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| 1 | A metabonomic investigation on the biochemical perturbation in liver failure patients caused by hepatitis b virus显示文摘 | Yu, K Sheng, GP Sheng, JF Chen, YM Xu, W Liu, XL Cao, HC Qu, HB Cheng, YY Li, LJ | 2007 | 中国生物学文摘2007，21，11： | 25 |
| 2 | Portal vein embolization by fine needle ethanol injection :experimental and clinicalstudies显示文摘AIM To improve the technique of intraportal embolization (PVE) therapy, a new embolic method, was devised and the safety, effectiveness and feasibility were evaluated. METHODS PVE with intraportal ethanol injection via a fine needle was performed in 28 normal dogs, 22 SD rats, and 24 cirrhotic SD rats. After PVE, portography, histological and functional alteration of the liver were evaluated in dogs and rats, and the changes in portal hemodynamics as well as hepatic anatomy were observed in rats. In the clinical study, PVE by ethanol injection was performed in 61 patients with hepatocellular carcinoma under the guidance of portoechography with intraportal injection of CO 2. The effect of PVE was evaluated by ultrasonography and laparotomy. RESULTS The effectiveness and toxicity were dependent on the dose of ethanol. In the dogs, 0 25*!mg/*!kg of ethanol caused incomplete embolization with least liver damage, while 1 0*!mg/*!kg induced complete embolization with a high mortality of 57 1% (4/*!7) due to respiratory arrest. The dose of 0 5*!mg/*!kg resulted in complete embolization with slight toxicity to the liver. In the rats, the survival rate was 100% in normal group but 40 9% in cirrhotic models after ethanol injection by dose of 0 05*!mg/*!100*!g . PVE for cirrhotic rats with 0 03*!mg/*!100*!g of ethanol induced satisfactory embolization with significant hypertrophy in nonembolized lobes, and only slight damage to the hepatic parenchyma, and transient alteration in liver function, portal pressure and portal flow. In the clinical study, 12 cases with reverse portal flow were excluded judged by portoechography. Satisfactory embolization was gained in 90 2% (55/*!61) of the remaining patients determined by ultrasonography and surgery. All cases ran an uneventful postembolization course with no aberrant embolization. CONCLUSION PVE with intraportal ethanol injection of appropriate dosage via a fine needle is safe and effective and has several advantages comparing with transcatheter method. Portoechography is a mandatory approach for the prevention of aberrant embolization. | Lu MD Chen JW Xie XY Liang LJ Huang JF | 1999 | World Journal of Gastroenterology1999，5，6： | 15 |
| 3 | Higher numbers of T-bet ( + ) intratumoral lymphoid cells correlate with better surviv- al in gastric cancer 显示文摘 | Chen LJ Zheng X Shen YP et aZ | 2013 | Cancer Immunol Immunother2013，62，： | 1 |
| 4 | Improved genome annotation for Zymomonasmobilis 显示文摘 | Yang S Pappas KM Hauser LJ Land ML Chen GL Hurst GB PanC Kouvelis VN Typas MA Pelletier DA Klinqeman DM Chanq YJ Samatova NF Brown SD | 2009 | Nat Biotechnol2009，27，10： | 1 |
| 5 | The accuracy of endoscopic ultrasound,endoscopic retrograde cholangiopancreatography,computed tomography,and transabdominal ultrasound in the detection and staging of primary ampullary tumours显示文摘 | Chen CH Tseng LJ Yang CC | 2001 | Hepatogastroenterology2001，48，42： | 1 |
| 6 | A model for studying the effect of shear stress on interactions between vascular endothelial cells and smooth muscle cells显示文摘 | Chiu JJ Chen LJ Chen CN | 2004 | J Biomech2004，37，4： | 1 |
| 7 | Correlation of Coronary Angiography with 'Tombstoning' Electrocardiographic Pattern in Patients after Acute Myocardial Infarction显示文摘 | Guo XH Yap YG Chen LJ | 2000 | Clin Cardiol2000，23，5： | 1 |
| 8 | Outpatient minimally invasive para- thyroidectomy:a combination of sectamibi - SPECT localization, cervical block anesthesia, and intraoperative parathyroid hormone assay显示文摘 | Chen H Sokell LJ Udelsman R | 1999 | Surgery1999，126，： | 1 |
| 9 | Systematic qualitative and quantitative assessment of fatty acids in the seeds of 60 tree peony(Paeonia section Moutan)cultivars by GC-MS显示文摘 | Li SS Yuan RY Chen LG Wang LS Hao XH Wang LJ Zheng XC Du H | 2015 | Food Chem2015，173，15： | 1 |
| 10 | Additional use of an aldosterone antagonist in patients with mild to moderate chronic heart failure: a systematic review and meta-analysis 显示文摘 | Hu LJ Chen YQ Deng SB | 2013 | Br J Clin Pharmacol2013，75，5： | 1 |
| 11 | Shear stress inhibits adhesion molecule expression in vascular endothelial cells induced by co culture with smooth muscle cells显示文摘 | Chiu JJ Chen LJ Lee PL | 2005 | Blood2005，101，7： | 1 |
| 12 | Metahonomics research of diabetic nephropathy and type 2 diabetes mellitus based on UPLC-oa TOF-MS system显示文摘 | Zhang J Yan LJ Chen WG | 2009 | Anal Chim Acta2009，650，1： | 1 |
| 13 | How to achieve rapid separations in counter-current chromatography显示文摘 | Chen LJ Sutherland IA | 2006 | J Chromatogr A2006，1114，1： | 1 |
| 14 | Molecular genetics of glyco- gen-storage disease type I a in Chinese patients of Taiwan 显示文摘 | Wong LJ Hwu WL Dai P Chen TJ | 2001 | Mol Genet Metab2001，72，2： | 1 |
| 15 | Pandrug-resistant Acinetobacter baumannii causing nosocomial infections in a u- niversity hospital Taiwan显示文摘 | Huseh PR Teng LJ Chen CY | 2002 | Emerg Infect Dis2002，8，8： | 1 |
| 16 | Metabolism and disposition of 2, 2', 4, 4'- tetrabromodiphenyl ether following administration of single or multiple doses to rats and mice 显示文摘 | Sanders JM Chen LJ Lebetkin EH | 2006 | Xenobiotica2006，36，1： | 1 |
| 17 | Pandrug-resistant Acinetobacter baumannil causing nosocomial infections in a university hospital, Taiwan 显示文摘 | Hsueh PR Teng LJ Chen CY | 2002 | Emerg infect Dis2002，8，8： | 1 |
| 18 | Laboratory confirmation of a suspicious meningococcal meningitis death case 显示文摘 | Zhang TG He X Chen LJ | 2006 | J Microbiol2006，44，： | 1 |
| 19 | Liposomal quercetin effi ciently suppresses growth of solid tumors in murine models 显示文摘 | Yuan ZP Chen LJ Fan LY etal | 2006 | Clin Cancer Res2006，12，10： | 1 |
| 20 | Intraepithelial CDS+ tumor-infiltrating lymphocytes and a high CD8+/regnlatory T cell ratio are associated with favorable prognosis in ovarian cancer显示文摘 | Sato E Olson SH Ahn J Bundy B Nishikawa H Qian F Jungbluth AA Frosina D Gnjatic S Ambrosone C Kepner J Odunsi T Ritter G Lele S Chen YT Ohtani H Old LJ Odunsi K | 2005 | Proc Natl Acad Sci USA2005，102，18： | 1 |
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