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| 1 | 利妥昔单抗治疗重度ANCA相关性血管炎与常规免疫抑制剂疗效相同显示文摘新英格兰医学杂志2013年8月发表了美国学者的研究结果,18个月的单疗程利妥昔单抗治疗重度抗中性粒细胞胞浆抗体(antineutrophilcytoplasmicantibody,ANCA)相关性血管炎,与常规免疫抑制剂环磷酰胺联合硫唑嘌呤的疗效相同。 | Specks U Merkel PA Seo P 王建中 | 2013 | 中华肾病研究电子杂志2013，2，5： | 33 |
| 2 | Emerging roles of cardiolipin remodeling in mitochondrial dysfunction associated with diabetes,obesity,and cardiovascular diseases显示文摘Cardiolipin(CL)is a phospholipid exclusively localized in inner mitochondrial membrane where it is required for oxidative phosphorylation,ATP synthesis,and mitochondrial bioenergetics.The biological functions of CL are thought to depend on its acyl chain composition which is dominated by linoleic acids in metabolically active tissues.This unique feature is not derived from the de novo biosynthesis of CL,rather from a remodeling process that involves in phospholipases and transacylase/acyltransferase.The remodeling process is also believed to be responsible for generation of CL species that causes oxidative stress and mitochondrial dysfunction.CL is highly sensitive to oxidative damages by reactive oxygen species(ROS)due to its high content in polyunsaturated fatty acids and location near the site of ROS production.Consequently,pathological remodeling of CL has been implicated in the etiology of mitochondrial dysfunction commonly associated with diabetes,obesity,heart failure,neurodegeneration,and aging that are characterized by oxidative stress,CL deficiency,and abnormal CL species.This review summarizes recent progresses in molecular,enzymatic,lipidomic,and metabolic studies that support a critical regulatory role of pathological CL remodeling as a missing link between oxidative stress and mitochondrial dysfunction in metabolic diseases and aging. | Yuguang Shi Department of Cellular and Molecular Physiology,P ennsylvania State University College of Medicine,Hershey,PA 17033,U.S.A. | 2010 | The Journal of Biomedical Research2010，24，1： | 5 |
| 3 | Long-term postoperative cognitive dysfunction in the elderly: ISPOCD1 study显示文摘 | JT Moller P Cluitmans LS Rasmussen P Houx H Rasmussen J Canet P Rabbitt J Jolles K Larsen CD Hanning O Langeron T Johnson PM Lauven PA Kristensen A Biedler H van Beem O Fraidakis JH Silverstein JEW Beneken JS Gravenstein | 1998 | The Lancet . 1998 (9106)1998，，9106： | 2 |
| 4 | 高密度脂蛋白可追踪脑卒中恢复情况显示文摘前瞻性队列研究质疑高密度脂蛋白胆固醇(high density lipoprotein cholesterol,HDL-C)在脑卒中风险预测中的价值。该文旨在探讨长期功能恢复与高密度脂蛋白(high density lipoprotein,HDL)蛋白质组和功能的关系。方法与结果:测定急性缺血性脑卒中后2个时间点(24小时,35例;96小时,20例)和35例对照组HDL蛋白组成和功能(胆固醇流出能力)的变化。 | Plubell DL Fenton AM Rosario S Bergstrom P Wilmarth PA Clark WM Zakai NA Quinn JF Minnier J Alkayed NJ Fazio S Pamir N 刘青(译) 刘莉(摘/审校) | 2020 | 中华高血压杂志2020，28，11： | 2 |
| 5 | 卒中介入治疗培训指南:国际多学会共识文件显示文摘1背景
缺血性卒中是全球人口死亡和残疾的首要原因。很多急性大血管闭塞(emergent large vesselocclusion,ELVO)患者都会遗留长期残疾。事实上,这些颅内大动脉闭塞经常会导致大面积脑损伤,进而造成患者死亡或严重致残。 | Lavine SD Cockroft K Hoh B Bambakidis N Khalessi AA Woo H Riina H Siddiqui A Hirsch JA Chong W Rice H Wenderoth J Mitchell P Coulthard A Signh TJ Phatorous C Khangure M Klurfan P ter Brugge K Iancu D Gunnarsson T Pongpech S Rodesch G Soderman M Taylor A Krings T Orbach D Picard L Suh DC Zheng HQ Jansen O Muto M Szikora I Pierot L Brouwer P Gralla J Renowden S Andersson T Fiehler J Turjman F White P Januel AC Spelle L Kulcsar Z Chapot R Biondi A Dima S Taschner C Szajner M Krajina A Sakai N Matsumaru Y Yoshknura S Ezura M Fujinaka T Iihara K Ishii A Higashi T Hirohata M Hyodo A Ito Y Kawanishi M Kiyosue H Kobayashi E Kobayashi S Kuwayama N Matsumoto Y Miyachi S Murayama Y Nagata I Nakahara I Nemoto S Niimi Y Oishi H Satomi J Satow T Sugiu K Tanaka M Terada T Yamagami H Diaz O Lylyk P Jayaraman MV Patsalides A Gandhi CD Lee SK Abruzzo T Albani B Ansari SA Arthur AS Baxter BW Bulsara KR Chen M Almandoz JE Fraser JF Heck DV Hetts SW Hussain MS Klucznik RP Leslie-Mawzi TM Mack WJ McTaggart RA Meyers PM Mocco J Prestigiacomo CA Pride GL Rasmussen PA Starke RM Sunenshine PJ Tarr RW Frei DF Pabo M Nogueira RG Zaidat OO Jovin T Linfante I Yavagal D Liebeskind D Novakovic R Pongpech S 许岩 孙瑞 郭芮兵 | 2017 | 国际脑血管病杂志2017，25，5： | 2 |
| 6 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 7 | Team learning in medical education: initial experiences at ten institutions 显示文摘 | Searle NS Haidet P Kelly PA etc | 2003 | Acad Med2003，78，： | 1 |
| 8 | Human adipose tissue is a source of multipotent stem cells显示文摘 | Zuk PA Zhu M Ashjian P | 2002 | Mol Biol Cell2002，13，12： | 1 |
| 9 | An intravitreal device providing sustained release of cyclosporine and dexamethasone显示文摘 | Enyedi LB Pearson PA Ashton P Jaffe GJ | 1996 | Curr Eye Res1996，15，： | 1 |
| 10 | Shear fracture tests of concrete显示文摘 | Bazant Z P Pfeiffer PA | 1986 | Materials and Structures1986，19，： | 1 |
| 11 | Angiotropic large cell lymphoma (ALCL): Morphological, immunohistochemical and genotypic studies with analysis of previous reports显示文摘 | Domizio P Hall PA Cotter F | 1989 | Hematol Oncol1989，7，： | 1 |
| 12 | Human adipose tissue is a source of multipotent stem cells显示文摘 | Zuk PA Zhu M Ashjian P | 2002 | Mol Biol Cell2002，13，12： | 1 |
| 13 | Human adipose tissue is a source of multipotent stem cells显示文摘 | Zuk PA Zhu M Ashjian P | 2002 | Mol boil Ce112002，13，12： | 1 |
| 14 | Distance Protection based on traveling waves显示文摘 | Crossley PA Mclaran P G | | 0，，09： | 1 |
| 15 | In Situ Dynamics of Microbial Communities during Decomposition of Wheat,Rape,and Alfalfa Residues显示文摘 | Pascault N Cécillon L Mathieu O Hénault C Sarr A Lév(e)que J Fatty P Ranjard L Maron PA | | 0，，04： | 1 |
| 16 | In-hospital complicalions of percutaneous intraaortic balloon counterpulsation显示文摘 | ARCEO A URBAN P DORSAZ PA | 2003 | Angiology2003，45，5： | 1 |
| 17 | Y chromosome sequence variation and the history of human populations 显示文摘 | Underhill PA Shen P Lin AA | 2000 | Nat Genet2000，26，： | 1 |
| 18 | Multilineage cells from human adipose:implications for cell-based therapies显示文摘 | Zuk PA Zhu M Ashjian P | 2001 | Tissue Eng2001，7，2： | 1 |
| 19 | Declining estrogen receptor-beta expression defines malignant progression of human breast neoplasia显示文摘 | Shaaban AM O'Neill PA DaviesM P | 2003 | Am J Surg Pathol2003，27，： | 1 |
| 20 | Epilepsy and synaptic reorganization in a perinatal rat model of hypoxia- ischemia显示文摘 | Williams PA Dou P Dudek FE | 2004 | Epilepsia2004，45，： | 1 |
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