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| 1 | Physiological levels of ATP negatively regulate proteasome function显示文摘由 ubiquitin-proteasome 系统的细胞内部的蛋白质降级是 ATP 依赖者,和最佳的 ATP 集中激活 proteasome 在 vitro 的功能是 ~ 100 渭 M。细胞内部的 ATP 层次在在这个范围以内的水平通常在低 millimolar 范围,而是 ATP 被显示在 vitro 禁止 proteasome peptidase 活动。这里,我们报导支持在生理的层次的细胞内部的 ATP 双向地调整的一个假设的新证据 26S proteasome 在房间的解朊的功能。首先,我们证实 ATP 在 vitro 在 26S proteasome 上施加了双向规定,与最佳的 ATP 集中(在 50 和 100 渭 M 之间) 刺激 proteasome 像糜蛋白酶的活动。第二,我们发现操作细胞内部的 ATP 层次也在有教养的房间在 proteasome 特定的蛋白质底层的层次导致了双向变化。最后,测量增加提高的细胞内部的 ATP,当减少的细胞内部的 ATP 稀释了导致房间死亡的 proteasome 抑制的能力时。这些数据强烈建议在生理的集中范围以内的内长的 ATP 能在 proteasome 活动施加否定影响,允许房间到很快,在应力下面的 ATP 减小上的 upregulate proteasome 活动调节。 | Hongbiao Huang Xiaoyan Zhang Shujue Li Ningning Liu Wen Elan Emily McDowell Ping Zhou Canguo Zhao Haiping Guo Change Zhang Changshan Yang Guangmei Wen Xiaoxian Dong Li Lu Ningfang Ma Weihua Dong Q Ping Dou Xuejun Wang Jinbao Liu | 2010 | Cell Research2010，20，12： | 4 |
| 2 | Molecular analysis of increased iron status in moderately exercised rats显示文摘 | LIU Y Q DUAN X L CHANG Y Z | 2006 | Mol Cell Bioehem2006，282，12： | 1 |
| 3 | Formulation development and bioavailability evaluation of a self nanoemulsified drug delivery system of oleanolie acid 显示文摘 | Xi J Chang Q Chan C K | 2009 | AAPS Pharm Sci Tech2009，10，1： | 1 |
| 4 | Large-scale fabrication of single-Crystalline Mn3O4 nanowires via vapor phase growth显示文摘 | D P Yu Y Long | 2005 | Journal of Crystal Growth2005，279，： | 1 |
| 5 | Prognostic relevance of immunophenotyping in 379 patients with acute myeloid leukemia 显示文摘 | Chang H Salma F Yi Q L | 2004 | Leuk Res2004，28，1： | 1 |
| 6 | Fabrication of poly ( DL-lactic acid ) / wollastonite composite films with surface modified β -CaSiO3 particles 显示文摘 | Ye L Z Chang J Ning C Q | 2008 | J Biomater Appl2008，22，： | 1 |
| 7 | A quick evaluating method for automotive fuel cell lifetime 显示文摘 | PEI P C CHANG Q F TANG T | 2008 | International Journal of Hydrogen Energy2008，33，： | 1 |
| 8 | On uniqueness of entire functions in C^n and their partial differential polynomials显示文摘 | BERNSTEIN C A CHANG D C LIB Q | 1996 | Forum Math1996，8，： | 1 |
| 9 | Isothermal start-up of pipeline transporting waxy crude oil显示文摘 | Cheng Chang Nguyen Q Dzuy Hans Petter R?nningsen | 1999 | J Non-Newtonian Fluid Mech1999，87，： | 1 |
| 10 | Simultaneous determination of purity and potency of amphotericin B by HPLC显示文摘 | Y Chang Y H Wang C Q Hu | 2011 | Journal of Antibiotics2011，64，： | 1 |
| 11 | New semi-frag- ile image authentication watermarking techniques using random bias and nonuniform quantization 显示文摘 | MAENO K SUN Q CHANG S | 2006 | IEEE Transactions on Multimedia2006，8，1： | 1 |
| 12 | Molecular analysis of PinX1 in medulloblastomas显示文摘 | Chang Q Pang J C Li J | 2004 | Int J Cancer2004，109，2： | 1 |
| 13 | Discovery of l-(4-(4-propio- nylpiperazin-I -yl) -3-( trifluoromethyl ) phenyl) -9-(quinolin-3-yl) benzol hi 显示文摘 | Liu Q Chang JW Wang J | 2010 | J Med Chem2010，53，19： | 1 |
| 14 | Absence of human papillo-mavirus in patients with breast cancer in north-west China 显示文摘 | CHANG P WANG T YAO Q | 2012 | Med Oncol2012，29，2： | 1 |
| 15 | Decellularized tracheal matrix scaffold for tissue engineering显示文摘 | Zang M Zhang Q Chang EI | | 0，，： | 1 |
| 16 | Novel self-diverting- acid developed for matrix stimulation显示文摘 | Chang F Frenier Q Q Novel W A | 2001 | SPE 650332001，，： | 1 |
| 17 | The physicochemical prop- erties of swelled maize starch granules complexed with lauric acid 显示文摘 | Chang F D He X W Huang Q | 2013 | Food Hydrocolloids2013，32，2： | 1 |
| 18 | Methanol and ethanol ekectrooxidation on Pt and Pd supported on carbon microspheres in alkaline media显示文摘 | Xu C W Chang L Q Shen P K | 2007 | Electrochem Commun2007，9，5： | 1 |
| 19 | Finite element model updating for the Kap Shui Mun cable stayed bridge 显示文摘 | Zhang Q W Chang T Y P Chang C C | 2001 | Journal of Bridge Engineering2001，6，4： | 1 |
| 20 | An advanced SVPWM-based predict -tive current controller for three-phase inverters in distribute1 generation systems显示文摘 | ZENG Q R CHANG L C | 2008 | IEEE Transactions on Industrial Elec - tronics2008，55，3： | 1 |
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