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| 1 | The first offshore natural gas hydrate production test in South China Sea显示文摘Natural gas hydrates (NGH)is one of key future clean energy resources.Its industrialized development will help remit the huge demand of global natural gas,relieve the increasing pressure of the environment, and play a vital role in the green sustainable growth of human societies.Based on nearly two decades' studying on the reservoir characteristics in the South China Sea (SCS)and the knowledge of reservoir system,the China Geological Survey (CGS)conducted the first production test on an optimal target selected in Shenhu area SCS in 2017.Guided by the 'three-phase control'exploitation theory which focused on formation stabilization,technologies such as formation fluid extraction,well drilling and completing, reservoir stimulating,sand controlling,environmental monitoring,monitoring and preventing of secondary formation of hydrates were applied.The test lasted for 60 days from May 10^th when starting to pump, drop pressure and ignite to well killing on July 9^th,with gas production of 3.09×10^5 m^3 in total,which is a world record with the longest continuous duration of gas production and maximal gas yield.This successful test brings a significant breakthrough on safety control of NGH production. | Jin-fa Li Jian-liang Ye Xu-wen Qin Hai-jun Qiu Neng-you Wu Hai-long Lu Wen-wei Xie Jing-an Lu Fei Peng Zhen-qiang Xu Cheng Lu Zeng-gui Kuang Jian-gong Wei Qian-yong Liang Hong-feng Lu Bei-bei Kou | 2018 | China Geology2018，1，1： | 117 |
| 2 | The second natural gas hydrate production test in the South China Sea显示文摘Clayey silt reservoirs bearing natural gas hydrates(NGH)are considered to be the hydrate-bearing reservoirs that boast the highest reserves but tend to be the most difficult to exploit.They are proved to be exploitable by the first NGH production test conducted in the South China Sea in 2017.Based on the understanding of the first production test,the China Geological Survey determined the optimal target NGH reservoirs for production test and conducted a detailed assessment,numerical and experimental simulation,and onshore testing of the reservoirs.After that,it conducted the second offshore NGH production test in 1225 m deep Shenhu Area,South China Sea(also referred to as the second production test)from October 2019 to April 2020.During the second production test,a series of technical challenges of drilling horizontal wells in shallow soft strata in deep sea were met,including wellhead stability,directional drilling of a horizontal well,reservoir stimulation and sand control,and accurate depressurization.As a result,30 days of continuous gas production was achieved,with a cumulative gas production of 86.14×104 m3.Thus,the average daily gas production is 2.87×10^4 m^3,which is 5.57 times as much as that obtained in the first production test.Therefore,both the cumulative gas production and the daily gas production were highly improved compared to the first production test.As indicated by the monitoring results of the second production test,there was no anomaly in methane content in the seafloor,seawater,and atmosphere throughout the whole production test.This successful production test further indicates that safe and effective NGH exploitation is feasible in clayey silt NGH reservoirs.The industrialization of hydrates consists of five stages in general,namely theoretical research and simulation experiments,exploratory production test,experimental production test,productive production test,and commercial production.The second production test serves as an important step from the exploratory production test to experimental production test. | Jian-liang Ye Xu-wen Qin Wen-wei Xie Hai-long Lu Bao-jin Ma Hai-jun Qiu Jin-qiang Liang Jing-an Lu Zeng-gui Kuang Cheng Lu Qian-yong Liang Shi-peng Wei Yan-jiang Yu Chunsheng Liu Bin Li Kai-xiang Shen Hao-xian Shi Qiu-ping Lu Jing Li Bei-bei Kou Gang Song Bo Li He-en Zhang Hong-feng Lu Chao Ma Yi-fei Dong Hang Bian | 2020 | China Geology2020，3，2： | 22 |
| 3 | K-wire and tension band wire fixation in treating sternoclavicular joint dislocation显示文摘目的将评估可行性和由 K 电线和紧张乐队电线固定对待 sternoclavicular 关节脱臼的治疗学的效果,并且改进这种技术的安全和稳定性。这研究与平均数由 9 个盒子, 6 男性和 3 女性组成了的方法 25 年变老(范围, 9-62 年) 。原因是在 7 种情况中的交通事故,掉在在 1 种情况中的 1 种情况和战斗里。到操作的从损害的持续时间是到 7 天的 2 个小时。有 5 左脱臼和 4 正确脱臼;8 前面的脱臼和 1 以后的脱臼,包括一个与左 olecranon 骨折与左肩胛骨折和破裂结合了。用 K 电线和紧张乐队电线的开的减小和内部固定被执行对待脱臼。结果所有病人被跟随在上面为 6 ~ 24 个月, 10 个月平均。根据 Rockwood 手术后的 sternoclavicular 关节上的等级规模, 8 个盒子与 13.88 的一个平均分数完成了优秀结果,并且剩余的盒子与 12 的分数完成了好结果。解剖减小在所有情况中被获得。象严重感染没有如此的手术后的复杂并发症,对血容器和神经的损害,固定的失败,等等。病人们都对解剖减小和功能的恢复满意。K 电线和紧张乐队电线固定的技术是保险箱的结论,简单,有效,不太侵略并且成功地在矫形外科被使用了。它在尽管它有一些劣势,对待 sternoclavicular 关节脱臼是有效的。 | CHEN Qing-yu CHENG Shao-wen WANG Wei LIN Zhong-qin ZHANG Wei KOU Dong-quan SHEN Yue YING Xiao-zhou CHENG Xiao-jie LU Chuan-zhu PENG Lei | 2011 | Chinese Journal of Traumatology2011，14，1： | 7 |
| 4 | A Mini Review on Nanocarbon-Based 1D Macroscopic Fibers:Assembly Strategies and Mechanical Properties显示文摘Nanocarbon-based materials, such as carbon nanotubes(CNTs) and graphene have been attached much attention by scientific and industrial community. As two representative nanocarbon materials, one-dimensional CNTs and twodimensional graphene both possess remarkable mechanical properties. In the past years, a large amount of work have been done by using CNTs or graphene as building blocks for constructing novel, macroscopic, mechanically strong fibrous materials. In this review, we summarize the assembly approaches of CNT-based fibers and graphene-based fibers in chronological order, respectively. The mechanical performances of these fibrous materials are compared, and the critical influences on the mechanical properties are discussed. Personal perspectives on the fabrication methods of CNT-and graphene-based fibers are further presented. | Liang Kou Yingjun Liu Cheng Zhang Le Shao Zhanyuan Tian Zengshe Deng Chao Gao | 2017 | Nano-Micro Letters2017，9，4： | 6 |
| 5 | Parallel selection of distinct Tof5 alleles drove the adaptation of cultivated and wild soybean to high latitudes显示文摘Photoperiod responsiveness is a key factor limiting the geographic distribution of cultivated soybean and its wild ancestor.In particular,the genetic basis of the adaptation in wild soybean remains poorly understood.In this study,by combining whole-genome resequencing and genome-wide association studies we identified a novel locus,Time of Flowering 5(Tof5),which promotes flowering and enhances adaptation to high latitudes in both wild and cultivated soybean.By genomic,genetic and transgenic analyses we showed that Tof5 en-codes a homolog of Arabidopsis thaliana FRUITFULL(FUL).Importantly,further analyses suggested that different alleles of Tof5 have undergone parallel selection.The Tof5H1 allele was strongly selected by humans after the early domestication of cultivated soybean,while Tof5H2 allele was naturally selected in wild soybean,and in each case facilitating adaptation to high latitudes.Moreover,we found that the key flowering repressor E1 suppresses the transcription of Tof5 by binding to its promoter.In turn,Tof5 physically associates with the promoters of two important FLOWERING LOCUS T(FT),FT2a and FT5a,to upregulate their transcription and promote flowering under long photoperiods.Collectively,ourfindings provide insights into how wild soybean adapted to high latitudes through natural selection and indicate that cultivated soybean underwent changes in the same gene but evolved a distinct allele that was artificially selected after domestication. | Lidong Dong Qun Cheng Chao Fang Lingping Kong Hui Yang Zhihong Hou Yongli Li Haiyang Nan Yuhang Zhang Qingshan Chen Chunbao Zhang Kun Kou Tong Su Lingshuang Wang Shichen Li Haiyang Li Xiaoya Lin Yang Tang Xiaohui Zhao Sijia Lu Baohui Liu Fanjiang Kong | 2022 | Molecular Plant2022，15，2： | 5 |
| 6 | Novel Fluorescent Chemosensors Based on Tryptophan Unit for Cu2+ and Fe3+ in Aqueous Solution显示文摘 | CHENG Peng-fei XU Kuo-xi YAO Wen-yong KONG Hua-jie KOU Li MA Xiao-dan WANG Chao-jie | 2013 | Chemical Research in Chinese Universities2013，29，4： | 5 |
| 7 | Intramedullary nailing of clavicular midshaft fractures in adults using titanium elastic nail显示文摘ObjectiveStudies 证明代替的 midclavicular 破裂的钉的有弹性的稳定的 intramedullary (ESIN ) 有优秀结果,以及高复杂并发症率和特定的问题。目的 fractures.MethodsTotally 是讨论 midshaft 的 ESIN 锁骨的 60 个合格病人(年老的 18-63 年) 被使随机化到在 2007 年 1 月和 2008 年 5 月之间的 ESIN 组或非起作用的组。锁骨的弄短在损伤和骨状的巩固以后被测量。X 光线照相术的联合和复杂并发症被估计。包括经常的肩膀分数和手臂,肩膀和手(破折号) 的残疾的功能分析得分在 15 月的 follow-up.ResultsESIN 导致了一 signifcantly 更短的时间到联合以后,被执行,特别为简单破裂。在 ESIN 组,所有病人得到了骨折联合, 5 个盒子有中间的皮激怒,因为, 1 个病人需要修订外科植入失败。在 nonoperative 组,有 3 个不属于工会的盒子, 2 征兆的 malunions 发展了要求校正截骨术。在在 intramedullary 稳定以后的 15 个月,在 ESIN 组的病人是对肩膀和全面结果的外观满意的更多,并且他们从 traumatic 以后的大改进有益于很多锁骨的弄短。而且,破折号分数更低,经常的分数与非起作用的 group.ConclusionESIN 相对照是显著地更高的是有更低的复杂并发症率,到每日的活动的更快的回来,优秀化妆品和更好功能的结果的一种安全最低限度地侵略的外科的技术,为对待中间柄的锁骨的破裂的锁骨的长度的恢复,导致高全面的满足,它能作为板固定或 mid-shaf 的 nonoperative | CHEN Qing-yu KOU Dong-quan CHENG Xiao-jie ZHANG Wei WANG Wei LIN Zhang-qin CHENG Shao-wen SHEN Yue YING Xiao-zhou PENG Lei LU Chuan-zhu | 2011 | Chinese Journal of Traumatology2011，14，5： | 4 |
| 8 | Effect of calcium citrate on bone integration in a rabbit femur defect model显示文摘Objective:To explore effect of calcium citrate on bone integration in a rabbit femur defect model, and to compare the bone formation with different sizes by radiological and histological study. Methods:Twenty-four male Japanese white rabbits were randomly divided into three groups (Group A.B.C)in this study.Under anesthesia,defects of four sizes(1.2,1.5,2.0 and 2.5 mm) were created in each of the rabbits.Commercially pure calcium citrate powder was placed inside the medullary compartment of the femur(Experimental),while in the contralateral femur(Control) nothing was implanted.The defects were analyzed using radiography and histological analysis by using Imagepro-Plus 6.0 software after animal was sacrificed at 4th(Group A),6th(Group B) and 8th(Group C) weeks postoperatively.Four samples were analyzed for each size of defect and each healing period.Results:The histological and the radiologic evaluation were performed after sacrification of all rabbits on postoperative 4th and 6th weeks,It showed significant difference between the experimental group and the control group when these defects were less than or equal to 2.0 mm.No statistical difference was observed when these defects were larger than 2.0 mm at all healing periods except at the 4th week.Conclusions:Calcium citrate affects the early periods of hone defects healing mechanism in Japanese white rabbits positively,especially when the defect is not too large,We suggest further studies on calcium citrate to determine the effects of various dosages,administration ways and the experimental time on the bone defects. | Wei Zhang Wei Wang Qing-Yu Chen Zhong-Qin Lin Shao-Wen Cheng Dong-Quan Kou Xiao-Zhou Ying Yue Shen Xiao-Jie Cheng Peng-Fei Nie Xiu-Cui Li Ferdinand An Rompis Hang Huang Hua Zhang Zhong-Lin Mu Lei Peng | 2012 | Asian Pacific Journal of Tropical Medicine2012，5，4： | 3 |
| 9 | The Functional Roles of Lipid Rafts in T Cell Activation,Immune Diseases and HIV Infection and Prevention显示文摘The first appearance of lipid rafts,or lipid rafts-like structure,was occasionally observed by cryo-electronic microscopy in 1980s as cavity,such as caveolae. However,the fully understanding of lipid raft was attributed by the studies of T cell activation,virus entry/budding,and other membrane events. During the interaction of T cell and antigen presenting cell,a highly organized structure is formed at the interface of the two cells,where cholesterol and sphingolipids are enriched,and form a liquid ordered phase that facilitates the signaling proteins on and off. Lipid rafts are also involved in virus entry and assembly. In this review,we will discuss cholesterol-sphingolipid floating microdomain,the lipid raft as a unique compartment of the plasma membrane,with biological functions that ensure correct intracellular traffic of proteins and lipids,such as protein-protein interactions by concentrating certain proteins in these microdomains,while excluding others. We also discuss the disruption of lipid rafts is related to different diseases and aging,and we especially exploit the lipid rafts as pharmaceutical targets for anti-virus and anti-inflammation,particularly a new approach to control HIV infection for AIDS prevention and protection by inhibition or disruption of lipid rafts. | Cheng Luo Kou Wang Dequan Liu Yan Li Qinshi Zhao | 2008 | Cellular & Molecular Immunology2008，5，1： | 3 |
| 10 | Green Fabrication of Multifunctional Three‑Dimensional Superabsorbent Nonwovens with Thermo‑Bonding Fibers显示文摘Disposable hygiene products have evolved into the important parts for millions of people around the world,enhancing the convenience of daily lives.However,development of the disposable hygiene products is restricted by unsustainable production technology,complicated operation process,and poor liquid absorption performance of the absorbent core.Herein,integrated and three-dimensional(3D)multifunctional superabsorbent nonwovens with liquid-triggered fragrance release was prepared via green,fast and scalable multi efect hot-air anchoring method which physically crosslinking the joint thermobonding fbers and anchoring fragrance microcapsules/super absorbent polymer(SAP)onto adjacent thermo-bonding fbers simultaneously.The resulting composite nonwovens could three-dimensionally absorb water 33.14 times of its own weight without gel blockage between SAP,and correspondingly release increased intensity fragrance along with enhancing amount of water absorption.Absorption rate t1 and t2 is 83.62%and 50.62%higher than the commercial specimen respectively,and the air permeability is increased by 226.88%compared with the commercial specimen.The superabsorbent nonwovens with controllable fragrance release and odorant synergistic has the potential to be practically applied to functional textiles felds because of the excellent liquid absorption and controlled fragrance release performance,and is easy to be produced on a sustainable,pollution-free and large-scale industrial production. | Jiajia Ma Nan Zhang Ying Cheng Xingran Kou Yunwei Niu Xiangyu Jin Qinfei Ke Yi Zhao | 2022 | Advanced Fiber Materials2022，4，2： | 3 |
| 11 | Modulating intestinal mucus barrier for nanoparticles penetration by surfactants显示文摘Improving peroral delivery efficiency is always a persistent goal for both small-molecule and macromolecular drug development. However,intestinal mucus barrier which greatly impedes drug-loaded nanoparticles penetration is commonly overlooked. Therefore,in this study,taking fluorescent labeled PLGA(poly(lactic-co-glycolic acid)) nanoparticles as a tool,the influence of anionic and nonionic surfactants on mucus penetration ability of nanoparticles and their mucus barrier regulating ability were studied. The movement of PLGA nanoparticles in mucus was tracked by multiple particles tracking method(MPT).Alteration of mucus properties by addition of surfactants was evaluated by rheology and morphology study. Rat intestinal villus penetration study was used to further evaluate penetration enhancement of nanoparticles. The effective diffusivities of the nanoparticles in surfactants pretreated mucus were increased by 2–3 times and the mucus barrier regulating capacity was also surfactant type dependent. Sodium dodecyl sulfate(SDS) increased the complex viscosity and viscoelastic properties of mucus,but poloxamer presented a decreased trend. Tween 80 maintained the rheological property of the mucus. With the mucus barrier regulated by surfactants,the penetration of nanoparticles in intestinal villus was obviously increased. In summary,the mucus penetration ability of nanoparticles could be enhanced by altering mucus microenvironment with surfactants. Tween 80 which largely retains the original mucus rheology and morphology properties may be a promising candidate for facilitating nanoparticle penetration through the mucus barrier with good safety profile. | Xin Zhang Wei Dong Hongbo Cheng Meixia Zhang Yongqiang Kou Jian Guan Qiaoyu Liu Mingyue Gao Xiuhua Wang ShiruiMao | 2019 | Asian Journal of Pharmaceutical Sciences2019，14，5： | 2 |
| 12 | Osteogenic capability of autologous rabbit adipose-derived stromal cells in repairing calvarial defects显示文摘ObjectiveTo 评估在里面 vitro 并且在脂肪质导出 stromal 房间(ASC ) 的 vivo osteogenic 能力, .MethodASCs 从新西兰白兔子被孤立并且由染色的碱的磷酸酶(高山) 决定了, von Kossa 染色并且茜素红染色。osteogenic 区别的一些特定的标记包括高山, osteocalcin (OCN ) , osteopontin (OPN ) 被反向的抄写聚合酶链反应(RT-PCR ) 检验。在 vivo, demineralized 骨头矩阵(DBM )-ASCs composites 被植入进在纵的中线的每个方面创造的兔子 calvarial 缺点。在 6 个星期以后, transplants 的 histo 逻辑性质是 analyzed.ResultsASCs 成功地被导致进成骨。染色的高山, von Kossa 染色和茜素红染色显示出积极结果。高山, OCN 和 OPN 的表情在 osteogenic 媒介在耕作以后在 ASC 被检测。广泛的新骨头在与 DBM-ASCs composites.ConclusionASCs 移植的缺点被观察有潜力区分进 osteogenic 系和 DBM-ASCs 构造是为在骨头缺点的新生的一个有希望的方法。 | CHENG Shao-wen LIN Zhong-qin WANG Wei ZHANG Wei KOU Dong-quan YING Xiao-zhou CHEN Qing-yu SHEN Yue CHENG Xiao-jie PENG Lei LU Chuan-zhu | 2011 | Chinese Journal of Traumatology2011，14，5： | 2 |
| 13 | High-throughput sequencing reveals the disruption of methylation of imprinted gene in induced pluripotent stem cells显示文摘在导致的 pluripotent 干细胞(iPSCs ) 积累的反常 epigenetic 修正是否能最终影响 iPSC pluripotency,仍然保持争论。为了探查这个问题,有一样的基因背景的 iPSC 线和 proviral 集成地点,被建立,并且每根 iPSC 线的 pluripotency 状态用 tetraploid (4N ) 被描绘互补试金。随后,基因表示和 “ 的全球 epigenetic 修正; 4N-ON ”并且相应 “ 4N-OFF ”iPSC 线通过深定序 mRNA 表示,小 RNA 侧面, histone 修正(H3K27me3, H3K4me3,和 H3K4me2 ) ,和 DNA methylation 的分析被比较。我们发现了印的基因的那 methylation, Zrsr1,一致地与减少的 pluripotency 在 iPSC 线被破坏。而且,破坏 methylation 不能被改进文化条件或 iPSCs 的 subcloning 救。而且,在 iPSCs 的 Zrsr1 和 pluripotency 状态的 hypomethylation 之间的关系进一步在线从另外的 reprogramming 系统导出的独立 iPSC 被验证。 | Gang Chang Shuai Gao Xinfeng Hou Zijian Xu Yanfeng Liu Lan Kang Yu Tao Wenqiang Liu Bo Huang Xiaochen Kou Jiayu Chen Lei An Kai Miao Keqian Di Zhilong Wang Kun Tan Tao Cheng Tao Cai Shaorong Gao Jianhui Tian | 2014 | Cell Research2014，24，3： | 2 |
| 14 | Flexible organic light-emitting diodes for antimicrobial photodynamic therapy显示文摘Bacterial infection and the growth of antibiotic resistance is a serious problem that leads to patient suffering,death and increased costs of healthcare.To address this problem,we propose using flexible organic light-emitting diodes(OLEDs)as light sources for photodynamic therapy(PDT)to kill bacteria.PDT involves the use of light and a photosensitizer to generate reactive oxygen species that kill neighbouring cells.We have developed flexible top-emitting OLEDs with the ability to tune the emission peak from 669 to 737 nm to match the photosensitizer,together with high irradiance,low driving voltage,long operational lifetime and adequate shelf-life.These features enable OLEDs to be the ideal candidate for ambulatory PDT light sources.A detailed study of OLED–PDT for killing Staphylococcus aureus was performed.The results show that our OLEDs in combination with the photosensitizer methylene blue,can kill more than 99%of bacteria.This indicates a huge potential for using OLEDs to treat bacterial infections. | Cheng Lian Marta Piksa Kou Yoshida Saydulla Persheyev Krzysztof J.Pawlik Katarzyna Matczyszyn Ifor D.W.Samuel | 2019 | npj Flexible Electronics2019，3，1： | 2 |
| 15 | Admission hyperglycemia predicts poorer short‐ and long‐term outcomes after primary percutaneous coronary intervention for ST ‐elevation myocardial infarction显示文摘 | Pei‐Chi Chen Su‐Kiat Chua Huei‐Fong Hung Chung‐Yen Huang Chiu‐Mei Lin Shih‐Ming Lai Yen‐Ling Chen Jun‐Jack Cheng Chiung‐Zuan Chiu Shih‐Huang Lee Huey‐Ming Lo Kou‐Gi Shyu | 2014 | J Diabetes Invest2014，，1： | 1 |
| 16 | Nucleation and morphology of barium carbonate crystals in a semi-batch crystallizer显示文摘 | PCHEN P C CHENG G Y KOU M H | 2002 | Journal of Crystal Growth2002，34，3： | 1 |
| 17 | Crystal structure and magnetic behaviour of a two-dimendion- al step-shaped cyano-bridged complex 32· 6H2O显示文摘 | KOU Hui-zhong LIAO Dai-zheng PENG Cheng | 1997 | J Chem Soc Dalton Trans1997，9，： | 1 |
| 18 | Shikonin derivatives inhibited LPS-induced NOS in RAW 264.7 cells via downregulation of MAPK/NF-κB signaling显示文摘 | Yu Wen Cheng Ching Yi Chang Kou Lung Lin Chien Ming Hu Cheng Hui Lin Jaw Jou Kang | 2008 | Journal of Ethnopharmacology2008，，2： | 1 |
| 19 | Mesoscale analyses of Sichuan flood ca- tastrophe, 11-15 July 1981 显示文摘 | Kou Y H Cheng L Anthes R A | 1986 | Mon wea Rev1986，114，： | 1 |
| 20 | Network reconfiguration in distribution systems using simulated annealing显示文摘 | Cheng H C Kou C C | 1994 | Elect Power Syst Res1994，29，： | 1 |
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