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| 1 | Engineering Innovation and the Development of the BDS-3 Navigation Constellation显示文摘1.Introduction On 23 June 2020,the third geostationary Earth orbit satellite(GEO-3),the last satellite of the China's BeiDou Navigation Satellite System(BDS)-3 space segment construction project,was successfully launched,marking the completion of the BDS global constellation deployment and indicating the successful completion of the BDS“three-step”development strategy.The positioning,navigation,and timing(PNT)service and special-feature services provided by the BDS have been widely used in key infrastructures of the national economy and defense security;they have also promoted a transformation of the production method and upgraded industrial infrastructure in China. | Jun Xie Chengbin Kang | 2021 | Engineering2021，7，5： | 10 |
| 2 | Unidirectionally aligned bright quantum rods films,using T-shape ligands,for LCD application显示文摘Unidirectionally aligned nanorods(NRs)are of great importance for different applications,including displays,lighting,and photodetectors.Recently,many alignment techniques were studied to align quantum rods(QRs).However,the brightness of these films,due to the limited concentration of aligned quantum rods in the film,is not enough for their implementation as brightness enhancement films(BEFs)in displays.This can be ascribed to the poor miscibility of quantum rods in polymer and strong concentration dependence of the polarized emission.The ligands of NR are very important for the alignment and brightness.In this article,we proposed a ligand combination comprising T-shape promesogenic phosphonic acid,which on being photoaligned provides mutually parallel alignment of the quantum rods.The T-shape ligands enable the fabrication of hybrid films with a QRs concentration as high as 10 wt.%–20 wt.%retaining high brightness and luminescence polarization property.Later,we used these films in the in-plane switching(IPS)display backlight that shows the color gamut up to 121%of national television system committee(NTSC)(CIE1931),liquid-crystal display(LCD)efficiency up to 7.9%,power efficacy 103±2 nits/W,and the high brightness of~550±10 nits.Thus,the proposed ligands can be used for the alignment of a variety of nanorods. | Maksym F.Prodanov Chengbin Kang Swadesh K.Gupta Valerii V.Vashchenko Yuhao Li Minchao Qin Xinhui Lu Abhishek K.Srivastava | 2022 | Nano Research2022，15，6： | 0 |
| 3 | The SARS-CoV-2 spike L452R-E484Q variant in the Indian B.1.617 strain showed significant reduction in the neutralization activity of immune sera显示文摘To assess the impact of the key non-synonymous amino acid substitutions in the RBD of the spike protein of SARS-CoV-2 variant B.1.617.1(dominant variant identified in the current India outbreak)on the infectivity and neutralization activities of the immune sera,L452R and E484Q(L452R-E484Q variant),pseudotyped virus was constructed(with the D614G background).The impact on binding with the neutralizing antibodies was also assessed with an ELISA assay.Pseudotyped virus carrying a L452R-E484Q variant showed a comparable infectivity compared with D614G.However,there was a significant reduction in the neutralization activity of the immune sera from non-human primates vaccinated with a recombinant receptor binding domain(RBD)protein,convalescent patients,and healthy vaccinees vaccinated with anmRNA vaccine.In addition,there was a reduction in binding of L452R-E484Q-D614G protein to the antibodies of theimmune sera fromvaccinated nonhuman primates.These results highlight the interplay between infectivity and other biologic factors involved in the natural evolution of SARS-CoV-2.Reduced neutralization activities against the L452R-E484Q variant will have an impact on health authority planning and implications for the vaccination strategy/newvaccine development. | Gen Li Zhongcheng Zhou Peng Du Meixing Yu Ning Li Xinxin Xiong Hong Huang Zhihai Liu Qinjin Dai Jie Zhu Chengbin Guo ShanyunWu Daniel T.Baptista-Hon Man Miao LamWai Ming Yong Wu Fanxin Zeng Charlotte L.Zhang Edward D.Zhang Haifeng Song Jianghai Liu Johnson Yiu-Nam Lau Andy P.Xiang Kang Zhang | 2021 | Precision Clinical Medicine2021，4，3： | 0 |
| 4 | Hallmark guided identification and characterization of a novel immune-relevant signature for prognostication of recurrence in stageⅠ-Ⅲlung adenocarcinoma显示文摘The high risk of postoperative mortality in lung adenocarcinoma(LUAD)patients is principally driven by cancer recurrence and low response rates to adjuvant treatment.Here,A combined cohort containing 1,026 stageⅠ-Ⅲpatients was divided into the learning(n Z 678)and validation datasets(n Z 348).The former was used to establish a 16-mRNA risk signature for recurrence prediction with multiple statistical algorithms,which was verified in the valida-tion set.Univariate and multivariate analyses confirmed it as an independent indicator for both recurrence-free survival(RFS)and overall survival(OS).Distinct molecular characteristics between the two groups including genomic alterations,and hallmark pathways were compre-hensively analyzed.Remarkably,the classifier was tightly linked to immune infiltrations,high-lighting the critical role of immune surveillance in prolonging survival for LUAD.Moreover,the classifier was a valuable predictor for therapeutic responses in patients,and the low-risk group was more likely to yield clinical benefits from immunotherapy.A transcription factor regulato-ry proteineprotein interaction network(TF-PPI-network)was constructed via weighted gene co-expression network analysis(WGCNA)concerning the hub genes of the signature.The con-structed multidimensional nomogram dramatically increased the predictive accuracy.There-fore,our signature provides a forceful basis for individualized LUAD management with promising potential implications. | Yongqiang Zhang Zhao Yang Yuqin Tang Chengbin Guo Danni Lin d Linling Cheng Xun Hu Kang Zhang Gen Li | 2023 | Genes & Diseases2023，10，4： | 0 |
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