|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Mechanism and clinical significance of cyclooxygenase-2 expression in gastric cancer显示文摘AIM: To determine the correlation between methylation status of 5' CpG island of cyclooxygenase-2 (COX-2)gene and protein expression in gastric cancer tissues for distinguishing the molecular characters of gastric cancers.METHODS: Methylation status of 5' CpG island of COX-2gene was studied by PCR amplification after HpaⅡ and Hha Ⅰ restrictive enzyme digestion; COX-2 expression was evaluated by immunohistochemical method. RESULTS: Hpa Ⅱ and HhaI site were all methylated in 12 normal gastric mucosa tissues, whereas they were demethylated in 77.27% (34/44) and 84.09% (37/44) gastric cancer tissues, respectively. Expression of COX-2 was detected in 68.18% (30/44) gastric cancer tissues, but no expression was found in normal gastric mucosa tissues. In gastric cancer tissues, COX-2 expression was correlated significantly with HpaⅡ site demethylation (29/30 vs 5/14, P<0.001 and HhaI site demethylation (28/30 vs9/14, P<0.05).CONCLUSION: The demethylation of 5' CpG island of gene is necessary for COX-2 expression in human gastric cancer. The expression status of COX-2 may provide theoretical basis for COX-2 targeting gastric cancer treatments. | Bao-CanWang Chang-QingGuo ChaoSun Qiao-LingSun Guo-YongLiu Ding-GuoLi | 2005 | World Journal of Gastroenterology2005，11，21： | 5 |
| 2 | Transcript profiles of Panax quinquefolius from flower, leaf and root bring new insights into genes related to ginsenosides biosynthesis and transcriptional regulation显示文摘 | QiongWu JingyuanSong YongqiaoSun FengmeiSuo ChenjiLi HongmeiLuo YingLiu YingLi XiaoweiZhang HuiYao XiwenLi SongnianHu ChaoSun | 2010 | Physiologia Plantarum2010，，2： | 1 |
| 3 | Transplantation of urokinase‐type plasminogen activator gene‐modified bone marrow‐derived liver stem cells reduces liver fibrosis in rats显示文摘 | ChaoSun Ding‐GuoLi Yuan‐WenChen Ying‐WeiChen Bao‐CanWang Qiao‐LingSun Han‐MingLu | 2008 | Gene Med2008，，8： | 1 |
| 4 | Carrier Density and Plasma Frequency of Alummum Nanofilms显示文摘In this work, the prerequisite and mode of electromagnetic response of Al nanofilms to electromagnetic wave field was suggested.Reflectance, transmittance in infrared region and carrier density of the films was measured. With the carrier density of the films, the dependence of their plasma frequencies on the film thickness was obtained. On the other hand, the dependence of absorptance on the frequency of electromagnetic wave field was set up by using the measured reflectance and transmittance,which provided plasma frequency-film thickness relation as well. Similarity of both plasma frequency-film thickness relations proved plasma resonance as a mode of electromagnetic response in Al nanofilms. | HaoDU JunGONG ChaoSUN RongfangHUANG lISHIWEN W.Y.Cheung S.P.Wong | 2003 | Journal of Materials Science & Technology2003，19，4： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员