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| 1 | New Insights into the Depositional Environments of Ordovician Carbonate Formations in the Yubei Area of Tarim Basin Based on Standard Microfacies Types显示文摘Objective The Yubei area is located in the mid-east Maigaiti slope of southwestern Tarim Basin,China,with an exploration history of several years.Recent exploration has preliminarily indicated that the Ordovician carbonate formations in this area have some oil and gas potential.Carbonate microfacies provides material basis for reservoir development,seal formation and | HUANG Chenjun LIU Geyun MA Yongsheng LIU Bo LIU Hongguang SHI Kaibo | 2017 | Acta Geologica Sinica(English Edition)2017，91，2： | 5 |
| 2 | Hydrocarbon migration in fracture-cave systems of carbonate reservoirs under tectonic stresses:A modeling study显示文摘The Tahe oilfield,located in the southwest of the Akekule nosing structure,northern Tarim basin,was the most prolific oilfield targeting at the Ordovician carbonate reservoirs in China.The reservoir space was dominant with fracture-cave systems commonly induced by tectonics and karstification.Although hydrocarbon production had proceeded for two decades in the Tahe oilfiled,the control of oil and gas accumulations was still doubtful.In this work,the periodic fluid flow induced by cyclic tectonic stresses was proposed as the mechanism of hydrocarbon migration in the fracture-cave systems of carbonate reservoirs.The fracture networks formed conduits for fluid flow,and the fluid pressure in caves transmitted from stress field provided the driving force.The constitutive equations were established among stresses,fracture densities and flow velocities.Four quasi-3D geological models were constructed to simulate the flow velocities on the Ordovician surface of Akekule nosing structure in the critical tectonic stages.The simulated results supplied indicative information on oil and gas migration and accumulation in the tectonic stages.Combining with the oil and gas charge history,a conceptual model was built to reveal the multi-stage oil and gas charge and accumulation in the Ordovician of Akekule nosing structure. | Chenjun Huang Geyun Liu Yongsheng Ma Xingui Zhou Linyan Zhang Jinyin Yin Jinrui Guo | 2019 | Petroleum Research2019，4，4： | 2 |
| 3 | Hydrocarbon migration in fracture-cave systems of carbonate reservoirs under tectonic stresses: A mechanism study显示文摘The fracture-cave systems of carbonate reservoirs have almost stored 30% of recoverable oil and gasaround the world. However, it is still doubtful about the mechanism of hydrocarbon migration in thefracture-cave systems. In this work, deducing from the Eshelby’ solution, we derived the equation tocalculate the bulk strain of elliptic cylinder caves applied by stresses. Calculated results indicate that thebulk strain of caves negatively increases with the radius ratio of the elliptic cave axials under fixedstresses. In the case of the effective horizontal stress increasing from 30 MPa to 80 MPa, the bulk straindifference of a cave could be up to 0.5%. It may result in 0.4% of the total cave volume of fluid transportingthrough the fracture-cave systems within such a stress cycle. Since the tectonic stresses transform in acyclic way, the volumetric ratio of new-to-old fluid in a cave would increase with the number of stresscycles. As a result, we proposed that the periodic fluid flow induced by cyclic tectonic stresses could be animportant mechanism for hydrocarbon migration in the fracture-cave systems of carbonate reservoirs. | Chenjun Huang Geyun Liu Kaibo Shi Jinyin Yin Jinrui Guo Chongzhi Tao | 2020 | Petroleum Research2020，5，2： | 1 |
| 4 | Impact of apolipoprotein A1 on tumor immune microenvironment, clinical prognosis and genomic landscape in hepatocellular carcinoma显示文摘Background:Current knowledge on apolipoprotein A1(APOA1)in hepatocellular carcinoma(HCC)is fragmented and even contradic-tory.Multi-dimensional analyses are required to comprehensively elucidate its value and underlying mechanism.Methods:We collected 49 RNA-seq datasets,40 cell line types data and 70 scRNA pan-cancer datasets public available,including 17 HCC datasets(1754 tumor samples),and enrolled 73 pairs of HCC tissue and 516 blood samples independently from our clinics.APOA1 impacting on the HCC tumor microenvironment(TME)was analyzed using intensive data mining.Methylation sequencing,flow cy-tometry,quantitative PCR,western blot,immunohistochemistry and clinical chemistry assays were conducted for wet experimental investigation.Results:The APOA1 ontology fingerprint indicated that it played various crucial biological roles in HCC,primarily involved in choles-terol efflux.Consistent findings at histology,serology,and clinical follow-up revealed that high APOA1 was a good prognosis indicator of HCc.Hypermethylation in the APOA1 promoter region was found in clinical samples which is in accordance with the reduction of APOA1 in HCC.The cell cycle,DNA replication,mismatch repair pathways,and tumor cell proliferation were less observed in the HCC APOAihigh subgroup.The favorable immunoregulatory abilities of APOA1 showed interesting findings:a positive correlation between APOA1 and anti-tumor immune cells(NK,CD8+T cells)and a negative association with immune cells exerting immunosuppressive effects,including M2 macrophages.Conclusion:This is an integrative multidimensional exploration of APOA1 using bioinformatics and experiments.Both the prognostic value and anti-tumor effects based on APOA1 panoramic exploration in the HCC TME demonstrate a new potential clinicai target for HCC assessment and intervention in the future. | Ying Wang Shipeng Chen Xiao Xiao Fan Yang Jinhan Wange Hui Zong Yuzhen Gao Chenjun Huang Xuewen Xu Meng Fang Xiaoyan Zhang Chunfang Gao | 2023 | Precision Clinical Medicine2023，6，3： | 0 |
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