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| 1 | NAD+metabolism:pathophysiologic mechanisms and therapeutic potential显示文摘Nicotinamide adenine dinucleotide(NAD^(+))and its metabolites function as critical regulators to maintain physiologic processes,enabling the plastic cells to adapt to environmental changes including nutrient perturbation,genotoxic factors,circadian disorder,infection,inflammation and xenobiotics.These effects are mainly achieved by the driving effect of NAD^(+)on metabolic pathways as enzyme cofactors transferring hydrogen in oxidation-reduction reactions.Besides,multiple NAD^(+)-dependent enzymes are involved in physiology either by post-synthesis chemical modification of DNA,RNA and proteins,or releasing second messenger cyclic ADPribose(cADPR)and NAADP^(+).Prolonged disequilibrium of NAD^(+)metabolism disturbs the physiological functions,resulting in diseases including metabolic diseases,cancer,aging and neurodegeneration disorder.In this review,we summarize recent advances in our understanding of the molecular mechanisms of NAD^(+)-regulated physiological responses to stresses,the contribution of NAD^(+)deficiency to various diseases via manipulating cellular communication networks and the potential new avenues for therapeutic intervention. | Na Xie Lu Zhang Wei Gao Canhua Huang Peter Ernst Huber Xiaobo Zhou Changlong Li Guobo Shen Bingwen Zou | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 5 |
| 2 | Caching resource management of mobile edge network based on Stackelberg game显示文摘Mobile edge caching technology is gaining more and more attention because it can effectively improve the Quality of Experience (QoE) of users and reduce backhaul burden. This paper aims to improve the utility of mobile edge caching technology from the perspectie of caching resource management by examining a network composed of one operator, multiple users and Content Providers (CPs). The caching resource management model is constructed on the premise of fully considering the QoE of users and the servicing capability of the Base Station (BS). In order to create the best caching resource allocation scheme, the original problem is transformed into a multi-leader multi-follower Stackelberg game model through the analysis of the system model. The strategy combinations and the utility functions of players are analyzed. The existence and uniqueness of the Nash Equilibrium (NE) solution are also analyzed and proved. The optimal strategy combinations and the best responses are deduced in detail. Simulation results and analysis show that the proposed model and algorithm can achieve the optimal allocation of caching resource and improve the QoE of users. | Qiang Li Changlong Lu Bin Cao Qinyu Zhang | 2019 | Digital Communications and Networks2019，5，1： | 2 |
| 3 | Influences of Reservoir Heterogeneity and Anisotropy on CO_2 Sequestration and Heat Extraction for CO_2-Based Enhanced Geothermal System显示文摘Enhanced geothermal systems(EGS) have a great potential to extract geothermal energy and have attracted much interest. In this paper, based on a 3D thermal-hydrologic model considering CO_2 sequestration, the influences of reservoir heterogeneity and anisotropy on CO_2 sequestration and heat extraction in CO_2-based EGS are investigated. Different heterogeneous reservoirs and homogeneous reservoir are compared, and different ratios among reservoir permeability components are compared. The results show that greater reservoir heterogeneity enhances CO_2 sequestration and restrains heat extraction. Higher ratio between horizontal(x and y directions) and vertical permeability components enhances CO_2 sequestration and heat extraction, and vertical permeability component has a little effect. With the increasing ratio between x-directional(perpendicular to the line of the injection well and the production well) and y-directional(perpendicular to x direction) reservoir permeability components(i.e. kx:ky), both CO_2 sequestration amount and steady-state heat extraction rate first increase and then decrease, and thermal breakthrough time increases, showing that there exists an optimum kx:ky, which is about 1:1. The results of this paper indicate that reservoir heterogeneity and anisotropy have important influences on CO_2 sequestration and heat extraction. | WANG Changlong HUANG Zhijia LU Yuehong TANG Gang LI Huan | 2019 | Journal of Thermal Science2019，28，2： | 1 |
| 4 | High-frequency enhanced response based on Sb_(2)Te_(3)topological insulators显示文摘Topological insulators represent a new quantum phase of matter with spin-polarized surface states that are protected from backscattering, exhibiting electronic responses to light, such as topological quantum phase transitions. However, the effects of high-frequency driving topological intrinsic systems have remained largely unexplored challenges experimentally for high-sensitivity terahertz detection. In this study, by integrating Sb2Te3 topological insulators with subwavelength metal antennas through micro-nano processing, a high-frequency terahertz detector with high sensitivity is proposed. The enhanced response originates from the asymmetric scattering of the surface electrons in the Sb_(2)Te_(3) flakes induced by the terahertz wave. The device displays room-temperature photodetection with a responsivity of 192 mA/W and equivalent noise power of less than 0.35 nW/Hz^(1/2) in the frequency range from 0.02 to 0.3 THz. These results pave the way for the exploitation of topological insulators for high-frequency operation in real-time imaging within long-wavelength optoelectronics. | SHI ZHANG CHAOFAN SHI WEIWEI TANG LIBO ZHANG LI HAN CHENGSEN YANG ZHENGYANG ZHANG JIAN WANG MIAO CAI GUANHAI LI CHANGLONG LIU LIN WANG XIAOSHUANG CHEN WEI LU | 2022 | Photonics Research2022，10，10： | 1 |
| 5 | Nucleic acids analysis显示文摘Nucleic acids are natural biopolymers of nucleotides that store, encode, transmit and express genetic information, which play central roles in diverse cellular events and diseases in living things. The analysis of nucleic acids and nucleic acids-based analysis have been widely applied in biological studies, clinical diagnosis, environmental analysis, food safety and forensic analysis.During the past decades, the field of nucleic acids analysis has been rapidly advancing with many technological breakthroughs.In this review, we focus on the methods developed for analyzing nucleic acids, nucleic acids-based analysis, device for nucleic acids analysis, and applications of nucleic acids analysis. The representative strategies for the development of new nucleic acids analysis in this field are summarized, and key advantages and possible limitations are discussed. Finally, a brief perspective on existing challenges and further research development is provided. | Yongxi Zhao Xiaolei Zuo Qian Li Feng Chen Yan-Ru Chen Jinqi Deng Da Han Changlong Hao Fujian Huang Yanyi Huang Guoliang Ke Hua Kuang Fan Li Jiang Li Min Li Na Li Zhenyu Lin Dingbin Liu Juewen Liu Libing Liu Xiaoguo Liu Chunhua Lu Fang Luo Xiuhai Mao Jiashu Sun Bo Tang Fei Wang Jianbin Wang Lihua Wang Shu Wang Lingling Wu Zai-Sheng Wu Fan Xia Chuanlai Xu Yang Yang Bi-Feng Yuan Quan Yuan Chao Zhang Zhi Zhu Chaoyong Yang Xiao-Bing Zhang Huanghao Yang Weihong Tan Chunhai Fan | 2021 | Science China Chemistry2021，64，2： | 1 |
| 6 | Metabolic profile of chiral cobalt oxide nanoparticles in vitro and in vivo显示文摘In this study,we investigated the in vivo behaviors of chiral cobalt oxide nanoparticles(Co_(3)O_(4) NPs)stabilized with D-or L-cysteine(denoted D-or L-NPs,respectively),as representative chiral metal oxide NPs.Chiral Co_(3)O_(4) NPs exerted no observable cytotoxicity within the tested dose range.Both D-NPs and L-NPs were internalized by dendritic cells through caveola-dependent endocytosis,and L-NPs entered the cells faster than D-NPs.Significantly,a metabolic analysis indicated that chiral L-NPs had the same effect on the level of bile acids in the liver as D-NPs,which is attributed to the almost equal amount of farnesoid X receptor(FXR)induced by the chiral NPs.This study suggests that low chiroptical activity nanomaterials would not affect the metabolism and kinetics under physiological conditions even if there is some difference in their transport. | Si Li Liwei Xu Meiru Lu Maozhong Sun Liguang Xu Changlong Hao Xiaoling Wu Chuanlai Xu Hua Kuang | 2021 | Nano Research2021，14，7： | 0 |
| 7 | Differential protein expression in low-grade astrocytomas and peritumoral human brain tissues显示文摘Differential protein expression between various pathological grades of glioma has been shown in studies of glioma proteomics. However,very little data is available regarding normal brain tissues and glioma differential protein expression,because normal human brain tissues are difficult to harvest. The present study selected samples from low-grade astrocytomas and peritumoral brain tissues to analyze differential protein expression by two-dimensional(2D) electrophoresis and mass spectrometry techniques. Results revealing 36 protein spots by 2D electrophoresis,including 23 spots revealing increased expression and 13 spots revealing decreased expression. However,25 differential proteins were identified by mass spectrometry,including 16 proteins with increased expression and 9 with decreased expression. Western blot analysis confirmed the mass spectrometry results,i.e.,heat shock protein 70(HSP70) and human transthyretin(TTR) expressions were increased,but glial fibrillary acidic protein(GFAP) was decreased,in astrocytomas. The present study constructed a 2D electrophoresis pattern between low-grade astrocytomas in the human brain and peritumoral tissues. Results demonstrated that a majority of differential proteins,such as HSP70,TTR,and GFAP,participate in malignant progression of gliomas. | Guangzhong Xiong Huisheng Xiao Junxian Lu Dongshan Zhang Changlong Bi Li Peng Ge Xiong Li Xiong Ping Chen Songping Liang | 2010 | Neural Regeneration Research2010，5，24： | 0 |
| 8 | Highly efficient hydrogen peroxide electrosynthesis on oxidized carbon nanotubes by thermally activated-persulfate显示文摘Electrochemical synthesis of hydrogen peroxide(H_(2)O_(2))through two-electron oxygen reduction represents an attractive alternative for on-site H_(2)O_(2) generation.Here,we develop a facile thermally activatedpersulfate approach to obtain oxidized carbon nanotubes(O-CNTs-x,x represents oxidation time)with enhanced H_(2)O_(2) electrosynthesis performance.Electrochemical studies have demonstrated that the optimized O-CNTs-6(i.e.,oxidation time is 6 h)could deliver a sustained high selectivity of around 92%for H_(2)O_(2) over a wide voltage window in 0.1 mol/L KOH and a high H_(2)O_(2) production rate of 296.84 mmol/L g^(-1) cat h^(-1).Compared with pristine CNTs,the enhanced catalytic activity primarily stems from the newly-generated oxygen-containing functional groups and some defects created on the surface of O-CNTs-x.Importantly,the proposed oxidation process is proved to be valid for promoting H_(2)O_(2) electrosynthesis performance of the Ketjen black.This study provides an universal oxidation method to obtain highly active carbon-based catalysts and initiates new opportunities for the exploration of highperformance electrosynthesis H_(2)O_(2) catalysts. | Wendong Liu Changlong Li Guanqing Ding Guangbin Duan Yuanyuan Jiang Yizhong Lu | 2022 | Journal of Materiomics2022，8，1： | 0 |
| 9 | Protein Kinase C Controls the Excitability of Cortical Pyramidal Neurons by Regulating Kv2.2 Channel Activity显示文摘The family of voltage-gated potassium Kv2 channels consists of the Kv2.1 and Kv2.2 subtypes.Kv2.1 is constitutively highly phosphorylated in neurons and its function relies on its phosphorylation state.Whether the function of Kv2.2 is also dependent on its phosphorylation state remains unknown.Here,we investigated whether Kv2.2 channels can be phosphorylated by protein kinase C(PKC)and examined the effects of PKC-induced phosphorylation on their activity and function.Activation of PKC inhibited Kv2.2 currents and altered their steadystate activation in HEK293 cells.Point mutations and specific antibodies against phosphorylated S481 or S488 demonstrated the importance of these residues for the PKC-dependent modulation of Kv2.2.In layer Ⅱ pyramidal neurons in cortical slices,activation of PKC similarly regulated native Kv2.2 channels and simultaneously reduced the frequency of action potentials.In conclusion,this study provides the first evidence to our knowledge that PKC-induced phosphorylation of the Kv2.2 channel controls the excitability of cortical pyramidal neurons. | Zhaoyang Li Wenhao Dong Xinyuan Zhang Jun-Mei Lu Yan-Ai Mei Changlong Hu | 2022 | Neuroscience Bulletin2022，38，2： | 0 |
| 10 | Characteristics of Gas-Liquid Slug Flow in Microchannel by Instantaneous Liquid Film Thickness Measurement显示文摘This paper seeks to decipher the exact relationship between the liquid film thickness and the hydrodynamics of gas-liquid slug flows. An instantaneous measurement system is developed by integrating the laser focus displacement meter(LFDM) and high-speed camera to characterize the temporal evolution of the liquid film and the dynamic characteristics of continuous slug flows. A glass tube with internal diameter of 0.75 mm is used and the tested ranges of superficial gas and liquid velocities are 0.01–1.2 m/s and 0.01–0.09 m/s respectively. The non-zero signals of LFDM representing the bubble slug flows changed from regular periodic intervals to chaotic fluctuations when slug-annular flow pattern appears. The dominant frequencies of the periodic intermittent slug flows increased from about 0.5–2 Hz to nearly 10–20 Hz as the superficial gas velocity rised from 0.025 to 0.78 m/s. The bubble and liquid slug lengths calculated by the time interval of liquid film thickness and bubble velocity correlated well with the empirical model. Meantime, the average value of void fraction derived from the calculation of transient liquid film thickness shows a linear growth with the gas holdup ratio. | SUN Yanhong CHEN Wenjie LU Jinli WANG Changlong | 2022 | Journal of Thermal Science2022，31，4： | 0 |
| 11 | TRIM21-dependent ultrasmall chiral gold nanoparticles for preventing microglia senescence against Alzheimer's disease显示文摘Tripartite motif 21(TRIM21)is an E3 ubiquitin ligase that shows great promise for protein degradation through ubiquitination.Here,ultrasmall chiral gold nanoparticles(D-or L-NPs)modified by D-or L-glutathione ligands were fabricated.After conjugated with an NLR family pyrin domain-containing protein 3(NLRP3)antibody(D-NP-a NLRP3 or L-NP-a NLRP3),DNP-a NLRP3 showed effective delivery efficiency of the antibody into microglia and prevented Aβ-mediated microglia senescence,and p16^(ink4a),a marker of senescence,in the microglia was reduced by 90.3%±7.8% while L-NP-a NLRP3 decreased by 48.01%±3.1%.Mechanistic investigations revealed that the D-NP-a NLRP3((1.5±0.3)×10^(7)M^(-1))exhibited sixteen-fold larger binding affinity to transmembrane glycoprotein SLC3A2 than L-type((9.5±2.7)×10^(5)M^(-1)),which led to a high efficiency of antibody delivery and TRIM21-dependent NLRP3 degradation.Notably,the blood-brain barrier(BBB)-crossing ability of chiral NP-a NLRP3 as well as NLRP3 degradation was demonstrated in vivo.The APP/PS1 Alzheimer's disease(AD)model mice experiments exhibited a reduction of 89.7%±6.8% for the NLRP3 protein and 84.2±7.5% for p16^(ink4a)following the intravenous administration of D-NP-a NLRP3 once a week for 60 days.Furthermore,the levels of the AD markers Aβ and phosphorylatedTau in the brains were reduced by 86.2%±8.2% and 81.6%±9.1%;these were 2.1-fold and 1.9-fold higher than those treated with L-NP-a NLRP3,respectively.The studies provide a method to rescue AD-like pathologies and prevent senescence. | Meiru Lu Changlong Hao Liguang Xu Feng Yu Jiwei Jiang Yanli Wang Jun Xu Hua Kuang Chuanlai Xu Maozhong Sun | 2024 | Science China Chemistry2024，67，4： | 0 |
| 12 | Chiral Cu_(x)Co_(y)S Supraparticles Ameliorate Parkinson’s Disease显示文摘Protein aggregation causes alpha-synuclein(α-syn)to change from its original physiological role to a pathological state,which is a potential pathogenic mechanism in Parkinson’s disease(PD).Chiral _(L/D)-Cu_(x)Co_(y)S supraparticles(_(L/D)-SPs)with a circular dichroism value of 35 mdeg at 805 nm were fabricated using a simple wet-chemical method.The _(L/D)-SPs prevented the α-syn monomers from forming fibrils and triggered the α-syn fibrils to turn into monomers under 808 nm near-infrared(NIR)light.In living MN9D cells,D-SPs reduced cellular damage,neuronal functional deficits,and neuron loss caused by α-syn fibrils after NIR spectroscopy treatment within 10 min to prevent α-syn aggregation.Significantly,the reactive oxygen species produced by _(D)-SPs were 1.42 times higher than those produced by _(L)-SPs.In vivo experiments showed that _(D)-SPs had a protective effect on neuron damage caused by α-syn aggregate deposition,reduced the symptoms in a mouse model of PD,and restored cognitive ability.After NIR light treatment,the amount of α-syn in a mouse model of PD decreased by more than 67.5%.At the same time,_(D)-SPs gradually decomposed into small nanoparticleswithin 60 days and were excreted through the blood-brain barrier.This discovery paves theway for the treatment of neurodegenerative diseases using chiral SPs under NIR light irradiation. | Baimei Shi Aihua Qu Weiwei Wang Meiru Lu Zhuojia Xu Chen Chen Changlong Hao Maozhong Sun Liguang Xu Chuanlai Xu Hua Kuang | 2022 | CCS Chemistry2022，4，7： | 0 |
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