weeks to 41 weeks; 34 (43.5%) were primi gravida. Thirty (38.4%) patients had mild preeclampsia, 46 (59%) had severe preeclampsia and 2(2.5%) had eclampsia. Retinal changes (hypertensive retinopathy) were noted in 46 (59%) patients --- grade I in 41 (52.6%) and grade II in 5 (6.4%). Haemorrhages or exudates or retinal detachment were not seen in any patient. There was statistically significant positive association of retinal changes and blood pressure (P =0.001), proteinuria (P =0.018) and severity of the PIH (P =0.024). CONCLUSION: Retinal changes (grade I and II hypertensive retinopathy) were seen in 59% of patients with PIH and they were significantly associated with blood pressure, proteinuria and severity of the disease. Fundus examination helps in assessing the severity of PIH. | Sagili Chandrasekhara Reddy Sivalingam Nalliah Sheila Rani a/pKovil George Tham Seng Who | 2012 | International Journal of Ophthalmology(English edition)2012，5，6： | 3 |
| 3 | Detection of Circulating Pancreas Epithelial Cells in Patients with Pancreatic Cystic Lesions显示文摘 | Andrew D. Rhim Fredrik I. Thege Steven M. Santana Timothy B. Lannin Trisha N. Saha Shannon Tsai Lara R. Maggs Michael L. Kochman Gregory G. Ginsberg John G. Lieb Vinay Chandrasekhara Jeffrey A. Drebin Nuzhat Ahmad Yu- Xiao Yang Brian J. Kirby Ben Z. Stang | 2013 | Gastroenterology2013，，： | 3 |
| 4 | 他克莫司和吲哚美辛可安全有效降低肝移植患者经内镜逆行胰胆管造影术后胰腺炎发生率显示文摘肝移植术后胆管并发症的发生率高达25%,且通常需要经内镜逆行胰胆管造影(ERCP)介入治疗。胰腺炎(PEP)是ERCP术后最常见的不良事件。他克莫司(一种钙调神经磷酸酶抑制剂)和直肠吲哚美辛均有报告可降低ERCP术后PEP的发生风险。来自美国加州大学旧金山分校等机构的研究者进行了一项回顾性队列分析,探讨了肝移植患者接受ERCP诊治的PEP发生率和他克莫司和(或)吲哚美辛降低PEP风险的有效性。 | 李家速 方军 THIRUVENGADAM NR FORDE KA CHANDRASEKHARA V | 2020 | 临床肝胆病杂志2020，36，7： | 2 |
| 5 | Percutaneous transluminal angioplasty balloons for endoscopic ultrasound-guided pancreatic duct interventions显示文摘BACKGROUND Endoscopic ultrasound(EUS)-guided main pancreatic duct(PD)access may be used when conventional endoscopic retrograde cholangiopancreatography(ERCP)techniques fail.The use of a percutaneous transluminal angioplasty balloon(PTAB),originally developed for vascular interventions,can be used to facilitate transmural(e.g.,transgastric)PD access and to dilate high-grade pancreatic strictures.AIM To describe the technique,efficacy,and safety of PTABs for EUS-guided PD interventions.METHODS Patients who underwent EUS with use of a PTAB from March 2011 to August 2021 were retrospectively identified from a tertiary care medical center supply database.PTABs included 3-4 French angioplasty catheters with 3-4 mm balloons designed to use over a 0.018-inch guidewire.The primary outcome was technical success.Secondary outcomes included incidence of adverse events(AEs)and need for early reintervention.RESULTS A total of 23 patients were identified(48%female,mean age 55.8 years).Chronic pancreatitis was the underlying etiology in 13(56.5%)patients,surgically altered anatomy(SAA)with stricture in 7(30.4%),and SAA with post-operative leak in 3(13.0%).Technical success was achieved in 20(87%)cases.Overall AE rate was 26%(n=6).All AEs were mild and included 1 pancreatic duct leak,2 cases of post-procedure pancreatitis,and 3 admissions for post-procedural pain.No patients required early re-intervention.CONCLUSION EUS-guided use of PTABs for PD access and/or stricture management is feasible with an acceptable safety profile and can be considered in patients when conventional ERCP cannulation fails. | Jad P AbiMansour Barham K Abu Dayyeh Michael J Levy Andrew C Storm John A Martin Bret T Petersen Ryan J Law Mark D Topazian Vinay Chandrasekhara | 2022 | World Journal of Gastrointestinal Endoscopy2022，14，8： | 2 |
| 6 | End-stage renal disease is associated with increased post endoscopic retrograde cholangiopancreatography adverse events in hospitalized patients显示文摘AIM To determine if end-stage renal disease (ESRD) is a risk factor for post endoscopic retrograde cholangio-pancreatography (ERCP) adverse events (AEs). METHODS We performed a retrospective cohort study using the Nationwide Inpatient Sample (NIS) 2011-2013. We identified adult patients who underwent ERCP using the International Classification of Diseases 9^(th) Revision (ICD-9-CM). Included patients were divided into three groups: ESRD, chronic kidney disease (CKD), and control. The primary outcome was post-ERCP AEs including pancreatitis, bleeding, and perforation determined based on specific ICD-9-CM codes. Secondary outcomes were length of hospital stay, in-hospital mortality, and admission cost. AEs and mortality were compared using multivariate logistic regression analysis.RESULTS There were 492175 discharges that underwent ERCP during the 3 years. The ESRD and CKD groups contained 7347 and 39403 hospitalizations respectively, whereas the control group had 445424 hospitalizations. Post-ERCP pancreatitis (PEP) was significantly higher in the ESRD group (8.3%) compared to the control group (4.6%) with adjusted odd ratio (aOR) = 1.7 (95% CI: 1.4-2.1, ~aP < 0.001). ESRD was associated with significantly higher ERCP-related bleeding (5.1%) compared to the control group 1.5% (aOR = 1.86, 95%CI: 1.4-2.4, ~aP < 0.001). ESRD had increased hospital mortality 7.1% vs 1.15% in the control OR = 6.6 (95%CI: 5.3-8.2, ~aP < 0.001), longer hospital stay with adjusted mean difference (aMD) = 5.9 d (95% CI: 5.0-6.7 d, ~aP < 0.001) and higher hospitalization charges aMD = $+82064 (95%CI: $68221-$95906, ~aP < 0.001). CONCLUSION ESRD is a risk factor for post-ERCP AEs and is associated with higher hospital mortality. Careful selection and close monitoring is warranted to improve outcomes. | Tarek Sawas Fateh Bazerbachi Samir Haffar Won K Cho Michael J Levy John A Martin Bret T Petersen Mark D Topazian Vinay Chandrasekhara Barham K Abu Dayyeh | 2018 | World Journal of Gastroenterology2018，24，41： | 2 |
| 7 | Antibiotic Prophylaxis for Gi Endoscopy显示文摘 | Mouen A. Kashab Ruben D. Acosta David H. Bruining Vinay Chandrasekhara Krishnavel V. Chithadi Mohamad A. Eloubeidi Robert D. Fanelli S.A.G.E.S. Representative Ashley L. Faulx Lisa Fonkalsrud Jenifer R. Lightdale V. Raman Muthusamy Shabana F. Pasha John R. | 2014 | Gastrointestinal Endoscopy2014，，： | 2 |
| 8 | Superglue injuries of the eye显示文摘AIM: To report various ocular lesions caused by accidental instillation of superglue. METHODS: Three cases of ocular injuries are described in children aged 6 years, 3 years and 8 months, following accidental instillation of superglue in the eye. RESULTS: In the first case there was sticking of eyelashes in the medial 1/3 of eyelids in both eyes. In the second case sticking of eye lashes was present in the lateral 1/3 of eyelids in the left eye. In the third case, superglue was present on the right cheek, above the right ear and sticking of eyelids in medial 1/3 in right eye. The eyelids were separated by pulling the lid margins with fingers in the first case and later on superglue was removed by trimming the eyelashes; and by direct trimming the eyelashes in second and third cases. There was no injury to other structures of anterior segment in the first two cases. However, removal of the superglue on the cornea resulted in corneal abrasion in the third case which healed with medical treatment and patching of the right eye. CONCLUSION: Accidental instillation of superglue is possible because of the appearance of the tube like eye ointment tube. Immediate medical aid will prevent ocular morbidity. | Sagili Chandrasekhara Reddy | 2012 | International Journal of Ophthalmology(English edition)2012，5，5： | 2 |
| 9 | 内镜下胰管支架置入术用于缓解胰腺癌患者的疼痛:系统综述与meta分析显示文摘背景:腹痛是一种致人衰弱的症状,大约80%的胰腺癌患者都会出现腹痛。胰管减压虽然未被广泛采纳,但有报道该方法能缓解腹痛症状。本研究旨在评估内镜下胰管减压对于缓解胰腺癌患者餐后梗阻型腹痛的作用、效果及安全性。方法:该系统综述的文献检索时间截至2020年10月7日。由两位研究者独立地筛选文献、提取数据,并对文献质量进行评估。结果:12篇文献共计192例有腹痛症状且尝试胰管减压的胰腺癌患者纳入研究。其中,167例患者成功完成胰管减压(平均年龄62.5岁,58.7%为男性)。159(95.2%)例患者采用塑料支架。所有被纳入的研究均报道了胰管支架置入术后患者疼痛部分或完全缓解,缓解率为93%(95%CI:79%-100%)。平均的疼痛缓解期为94˘16天。内镜逆行性胰胆管造影(ERCP)相关的不良反应包括括约肌切开术后出血(1.8%)、ERCP后胰腺炎(0.6%)和胰管出血(0.6%)。2例行内镜超声引导的胰管减压患者未报道任何不良反应。在成功置入支架的167例患者中,支架移位和支架阻塞的发生率分别为3.6%和3.0%。未报道不良反应相关的死亡病例。文献质量评估提示,绝大部分文献质量较低或难以评价。结论:初步分析结果表明,对于部分经选择的胰腺癌病例,内镜下胰管引流可能是缓解梗阻型疼痛一种安全有效的方法。但该侵入性方法的作用尚需随机对照研究来进一步明确。 | Pradeep K.Siddappa Fadi Hawa Larry J.Prokop MHassan Murad Barham K.Abu Dayyeh Vinay Chandrasekhara Mark D.Topazian Fateh Bazerbachi | 2021 | Gastroenterology Report2021，9，2： | 2 |
| 10 | Guidelines for endoscopy in pregnant and lactating women显示文摘 | Amandeep K. Shergill Tamir Ben-Menachem Vinay Chandrasekhara Krishnavel Chathadi G. Anton Decker John A. Evans Dana S. Early Robert D. Fanelli Deborah A. Fisher Kimberly Q. Foley Norio Fukami Joo Ha Hwang Rajeev Jain Terry L. Jue Khalid M. Khan Jennifer L | 2012 | Gastrointestinal Endoscopy2012，，1： | 2 |
| 11 | Effect of black pepper and piperine on bile secretion and composition in rats显示文摘 | Bhat BG Chandrasekhara N | 1987 | Die Nahrung1987，31，： | 1 |
| 12 | Bioaugmentation of an anaerobic sequencing batch biofilm reactor (AnSBBR) with immobilized sul- phate reducing bacteria ( SRB ) for the treatment of sul- phate bearing chemical wastewater显示文摘 | Venkata Mohan S Chandrasekhara Rao N Krishna Prasad K | 2005 | Process Biochem2005，40，4： | 1 |
| 13 | The role of endoscopy in Barrett’s esophagus and other premalignant conditions of the esophagus显示文摘 | John A. Evans Dayna S. Early Norio Fukami Tamir Ben-Menachem Vinay Chandrasekhara Krishnavel V. Chathadi G. Anton Decker Robert D. Fanelli Deborah A. Fisher Kimberly Q. Foley Joo Ha Hwang Rajeev Jain Terry L. Jue Khalid M. Khan Jenifer Lightdale Phyllis M | 2012 | Gastrointestinal Endoscopy2012，，6： | 1 |
| 14 | Optimum Gurney flap height determination for' lost-lift' recovery in compressible dynamic stall control 显示文摘 | Chandrasekhara M S | 2010 | Aerospace Science and Technology2010，14，8： | 1 |
| 15 | Metaboli- sm of curcumin-studies with curcumin 显示文摘 | RAVINDRANATH V CHANDRASEKHARA N | 1982 | Toxicology1982，22，4： | 1 |
| 16 | Bioaug mentation of an anaerobic sequen eing batch biofilm reactor (AnSBBR)with immobilized sulphate reducing bacteria (SRB)for the treatment of sulphate bearing chemical wastewater 显示文摘 | Mohan S Venkata Rao N Chandrasekhara Prasad K Krishna | 2005 | Process Biochem2005，40，4： | 1 |
| 17 | The prevalence and associations of sleep disturbances in patients with systemic lupus erythematosus 显示文摘 | Chandrasekhara PK Jayachandran NV Rajasekhar L | 2009 | Mod Rheumato12009，19，4： | 1 |
| 18 | Endoscopic management of gastroin- testinal stromal tumors显示文摘 | Chandrasekhara V Ginsberg G G | 2011 | Curt Gastroenterol Rep2011，13，6： | 1 |
| 19 | Convergent approach for commercial synthesis of gefitinib and erlotinib显示文摘 | Chandregowda V Venkateshwara R G Chandrasekhara R G | 2007 | Org Process Res Dev2007，11，： | 1 |
| 20 | Improved synthesis of Gefitinib and Erlotinib hydrochloride -anti-cancer agents显示文摘 | Chandregowda V Venkateshwara Rao G Chandrasekhara R G | 2007 | Synth Commun2007，27，： | 1 |
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