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| 1 | Transmutation of ancient settlements and environmental changes between 6000-2000 aBP in the Chaohu Lake Basin, East China显示文摘Based on the temporal-spatial distribution features of ancient settlement sites from the middle and late Neolithic Age to the Han dynasty in the Chaohu Lake Basin of Anhui Province,East China,using the methods of GIS combined with the reconstructed paleoenvironment by the records of lake sediment since Holocene,the transmutation of ancient settlements with response to environmental changes in this area has been discussed.Studies show that the main feature of transmutation of ancient settlements from the middle and late Neolithic Age to the Han Dynasty was that the distribution of settlements in this area changed from high altitudes to low ones and kept approaching the Chaohu Lake with the passage of time.These could be the response to the climate change from warm-moist to a relatively warm-dry condition during the middle Holocene,leading to the lake level fluctuations.The large area of exposed land provided enough space for human activities.These indicate that the above changes in geomorphologic evolution and hydrology influenced by climate conditions affected the transmutation of ancient settlements greatly.The distribution pattern of settlement sites was that the number of sites in the west was more than in the east.This pattern may be related to the geomorphologic conditions such as frequent channel shifting of the Yangtze River as well as flood disasters during the Holocene optimum.Therefore,climate change was the inducement of the transmutation of ancient settlements in the Chaohu Lake Basin,which exerted great influence on the distribution,expansion and development of the ancient settlements. | WU Li WANG Xinyuan ZHOU Kunshu MO Duowen ZHU Cheng GAO Chao ZHANG Guangsheng LI Lan LIU Li HAN Weiguang | 2010 | Journal of Geographical Sciences2010，20，5： | 16 |
| 2 | Real-Time Position and Attitude Estimation for Homing and Docking of an Autonomous Underwater Vehicle Based on Bionic Polarized Optical Guidance显示文摘As an important tool for marine exploration, the autonomous underwater vehicle(AUV) must home in and dock at a docking station(DS) to be recharged, repaired, or to exchange information at set intervals. However, the complex and hostile underwater environment makes this process challenging. This study proposes a real-time method based on polarized optical guidance for determining the position and attitude of the AUV relative to its DS. Four polarized artificial underwater landmarks are positioned at the DS, which are recognized by the AUV vision system. Compared with light intensity, the polarization of a light beam is known to be better maintained at greater propagation distances, especially in underwater environments. The proposed method, which is inspired by the ability of marine animals to communicate, calculates the pose parameters in less than 10 ms without any other navigational information. The simulation results reveal that the angle errors are small and the position errors are no more than 0.116 m within 100 m in the coastal ocean. The results of underwater experiments further demonstrate the feasibility of the proposed method, which extends the operating distance of the AUV beyond what is currently possible while maintaining the precision of traditional optical guidance. | CHENG Haoyuan CHU Jinkui ZHANG Ran GUI Xinyuan TIAN Lianbiao | 2020 | Journal of Ocean University of China2020，19，5： | 6 |
| 3 | Extraction of palaeochannel information from remote sensing imagery in the east of Chaohu Lake, China显示文摘Palaeochannels 是 unconsolidated 沉积或在古老的、当前不活跃的河和流隧道系统里扔的巩固半的沉积岩石的存款。它从当前活跃的河隧道的 overbank 存款是不同的,包括定期不流动的短暂的水功课。我们介绍了一光谱从有特殊时间阶段的 SPOT-5 形象的基于特征的 palaeochannel 信息抽取模型,它被遥感机制的分析的优点造了并且光谱 palaeochannel 的特征,从空间分发与它的区别结合了并且光谱当前活跃的河隧道的特征,另外,随遥感判定的建立,在遥感的 palaeochannel 的特征想象。这个模型跟随监督分类的进程[箭头权利] 掩盖的农田和主要部件分析[箭头权利] 地下的 palaeochannel 信息抽取[箭头权利] 信息联合[箭头权利] palaeochannel 系统图象。在乔胡·莱克的东方的 Zhegao 河山谷作为一个学习区域被选择,并且 SPOT-5 形象被用作数据的来源。当这个方法成功地被使用了提取 palaeochannel 信息时,结果是令人满意的,它能为地区性的遥感考古学和 neotectonic 研究提供好参考。然而,这个方法的适用性需要作为空间特征在另外的区域进一步被测试并且光谱 palaeochannel 的反应可能是不同的[出版摘要] | Xinyuan WANG Zhenya GUO Li WU Cheng ZHU Hui HE | 2012 | Frontiers of Earth Science2012，6，1： | 4 |
| 4 | Targeting strategies for adeno-associated viral vector显示文摘Adeno-associated virus (AAV) has rapidly become a promising gene delivery vector for its excellent advantages of low pathogenicity and long-term gene expression over other viral vectors for human gene therapy. However, the disadvantage of AAV for clinical gene therapy is the broad host range and the lack of tissue or cell specificity, which makes AAVs relatively inefficient gene delivery to target cells and short of safety. Therefore, it is required to improve the targeting capability of recombinant adeno-associated virus (rAAV) for successful gene therapy. At present, the successful identification of vari- ous-serotype AAVs and the improvement of rAAV production technology make it feasible to explore new applications of rAAV vector in clinical gene therapy trials. Moreover, the current development in targeting strategy has brought a bright prospect to rAAV vectors. Many studies have demonstrated that targeting gene therapy based on rAAV vectors could be achieved through transcription targeted, con-jugate targeted, receptor targeted, gene recombinant targeted strategies, etc. This report gives a com- prehensive review of the recent developments of targeting strategies for rAAV vectors. | WANG YiGang HUANG Fang CAI Rong QIAN Cheng LIU XinYuan | 2007 | Chinese Science Bulletin2007，52，12： | 3 |
| 5 | 3D printing“wire-on-sphere”hierarchical SiC nanowires/SiC whiskers foam for efficient high-temperature electromagnetic wave absorption显示文摘Electromagnetic wave absorption(EWA)materials for use in extreme environments are of great interest.Herein,SiC nanowires/SiC whiskers(SiC_(nw)/SiC_(w))foam with unique“wire-on-sphere”hierarchical structure was developed for efficient high-temperature EWA.SiC_(w)were assembled to porous SiC_(w)spheres via spray drying and then SiC_(w)spheres were 3D printed to SiC_(w)foam.The catalyst-free precursor infiltration pyrolysis process was first developed to ensure that SiCnwcan intentionally grow in situ on the surface of SiC_(w)spheres,thereby achieving“wire-on-sphere”hierarchical structure foam.At room-temperature,the maximum electromagnetic wave effective absorption bandwidth(EAB_(max))and minimum electromagnetic wave reflection coefficient(RC_(min))of SiC_(nw)/SiC_(w)foam can reach 4 GHz and-57 dB,respectively.At600℃,the EAB_(max)and RC_(min) were 3 GHz and-15 dB,respectively.Furthermore,even oxidized at 1000-1500℃,SiC_(nw)/SiC_(w)foam can still retain EAB_(max)ranging from 2.7 to 3.9 GHz and RC_(min)ranging from-16 dB to-64 dB,because the formation of SiO_(2)layer with appropriate thickness can boost interfacial polarization and regulate impedance matching.The SiC_(nw)/SiC_(w)foam also shows the flexural strength as high as 17.05 MPa.All results demonstrate that the SiC nw/SiC_(w)foam is a promising EWA material for applications of harsh environments.And the material-independent“wire-on-sphere”hierarchical structure and its novel preparation process should find the widespread use in the design and fabrication of high-efficiency EWA micro-nano materials. | Xinyuan Lv Fang Ye Laifei Cheng Litong Zhang | 2022 | Journal of Materials Science & Technology2022，，14： | 2 |
| 6 | 100 Hertz frame-rate switching threedimensional orbital angular momentum multiplexing holography via cross convolution显示文摘The orbital angular momentum(OAM)of light has been implemented as an information carrier in OAM holography.Holographic information can be multiplexed in theoretical unbounded OAM channels,promoting the applications of optically addressable dynamic display and high-security optical encryption.However,the frame-rate of the dynamic extraction of the information reconstruction process in OAM holography is physically determined by the switching speed of the incident OAM states,which is currently below 30 Hz limited by refreshing rate of the phase-modulation spatial light modulator(SLM).Here,based on a cross convolution with the spatial frequency of the OAM-multiplexing hologram,the spatial frequencies of an elaborately-designed amplitude distribution,namely amplitude decoding key,has been adopted for the extraction of three-dimensional holographic information encoded in a specific OAM information channel.We experimentally demonstrated a dynamic extraction frame rate of 100 Hz from an OAM multiplexing hologram with 10 information channels indicated by individual OAM values from-50 to 50.The new concept of cross convolution theorem can even provide the potential of parallel reproduction and distribution of information encoded in many OAM channels at various positions which boosts the capacity of information processing far beyond the traditional decoding methods.Thus,our results provide a holographic paradigm for high-speed 3D information processing,paving an unprecedented way to achieve the high-capacity short-range optical communication system. | Weijia Meng Yilin Hua Ke Cheng Baoli Li Tingting Liu Qinyu Chen Haitao Luan Min Gu Xinyuan Fang | 2022 | Opto-Electronic Science2022，1，9： | 2 |
| 7 | In vitro fluidic systems: Applying shear stress on endothelial cells显示文摘Endothelial cells(ECs)that reside on the surface of blood vessels are constantly exposed to mechanical stimulation,including shear stress.Fluid shear stress(FSS)controls multiple physiological processes in ECs,regulating various pathways that maintain vascular tone and homeostasis function.The complexity of in vivo biological systems raises a demand for better in vitro techniques,which can generate FSS to closely mimic the cellular microenvironment.Through the rational design and use of flow chamber devices,in vitro fluidic systems are critical for a deeper understanding of endothelial responses to various shear conditions.The paper describes principal types of FSS systems,including functional attributes,development process and recent experiments on ECs.Finally,we prospect their possible contribution in the field of endothelial diseases. | Fanzhe Meng Hong Cheng Jiayi Qian Xinyuan Dai Yan Huang Yubo Fan | 2022 | Medicine in Novel Technology and Devices2022，，3： | 1 |
| 8 | Facing small and biased data dilemma in drug discovery with enhanced federated learning approaches显示文摘Artificial intelligence(AI)models usually require large amounts of high-quality training data,which is in striking contrast to the situation of small and biased data faced by current drug discovery pipelines.The concept of federated learning has been proposed to utilize distributed data from different sources without leaking sensitive information of the data.This emerging decentralized machine learning paradigm is expected to dramatically improve the success rate of AI-powered drug discovery.Here,we simulated the federated learning process with different property and activity datasets from different sources,among which overlapping molecules with high or low biases exist in the recorded values.Beyond the benefit of gaining more data,we also demonstrated that federated training has a regularization effect superior to centralized training on the pooled datasets with high biases.Moreover,different network architectures for clients and aggregation algorithms for coordinators have been compared on the performance of federated learning,where personalized federated learning shows promising results.Our work demonstrates the applicability of federated learning in predicting drug-related properties and highlights its promising role in addressing the small and biased data dilemma in drug discovery. | Zhaoping Xiong Ziqiang Cheng Xinyuan Lin Chi Xu Xiaohong Liu Dingyan Wang Xiaomin Luo Yong Zhang Hualiang Jiang Nan Qiao Mingyue Zheng | 2022 | Science China(Life Sciences)2022，65，3： | 1 |
| 9 | Tumor Microenvironment-Adaptive Nanoplatform Synergistically Enhances Cascaded Chemodynamic Therapy显示文摘Chemodynamic therapy(CDT),a noninvasive strategy,has emerged as a promising alternative to conventional chemotherapy for treating tumors.However,its therapeutic effect is limited by the amount of H_(2)O_(2),pH value,the hypoxic environment of tumors,and it has suboptimal tumor-targeting ability.In this study,tumor cell membrane-camouflaged mesoporous Fe_(3)O_(4) nanoparticles loaded with perfluoropentane(PFP)and glucose oxidase(GOx)are used as a tumor microenvironment-adaptive nanoplatform(M-mFeP@O_(2)-G),which synergistically enhances the antitumor effect of CDT.Mesoporous Fe_(3)O_(4) nanoparticles are selected as inducers for photothermal and Fenton reactions and as nanocarriers.GOx depletes glucose within tumor cells for starving the cells,while producing H2O2 for subsequent⋅OH generation.Moreover,PFP,which can carry O_(2),relieves hypoxia in tumor cells and provides O_(2) for the cascade reaction.Finally,the nanoparticles are camouflaged with osteosarcoma cell membranes,endowing the nanoparticles with homologous targeting and immune escape abilities.Both in vivo and in vitro evaluations reveal high synergistic therapeutic efficacy of M-mFeP@O_(2)-G,with a desirable tumor-inhibition rate(90.50%),which indicates the great potential of this platform for clinical treating cancer. | Yuemin Wang Duan Wang Yuyue Zhang Hong Xu Luxuan Shen Jing Cheng Xinyuan Xu Hong Tan Xingyu Chen Jianshu Li | 2023 | Bioactive Materials2023，，4： | 1 |
| 10 | Ancient culture decline after the Han Dynasty in the Chaohu Lake basin, East China: A geoarchaeological perspective显示文摘 | Li Wu Xinyuan Wang Cheng Zhu Guangsheng Zhang Feng Li Lan Li Suyuan Li | 2011 | Quaternary International2011，，： | 1 |
| 11 | Improving anammox activity and reactor start-up speed by using CO_(2)/NaHCO_(3) buffer显示文摘Anammox bacteria grow slowly and can be affected by large pH fluctuations.Using suitable buffers could make the start-up of anammox reactors easy and rapid.In this study,the effects of three kinds of buffers on the nitrogen removal and growth characteristics of anammox sludge were investigated.Reactors with CO_(2)/NaHCO_(3)buffer solution(CCBS)performed the best in nitrogen removal,while 4-(2-hydroxyerhyl)piperazine-1-ethanesulfonic acid(HEPES)and phosphate buffer solution(PBS)inhibited the anammox activity.Reactors with 50 mmol/L CCBS could start up in 20 days,showing the specific anammox activity and anammox activity of 1.01±0.10 gN/(gVSS·day)and 0.83±0.06 kgN/(m^(3)·day),respectively.Candidatus Kuenenia was the dominant anammox bacteria,with a relative abundance of 71.8%.Notably,anammox reactors could also start quickly by using 50 mmol/L CCBS under nonstrict anaerobic conditions.These findings are meaningful for the quick start-up of engineered anammox reactors and prompt enrichment of anammox bacteria. | Shaoan Cheng Huahua Li Xinyuan He Hua Chen Longxin Li | 2024 | Journal of Environmental Sciences2024，，5： | 0 |
| 12 | Mink Circovirus Can Infect Minks, Foxes and Raccoon Dogs显示文摘Dear Editor,Mink circovirus (MiCV), which is clustered in the genus Circovirus of the family Circoviridae, was first described in minks from farms in Dalian, China in 2013 (Lian et al.2014). The complete single-stranded circular genome of the virus is 1,753 nucleotides long and contains two major open reading frames (ORFs), designated ORF1 (Rep gene)and ORF2 (Cap gene)(Lian et al. 2014;Ge et al. 2018). | Yanling Yang Yuening Cheng Nan Li Shipeng Cheng Li Guo Yucheng Zhou Haiwei Zhang Xinyuan Zhang Linzhu Ren | 2018 | Virologica Sinica2018，33，6： | 0 |
| 13 | Evaluating cost and benefit of air pollution control policies in China:A systematic review显示文摘China has put great efforts into air pollution control over the past years and recently committed to its most ambitious climate target.Cost and benefit analysis has been widely used to evaluate the control policies in terms of past performance,future reduction potential,and direct and indirect impacts.To understand the cost and benefit analysis for air pollution control in China,we conducted a bibliometric review of more than 100 studies published over the past two decades,including the current research progress,most commonly adopted methods,and core findings.The control target in cost and benefit analysis has shifted in three stages,from individual and primary pollution control,moving to joint prevention of multiple and secondary pollutants,and then towards synergistic control of air pollution and carbon.With the expansion of the research scope,the integrated assessment model has gradually demonstrated the necessity for long-term ex-anti policy simulation,especially for dealing with complex factors.To ensure long-term air quality,climate,public health,and sustainable economic development,substantial evidence from published studies has suggested that China needs to continue its efforts in the upstream adjustment of the energy system and industrial structure with multi-regional and-sector collaboration.This cost and benefit review paper provides decision-makers with the fundamental information and knowledge gaps in air pollution control strategies in China,and direction for facing future challenges. | Xinyuan Liu Chaoyi Guo Yazhen Wu Chen Huang Keding Lu Yuanhang Zhang Lei Duan Miaomiao Cheng Fahe Chai Fengqiao Mei Hancheng Dai | 2023 | Journal of Environmental Sciences2023，，1： | 0 |
| 14 | Orbital angular momentum-mediated machine learning for high-accuracy mode-feature encoding显示文摘Machine learning with optical neural networks has featured unique advantages of the information processing including high speed,ultrawide bandwidths and low energy consumption because the optical dimensions(time,space,wavelength,and polarization)could be utilized to increase the degree of freedom.However,due to the lack of the capability to extract the information features in the orbital angular momentum(OAM)domain,the theoretically unlimited OAM states have never been exploited to represent the signal of the input/output nodes in the neural network model.Here,we demonstrate OAM-mediated machine learning with an all-optical convolutional neural network(CNN)based on Laguerre-Gaussian(LG)beam modes with diverse diffraction losses.The proposed CNN architecture is composed of a trainable OAM mode-dispersion impulse as a convolutional kernel for feature extraction,and deep-learning diffractive layers as a classifier.The resultant OAM mode-dispersion selectivity can be applied in information mode-feature encoding,leading to an accuracy as high as 97.2%for MNIST database through detecting the energy weighting coefficients of the encoded OAM modes,as well as a resistance to eavesdropping in point-to-point free-space transmission.Moreover,through extending the target encoded modes into multiplexed OAM states,we realize all-optical dimension reduction for anomaly detection with an accuracy of 85%.Our work provides a deep insight to the mechanism of machine learning with spatial modes basis,which can be further utilized to improve the performances of various machine-vision tasks by constructing the unsupervised learning-based auto-encoder. | Xinyuan Fang Xiaonan Hu Baoli Li Hang Su Ke Cheng Haitao Luan Min Gu | 2024 | Light(Science & Applications)2024，13，3： | 0 |
| 15 | Study on Holocene Paleoearthquakes in Xizhang Trench on the Jiaocheng Fault Zone,Shanxi Province显示文摘Xizhang trench is located 10 km northwest of Taiyuan city,Shanxi Province,in front of a NNW-trending scarp of 4.6m height on the northern segment of the Jiaocheng fault zone.The dimensions of the trench are 108m in length,8m in width,and 10m in depth.There are 18 horizons revealed in the trench.The upper strata are sandy loam;the upper strata of the downthrown block of the fault are gravels,the lower ones are an interbed of brown loam and sandy loam.The strata on the upthrown block of the fault are sandy loam containing gravel.The trench shows 3 fault planes,and the upper offset point on the fault plane is 1.5m below the ground surface,the newest dislocated stratum is(3.74±0.06)ka BP.The trench reveals a lot of deformation traces,such as fault planes,dislocated strata,colluvial wedges and formation tilting.The relationship between strata and faults in the trench shows that 3 paleoearthquake events have occurred at the Jiaocheng fault zone since the Early Holocene,they are about(3.74±0.06)~(3.06±0.26)ka BP,(8.35±0.09)ka~(3.74±0.06)ka BP,and(10.66±0.85)~(8.35±0.09)ka BP.The average interval among the events is 2.6~3.6ka.The minimum coseismic vertical displacements of the 3 events are 3.0m,2.5m and 3.2m,respectively.The significance of Xizhang trench is that the Jiaocheng fault used to be active thousands of years ago,though there is no M≥7.0 earthquake recorded in historical documents.Evidence of new Jiaocheng fault zone activity during the Holocene is important for the earthquake safety assessment of Taiyuan city in the future. | Xie Xinsheng Zhao Jinquan Jiang Wali An Weiping Li Zihong Zhang Dawei Cheng Xinyuan Gao Shuyi Wang Chunhe Sun Changbin Yan Chengguo | 2008 | Earthquake Research in China2008，22，4： | 0 |
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