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您的检索式：作者名="Chengfeng Yue"
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| 1 | Cystatin C Induces Insulin Resistance in Hippocampal Neurons and Promotes Cognitive Dysfunction in Rodents显示文摘Dear Editor,Cognitive impairment is a hallmark of neurodegenerative disorders such as Alzheimer’s disease(AD)and Parkinson’s disease.Growing evidence has demonstrated that cognitive impairment is closely associated with | Lan Luo Jinyu Ma Yue Li Zongkang Hu Chengfeng Jiang Hao Cai Cheng Sun | 2018 | Neuroscience Bulletin2018，34，3： | 8 |
| 2 | Decoding of Raman spectroscopy-encoded suspension arrays based on the detail constraint cycle domain adaptive model显示文摘Previous studies have already shown that Raman spectroscopy can be used in the encoding of suspension array technology.However,almost all existing convolutional neural network-based decoding approaches rely on supervision with ground truth,and may not be well generalized to unseen datasets,which were collected under different experimental conditions,applying with the same coded material.In this study,we propose an improved model based on CyCADA,named as Detail constraint Cycle Domain Adaptive Model(DCDA).DCDA implements the clasification of unseen datasets through domain adaptation,adapts representations at the encode level with decoder-share,and enforces coding features while leveraging a feat loss.To improve detailed structural constraints,DCDA takes downsample connection and skips connection.Our model improves the poor generalization of existing models and saves the cost of the labeling process for unseen target datasets.Compared with other models,extensive experiments and ablation studies show the superiority of DCDA in terms of classification stability and generalization.The model proposed by the research achieves a classification with an accuracy of 100%when applied in datasets,in which the spectrum in the source domain is far less than the target domain. | Yu Yao Kaiwen Xue Liwang Liu Shanshan Zhu Chengfeng Yue Yanhong Ji | 2022 | Journal of Innovative Optical Health Sciences2022，15，4： | 0 |
| 3 | A redox-responsive self-assembling COA-4-arm PEG prodrug nanosystem for dual drug delivery suppresses cancer metastasis and drug resistance by downregulating hsp90 expression显示文摘Metastasis and resistance are main causes to affect the outcome of the current anticancer therapies.Heat shock protein 90(Hsp90)as an ATP-dependent molecular chaperone takes important role in the tumor metastasis and resistance.Targeting Hsp90 and downregulating its expression show promising in inhibiting tumor metastasis and resistance.In this study,a redox-responsive dual-drug nanocarrier was constructed for the effective delivery of a commonly used chemotherapeutic drug PTX,and a COAmodified 4-arm PEG polymer(4PSC)was synthesized.COA,an active component in oleanolic acid that exerts strong antitumor activity by downregulating Hsp90 expression,was used as a structural and functional element to endow 4PSC with redox responsiveness and Hsp90 inhibitory activity.Our results showed that 4PSC/PTX nanomicelles efficiently delivered PTX and COA to tumor locations without inducing systemic toxicity.By blocking the Hsp90 signaling pathway,4PSC significantly enhanced the antitumor effect of PTX,inhibiting tumor proliferation and invasiveness as well as chemotherapy-induced resistance in vitro.Remarkable results were further confirmed in vivo with two preclinical tumor models.These findings demonstrate that the COA-modified 4PSC drug delivery nanosystem provides a potential platform for enhancing the efficacy of chemotherapies. | Yi Zhou Yingling Miao Qiudi Huang Wenwen Shi Jiacui Xie Jiachang Lin Pei Huang Chengfeng Yue Yuan Qin Xiyong Yu He Wang Linghao Qin Jianhai Chen | 2023 | Acta Pharmaceutica Sinica B2023，13，7： | 0 |
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