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| 1 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 2 | Common variants associated with plasma triglycerides and risk for coronary artery disease显示文摘 | DO R WILLER CJ SCHMIDT EM | 2013 | Nat Genet2013，45，11： | 1 |
| 3 | Common va-riants at 30 loci contribute to polygenic dyslipidemia显示文摘 | Kathiresan S Willer CJ Peloso GM | 2009 | Nat Genet2009，41，1： | 1 |
| 4 | Newly identifiedloci that influence lipid concentrations and risk of coronaryartery disease显示文摘 | Willer CJ Sanna S Jackson AU | 2008 | Nat Genet2008，40，2： | 1 |
| 5 | Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index显示文摘 | Speliotes EK Willer CJ Berndt SI | | 0，，11： | 1 |
| 6 | Screening of 134 single nucleotide polymorphisms(SNPs) previously associated with type 2 diabetes replicates association with 12 SNPs in nine genes显示文摘 | Willer CJ Bonnycastle LL Conneely KN | 2007 | Diabetes2007，56，1： | 1 |
| 7 | Canadian Cotlahorative Study Group, Twin concordance and sibling recurrence rates in multiple sclerosis显示文摘 | Willer CJ Dyment DA Riseh NJ | 2003 | Proc Natl Acad Sci USA2003，100，12： | 1 |
| 8 | Common variants associated with plasma triglycerides and risk for coronary artery disease显示文摘 | Do R Willer CJ Schmidt EM | 2013 | Nat Genet2013，45，11： | 1 |
| 9 | Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index显示文摘 | Speliotes EK Willer CJ Berndt SI | 2010 | Nat Genet2010，42，11： | 1 |
| 10 | Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index显示文摘 | Speliotes EK Willer CJ Berndt SI | 2010 | Nat Genet2010，42，11： | 1 |
| 11 | An extended genome scan in 442 Canadian multiple sclerosis-affected sibships:a report from the Canadian Collaborative Study Group显示文摘 | Dyment DA Sadovnick AD Willer CJ | 2004 | Hum Mol Genet2004，13，10： | 1 |
| 12 | Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index显示文摘 | Speliotes EK Willer CJ Berndt SI | 2010 | Nat Genet2010，42，： | 1 |
| 13 | Microchimerism in autoimmunity and transplantation: potential relevance to multiple sclerosis 显示文摘 | Willer CJ Sadovnick AD Ebers GC | 2002 | J Neuroimmunol2002，126，： | 1 |
| 14 | Common variants at 30 loci contribute to polygenic dyslipidemia显示文摘 | Kathiresan S Willer CJ Peloso GM | 2009 | Nat Genet2009，41，1： | 1 |
| 15 | Newly identified loci that influence lipid concentrations and risk of coronary artery disease 显示文摘 | Willer CJ Sanna S Jackson AU | 2008 | Nat Genet2008，40，2： | 1 |
| 16 | A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants 显示文摘 | Scott L J Mohlke K L Bonnycastle L L Willer CJ Li Y Duren W L | 2007 | Science2007，316，： | 1 |
| 17 | Discovery and refinement of loci associated with lipid levels显示文摘 | Willer CJ Schmidt EM Sengupta S | 2013 | Nat Genet2013，45，11： | 1 |
| 18 | Common variants associated with plasma triglycerides and risk for coronary artery disease显示文摘 | Do R Willer CJ Schmidt EM | 2013 | Nat Genet2013，45，11： | 1 |
| 19 | Newly identified loci that influence lipid concentrations and risk of coronary artery disease显示文摘 | Willer CJ Sanna S Jackson AU | 2008 | Nat Genet2008，40，2： | 1 |
| 20 | Common variants in matarity-onset diabetes of the young genes contribute to risk of type 2 diabetes in Finns显示文摘 | Bonnycastle LL Willer CJ Conneely KN | | 0，，9： | 1 |
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