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| 1 | Highly efficient derivation of ventricular cardiomyocytes from induced pluripotent stem cells with a distinct epigenetic signature显示文摘从 pluripotent 干细胞导出的 Cardiomyocytes 能在药测试,疾病建模和基于房间的治疗被使用。没有 procardiogenic 生长因素,然而,从 pluripotent 干细胞的 cardiomyogenesis 的效率通常是低的,产生 cardiomyocyte 人口是异构的。这里,我们证明导致的 pluripotent 干细胞( iPSCs )能从鼠科的室的 myocytes ( VM )被导出,并且与从各种各样的体的房间类型导出的 iPSCs 的另外的报告一致,自发地作为与遗传上匹配的胚胎的干细胞(转换字符)或 iPSCs 相比区分 cardiomyocytes 进跳动的显著地更高的倾向从尾巴尖端成纤维细胞导出的 导出VM 的 iPSCs ( ViPSCs )展览。惊人地,导出 ViPSC 的 cardiomyocytes 显示的多数室的显型。在 ViPSCs 的提高的室的 myogenesis 在区别的早阶段经由心血管的祖先的增加的数字被调停。以便从 ViPSCs 调查提高的室的 myogenesis 的机制,我们执行了全球基因表示和 DNA methylation 分析,它揭示了可以涉及在 pluripotent 干细胞指定 VM 命运的不同 epigenetic 签名。 | Huansheng Xu B Alexander Yi Hao Wu Christoph Bock Hongcang Gu Kathy O Lui Joo-Hye C Park Ying Shao Alyssa K Riley Ibrahim J Domian Erding Hu Robert Willette John Lepore Alexander Meissner Zhong Wang Kenneth R Chien | 2012 | Cell Research2012，22，1： | 7 |
| 2 | GFAP-deficient astrocytes are capable of stellation in vitro when cocultured with neurons and exhibit a reduced amount of intermediate filaments and an increased cell saturation density显示文摘 | Pekny M Eliasson C Chien C L | 1998 | Exp Cell Res1998，239，2： | 2 |
| 3 | Acute exacerbation and hepatits B virus clearance after emergence of YMDD motif mutantion lamivudine therapy显示文摘 | LIAW Y F CHIEN R N YEH C T | 1999 | Hepatology1999，20，2： | 2 |
| 4 | Acute exacerbation and hepatitis B virus clearance after emergence of YMDD motif mutation during lamivudine therapy 显示文摘 | Liaw Y F Chien R N Yeh C T | 1999 | Hepatology1999，30，2： | 1 |
| 5 | Relevant term suggestion in interactive Web search based on contextual information in query session logs显示文摘 | Huang C K Chien L F Oyang Y J | 2003 | JASIST2003，54，7： | 1 |
| 6 | Skin color detection through estimation and conversion of illuminant color under various illuminations 显示文摘 | Do H C You J Y Chien S | 2007 | IEEE Transactions on Consumer Electronics2007，53，3： | 1 |
| 7 | Resistance to ammonia stress of Penaeus monodon Fabricius Juvenile fed diets supplemented with astaxanthin 显示文摘 | PAN C H CHIEN Y H HUNTER B T | 2003 | J Exp Marine Biol Ecol2003，297，1： | 1 |
| 8 | Relevant term suggestion in interactive web search based on contextual information in query session logs 显示文摘 | Huang C K Chien L F Oyang Y J | 2003 | Journal of the American Society for Information Science and Technology2003，54，7： | 1 |
| 9 | A simplified transient three - dimensional model for estimating the thermal performance of the vapor chambers显示文摘 | Chen Y S Chien K H Wang C C | 2006 | Applied Thermal Engineering2006，26，： | 1 |
| 10 | Accumulation of ammonium in rice leaves in response to excess cadmium显示文摘 | CHIEN H F KAO C H | 2000 | Plant Science2000，156，： | 1 |
| 11 | Surface conjugation of zwitterionie polymers to inhibit cell adhesion and protein ad- sorption 显示文摘 | CHIEN H W TSAI C C TSAI W B | 2013 | Colloids and Surface B: Biointerfaces2013，107，： | 1 |
| 12 | Using Bayesian Network for Fault Location on Distribution Feeder of Electrical Power Delivery System显示文摘 | Chien C Chen S Lin Y | | 0，，13： | 1 |
| 13 | A fast and simple method to fabricate circular mierochannels in polydimethylsi- loxane (PDMS)显示文摘 | Abdelgawad M Wu C Chien W Y | 2011 | Lab Chip2011，11，3： | 1 |
| 14 | Mitogenic effect of oxidized low density lipoprotein on vascular smooth muscle cells mediated by activation of Ras/Raf/MEK/MAPK pathway显示文摘 | Chien C S Hsiao L D | 2001 | Br J Pharmacol2001，132，7： | 1 |
| 15 | RNA-protein interactions,involvement of NS3,NS5,and 3′noncoding region of Japanese encephalitis virus genomic RNA显示文摘 | Kuro M D Chien L J | 1997 | J Virol1997，71，： | 1 |
| 16 | Elimination of false positives that arise in using the two-hybrid system显示文摘 | Bartel P L Chien C T Sternglanz R | 1993 | Biotechniques1993，14，： | 1 |
| 17 | Cloud droplet growth by condensotion in cumulus显示文摘 | Mason B J Chien C W | 1962 | Quarterly Journal of the Royal Meteorological Society1962，88，136： | 1 |
| 18 | Correlation between processing parameters and microstructure of electrospun poly(D, L-lactic acid) nanofibers显示文摘 | Wang C Chien H S Yan K W | 2009 | Polymer2009，50，25： | 1 |
| 19 | Three-dimensional transient elastodynamic analysis by a space and time- discontinuous Galerkin finite element method显示文摘 | Chien C C Yang C S Tang J H | 2003 | Finite Elements in Analysis and Design2003，39，： | 1 |
| 20 | Changes in B-type natriuretic peptide improve weaning outcome predicted by spon- taneous breathing trial显示文摘 | CHIEN J Y LIN M S HUANG Y C | 2008 | Crit Care Med2008，36，5： | 1 |
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