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| 1 | Gastric cancer risk in relation to tobacco use and alcohol drinking in Kerala, India-Karunagappally cohort study显示文摘AIM: To assess the risk of gastric cancer(GC) in relation to tobacco use and alcohol drinking in the Karunagappally cohort in Kerala, South India.METHODS: This study examined the association of tobacco use and alcohol drinking with GC incidence among 65553 men aged 30-84 in the Karunagappally cohort. During the period from 1990-2009, 116 GC cases in the cohort were identified as incident cancers. These cases were identified from the populationbased cancer registry. Information regarding risk factors such as socioeconomic factors and tobacco and alcohol habits of cohort members were collected from the database of the baseline survey conducted during 1990-1997. The relative risks(RRs) and the corresponding 95% confidence intervals(95%CIs) fortobacco use were obtained from Poisson regression analysis of grouped survival data, considering age, follow-up period, occupation and education.RESULTS: Bidi smoking was associated with GC risk(P = 0.042). The RR comparing current versus never smokers was 1.6(95%CI: 1.0-2.5). GC risk was associated with the number of bidis smoked daily(P = 0.012) and with the duration of bidi smoking(P = 0.036). Those who started bidi smoking at younger ages were at an elevated GC risk; the RRs for those starting bidi smoking under the age of 18 and ages 18-22 were 2.0(95%CI: 1.0-3.9) and 1.8(95%CI: 1.1-2.9), respectively, when their risks were compared with lifetime non-smokers of bidis. Bidi smoking increased the risk of GC among never cigarette smokers more evidently(RR = 2.2; 95%CI: 1.3-4.0). GC risk increased with the cumulative amount of bidi smoking, which was calculated as the number of bidis smoked per day x years of smoking(bidi-year; P = 0.017). Cigarette smoking, tobacco chewing or alcohol drinking was not significantly associated with GC risk. CONCLUSION: Among a male cohort in South India, gastric cancer risk increased with the number and duration of bidi smoking. | Padmavathy Amma Jayalekshmi Soroush Hassani Athira Nandakumar Chihaya Koriyama Paul Sebastian Suminori Akiba | 2015 | World Journal of Gastroenterology2015，21，44： | 19 |
| 2 | Epstein-Barr virus-associated gastric carcinoma: Evidence of age-dependence among a Mexican population显示文摘AIM: To investigate features of Epstein-Barr virus (EBV)-associated gastric carcinoma (EBVaGC) among a Mexican population.METHODS: Cases of primary gastric adenocarcinoma were retrieved from the files of the Departments of anatomic site of the gastric neoplasia was identified, and carcinomas were histologically classified as intestinal and diffuse types and subclassified as proposed by the Japanese Research Society for Gastric Cancer. EBV-encoded small non-polyadenylated RNA-1 (EBER-1)in situ hybridization was conducted to determine the presence of EBV in neoplastic cells.RESULTS: We studied 330 consecutive, non-selected,primary gastric carcinomas. Among these, there were173 male and 157 female patients (male/female ratio1.1/1). EBER-1 was detected in 24 (7.3%) cases (male/female ratio: 1.2/1). The mean age for the entire group was 58.1 years (range: 20-88 years), whereas the mean age for patients harboring EBER-1-positive gastric carcinomas was 65.3 years (range: 50-84 years). Age and histological type showed statistically significant differences, when EBER-1-positive and -negative gastric carcinomas were compared. EBER-1 was detected in hyperplastic- and dysplastic-gastric mucosa surrounding two EBER-1-negative carcinomas, respectively.CONCLUSION: Among Latin-American countries, Mexico has the lowest frequency of EBVaGC. Indeed, the Mexican population >50 years of age was selectively affected. Ethnic variations are responsible for the epidemiologic behavior of EBVaGC among the worldwide population. | Roberto Herrera-Goepfert Suminori Akiba Chihaya Koriyama Shan Ding Edgardo Reyes Tetsuhiko Itoh Yoshie Minakami Yoshito Eizuru | 2005 | World Journal of Gastroenterology2005，11，39： | 14 |
| 3 | Risk factors of gastric cancer specific for tumor location and histology in Cali,Colombia显示文摘AIM: To examine histology- and tumor-location specific risk factors of gastric cancer (GC). METHODS: This was a case-control study. The study subjects were 216 GC patients newly diagnosed during the period 2000-2002 and 431 controls selected from non-cancer patients matching in age, gender, and hospital. We obtained information on lifestyles, dietary habits, and others by a questionnaire. RESULTS: The subjects who were not eldest among his/her siblings were at a slightly elevated GC risk (OR 1.3; 95% CI 0.8-2.0). Salting meals before tasting was related to an increased GC risk (OR 3.5; 95% CI 1.6- 7.3). Frequent consumptions of fruits (OR 0.3; 95% CI 0.1-1.0) and vegetables (OR 0.3; 95% CI 0.1-1.0) were related to decreased GC risks. On the other hand, frying foods (OR 1.9; 95% CI 1.0-3.6) and cooking with coal (OR 1.8; 95% CI 1.3-2.6) were related to increased GC risks. Neither Lauren’s histological classification (intestinal and diffuse types) nor tumor location significantly affected those associations except birth order. The subjects who were not eldest among his/her siblings had an increased risk of GCs in the distal and middle thirds, and their ORs were 1.7 (95% CI 1.0-2.8) and 1.9 (95% CI 0.8-4.3), respectively. The corresponding OR in the upper third stomach was 0.3 (95% CI 0.1-0.9). The differences of those three ORs were statistically significant (P = 0.010). CONCLUSION: The present study shows that birth or- der, salt intake, consumption of fruits and vegetables, the type of cooking, and cigarette smoking are related to GC risk. In histology and tumor-location specific analy- ses, non-eldest person among their siblings is related to an increased GC risk in the distal and middle thirds of the stomach, and is related to a decreased GC risk in the cardia. | Francia Campos Gabriel Carrasquilla Chihaya Koriyama Mauricio Serra Edwin Carrascal Tetsuhiko Itoh Mitsuharu Nomoto Suminori Akiba | 2006 | World Journal of Gastroenterology2006，12，36： | 11 |
| 4 | Human papillomavirus in esophageal squamous cell carcinoma in Colombia and Chile显示文摘AIM: To examine the presence of human papillomavirus (HPV) in esophageal squamous cell carcinoma (ESCC) specimens collected from Colombia and Chile located in the northern and southern ends of the continent, respectively. METHODS: We examined 47 and 26 formalin-fixed and paraffin-embedded ESCC specimens from Colombia and Chile, respectively. HPV was detected using GP5+/GP6+ primer pair for PCR, and confirmed by Southern blot analysis. Sequencing analysis of L1 region fragment was used to identify HPV genotype. In addition, P16INK4A protein immunostaining of all the specimens was conducted. RESULTS: HPV was detected in 21 ESCC specimens (29%). Sequencing analysis of L1 region fragment identified HPV-16 genome in 6 Colombian cases(13%) and in 5 Chilean cases (19%). HPV-18 was detected in 10 cases (21%) in Colombia but not in any Chilean case. Since Chilean ESCC cases had a higher prevalence of HPV-16 (without statistical significance), but a significantly lower prevalence of HPV-18 than in Colombian cases (P = 0.011) even though the two countries have similar ESCC incidence rates, the frequency of HPV-related ESCC may not be strongly affected by risk factors affecting the incidence of ESCC. HPV-16 genome was more frequently detected in p16 positive carcinomas, although the difference was not statistically significant. HPV-18 detection rate did not show any association with p16 expression. Well-differentiated tumors tended to have either HPV-16 or HPV-18 but the association was not statistically significant. HPV genotypes other than HPV-16 or 18 were not detected in either country. CONCLUSION: HPV-16 and HPV-18 genotypes can be found in ESCC specimens collected from two South American countries. Further studies on the relationship between HPV-16 presence and p16 expression in ESCC would aid understanding of the mechanism underlying the presence of HPV in ESCC. | Andres Castillo Francisco Aguayo Chihaya Koriyama Miyerlandi Torres Edwin Carrascal Alejandro Corvalan Juan P Roblero Cecilia Naquira Mariana Palma Claudia Backhouse Jorge Argandona Tetsuhiko Itoh Karem Shuyama Yoshito Eizuru Suminori Akiba | 2006 | World Journal of Gastroenterology2006，12，38： | 11 |
| 5 | Coexistence of esophageal superficial carcinoma and multiple leiomyomas:A case report显示文摘平滑肌瘤是食管的最普通的良性瘤。他们通常作为单个损害或作为二或三个小瘤发生。仅仅包括超过 10 个小瘤的食道的多重平滑肌瘤的二个案例以前被报导了。而且,有食道的有鳞的房间癌覆闷死粘膜下层肿瘤的很少报告。我们描述作为有表面的食道的癌症与二或三个平滑肌瘤小瘤共存被诊断的一个 71 岁的人。在外科期间, 10 或一直不外科手术前地是明显的更多的小瘤在整个食管在粘膜下层和肌层是摸得出的。当食道的癌症的内部转移被怀疑,我们认为另外的淋巴是腺切除术,但是因为病人的严重血缺氧,不得不排除这种选择。显微镜检查表明所有小瘤是平滑肌瘤(20 损害,在直径的多达 3 厘米) ,并且癌房间的那侵略被限制到粘膜下层层 overlying 一个相对大的平滑肌瘤。这是与众多的独居的平滑肌瘤共存的表面的食道的癌症的第一份报告。多重极小的平滑肌瘤经常也在一个癌损害罐头的底作为内部转移,和一个平滑肌瘤被误诊作为肿瘤侵略被误诊。现在的案例证明那精确诊断与共存为病人的管理被要求表面的食道的癌症和多重平滑肌瘤。 | Takeshi Iwaya Chihaya Maesawa Noriyuki Uesugi Toshimoto Kimura Kenichiro Ikeda Yusuke Kimura Shingo Mitomo Kaoru Ishida Nobuhiro Sato Go Wakabayashi | 2006 | World Journal of Gastroenterology2006，12，28： | 7 |
| 6 | E-cadherin and beta-catenin expression in Epstein-Barr virus-associated gastric carcinoma and their prognostic significance显示文摘AIM: To examine the role of E-cadherin and beta- catenin in carcinogenesis and to assess their prognostic implication in Epstein-Barr virus-associated gastric carcinomas (EBV-GCs). METHODS: We compared the frequency of E-cadherin and beta-catenin expression in 59 EBV-GCs and 120 non-EBV-GCs, and examined the association between patients' prognosis and the expressions of these proteins. RESULTS: Neither the cellular-membranous nor the cytoplasmic E-cadherin expression showed any difference between EBV-GCs and non-EBV-GCs. On the other hand, loss of membranous expression of beta- catenin occurred more frequently in non-EBV-GCs than EBV-GCs [odds ratio = 0.41; 95% confidence interval (CI), 0.19-0.90]. Furthermore, the nuclear and/or cytoplosmic expression of beta-catenin was seen more frequentlyin EBV-GCs than non-EBV-GCs (odds ratio = 2.23; 95% CI, 0.97-5.09), and was observed in a larger proportion of carcinoma cells of EBV-GCs than non-EBV-GCs (P = 0.024). Survival analysis for non-EBV-GC revealed that lymph node metastasis was significantly associated with poor prognosis (P < 0.001). Among EBV- GCs, the depth of invasion (P = 0.005), lymph node metastasis (P = 0.004) and an intestinal type by Lauren classification (hazard ratio = 9.47; 95% CI, 2.67-33.6) were significantly associated with poor prognosis. On the other hand, nuclear and/or cytoplasmic expression of beta-catenin was associated with a better prognosis in patients with EBV-GC (hazard ratio = 0.32; 95% CI, 0.11-0.93). CONCLUSION: We observed more frequent preservation of beta-catenin in cell membrane and accumulation in nuclei and/or cytoplasm in EBV-GCs than in non-EBV- GCs. Factors involved in the prognosis of EBV-GCs and non-EBV-GCs are different in the two conditions. | Chihaya Koriyama Suminori Akiba Tetsuhiko Itoh Kazunobu Sueyoshi Yoshie Minakami Alejandro Corvalan Suguru Yonezawa Yoshito Eizuru | 2007 | World Journal of Gastroenterology2007，13，29： | 6 |
| 7 | Liver cirrhosis induced by long-term administration of a daily low dose of amiodarone: A case report显示文摘The anti-arrhythmic agent amiodarone (AD) is associated with numerous adverse effects, but serious liver disease is rare. The improved safety of administration of daily low doses of AD has already been established and this regimen is used for long-term medication. Nevertheless,asymptomatic continuous liver injury by AD may increase the risk of step-wise progression of non-alcoholic fatty liver disease. We present an autopsy case of AD-induced liver cirrhosis in a patient who had been treated with a low dose of AD (200 mg/d) daily for 84 mo. The patient was a 85-year-old male with a history of ischemic heart disease.Seven years after initiation of treatment with AD, he was admitted with cardiac congestion. The total dose of AD was 528 g. Mild elevation of serum aminotransferase and hepatomegaly were present. Liver biopsy specimens revealed cirrhosis, and under electron microscopy numerous lysosomes with electron-dense, whorled, lamellar inclusions characteristic of a secondary phospholipidosis were observed. Initially, withdrawal of AD led to a slight improvement of serum aminotransferase levels, but unfortunately his general condition deteriorated and he died from complications of pneumonia and renal failure.Long-term administration of daily low doses of AD carries the risk of progression to irreversible liver injury. Therefore,periodic examination of liver function and/or liver biopsy is required for the management of patients receiving long-term treatment with AD. | Hiroki Oikawa Chihaya Maesawa Ryo Sato Kanta Oikawa Hiroyuki Yamada Seizo Oriso Sadahide Ono Akiko Yashima-Abo Koji Kotani Kazuyuki Suzuki Tomoyuki Masuda | 2005 | World Journal of Gastroenterology2005，11，34： | 4 |
| 8 | Case–case comparison of smoking and alcohol risk associations with Epstein–Barr virus‐positive gastric cancer显示文摘 | M. Constanza Camargo Chihaya Koriyama Keitaro Matsuo Woo‐Ho Kim Roberto Herrera‐Goepfert Linda M. Liao Jun Yu Gabriel Carrasquilla Joseph J.Y. Sung Isabel Alvarado‐Cabrero Jolanta Lissowska Fernando Meneses‐Gonzalez Yashushi Yatabe Ti Ding Nan Hu Philip R | 2014 | Int J Cancer2014，，4： | 1 |
| 9 | Cell-Type-Specific Repression of the Maspin Gene Is Disrupted Frequently by Demethylation at the Promoter Region in Gastric Intestinal Metaplasia and Cancer Cells显示文摘 | Yuji Akiyama Chihaya Maesawa Satoshi Ogasawara | 2003 | American Journal of Pathology2003，163，5： | 1 |
| 10 | Analysis of rainbow trout peripheral blood leucocytes separated by cytometry cell sorting显示文摘 | Akkashi K Chihaya N | 1999 | Fish Path1999，34，1： | 1 |
| 11 | Retinoic acid enhances the gene expression of human polymenic immunoglobulin receptor (pIgR) by TNF-α显示文摘 | Takenouchi-ohkubo N Asano M Chihaya H | 2004 | Clin Exp Immunol2004，135，： | 1 |
| 12 | High-effi- ciency yellow double-doped organic light-emitting devices based on phosphor-sensitized fluorescence显示文摘 | Brian W D' A Marc A B Chihaya A | 2001 | Appl Phys Lett2001，79，7： | 1 |
| 13 | 电磁式可变气门正时系统的研究显示文摘预料能减少燃油耗的无节流技术越来越受到人们的关注。介绍基于电磁式可变气门正时机构(电磁式气门机构)的无节流技术的研究。电磁式气门机构能确保气门开/关的高效率和稳定控制。介绍了本研究的详细信息和结果。此外,还阐述了电磁式气门机构在均质充量压燃(HCCI)发动机上应用的优点。 | Chihaya Sugimoto | 2006 | 国外内燃机2006，38，4： | 1 |
| 14 | Highly Efficient Organic Light‐Emitting Diode Based on a Hidden Thermally Activated Delayed Fluorescence Channel in a Heptazine Derivative显示文摘 | Jie Li Tetsuya Nakagawa James MacDonald Qisheng Zhang Hiroko Nomura Hiroshi Miyazaki Chihaya Adachi | 2013 | Adv Mater2013，，24： | 1 |
| 15 | Quantitative assessment of minimal residual disease in childhood lymphoid malignancies using an allele-specific oligonucleotide real-time quantitative polymerase chain reaction显示文摘 | Mitsu Tarusawa Akiko Yashima Mikiya Endo Chihaya Maesawa | 2002 | International Journal of Hematology2002，，2： | 1 |
| 16 | Enhanced Electroluminescence Efficiency in a Spiro‐Acridine Derivative through Thermally Activated Delayed Fluorescence显示文摘 | Gábor Méhes Hiroko Nomura Qisheng Zhang Tetsuya Nakagawa Chihaya Adachi | 2012 | Angew Chem Int Ed2012，，45： | 1 |
| 17 | The usefulness of cyclophosphamide pretreatment for subrenal capsule assay against human esophageal cancer显示文摘 | Masanori Terashima MD Kenichiroh Ikeda Shuji Kawamura Chihaya Maesawa Kaoru Ishida Masao Sato Kazuyoshi Saito | 1991 | The Japanese Journal of Surgery1991，，2： | 1 |
| 18 | Association of ser- um levels of polychlorinated biphenyls with IL-8 mRNA expres- sion in blood samples from asthmatic and non-asthmatic Japa- nese children显示文摘 | Mayumi T Christoph FAV Chihaya K | 2012 | Chemosphere: Environmental toxicology and risk assessment2012，87，11： | 1 |
| 19 | Impaired Fertility in Female Mice Lacking Urinary Trypsin Inhibitor显示文摘 | Hiroyuki Sato Satoshi Kajikawa Shoko Kuroda Yoshifumi Horisawa Norio Nakamura Nobuhiko Kaga Chihaya Kakinuma Katsuaki Kato Hideaki Morishita Hitoshi Niwa Jun-ichi Miyazaki | 2001 | Biochemical and Biophysical Research Communications2001，，5： | 1 |
| 20 | A disintegrin and metalloproteinase 17 (ADAM17) mediates epidermal growth factor receptor transactivation by angiotensin II on hepatic stellate cells显示文摘 | Hiroki Oikawa Chihaya Maesawa Yoshinori Tatemichi Yutaka Nishinari Masao Nishiya Hisata Mizugai Aya Ikeda Kanta Oikawa Yasuhiro Takikawa Tomoyuki Masuda | 2014 | Life Sciences2014，，： | 1 |
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