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| 1 | Immune checkpoint inhibitors for treatment of advanced gastric or gastroesophageal junction cancer:Current evidence and future perspectives显示文摘Despite the application of conventional therapies,the prognosis of advanced gastric cancer(GC)or gastroesophageal junction cancer(GEJC)is still poor.In recent years,immune checkpoint inhibitors(ICIs)have reshaped the paradigm of cancer therapy.Emerging evidence support the feasibility of programmed cell death-1(PD-1)and its ligand(PD-L1)inhibition in chemo-refractory GC/GEJC.Nivolumab and pembrolizumab have initially been approved in Japan and United States,respectively for the third-line treatment of progressive GC or GEJC.In March 2020,nivolumab has also been licensed in China for treating advanced GC/GEJC who received≥2 lines of systemic therapies.Current studies are moving forward to the first-line application or focusing on combination strategies,though data are insufficient and disputable.In this review,we summarize the recently reported and ongoing clinical trials in ICIs for advanced GC/GEJC.Molecular characteristics and clinical implications of different tumor subtypes are also reviewed.We further discuss the safety profile and biomarkers for predicting the response of ICIs,which has guiding values in clinical practice. | Zhening Zhang T ong Xie Xiaotian Zhang Changsong Qi Lin Shen Zhi Peng | 2020 | Chinese Journal of Cancer Research2020，32，3： | 10 |
| 2 | Clinical characteristics of 310 SARS-CoV-2 Omicron variant patients and comparison with Delta and Beta variant patients in China显示文摘Although the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)Omicron variant has spread,data on the clinical characteristics of infected patients are limited.In this study,the demographic,clinical characteristics,and laboratory data of 310 SARS-CoV-2 Omicron variant patients treated at Haihe Hospital of Tianjin were collected and analyzed.Information on these patients was compared to 96 patients with the Delta variant of concern(VOC)and 326 patients with the Beta VOC during the previous coronavirus disease 2019(COVID-19)outbreak in Harbin.Of the 310 patients infected with the Omicron variant,the median age was 35 years.Most patients were clinically classified as mild(57.74%),and the most common symptoms were cough(48.71%),fever(39.35%),and sore throat(38.26%).The results for different vaccination groups in the Omicron group showed that the median of“SARS-CoV-2 specific IgG”after 2 or 3 doses of vaccination was higher than the unvaccinated group(all Ps<0.05).Older age was associated with a higher proportion of moderate cases and lower asymptomatic and mild cases based on clinical classifications.Compared to the Delta and Beta groups,the median age of the Omicron group was younger.The total number of asymptomatic patients and mild patients in the Omicron virus group was higher than the Delta and Beta groups(60.97%vs.54.17%vs.47.55%).This study presented the clinical characteristics of the first group of patients infected with the Omicron variant in Tianjin,China,and compared their clinical features with patients infected by the Delta and Beta variants,which would increase our understanding of the characteristics of SARS-CoV-2 Omicron variant. | Wei Yang Songliu Yang Lei Wang Yuxin Zhou Yu Xin Hongxu Li Wenjing Mu Qi Wu Lei Xu Mingyan Zhao Changsong Wang Kaijiang Yu | 2022 | Virologica Sinica2022，37，5： | 4 |
| 3 | First experimental constraints on WIMP couplings in the effective field theory framework from CDEX显示文摘We present weakly interacting massive particles(WIMPs) search results performed using two approaches of effective field theory from the China Dark Matter Experiment(CDEX), based on the data from both CDEX-1B and CDEX-10 stages. In the nonrelativistic effective field theory approach, both time-integrated and annual modulation analyses were used to set new limits for the coupling of WIMP-nucleon effective operators at 90% confidence level(C.L.) and improve over the current bounds in the low mχregion. In the chiral effective field theory approach, data from CDEX-10 were used to set an upper limit on WIMP-pion coupling at 90% C.L. We for the first time extended the limit to the m_(χ)<6 GeV/c^(2) region. | Yi Wang Zhi Zeng Qian Yue LiTao Yang KeJun Kang YuanJing Li Mehment Agartioglu HaiPeng An JianPing Chang JingHan Chen YunHua Chen JianPing Cheng Cheng Yi Chiang WenHan Dai Zhi Deng ChangHao Fang XinPing Geng Hui Gong QiuJu Guo XuYuan Guo HongJian He Li He ShengMing He JinWei Hu TuChen Huang HanXiong Huang HaiTao Jia LiPing Jia Xi Jiang HauBin Li JianMin Li Jin Li MingXuan Li RenMingJie Li Xia Li YuLan Li Bin Liao FongKay Lin ShinTed Lin ShuKui Liu YanDong Liu Yu Liu YuanYuan Liu ZhongZhi Liu Hao Ma YuCai Mao QiYuan Nie JinHua Ning Hui Pan NingChun Qi Jie Ren XiChao Ruan ChangSong Shang Vivek Sharma Ze She Lakhwinder Singh Monoj Kumar Singh TianXi Sun ChangJian Tang WeiYou Tang Yang Tian GuangFu Wang Li Wang Qing Wang Yu Chen Wang YunXiang Wang Zhen Wang Henry Tsz-King Wong ShiYong Wu YuCheng Wu HaoYang Xing Yin Xu Tao Xue YuLu Yan Nan Yi ChunXu Yu HaiJun Yu JianFeng Yue Ming Zeng BingTao Zhang Lei Zhang FengShou Zhang ZhenYu Zhang KangKang Zhao MingGang Zhao JiFang Zhou ZuYing Zhou JingJun Zhu | 2021 | Science China(Physics,Mechanics & Astronomy)2021，64，8： | 3 |
| 4 | Protective immunity against Rickettsia heilongjiangensis in a C3H/HeN mouse model mediated by outer membrane protein B-pulsed dendritic cells显示文摘Rickettsia heilongjiangensis is an obligate intracellular bacterium that causes Far-Eastern tick-borne spotted fever. Outer membrane protein B(Omp B) is an important surface protein antigen of rickettsiae. In the present study, the omp B gene of R. heilongjiangensis was divided into four fragments, resulting in four recombinant proteins(OmpB-p1, Omp B-p2, Omp B-p3, and Omp B-p4). Each Omp B was used in vitro to stimulate murine bone marrow-derived dendritic cells(BMDCs) of C3H/He N mice, and the Omp B-pulsed BMDCs were transferred to naive C3H/He N mice. On day 14 post-transfer of BMDCs, the mice were challenged with R. heilongjiangensis and the rickettsial loads in the mice were quantitatively determined on day 7 post-challenge. Mice receiving BMDCs pulsed with Omp B-p2, Omp B-p3, or Omp B-p4 exhibited significantly lower bacterial load compared with mice receiving Omp B-p1-pulsed BMDCs. CD4+ and CD8+ T cells isolated from the spleen of C3H/He N mice receiving BMDCs pulsed with each OmpB were co-cultured with BMDCs pulsed with the respective cognate protein. In flow cytometric analysis, the expression level of CD69 on CD4+ or CD8+ T cells from mice receiving BMDCs pulsed with Omp B-p2, OmpB-p3, or Omp B-p4 was higher than that on cells from mice receiving Omp B-p1-pulsed BMDCs, while the expression level of tumor necrosis factor(TNF)-α on CD8+ T cells and interferon(IFN)-γ on the CD4+ and CD8+ T cells from mice receiving Omp B-p2,-p3, or-p4 was significantly higher than on cells from mice receiving Omp B-p1-pulsed BMDCs. Our results suggest that the protective Omp Bs could activate CD4+ and CD8+ T cells and drive their differentiation toward CD4+ Th1 and CD8+ Tcl cells, respectively, which produce greater amounts of TNF-α and, in particular, IFN-γ, to enhance rickettsicidal activity of host cells. | MENG YanFen XIONG XiaoLu QI Yong DUAN ChangSong GONG WenPing JIAO Jun WEN BoHai | 2015 | Science China(Life Sciences)2015，58，3： | 2 |
| 5 | Status and Suggestions of the Pesticide Use in the Protected Vegetable Fields in Shandong Province显示文摘This paper briefly introduced the issues of food safety and environmental pollution caused by pesticide residues in protected vegetables, discussed the status and problems of pesticide use in the protected vegetables in Shandong Province, and analyzed the main factors leading to the pesticide residues, including the low education of most farmers, lack of correct identification of diseases and insect pests, use of pesticides based on personal experience, pesticide preparation by bare hands, large dose of pesticide, frequent application, pesticide spraying without protection, uneven spraying, leakage of pesticide from the sprayers, etc.. Finally, based on the vegetable planting features and advantages in Shandong Province, some suggestions were proposed for references, such as, to enhance the monitoring of pesticide residue, to improve the educational level of farmers and to scentifically use the pesticide. | Bo ZHANG Yan LI Xinhao GAO Changsong LI Junshan QI Yueli ZHANG Wei ZHAO | 2013 | Asian Agricultural Research2013，5，4： | 2 |
| 6 | Design of Remote Monitoring System for Aquaclture Cages Based on 3G Network and ARM-Android Embedded System显示文摘 | Yanle Wang Changsong Qi Hongjun Pan | 2012 | Rrocedia Engineering2012，，29： | 1 |
| 7 | Non-Exchangeable Error Compensation for Strapdown Inertial Navigation System in High Dynamic Environment显示文摘Strapdown non-exchangeable error compensation technology in high dynamic environment is one of the key technologies of strapdown inertial navigation system.Mathematical platform is used in strapdown inertial navigation system instead of physical platform in traditional platform inertial navigation system,which improves reliability and reduces cost and volume of system.The maximum error source of attitude matrix solution is the non-exchangeable error of rotation due to the non-exchangeable of finite rotation of rigid bodies.The rotation non-exchangeable error reaches the maximum in coning motion,although it can be reduced by shortening the correction period and increasing the real-time calculation.The equivalent rotation vector method is used to modify the attitude to reduce the coning error in this paper.Simulation experiments show that the equivalent rotation vector method can effectively suppress the non-exchangeable error and improve the accuracy of attitude calculation. | Qi Wang Changsong Yang Shao’en Wu | 2020 | Computers, Materials & Continua2020，，8： | 1 |
| 8 | 显示文摘 | Li G Qi Changsong Ran Junguo | 1999 | Thin Solid Film1999，345，： | 1 |
| 9 | On the mitigation of the Dif- ferential Decoding Penalty in 100(3 PDM-QPSK Digital Coherent Receivers for multirate WDM Transmission 显示文摘 | QI Juan ZHAO Yu XIE Changsong | 2012 | IEEE Photonics Journal2012，24，6： | 1 |
| 10 | Model net: A representation of the static structure of model base 显示文摘 | QI Changsong SUN Jigui | 2007 | International Journal of Pattern Recognition and Artificial Intelligence2007，21，4： | 1 |
| 11 | SiC film deposition by DC magnetron sputtering 显示文摘 | GOU LI QI CHANGSONG RAN JUNGGUO | 1999 | Thin Solid Films1999，345，1： | 1 |
| 12 | Polar motion prediction using the combination of SSA and ARMA显示文摘High-precision polar motion(PM) prediction is of important significance in astronomy, geodesy, aviation,hydrographic mapping, interstellar navigation, and so on. SSA can effectively extract the trend and period terms of PM,in the process of achieving high-precision medium-and long-term polar motion prediction,it is necessary to solve the end effect problem and overfitting problem of SSA forecasting method;therefore, ARMA was applied to decreasethe end effect, and a suitable combination of reconstructed components was determined to avoid the high variance reaction of SSA overfitting. Based on the decomposition and reconstruction of the PM by SSA, the reconstructed components are determined to participate in the SSA iterative fitting model according to the variance contribution rate. The combination of the reconstructed components representing the polar motion period term and the trend term is determined according to the correlation analysis of the selected reconstructed components. After the above work, the principal component prediction sequence is obtained by fitting the period term and the trend term to convergence, respectively, and then, the SSA end effect is modified, and the residual term is predicted based on ARMA. The test results show that he prediction accuracy of SSA + ARMA at the front of the X and Y directions are improved by 96.90% and 97.53% compared with those of SSA, respectively,and the forecast accuracy of 365 days are improved by 37.93% and 19.53% in the X and Y directions compared with those of Bulletin A, respectively. | Qiaoli Kong Jingwei Han Xin Jin Changsong Li Tianfa Wang Qi Bai Yanfei Chen | 2023 | Geodesy and Geodynamics2023，14，4： | 0 |
| 13 | An improved particle filter indoor fusion positioning approach based on Wi-Fi/PDR/geomagnetic field显示文摘The existing indoor fusion positioning methods based on Pedestrian Dead Reckoning(PDR)and geomagnetic technology have the problems of large initial position error,low sensor accuracy,and geomagnetic mismatch.In this study,a novel indoor fusion positioning approach based on the improved particle filter algorithm by geomagnetic iterative matching is proposed,where Wi-Fi,PDR,and geomagnetic signals are integrated to improve indoor positioning performances.One important contribution is that geomagnetic iterative matching is firstly proposed based on the particle filter algorithm.During the positioning process,an iterative window and a constraint window are introduced to limit the particle generation range and the geomagnetic matching range respectively.The position is corrected several times based on geomagnetic iterative matching in the location correction stage when the pedestrian movement is detected,which made up for the shortage of only one time of geomagnetic correction in the existing particle filter algorithm.In addition,this study also proposes a real-time step detection algorithm based on multi-threshold constraints to judge whether pedestrians are moving,which satisfies the real-time requirement of our fusion positioning approach.Through experimental verification,the average positioning accuracy of the proposed approach reaches 1.59 m,which improves 33.2%compared with the existing particle filter fusion positioning algorithms. | Tianfa Wang Litao Han Qiaoli Kong Zeyu Li Changsong Li Jingwei Han Qi Bai Yanfei Chen | 2024 | Defence Technology(防务技术)2024，32，2： | 0 |
| 14 | Determination of Double Beta Decay Half-Life of 136Xe with the PandaX-4T Natural Xenon Detector显示文摘Precise measurement of two-neutrino double beta decay(DBD)half-life is an important step for the searches of Majorana neutrinos with neutrinoless double beta decay.We report the measurement of DBD half-life of 136xe using the Pandax-4T dual-phase Time Projection Chamber(TPC)with 3.7-tonne natural xenon and the first 94.9-day physics data release. | Lin Si Zhaokan Cheng Abdusalam Abdukerim Zihao Bo Wei Chen Xun Chen Yunhua Chen Chen Cheng Yunshan Cheng Xiangyi Cui Yingjie Fan Deqing Fang Changbo Fu Mengting Fu Lisheng Geng Karl Giboni Linhui Gu Xuyuan Guo Ke Han Changda He Jinrong He Di Huang Yanlin Huang Zhou Huang Ruquan Hou Xiangdong Ji Yonglin Ju Chenxiang Li Jiafu Li Mingchuan Li Shu Li Shuaijie Li Qing Lin Jianglai Liu Xiaoying Lu Lingyin Luo Yunyang Luo Wenbo Ma Yugang Ma Yujun Mao Yue Meng Nasir Shaheed Xiaofeng Shang Xuyang Ning Ningchun Qi Zhicheng Qian Xiangxiang Ren Changsong Shang Guofang Shen Wenliang Sun Andi Tan Yi Tao Anqing Wang Meng Wang Qiuhong Wang Shaobo Wang Siguang Wang Wei Wang Xiuli Wang Zhou Wang Yuehuan Wei Mengmeng Wu Weihao Wu Jingkai Xia Mengjiao Xiao Xiang Xiao Pengwei Xie Binbin Yan Xiyu Yan Yong Yang Chunxu Yu Jumin Yuan Ying Yuan Zhe Yuan Dan Zhang Minzhen Zhang Peng Zhang Shibo Zhang Shu Zhang Tao Zhang Li Zhao Qibin Zheng Jifang Zhou Ning Zhou Xiaopeng Zhou Yong Zhou | 2023 | Research2023，，2： | 0 |
| 15 | Lever Arm Compensation of Autonomous Underwater Vehicle for Fast Transfer Alignment显示文摘Transfer alignment is used to initialize SINS(Strapdown Inertial Navigation System)in motion.Lever-arm effect compensation is studied existing in an AUV(Autonomous Underwater Vehicle)before launched from the mother ship.The AUV is equipped with SINS,Doppler Velocity Log,depth sensor and other navigation sensors.The lever arm will cause large error on the transfer alignment between master inertial navigation system and slave inertial navigation system,especially in big ship situations.This paper presents a novel method that can effectively estimate and compensate the flexural lever arm between the main inertial navigation system mounted on the mother ship and the slave inertial navigation system equipped on the AUV.The nonlinear measurement equation of angular rate is derived based on three successive rotations of the body frame of the master inertial navigation system.Nonlinear filter is utilized as the nonlinear estimator for its capability of non-linear approximation.Observability analysis was conducted on the SINS state vector based on singular value decomposition method.State equation of SINS was adopted as the system state equation.Simulation experiments were conducted and results showed that the proposed method can estimate the flexural lever arm more accurately,the precision of transfer alignment was improved and alignment time was shortened accordingly. | Qi Wang Changsong Yang Shaoen Wu Yuxiang Wang | 2019 | Computers, Materials & Continua2019，，4： | 0 |
| 16 | Preparing a wettability-controllable stainless-steel mesh and its oil-water separation performance显示文摘The ability to regulate and apply surface wettability has attracted much attention in the surface engineering field.In this study,a simple chemical etching method was used to construct a rough micro/nano structure on 304 stainless steel mesh;this rough surface was subsequently decorated with fatty acids of varying chain length to regulate wettability.The wettability,composition,and morphology of the surface were characterized and ana-lyzed by measuring contact angles,and by atomic force microscopy,scanning electron microscopy,and Fourier-transform infrared spectroscopy.The superhydrophobic and superoleophilic properties of the mesh modified with long-chain fatty acids were examined for oil-water separation performance and reusability.The surface had a micro/nano hierarchical morphology with ordered carbon chains,and the hydrophilic-to-superhydrophobic transformation was achieved by adjusting the chain length of the fatty acid to deliver contact angles in the range of 30°~154°.The oil contact angle was always 0°,irrespective of the chain length fatty acid,and oil drops quickly penetrated the mesh surface.A fatty acid with a longer chain afforded a more hydrophobic and oleophilic mesh surface and better oil-water separation efficiency(up to 96%),which still exceeded 85%after 50 cycles of oil-water separation testing.Consequently,the prepared surface with controllable wettability has excellent prospects for use in intelligent response interfaces and oil-water separation applications. | Bohao Qi Wenjing Yi Changsong Liu Xinsheng Zhao Xinming Li | 2022 | ChemPhysMater2022，1，2： | 0 |
| 17 | Study on Initial Alignment Under Large Misalignment Angle显示文摘Misalignment angle error model describing the SINS mathematical platform error is presented in this paper following the idea of small misalignment angle error model and large azimuth misalignment angle error model.It can be considered that the three misalignment angles are independent of the rotational sequence in the misalignment error model,but not suitable in the large misalignment error model.The error angle of Euler platform is used to represent the three misalignment angles from theoretical navigation coordinate system to computational navigation coordinate system.The Euler platform error angle is utilized to represent the mathematical platform error and its physical meaning is very clear.The SINS nonlinear error model is deduced by using the error angle of Euler platform and is simplified under the condition of large azimuth error and small error.The simplified results are more comprehensive and accurate than the large azimuth misalignment error model.The damping SINS algorithm and its error model are proposed to change the structure of the strapdown inertial navigation algorithm by using the external damping information.The accuracy of SINS error model of large Euler platform error angle is simulated,and has strong practicability in initial alignment and is conducive to reducing the amount of calculation. | Qi Wang Changsong Yang Shaoen Wu | 2019 | Journal of Information Hiding and Privacy Protection2019，1，3： | 0 |
| 18 | Alterations in DNA damage response and repair genes as potential biomarkers for immune checkpoint blockade in gastrointestinal cancer显示文摘Objective:Immune checkpoint inhibitors(ICIs)have achieved remarkable results in cancer treatments.However,there is no effective predictive biomarker for gastrointestinal(GI)cancer.Methods:We conducted integrative analyses of the genomic and survival data of ICI-treated GI cancer patients from the Memorial Sloan Kettering Cancer Center cohort(MSK-GI,n=227),the Janjigian cohort(n=40),and the Peking University Cancer Hospital&Institute cohort(PUCH,n=80)to determine the possible associations between DNA damage response and repair(DDR)gene mutations and clinical outcomes.Data from The Cancer Genome Atlas database were analyzed to determine the possible correlations between DDR gene mutations and the tumor microenvironment.Results:In the MSK cohort,the presence of≥2 DDR gene mutations was correlated with prolonged overall survival(OS).The Janjigian and PUCH cohorts further confirmed that subgroups with≥2 DDR gene mutations displayed a prolonged OS and a higher durable clinical benefit.Furthermore,the DDR gene mutation load could be considered as an independent prognostic factor,and exhibited a potential predictive value for survival in GI cancer patients treated with ICIs.Mechanistically,we showed that the presence of≥2 DDR gene mutations was correlated with higher levels of tumor mutation burden,neoantigen,and T cell infiltration.Conclusions:The DDR gene mutation status was correlated with favorable clinical outcomes in GI cancer patients receiving ICIs,which could serve as a potential biomarker to guide patient selection for immunotherapy. | Yujiao Wang Xi Jiao Shuang Li Huan Chen Xin Wei Chang Liu Jifang Gong Xiaotian Zhang Xicheng Wang Zhi Peng Changsong Qi Zhenghang Wang Yanni Wang Na Zhuo Jianling Zou Henghui Zhang Jian Li Lin Shen Zhihao Lu | 2022 | Cancer Biology & Medicine2022，19，8： | 0 |
| 19 | Cytokine levels and pathological characteristics of a patient with severe coronavirus disease 2019:a case report显示文摘To the Editor:The clinical spectrum of coronavirus disease 2019(COVID-19)appears to be wide,ranging from asymptomatic to severe progressive pneumonia with respiratory failure,multiorgan failure,and even death.Here,we investigated the clinical and pathological characteristics of a patient who died from severe COVID-19.Our findings will facilitate a deeper understanding of the pathogenesis and progression of COVID-19 and improve clinical strategies to combat the disease.On January 23,2020,a 57-year-old man without relevant history presented with fatigue and fever after attending a family party 2 days prior.Among the members of the family party,one relative had traveled from Wuhan.Over 9 days,the fever and cough developed,and the patient visited the emergency department.A throat swab was positive for severe acute respiratory syndrome coronavirus 2(SARS-COV-2)on real-time reverse-transcription polymerase chain reaction.He was admitted to the local hospital and received supportive therapies,anti-viral agents,atomized inhalation of interferon-γ,and oxygen therapy.Cough,fever,and dyspnea further developed on February 8.He received non-invasive mechanical ventilation therapy.On February 18,he was transferred to a superior hospital with shortness of breath. | Kai Kang Yang Gao Mingyan Zhao Dongsheng Fei Ming Ye Yan Gao Wei Yang Changsong Wang Haitao Liu Guangping Chang Xianxin Kang Yunpeng Luo Xue Du Jiping Qi Lin Tian Min Zhou Chunfang Hao Kaijiang Yu | 2022 | Chinese Medical Journal2022，，1： | 0 |
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