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您的检索式：作者名="Changning BAI"
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| 1 | Adhesion and friction performance of DLC/rubber:The influence of plasma pretreatment显示文摘Diamond-like carbon(DLC)films are deposited on rubber surfaces to protect the rubber components,and surface pretreatment of the rubber substrates prior to the film deposition can improve the adhesion between the DLC films and the rubber.Thus,the principal purpose of this work concentrates on determining the effects of argon(Ar),oxygen(O_(2)),nitrogen(N_(2)),and hydrogen(H_(2))plasma pretreatments on the adhesion and friction performance of the DLC films deposited on rubber(DLC/rubber).The results indicated that the Ar plasma pretreatment promoted the formation of a compact layer on the rubber surface.By contrast,massive fillers were exposed on the rubber surface after oxygen or nitrogen plasma pretreatments.Moreover,the typical micrometer-scale patches divided by random cracks were observed on the surface of DLC/rubber,except for the sample pretreated with oxygen plasma.The adhesion of DLC/rubber was found to strengthen with the removal of weak boundary layers and the generation of free radicals on the rubber surface after plasma pretreatment.The tribo-tests revealed that DLC/rubber with O_(2),N_(2),and H_(2) plasma pretreatments cannot achieve optimal friction performance.Significantly,DLC/rubber with Ar plasma pretreatment exhibited a low and stable friction coefficient of 0.19 and superior wear resistance,which was correlated to the high adhesion,good load-bearing of the rubber surface,and the approximate sine function of the surface profile of the DLC film. | Changning BAI Zhenbin GONG Lulu AN Li QIANG Junyan ZHANG Georgy YUSHKOV Alexey NIKOLAEV Maxim SHANDRIKOV Bin ZHANG | 2021 | Friction2021，9，3： | 2 |
| 2 | Optimizing the tribological performance of DLC-coated NBR rubber:The role of hydrogen in films显示文摘Diamond-like carbon(DLC)films directly deposited on rubber substrate is undoubtedly one optimal option to improve the tribological properties due to its ultralow friction,high-hardness as well as good chemical compatibility with rubber.Investigating the relationship between film structure and tribological performance is vital for protecting rubber.In this study it was demonstrated that the etching effect induced by hydrogen incorporation played positive roles in reducing surface roughness of DLC films.In addition,the water contact angle(CA)of DLC-coated nitrile butadiene rubber(NBR)was sensitive to the surface energy and sp?carbon clustering of DLC films.Most importantly,the optimum tribological performance was obtained at the 29 at%H-containing DLC film coated on NBR,which mainly depended on the following key factors:(1)the DLC film with appropriate roughness matched the counterpart surface;(2)the contact area and surface energy controlled interface adhesive force;(3)the microstructure of DLC films impacted load-bearing capacity;and(4)the generation of graphitic phase acted as a solid lubricant.This understanding may draw inspiration for the fabrication of DLC films on rubber to achieve low friction coefficient. | Changning BAI Li QIANG Bin ZHANG Kaixiong GAO Junyan ZHANG | 2022 | Friction2022，10，6： | 0 |
| 3 | Development of a potential PET probe for HDAC6 imaging in Alzheimer's disease显示文摘Although the epigenetic regulatory protein histone deacetylase 6(HDAC6)has been recently implicated in the etiology of Alzheimer’s disease(AD),little is known about the role of HDAC6 in the etiopathogenesis of AD and whether HDAC6 can be a potential therapeutic target for AD.Here,we performed positron emission tomography(PET)imaging in combination with histopathological analysis to better understand the underlying pathomechanisms of HDAC6 in AD.We first developed[^(18)F]PB118 which was demonstrated as a valid HDAC6 radioligand with excellent brain penetration and high specificity to HDAC6.PET studies of[^(18)F]PB118 in 5xFAD mice showed significantly increased radioactivity in the brain compared to WT animals,with more pronounced changes identified in the cortex and hippocampus.The translatability of this radiotracer for AD in a potential human use was supported by additional studies,including similar uptake profiles in non-human primates,an increase of HDAC6 in ADrelated human postmortem hippocampal tissues by Western blotting protein analysis,and our ex vivo histopathological analysis of HDAC6 in postmortem brain tissues of our animals.Collectively,our findings show that HDAC6 may lead to AD by mechanisms that tend to affect brain regions particularly susceptible to AD through an association with amyloid pathology. | Ping Bai Prasenjit Mondal Frederick A.Bagdasarian Nisha Rani Yan Liu Ashley Gomm Darcy R.Tocci Se Hoon Choi Hsiao-Ying Wey Rudolph E.Tanzi Can Zhang Changning Wang | 2022 | Acta Pharmaceutica Sinica B2022，12，10： | 0 |
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