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| 1 | 国际卒中遗传学联盟的推荐意见(第1部分):标准化表型数据收集显示文摘与几乎所有复杂疾病一样,卒中的患病风险和临床转归也是多基因作用的[1]。探索相关基因突变有望为新型个体化治疗方法奠定基础,从而显著减少卒中对全球健康造成的毁灭性影响。为了达到足够的统计学效能以确认多个风险性等位基因,需要很大的样本量。尽管卒中是全世界范围内第二大致死病因和成年人致残的主要原因[2],但没有任何一家研究机构能独立收集到足够的样本。在认识到这一挑战之后,来自世界各地的卒中研究者们于2007年成立了国际卒中遗传学联盟( International Stroke Genetics Consortium, ISGC; http://www. strokegenetics.org),其使命是通过研究在全球多个研究机构入组的患者来识别影响卒中患病风险、临床预后和治疗效果的遗传学因素。尽管先前已取得了一些成功[3-5],仍有大量工作有待进行,这不仅是为了发现风险性等位基因从而达到卒中个体化医疗的最终目标,更是为了开发综合性卒中风险评估手段以及得到足以改变临床实践的结果[6]。根据糖尿病和冠状动脉疾病等其他复杂疾病的研究进展,为了识别与卒中相关的所有基因突变,需要100000~200000个样本。为了达到这个样本量,需要进行更为广泛的协作。 | Jennifer J. Majersik John W.Cole Jonathan Golledge Natalia S. Rost Yu-Feng Yvonne Chan M. Edip Gurol Ame G. Lindgren Daniel Woo Israel Fernandez-Cadenas Donna T. Chen Vincent Thijs Bradford B. Worrall Ayeesha Kamal Paul Bentley Joanna M. Wardlaw Ynte M. Ruigrok Thomas W.K Battey Reinhold Schmidt Joan Montaner Anne-Katrin Giese Jaume Roquer Jordi Jimenez-Conde Chaeyoung Lee Hakan Ay Juan Jose Martin 李海峰 岳耀先 徐军 | 2015 | 国际脑血管病杂志2015，23，9： | 3 |
| 2 | 强化与标准降压治疗对脑卒中亚型的影响显示文摘在收缩压干预试验(systolic blood pressure intervention trial, SPRINT)中,各治疗组的脑卒中发生比例差异无统计学意义,但脑卒中亚型的病因不同,可能对强化降压治疗的反应不同。SPRINT纳入患者(n=9 361)随机分为目标收缩压<120 mm Hg(1 mm Hg=0.133 kPa)的强化治疗与目标收缩压<140 mm Hg的标准治疗组。 | Wright CB Auchus AP Lerner A Ambrosius WT Ay H Bates JT Chen J Meschia JF Pancholi S Papademetriou V Rastogi A Sweeney M Willard JJ Yee J Oparil S 赵狄(摘译) 郑武洪(审校) | 2021 | 中华高血压杂志2021，29，3： | 2 |
| 3 | Changes in treatment of advanced laryngeal cancer 1985 -2001 显示文摘 | Chen Ay Schraq Hao Y | 2006 | Otolaryngology Head and Neck Surgery2006，135，： | 1 |
| 4 | Baseline risk of major bleeding in non-ST-segment-elevation myocardial infarction: the CRUSADE (Can Rapid risk stratifi cation of Unstable anginapatients Suppress ADverse outcomes with Early implementation of the ACC/AHA Guidelines) Bleeding Score 显示文摘 | Subherwal S Bach RG Chen AY | 2009 | Circulation2009，19，14： | 1 |
| 5 | Long-term adherence to evidence-based secondary prevention therapies in coronary artery disease 显示文摘 | Newby LK LaPointe NM Chen AY | 2006 | Circulation2006，113，2： | 1 |
| 6 | Increasing incidence of differentia- ted thyroid cancer in the United States, 1988-2005 显示文摘 | Chen AY Jenaal A Ward EM | 2009 | Cancer2009，115，16： | 1 |
| 7 | Sex differences in major bleeding with glycopmtein GP Ⅱ b/Ⅲ a inhibitors : results from the CRUSADE ( Can rapid risk stratification of unstable angina patients suppress adverse outcomes with early implementation of the ACC/AHA guidelines) initiative 显示文摘 | Alexander KP Chen AY Newby LK | 2006 | Circulation2006，114，13： | 1 |
| 8 | The impact of comarbidity on treatment (chemoradiation and laryngectomy ) of advanced, nondistant metastatic laryngeal cancer: a review of 16 849 cases from the national cancer database ( 2003-2008 ) 显示文摘 | Zhu J Fedewa S Chen AY | 2012 | Arch Otolaryngol Head Neck Surg2012，138，12： | 1 |
| 9 | Obesity and age of first non-ST-segment elevation myocardial infarction显示文摘 | Madalam MC Franklin BA Chen AY | | 0，，： | 1 |
| 10 | Glomuvenous malformation in a boy with transposition of the great vessels : a ease report and review of literature显示文摘 | Chen AY Eide M Shwayder T | 2009 | Pediatr Dermatol2009，26，1： | 1 |
| 11 | Factors in fluencing longterm survival following salvage total laryngectomy after initial radiotherapy or conservative surgery显示文摘 | Fowler BZ Muller S Chen AY | 2006 | Head Neck2006，28，2： | 1 |
| 12 | Increasing incidence of differentiated thyroid cancer in the United States,1988-2005显示文摘 | Chen AY Jemal A Ward EM | 2009 | Cancer2009，15，16： | 1 |
| 13 | Pelvic embolization for treatment of hemorrhage related to spontaneous and induced abortion显示文摘 | Borgatta L Chen AY Reid SK | 2001 | Am J Obstet Gynecol2001，185，3： | 1 |
| 14 | Dietary substitution of medium-chain triglycerides improves insulin-mediated glucose metabolism in NIDDM subjects显示文摘 | Eckel RH Hanson AS Chen AY | 1992 | Diabetes1992，41，： | 1 |
| 15 | Off-pump coronary artery bypass grafting decreases risk-adjusted mortality and morbidity显示文摘 | Cleveland JC Jr Shroyer AL Chen AY | 2001 | Ann Thorac Surg2001，72，4： | 1 |
| 16 | Prevalence of obesity a- mong children with chronic conditions 显示文摘 | CHEN AY KIM SE HOUTROW AJ | 2010 | Obesity ( Silver Spring)2010，18，1： | 1 |
| 17 | Frequency and clinical implications of discordant creatin kinase-MB and troponin measurements in acute coronary syndromes显示文摘 | Newby LK Roe MT Chen AY | 2006 | J Am Coil Cardiol2006，47，2： | 1 |
| 18 | Impact of congestive heart failure in patients with non-ST-segment elevation acute coronary syndromes显示文摘 | Roe MT Chen AY Riba AL | 2006 | Am J Cardiol2006，97，12： | 1 |
| 19 | Dalbavancin:a novel antimicrobial显示文摘 | Chen AY Zervos MJ Vazquez JA | 2007 | Int J Clin Pract2007，61，5： | 1 |
| 20 | Simulation analysis of conduction block in myelinated axons using three models显示文摘 | Yu L Zhang X Chen AY | 2008 | IEEE Trans on Biomed Eng2008，2，1： | 1 |
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