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| 1 | Clinical characteristics and prognostic factors of splenic abscess:A review of 67 cases in a single medical center of Taiwan显示文摘瞄准:在 19 年的一个时期期间在台湾的一个医学中心分析脾的脓肿的 67 个盒子。方法:从 1986 年 1 月到 2004 年 12 月,有脾的脓肿的 67 个病人的一个总数为回顾的学习被注册。临床的特征,内在的疾病,有机体系列,治疗学的方法, APACHE II 分数,和死亡率被分析。结果:与 54.1+/-14.1 年的吝啬的年龄有 41 男性和 26 女性。为 28.4% 的多重脾的脓肿(MSA ) 报道和在 71.6% 病人的独居的脾的脓肿。57 个病人(35.8%) 中的 26 个有额外的脾的脓肿,与肝(34.6%) 的领先的地点。微生物学文化在血文化在 58 个病人(86.6%) 是积极的,与 71.8% 并且 93.5% 在脓肿文化。与肺炎杆菌(22.4%) 的领先的病原体,支配的克否定杆菌(GNB ) 感染(55.2%) 由克跟随了积极球菌(GPC ) 感染(31%) 。脾切除术在 26 被执行在 21 的病人(38.8%) ,经皮的排水或渴望(31.3%) ,和在 20 个病人(29.9%) 独自一个的抗菌素治疗。最后, 67 个病人中的 12 个到期了(17.9 %) 。由统计,感染 GNB 的怒气是可能的与 GPC (P=0.036 ) 与感染相比开发多发性脓肿。有 GNB 感染(P=0.009 ) 和多发性脓肿(P=0.011 ) 的病人与 GPC 感染和独居的脓肿比病人经历了更高的死亡率。12 的吝啬的 APACHE II 分数到期了病人(16.3+/-3.2 ) 比 55 幸存(7.2+/-3.8 )(P<0.001 ) 的显著地高。结论:MSA, GNB 感染,和高 APACHE II 分数是差的预示的因素。当这些风险因素是在场的时,早外科的干预应该被鼓励。 | Kuo-Chin Chang Seng-Kee Chuah Chi-Sin Changchien Tung-Lung Tsai Sheng-Nan Lu Yi-Chun Chiu Yaw-Sen Chen Chih-Chi Wang Jui-Wei Lin Chuan-Mo Lee Tsung-Hui Hu | 2006 | World Journal of Gastroenterology2006，12，3： | 16 |
| 2 | Current status in the treatment options for esophageal achalasia显示文摘Recent advances in the treatment of achalasia include the use of high-resolution manometry to predict the outcome of patients and the introduction of peroral endoscopic myotomy(POEM).The first multicenter randomized,controlled,2-year follow-up study conducted by the European Achalasia Trial group indicated that laparoscopic Heller myotomy(LHM)was not superior to pneumatic dilations(PD).Publications on the long-term success of laparoscopic surgery continue to emerge.In addition,laparoscopic single-site surgery is applicable to advanced laparoscopic operations such as LHM and anterior fundoplication.The optimal treatment option is an ongoing matter of debate.In this review,we provide an update of the current progress in the treatment of esophageal achalasia.Unless new conclusive data prove otherwise,LHM is considered the most durable treatment for achalasia at the expense of increased reflux-associated complications.However,PD is the first choice for non-surgical treatment and is more costeffective.Repeated PD according to an'on-demand'strategy based on symptom recurrence can achieve long-term remission.Decision making should be based on clinical evidence that identifies a subcategory of patients who would benefit from specific treatment options.POEM has shown promise but its long-term efficacy and safety need to be assessed further. | Seng-Kee Chuah Chien-Hua Chiu Wei-Chen Tai Jyong-Hong Lee Hung-I Lu Chi-Sin Changchien Ping-Huei Tseng Keng-Liang Wu | 2013 | World Journal of Gastroenterology2013，19，33： | 15 |
| 3 | 2011 update on esophageal achalasia显示文摘There have been some breakthroughs in the diagnosis and treatment of esophageal achalasia in the past few years.First,the introduction of high-resolution manometry with pressure topography plotting as a new diagnostic tool has made it possible to classify achalasia into three subtypes.The most favorable outcome is predicted for patients receiving treatment for type Ⅱ achalasia (achalasia with compression).Patients with typeⅠ(classic achalasia) and type Ⅲ achalasia (spastic achalasia) experience a less favorable outcome.Second,the first multicenter randomized controlled trial published by the European Achalasia Trial group reported 2-year follow-up results indicating that laparoscopic Heller myotomy was not superior to endoscopic pneumatic dilation (PD).Although the follow-up period was not long enough to reach a convincing conclusion,it merits the continued use of PD as a generally available technique in gastroenterology.Third,the novelendoscopic technique peroral endoscopic myotomy is a promising option for treating achalasia,but it requires increased experience and cautious evaluation.Despite all this good news,the bottom line is a real break-through from the basic studies to identify the actual cause of achalasia that may impede treatment success is still anticipated. | Seng-Kee Chuah Pin-I Hsu Keng-Liang Wu Deng-Chyang Wu Wei-Chen Tai Chi-Sin Changchien | 2012 | World Journal of Gastroenterology2012，18，14： | 14 |
| 4 | Endoscope-guided pneumatic dilation for treatment of esophageal achalasia显示文摘Pneumatic dilation(PD) is considered to be the first line nonsurgical therapy for achalasia.The principle of the procedure is to weaken the lower esophageal sphincter by tearing its muscle fibers by generating radial force.The endoscope-guided procedure is done without fluoroscopic control.Clinicians usually use a lowcompliance balloon such as Rigiflex dilator to perform endoscope-guided PD for the treatment of esophageal achalasia.It has the advantage of determining mucosal injury during the dilation process,so that a repeat endoscopy is not needed to assess the mucosal tearing.Previous studies have shown that endoscope-guided PD is an efficient and safe nonsurgical therapy with results that compare well with other treatment modalities.Although the results may be promising,long-term follow-up is required in the near future. | Seng-Kee Chuah Tsung-Hui Hu Chi-Sin Changchien | 2010 | World Journal of Gastroenterology2010，16，4： | 9 |
| 5 | Endosonographic surveillance of 1-3 cm gastric submucosal tumors originating from muscularis propria显示文摘AIM To observe the natural course of 1-3 cm gastric submucosal tumors originating from the muscularis propria(SMTMPs).METHODS By reviewing the computerized medical records over a period of 14 years(2000-2013), patients with 1-3 cm gastric SMTMPs who underwent at least two endoscopic ultrasound(EUS) examinations were enrolled. Tumor progression was defined as a ≥ 1.2 times enlargement in tumor diameter observed during EUS surveillance. All patients were divided into stationary and progressive subgroups and further analyzed. We also reviewed the patients in the progressive subgroup again in 2016.RESULTS A total of 88 patients were studied, including 25 in the progressive subgroup. The mean time of EUS surveillance was 24.6 mo in the stationary subgroup and 30.7 mo in the progressive subgroup. Risk factors for tumor progression included larger tumor size and irregular border. Initial tumor size > 14.0 mm may be considered a cut-off size for predicting tumor progression. Seventeen patients underwent surgery, of whom 13 had gastrointestinal stromal tumors(GISTs) and 4 had leiomyomas. Tumor progression was found only in patients with GISTs. All of the tumors exhibited benign behaviors without metastasis until 2016.CONCLUSION Most 1-3 cm gastric SMTMPs(71.6%) are indolent. Tumor progression was found only in GISTs, and it is a good predictor for differentiating GISTs from leiomyomas. Predictors of tumor progression include larger tumor size(> 14.0 mm) and irregular border. | ming-luen hu keng-liang wu chi-sin changchien seng-kee chuah yi-chun chiu | 2017 | World Journal of Gastroenterology2017，23，12： | 9 |
| 6 | Upper gastrointestinal carcinoid tumors incidentally found by endoscopic examinations显示文摘AIM: This study shares Asian clinical experiences of carcinoid tumors that originated in the upper gastrointestinal tract.METHODS: From May 1987 to June 2002, we had found only 13 cases of histologically confirmed carcinoid tumors in the upper gastrointestinal tract by endoscopic examinations. There were eight males and five females.The mean age was 53.16±20.51 years that ranged from 26 to 82 years. Each of their clinical presentations,locations, tumor morphology, and size and the treatment outcome were analyzed and discussed.RESULTS: One patient had a polypoid lesion at the lower esophagus, nine were stomach lesions and three located at the duodenum. All patients with polypoid and submucosal tumor types were of small size (<1.7 cm) and all patients survived after simple excision or polypectomy.Four of the five patients in tumor mass forms died and the tumors were more than 2.0 cm in size.CONCLUSION: Carcinoid tumors rarely originated from the upper gastrointestinal tract and are usually found accidentally after endoscopic study. Bigger size (more than 2 cm) tumor masses may indicate a more severe disease and poor prognosis. | Tsung-Hui Hu Chung-Mou Kuo King-Wah Chiu Chung-Huang Kuo Keng-Liang Wu Yeh-Pin Chou Sheng-Nan Lu Shue-Shian Chiou Chi-Sin Changchien Hock-Liew Eng | 2005 | World Journal of Gastroenterology2005，11，44： | 5 |
| 7 | Delayed presentation of intrathoracic esophageal perforation after pneumatic dilation for achalasia显示文摘Pneumatic dilation(PD)is considered to be a safe and effective first line therapy for achalasia.The major adverse event caused by PD is esophageal perforation but an immediate gastrografin test may not always detect a perforation.It has been reported that delayed management of perforation for more than 24 h is associated with high mortality.Surgery is the treatment of choice within 24 h,but the management of delayed perforation remains controversial.Hereby,we report a delayed presentation of intrathoracic esophageal perforation following PD in a 48-year-old woman who suffered from achalasia.She completely recovered after intensive medical care.A review of the literature is also discussed. | Ming-Tzung Lin King-Wah Chiu Yeh-Pin Chou Ming-Chao Tsai Tsung-Hui Hu Chuan-Mo Lee Chi-Sin Changchien Seng-Kee Chuah | 2009 | World Journal of Gastroenterology2009，15，35： | 5 |
| 8 | Role of body mass index in colon cancer patients in Taiwan显示文摘AIM:To determine the effect of body mass index(BMI) on the characteristics and overall outcome of colon cancer in Taiwan.METHODS:From January 1995 to July 2003,2138 patients with colon cancer were enrolled in this study.BMI categories(in kg/m 2) were established according to the classification of the Department of Health of Taiwan.Postoperative morbidities and mortality,and survival analysis including overall survival(OS),diseasefree survival(DFS),and cancer-specific survival(CSS) were compared across the BMI categories.RESULTS:There were 164(7.7%) underweight(BMI < 18.5 kg/m 2),1109(51.9%) normal-weight(BMI = 18.5-23.9 kg/m 2),550(25.7%) overweight(BMI = 24.0-26.9 kg/m 2),and 315(14.7%) obese(BMI ≥27 kg/m 2) patients.Being female,apparently anemic,hypoalbuminemic,and having body weight loss was more likely among underweight patients than among the other patients(P < 0.001).Underweight patients had higher mortality rate(P = 0.007) and lower OS(P < 0.001) and DFS(P = 0.002) than the other patients.OS and DFS did not differ significantly between normal-weight,overweight,and obese patients,while CSS did not differ significantly with the BMI category.CONCLUSION:In Taiwan,BMI does not significantly affect colon-CSS.Underweight patients had a higher rate of surgical mortality and a worse OS and DFS than the other patients.Obesity does not predict a worse survival. | Chih-Chien Chin Yi-Hung Kuo Chien-Yuh Yeh Jinn-Shiun Chen Reiping Tang Chung-Rong Changchien Jeng-Yi Wang Wen-Shih Huang | 2012 | World Journal of Gastroenterology2012，18，31： | 4 |
| 9 | Sedation-associated hiccups in adults undergoing gastrointestinal endoscopy and colonoscopy显示文摘AIM:To investigate whether the incidence of hiccups in patients undergoing esophagogastroduodenoscopy (EGD) or same-day bidirectional endoscopy (EGD and colonoscopy;BDE) with sedation is different from those without sedation in terms of quantity,duration and typical onset time.METHODS:Consecutive patients scheduled for elective EGD or same-day BDE at the gastrointestinal endoscopy unit or the health examination center were allocated to two groups:EGD without sedation (Group A) and BDE with sedation (Group B).The use of sedation was based on the patients' request.Anesthesiologists participated in this study by administrating sedative drugs as usual.A single experienced gastroenterologist performed both the EGD and the colonoscopic examinations for all the patients.The incidence,duration and onset time of hiccups were measured in both groups.In addition,the association between clinical variables and hiccups were analyzed.RESULTS:A total of 435 patients were enrolled in the study.The incidences of hiccups in the patients with and without sedation were significantly different (20.5% and 5.1%,respectively).The use of sedation for patients undergoing endoscopy was still significantly associated with an increased risk of hiccups (adjusted odds ratio:8.79,P < 0.001) after adjustment.The incidence of hiccups in males under sedation was high (67.4%).The sedated patients who received 2 mg midazolam developed hiccups more frequently compared to those receiving 1 mg midazolam (P = 0.0028).The patients with the diagnosis of gastroesophageal reflux disease (GERD) were prone to develop hiccups (P = 0.018).CONCLUSION:Male patients undergoing EGD or BDE with sedation are significantly more likely to suffer from hiccups compared to those without sedation.Midazolam was significantly associated with an increased risk of hiccups.Furthermore,patients with GERD are prone to develop hiccups. | Chien Cheng Liu Cheng Yuan Lu Chih Fang Changchien Ping Hsin Liu Daw Shyong Perng | 2012 | World Journal of Gastroenterology2012，18，27： | 4 |
| 10 | The efficacy of treatment schedules according to Barcelona Clinic Liver Cancer staging for hepatocellular carcinoma – Survival analysis of 3892 patients显示文摘 | Jing-Houng Wang Chi-Sin Changchien Tsung-Hui Hu Chuan-Mo Lee Kwong-Ming Kee Chih-Yun Lin Chao-Long Chen Tai-Yi Chen Yu-Jie Huang Sheng-Nan Lu | 2008 | European Journal of Cancer2008，，7： | 4 |
| 11 | Pre-S Deletion and Complex Mutations of Hepatitis B Virus Related to Advanced Liver Disease in HBeAg-Negative Patients显示文摘 | Chien–Hung Chen Chao–Hung Hung Chuan–Mo Lee Tsung–Hui Hu Jing–Houng Wang Jyh–Chwan Wang Sheng–Nan Lu Chi–Sin Changchien | 2007 | Gastroenterology2007，，5： | 2 |
| 12 | Primary colorectal lymphoma显示文摘 | Chung-Wei Fan M.D. Dr. Chung Rong Changchien M.D. Jeng-Yi Wang M.D. Jinn-Shiun Chen M.D. Kuan-Cheng Hsu M.D. Reiping Tang M.D. Jy-Ming Chiang M.D | 2000 | Diseases of the Colon & Rectum2000，，9： | 2 |
| 13 | Hepatocellular carcinoma surveillance and appropriate treatment options improve survival for patients with liver cirrhosis显示文摘 | Yuan-Hung Kuo Sheng-Nan Lu Chao-Long Chen Yu-Fan Cheng Chih-Yun Lin Chao-Hung Hung Chien-Hung Chen Chi-Sin Changchien Hsuan-Chih Hsu Tsung-Hui Hu Chuan-Mo Lee Jing-Houng Wang | 2009 | European Journal of Cancer2009，，4： | 2 |
| 14 | FibroScan and ultrasonography in the prediction of hepatic fibrosis in patients with chronic viral hepatitis显示文摘 | Jing-Houng Wang Chi-Sin Changchien Chao-Hung Hung Hock-Liew Eng Wei-Chih Tung Kwong-Ming Kee Chien-Hung Chen Tsung-Hui Hu Chuan-Mo Lee Sheng-Nan Lu | 2009 | Journal of Gastroenterology2009，，5： | 2 |
| 15 | Morphological and microcirculatory evaluation of the rat testis after detorsion with or without a capsular release with a tunica vaginalis flap显示文摘阴囊的扭转可以导致严肃的局部缺血,并且生存能力取决于扭转的持续时间和 ischemia-reperfusion 的效果。阴囊的解压缩和 tunica vaginalis 拍动应用程序技术被 Kutikov 等在 2008 介绍。我们试图在一个老鼠模型在阴囊的 microcirculation 和 hemorheological 参数上检验这个方法的影响。六只成年老鼠经历了双边的阴囊的探索。睾丸的 Intravaginal 扭转被 720 ° 创造;为 2 h 的双方上的旋转。在 detorsion 以后,正确睾丸经历了 tunica albuginea 切口和 tunica vaginalis 拍动申请。阴囊的 microcirculation 被监视, hematological 参数,红血球 deformability,和聚集是坚定的。大小在扭转前后被执行,直接在 detorsion 以后,在 1 st -2 nd 和 8 th 手术后的白天。在最后采样以后,睾丸被移开为组织学的考试决定他们的体积。microcirculatory 参数表明了睾丸之间的细微差别。睾丸与中间的地区相比提高了的左(nondecompressed ) 的顶端的地区(P <0.05 ) 。在 2 nd 和 8 th 白天,睾丸的 microcirculation 使正常化然而并非同等地。红血球聚集和 deformability 由 8 th 白天。睾丸经历了萎缩和上皮的坏死,但是减压的体积更低(1.07 ±0.08 对 1.25 ±0.31 ) 。组织学地,在上皮的损坏分数在之间没有重要差别减压并且 nondecompressed 睾丸。在结论, 2-h 局部缺血两个都在阴囊的 microcirculation,在体积的减小,在 hemorheological 参数的变化和严肃的上皮的坏死导致了改变在减压并且没有显著差别的 nondecompressed 睾丸。 | Tamas Jozsat Zoltan Klarik Ferenc Kiss Eniko Toth Anita Mester Zoltan Hargitai Yi-Che Changchien Magdalena Fossum Norbert Nemeth | 2016 | Asian Journal of Andrology2016，18，3： | 2 |
| 16 | Pseudoachalasia in a patient after truncal vagotomy surgery successfully treated by subsequent pneumatic dilations显示文摘Pseudoachalasia 是一个困难的条件让临床医生甚至由测压法,放射学的研究或内视镜检查法区分开来与自发的弛缓不能。它的病原学通常与肿瘤被联系。在大多数情况中,诊断在外科的探索以后被做。疾病的建议致病被看作远侧的食管的机械阻塞或在盒子的多数影响 meyenteric 丛的禁止的神经原的恶意的渗入。外科作为 pseudoachalasia 的一个原因被报导了。我们报导受不了 pseudo-achalasia 在树干的迷走神经切断术以后引起的 deglutination 混乱的一个 70 岁的人。病人在九年的后续和从在灵魂膨胀以后的 pseudoachalasia 的食道的活动性地位的完全的恢复以后是没有症状的。我们也考察了 pseudoachalasia 的文学。 | Seng-Kee Chuah Chung-Mou Kuo Keng-Liang Wu Chi-Sin Changchien Tsung-Hui Hu Chi-Chih Wang Yi-Chun Chiu Yeh-Pin Chou Pin-I Hsu King-Wah Chiu Chung-Huang Kuo Shue-Shian Chiou Chuan-Mo Lee | 2006 | World Journal of Gastroenterology2006，12，31： | 2 |
| 17 | Down-regulation of tumor suppressor gene PTEN, overexpression of p53,plus high proliferating cell nuclear antigen index predict poor patient outcomeof hepatocellular carcinoma after resection显示文摘 | Tsung-Hui Hu Chih-Chi Wang Chao-Cheng Huang Chao-Long Chen Chao-Hung Hung Chien-Hung Chen Jing-Houng Wang Sheng-Nan Lu Chuan-Mo Lee Chi-Sin Changchien Ming-Hong Tai | 2007 | Oncology Reports2007，，： | 2 |
| 18 | Correlation between ultrasonographic and pathologic diagnoses of hepatitis B and C virus-related cirrhosis显示文摘 | Chao-Hung Hung Sheng-Nan Lu Jing-Houng Wang Chuan-Mo Lee Tsung-Ming Chen Hung-Da Tung Chien-Hung Chen Wu-Shiung Huang Chi-Sin Changchien | 2003 | Journal of Gastroenterology2003，，2： | 1 |
| 19 | A modified TNM- based Japan Integrated Score combined with AFP level may serve as a better staging system for early-stage predominant hepatocellular carcinoma patients 显示文摘 | Yen YH Changchien CS Wang JH | 2009 | Dig Liver Dis2009，41，6： | 1 |
| 20 | A modified TNM-based Japan Integrated Score combined with AFP level may serve as a better staging system for early-stage predominant hepatocellular carcinoma patients显示文摘 | Yen YH Changchien CS Wang JH | 2009 | Dig Liver Dis2009，41，6： | 1 |
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