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| 1 | Clinical End Points in Coronary Stent Trials: A Case for Standardized Definitions显示文摘 | Donald E. Cutlip Stephan Windecker Roxana Mehran Ashley Boam David J. Cohen Gerrit-Anne van Es P Gabriel Steg Marie-angèle Morel Laura Mauri Pascal Vranckx Eugene McFadden Alexandra Lansky Martial Hamon Mitchell W. Krucoff Patrick W. Serruys | 2007 | Circulation2007，，17： | 4 |
| 2 | Thiopurine-methyltransferase variants in inflammatory bowel disease:Prevalence and toxicity in Brazilian patients显示文摘AIM:To analyze the prevalence of thiopurine-methyltransferase(TPMT)genotypes and their associationwith drug toxicity in inflammatory bowel disease(IBD)patients from southeastern Brazil.METHODS:A total of 219 consecutive patients with IBD,of which 146 had Crohn’s disease and 73 had ulcerative colitis,regularly seen at the outpatient unit of the Division of Gastroenterology at the University Hospital Pedro Ernesto of the State University of Rio de Janeiro,a tertiary referral center,were enrolled in this study from February 2009 to January 2011.We analyzed the presence of major TPMT genetic variants(TPMT*2,*3A,*3C)in IBD patients by means of a specific allele and RFLP-PCR.Genomic DNA was isolated from peripheral blood leukocytes by proteinase-K/Sodium Dodecyl Sulfate digestion and phenol-chloroform extraction.TPMT*2(C238G),TPMT*3A(G460A/A719G),and TPMT*3C(A719G)genotypes were detected by real-time polymerase chain reaction followed by direct sequencing with specific primers.Clinical data were systematically recorded,and correlated with the genotype results.RESULTS:The distribution of the selected TPMT gene polymorphism TPMT*2(C238G),TPMT*3A(G460A/A719G),and TPMT*3C(A719G)genotypes was 3.6%,5.4%,and 7.7%of the patients,respectively.Among the side effects recorded from patients taking azathioprine,14 patients presented with pancreatitis and/or an elevation of pancreatic enzymes,while 6 patients had liver toxicity,and 2 patients exhibited myelosuppression/neutropenia.TPMT polymorphisms were detected in 37/219 patients(8 heterozygous for*2,11 heterozygous for*3A,and 18 heterozygous for*3C).No homozygotic polymorphisms were found.Despite the prevalence of the TPMT*3C genotype,no differences among the genotype frequencies were significant.Although no association was detected regarding myelotoxicity or hepatotoxicity,a trend towards the elevation of pancreatic enzymes was observed for TPMT*2 and TPMT*3C genotypes.CONCLUSION:The prevalence of TPMT genotypes was high among Brazilian patients.Variants genes*2and*3C may be associated with azathioprine pancreatic toxicity in a IBD southeastern Brazilian population. | Ana Teresa P Carvalho Barbara C Esberard Renata S B Fróes Davy C M Rapozo Ana B Grinman Tatiana A Simo Juliana C V C Santos Antonio José V Carneiro Luis Felipe Ribeiro-Pinto Heitor S P de Souza | 2014 | World Journal of Gastroenterology2014，20，12： | 3 |
| 3 | Development of hepatorenal syndrome in bile duct ligated rats显示文摘AIM: To evaluate in bile duct ligated rats whether there were progressive alterations of renal function without changes in histopathology. METHODS: Male Wistar rats were submitted to sham-surgery or bile duct ligation (BDL) and divided according to the post-procedure time (2, 4 and 6-wk). To determine renal function parameters, rats wereplaced in metabolic cages and, at the end of the experiment, blood and urine samples were obtained. Histology and hydroxyproline content were analyzed in liver and renal tissue. RESULTS: Rats with 2 wk of BDL increased free water clearance (P = 0.02), reduced urinary osmolality (P = 0.03) and serum creatinine (P = 0.01) in comparison to the sham group. In contrast, rats at 6 wk of BDL showed features of HRS, including signif icant increase in serum creatinine and reductions in creatinine clearance, water excretion and urinary sodium concentration. Rats with 4 wk of BDL exhibited an intermediate stage of renal dysfunction. Progressive hepatic f ibrosis according to post-procedure time was confirmed by histology. The increased levels of liver hydroxyproline contrasted with the absence of structural changes in the kidney, as assessed by histology and unchanged hydroxyproline content in renal tissue. CONCLUSION: Our data show that BDL produced progressive renal dysfunction without structural changes in the kidney, characterizing HRS. The present model will be useful to understand the pathophysiology of HRS. | Regina M Pereira Robson AS dos Santos Eduardo A Oliveira Virgínia HR Leite Filipi LC Dias Alysson S Rezende Lincoln P Costa Lucíola S Barcelos Mauro M Teixeira Ana Cristina Sim■es e Silva | 2008 | World Journal of Gastroenterology2008，14，28： | 2 |
| 4 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 5 | Associations of leptin gene polymorphisms with production traits in pigs 显示文摘 | De Oliveira Peixoto J Facioni Guimar?es S E Savio Lopes P | 2006 | J Anita Breed Genet2006，123，6： | 1 |
| 6 | The sentinel fat pads: the relationship of the ROOF and SOOF to the tem- poral nerve in facial rejuvenation显示文摘 | SINGH D P FORTE A J APOSTOLII)ES J G el al | 2011 | Aesthet Surg J2011，31，1： | 1 |
| 7 | Immunological and viral factors associated with the response of vulval intraepithelial neoplasia to photodynamic therapy显示文摘 | AbdeI-Hady ES Martin-Hirsch P Duggan Keen M | | 0，，01： | 1 |
| 8 | Profile of microbial communities present in tibico(sugary kefir)grains from different Brazilian States显示文摘 | da CP MIGUEL M G CARDOSO P G MAGALHES K T | 2011 | World Journal of Microbiology and Biotechnology2011，27，8： | 1 |
| 9 | Relationship of oxidized phospholipids on apolipoprotein B100 particles to race/ethnicity, apolipoprotein (a) isoform size, and cardiovascular risk factors: results from the Dallas Heart Study显示文摘 | Tsimikas S Clopton P Brilakis ES | 2009 | Circulation2009，119，13： | 1 |
| 10 | Active learning paradigms for CBIR systems based on optimum-path forest classification 显示文摘 | da SILVA A T FALC?O A X MAGALH?ES L P | 2011 | Pattern Recognition2011，44，12： | 1 |
| 11 | Induction of replicative senescence biomarkers by sub- lethal oxidative stresses in normal human fibroblast 显示文摘 | Dumont P Burton M Chen QM Gonos ES Frippiat C Mazarati JB | 2000 | Free Radic Biol Med2000，28，3： | 1 |
| 12 | A parametric study of forced convection in an enclosure with stationary heated cylinders显示文摘 | Guimar?es P M Da Silva C E S | 2010 | International Communications in Heat and Mass Transfer2010，37，5： | 1 |
| 13 | Blood Pressure and Giancoma 显示文摘 | Costa ~P Arcieri ES Harris A | 2009 | Br J Ophthalmol2009，93，10： | 1 |
| 14 | Association of carotid artery intima-media thickness with complex aortic atherosclerosis in patients with recent stroke 显示文摘 | Fasseas P Brilakis ES Leybishkis B | 2002 | Angiology2002，53，2： | 1 |
| 15 | Knowledge management : a strategic agenda显示文摘 | QUITAS P LA FREER P JON ES G | 1997 | Long Range Planning1997，30，3： | 1 |
| 16 | Detection of Recurrence in Patients with Rectal Cancer:PET/CT after Abdominoperineal or Anterior Resection显示文摘 | Einat ES Yoav P Hedva L | 2004 | Radiology2004，232，9： | 1 |
| 17 | Immune re- sponses in Rhodnius prolixus: influence of nutrition and ecdysone 显示文摘 | FederD Mello CB Garcia ES Azambuja P | 1997 | Journal of Insect Physiology1997，43，： | 1 |
| 18 | Channels underlying neuronal calcium-activated potassium currents显示文摘 | Sah P Faber ES | 2002 | Prog Neurohiol2002，66，： | 1 |
| 19 | Targeted hyperthermia using met al nanoparticles显示文摘 | Cherukuri P Glazer ES Curley SA | 2010 | Advanced Drug Delivery Rev2010，62，3： | 1 |
| 20 | The Impact of Reduction Mammaplasty on Breast Sensation An Analysis of Multiple Surgical Techniques显示文摘 | Marcia ES Lillian BN Sharon P | 2012 | Ann Plast Surg2012，68，： | 1 |
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